Journal of Tuberculosis Research最新文献

Investigating Prevalence of Bovine Tuberculosis in Cattle in an Agro-Pastoral Community in Awdal Region, Somaliland 索马里兰Awdal地区农牧社区牛结核病流行情况调查

Journal of Tuberculosis Research Pub Date : 2023-01-01 DOI: 10.4236/jtr.2023.113014

Amina Husein Mohamed, Fred Wesonga, Abdullahi Sh. Mohamed, Osman Abdullahi Farah, Muse Mohamed Awaleh, Mustafe Ahmed Ismail

{"title":"Investigating Prevalence of Bovine Tuberculosis in Cattle in an Agro-Pastoral Community in Awdal Region, Somaliland","authors":"Amina Husein Mohamed, Fred Wesonga, Abdullahi Sh. Mohamed, Osman Abdullahi Farah, Muse Mohamed Awaleh, Mustafe Ahmed Ismail","doi":"10.4236/jtr.2023.113014","DOIUrl":"https://doi.org/10.4236/jtr.2023.113014","url":null,"abstract":"Awdal region is the most northwesterly province of Somaliland. The region is one of the agro-pastoral livelihood zones in Somaliland, where farming and agricultural production are the predominant livelihood sources. IGAD (Intergovernmental Authority on Development) Sheikh Technical University of Science (ISTUS) worked to study the prevalence of Bovine Tuberculosis (TB) among cattle in Awdal region of Somaliland. The aim was to inform public health and Veterinary experts on having one-health approach to infectious diseases among humans and animals. The serum that was stored at -20&#730C was transported to IGAD Sheikh Technical University of Science (ISTUS) for further analysis using BOVIGAM serological test (Sandwich ELISA). The results indicate that Bovine Tuberculosis is highly prevalent in the study area (10.1%). The high prevalence recorded in the current study could be due to the consumption of raw milk and lack of proper control strategies in place to control the transmission of the disease between animals, between animals and wildlife and between animals and humans. Hence, an awareness creation campaign should be created on bTB transmission and its public health significance to cattle owners, milk and meat consumers and people who are in close proximity to cattle. In addition, testing and eradication programme should be implemented where applicable.","PeriodicalId":17559,"journal":{"name":"Journal of Tuberculosis Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135698917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical Optimization of GeneXpert Ultra for Detection of Tuberculosis in CSF Samples GeneXpert Ultra检测脑脊液结核的分析优化

Journal of Tuberculosis Research Pub Date : 2023-01-01 DOI: 10.4236/jtr.2023.113013

Victoria L. Campodónico, Derek T. Armstrong, Gene Olinger, Erin A. Merritt, Ryan Howard, Margaret Megan Lemmon, Nikki Parrish

引用次数: 0

Identifying Risk Factors for Pulmonary Tuberculosis Diagnosis Delays in Mali a West-African Endemic Country. 确定西非肺结核流行国家马里肺结核诊断延误的风险因素。

Journal of Tuberculosis Research Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.4236/jtr.2022.101004

Dianguina Soumare, Bocar Baya, Khadidia Ouattara, Tenin Kanoute, Cheick M Sy, Seydou Karembé, Ibrahima Guindo, Lamine Coulibaly, Youssouf Kamian, Aime P Dakouo, Fatoumata Sidibe, Salif Koné, Drissa Kone, Oumar Yossi, Gaoussou Berthe, Yacouba Toloba

{"title":"Identifying Risk Factors for Pulmonary Tuberculosis Diagnosis Delays in Mali a West-African Endemic Country.","authors":"Dianguina Soumare, Bocar Baya, Khadidia Ouattara, Tenin Kanoute, Cheick M Sy, Seydou Karembé, Ibrahima Guindo, Lamine Coulibaly, Youssouf Kamian, Aime P Dakouo, Fatoumata Sidibe, Salif Koné, Drissa Kone, Oumar Yossi, Gaoussou Berthe, Yacouba Toloba","doi":"10.4236/jtr.2022.101004","DOIUrl":"10.4236/jtr.2022.101004","url":null,"abstract":"Background: Tuberculosis was the deadliest infectious agent before covid-19; 1.5 million deaths in 2020. Despite, a variety, of easy and cheap diagnostic tools, detection rates still fall below 90%; diagnosis delays are long exceeding 30 days in many continents. This study aimed to determine risk factors for pulmonary TB diagnosis delays in Mali.Methods: A cross-sectional study was conducted in Bamako to include pulmonary TB patients at treatment initiation centers. Verbal consent was obtained before the interview. Demographics, clinical, treatment cost, and patient, medical, and diagnostic delays were computed using SPSS 25.0 considering a significance level p < 0.05.Results: In total 266 patients were included, 80.8% were male, mean age was ± 12 years, primary education level was 50.4%, treatment cost before diagnosis was 100 - 200 thousand CFA in 65.4%, smokers were 42.1%, median patient, medical and total diagnostic delays were 58, 57 and 114 days respectively. Education level below university, social reasons, and non-request of health workers were identified as independent risk factors for diagnostic delay > 100 days in Mali.Conclusion: Diagnostic delay is relatively very long in Mali, there is an urgent need for identification and action to shorten the delays to limit the transmission chain and avoid disabling pulmonary sequels.","PeriodicalId":17559,"journal":{"name":"Journal of Tuberculosis Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9429805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40343336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of HIV Testing among Children and Adults with Tuberculosis, Vietnam. 越南儿童和成人结核病患者艾滋病毒检测的比较。

Journal of Tuberculosis Research Pub Date : 2017-12-01 Epub Date: 2017-12-29 DOI: 10.4236/jtr.2017.54030

Tyson Volkmann, Binh Nguyen, Ebelechukwu G Anyalechi, Kimberly N Chapman Hedges, Ho Van Anh, Pham Quang Tue, Nguyen Viet Nhung, Eleanor S Click

引用次数: 1

Drug-Induced Hypothyroidism during Anti-Tuberculosis Treatment of Multidrug-Resistant Tuberculosis: Notes from the Field. 耐多药结核病抗结核治疗中药物性甲状腺功能减退:来自现场的记录。

Journal of Tuberculosis Research Pub Date : 2016-09-01 Epub Date: 2016-08-23 DOI: 10.4236/jtr.2016.43013

Somashekar Munivenkatappa, Singarajipura Anil, Balaji Naik, Tyson Volkmann, Karuna D Sagili, Jayachamarajapura S Akshatha, Shashidhar Buggi, Manchenahalli A Sharada, Sudhendra Kulkarni, Vineet K Chadha, Patrick K Moonan

{"title":"Drug-Induced Hypothyroidism during Anti-Tuberculosis Treatment of Multidrug-Resistant Tuberculosis: Notes from the Field.","authors":"Somashekar Munivenkatappa, Singarajipura Anil, Balaji Naik, Tyson Volkmann, Karuna D Sagili, Jayachamarajapura S Akshatha, Shashidhar Buggi, Manchenahalli A Sharada, Sudhendra Kulkarni, Vineet K Chadha, Patrick K Moonan","doi":"10.4236/jtr.2016.43013","DOIUrl":"https://doi.org/10.4236/jtr.2016.43013","url":null,"abstract":"We followed 188 euthyroidic persons undergoing treatment for multidrug resistant tuberculosis (MDR-TB) in the state of Karnataka, India to determine the incidence of hypothyroidism during anti-tuberculosis treatment. Overall, among MDR-TB patients with valid thyroid stimulating hormone (TSH) values, about 23% developed hypothyroidism (TSH value ≥10 mIU/ml) during anti-tuberculosis treatment; the majority (74%) occurring after 3 months of treatment. Among 133 patients who received a regimen that contained ethionamide, 42 (32%) developed hypothyroidism. Among 17 patients that received a regimen that contained para-aminosalicylate sodium, 6 (35%) developed hypothyroidism. Among 9 HIV positive patients on anti-retroviral treatment, 4 (44%) developed hypothyroidism. These results differ from previously reported 4% incidence of hypothyroidism amongst patients who passively reported thyroidal symptoms during treatment, suggesting routine serologic monitoring of TSH throughout the course of treatment for MDR-TB is warranted.","PeriodicalId":17559,"journal":{"name":"Journal of Tuberculosis Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4236/jtr.2016.43013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34417632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Can Intensified Tuberculosis Case Finding Efforts at Nutrition Rehabilitation Centers Lead to Pediatric Case Detection in Bihar, India? 在印度比哈尔邦，营养康复中心加强肺结核病例发现工作能否导致小儿病例发现?

Journal of Tuberculosis Research Pub Date : 2016-03-30 DOI: 10.4236/jtr.2016.41006

Rajeev R Pathak, Bal Krishna Mishra, Patrick K Moonan, Sreenivas A Nair, Ajay M V Kumar, Mohit P Gandhi, Shamim Mannan, Smita Ghosh

{"title":"Can Intensified Tuberculosis Case Finding Efforts at Nutrition Rehabilitation Centers Lead to Pediatric Case Detection in Bihar, India?","authors":"Rajeev R Pathak, Bal Krishna Mishra, Patrick K Moonan, Sreenivas A Nair, Ajay M V Kumar, Mohit P Gandhi, Shamim Mannan, Smita Ghosh","doi":"10.4236/jtr.2016.41006","DOIUrl":"https://doi.org/10.4236/jtr.2016.41006","url":null,"abstract":"Introduction Seven district-level Nutritional Rehabilitation Centres (NRCs) in Bihar, India provide clinical and nutritional care for children with severe acute malnutrition (SAM). Aim To assess whether intensified case finding (ICF) strategies at NRCs can lead to pediatric case detection among SAM children and link them to TB treatment under the Revised National Tuberculosis Control Programme (RNTCP). Materials and Methods A retrospective cohort study was conducted that included medical record reviews of SAM children registered for TB screening and RNTCP care during July–December 2012. Results Among 440 SAM children screened, 39 (8.8%) were diagnosed with TB. Among these, 34 (87%) initiated TB treatment and 18 (53%) were registered with the RNTCP. Of 16 children not registered under the RNTCP, nine (56%) weighed below six kilograms—the current weight requirement for receiving drugs under RNTCP. Conclusion ICF approaches are feasible at NRCs; however, screening for TB entails diagnostic challenges, especially among SAM children. However, only half of the children diagnosed with TB were treated by the RNTCP. More effort is needed to link this vulnerable population to TB services in addition to introducing child-friendly drug formulations for covering children weighing less than six kilograms.","PeriodicalId":17559,"journal":{"name":"Journal of Tuberculosis Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34741749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Quality of Sputum Specimen Samples Submitted for Culture and Drug Susceptibility Testing at the National Tuberculosis Reference Laboratory-Uganda, July-October 2013. 2013年7月至10月乌干达国家结核病参比实验室提交用于培养和药敏试验的痰标本的质量

Journal of Tuberculosis Research Pub Date : 2015-09-01

Lilian Bulage, Joseph Imoko, Bruce J Kirenga, Terry Lo, Henry Byabajungu, Keneth Musisi, Moses Joloba, Emily Bloss

{"title":"Quality of Sputum Specimen Samples Submitted for Culture and Drug Susceptibility Testing at the National Tuberculosis Reference Laboratory-Uganda, July-October 2013.","authors":"Lilian Bulage, Joseph Imoko, Bruce J Kirenga, Terry Lo, Henry Byabajungu, Keneth Musisi, Moses Joloba, Emily Bloss","doi":"","DOIUrl":"","url":null,"abstract":"Setting: The Uganda National Tuberculosis Reference Laboratory (NTRL) in Kampala.Objective: The proportion of poor quality specimens received for drug susceptibility testing (DST) at the NTRL and factors contributing to poor specimen quality were assessed.Design: A cross-sectional study was conducted of sputum samples received at the NTRL from patients at high risk for multidrug-resistant tuberculosis (MDR TB) during July-October 2013. Demographic, clinical, and bacteriological data were abstracted from laboratory records. A poor quality sample failed to meet any one of four criteria: ≥3 milliliter (ml) volume, delivered within 72 hours, triple packaged, and non-salivary appearance.Results: Overall, 365 (64%) of 556 samples were of poor quality; 89 (16%) were not triple packaged, 44 (8%) were <3 mls, 164 (30%) were not delivered on time, and 215 (39%) were salivary in appearance. Poor quality specimens were more likely to be collected during the eighth month of TB treatment (OR = 2.5, CI = 1.2 - 5.1), from the East or Northeast zones (OR = 2.2, CI = 1.1 - 4.8), and from patients who previously defaulted from treatment (OR = 1.9, CI = 1.1 - 3.2).Conclusion: The majority of sputum samples had poor quality. Additional efforts are needed to improve quality of samples collected at the end of treatment, from East and Northeast zones, and from patients who had previously defaulted.","PeriodicalId":17559,"journal":{"name":"Journal of Tuberculosis Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0