{"title":"The Need for Basic, Translational, and Clinical Research in the Field of Hypertrophic Scars","authors":"B. Carney, J. Shupp, T. Travis","doi":"10.5772/intechopen.96943","DOIUrl":"https://doi.org/10.5772/intechopen.96943","url":null,"abstract":"Hypertrophic scar (HTS) is a fibrotic skin disorder that is marked by excessive inflammation and extracellular matrix deposition in response to cutaneous traumatic injuries such as burns, lacerations, incisions, and abrasions. HTS has various risk factors, available treatments, and treatment effectiveness. Research at the basic, translational, and clinical levels are in their infancy compared to fibrotic diseases in other organ systems. This chapter will review current in vitro and in vivo modeling, and highlight research needs to address gaps in the study of HTS. The following topics will be discussed in the chapter: a. Basic Science Research i. Seminal findings ii. Limitations to these models iii. Suggestions for topics of future research b. Translational Science Research i. Seminal findings ii. Limitations to these models iii. Suggestions for topics of future research c. Clinical Research i. Seminal findings ii. Limitations to these models iii. Suggestions for topics of future research.","PeriodicalId":173730,"journal":{"name":"Wound Healing [Working Title]","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132451521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ilomuanya, I. Cardoso-Daodu, Uloma N. Ubani-Ukoma, Adannaya C. Adebona
{"title":"Polymeric Biomaterials for Wound Healing Incorporating Plant Extracts and Extracellular Matrix Components","authors":"M. Ilomuanya, I. Cardoso-Daodu, Uloma N. Ubani-Ukoma, Adannaya C. Adebona","doi":"10.5772/INTECHOPEN.98556","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.98556","url":null,"abstract":"Biomaterials are constructed to promote or stimulate the processes of wound healing. Polymeric biomaterials can be used to hydrate the wound and serve as barrier to pathogens with plant extracts, antimicrobial agents and extracellular components incorporated to stimulate the healing process. The biological and physical augmentation provided by extracellular matrix derived implants continues facilitate innovation in biomaterials utilized in management of nonhealing wounds. Tissue-processing methodologies can birth extracellular matrix-based devices with characteristic post-implantation responses ranging from the classic foreign body encapsulation of a permanent implant, to one where the implant is degraded and resorbed, to one where the processed extracellular matrix implant is populated by local fibroblasts and supporting vasculature to produce, a viable and metabolically active tissue. Extracellular matrix components and plant extracts have been shown to possesses pharmacological properties with potential for use in the treatment of skin diseases and wound healing. Antioxidant, anti-inflammatory assays, and wound healing assays have been shown to support the dermatological and wound healing usage of these medicinal plants extracts.","PeriodicalId":173730,"journal":{"name":"Wound Healing [Working Title]","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117040968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Nicolaescu, Ș. Berteșteanu, R. Grigore, Mihnea Cojocărița-Condeescu, B. Popescu, C. B. Simion-Antonie, P. Bejenaru, Simona Gloria Munteanu
{"title":"Pharyngocutaneous Fistulas Following Total Laryngectomy","authors":"A. Nicolaescu, Ș. Berteșteanu, R. Grigore, Mihnea Cojocărița-Condeescu, B. Popescu, C. B. Simion-Antonie, P. Bejenaru, Simona Gloria Munteanu","doi":"10.5772/INTECHOPEN.97848","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.97848","url":null,"abstract":"Total laryngectomy is still the final therapeutic solution in cases of locally advanced laryngeal cancer, as well as in cases of therapeutic failure of organ-sparing surgery or radiation therapy. Following excision of the larynx, the remaining pharynx is reconstructed to obtain continuity of the upper digestive tract. One of the most common complications in these patients, despite constant refinement of the procedure, is the development of a pharyngo-cutaneous fistula. These fistulas prolong hospital stay and often require a second surgical procedure, increasing morbidity and cost for the patient, while diminishing his quality of life. Some risk-factors have been identified, but only some may be corrected before surgery to lower this risk. Managing the fistula once present depends on multiple factors, essential being the size of the fistula as well as the position and concomitant factors, with options ranging from conservative measures to aggressive reconstructive surgery with local miocutaneous flaps. Modern vocal rehabilitation with T.E.P. (tracheo-esophageal puncture) and vocal prosthesis placement presents a new challenge – because of the risk of developing a tracheo-esophageal fistula, with an even higher risk for the patient because of tracheal aspiration. Understanding healing mechanisms of these structures is key to proper management of this complication.","PeriodicalId":173730,"journal":{"name":"Wound Healing [Working Title]","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133810692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronic Venous Ulcer","authors":"Walid A.M. Ganod","doi":"10.5772/intechopen.97709","DOIUrl":"https://doi.org/10.5772/intechopen.97709","url":null,"abstract":"This research review is endeavoring to shed the light on the cause and effect of Chronic Venous Ulcer (CVU) in line with its therapeutic procedures. In the last two decades, a lot of the changes occurred in strategy of wound management through developing adjunctive therapy that supported wound healing. Eventually, the latest development was in platelet concentration technology produced the platelet-rich fibrin (PRF). It was categorized as the 2nd generation of platelet concentration family after Platelet Rich Plasma (PRP). Considering that Venous Leg Ulcers (VLUs) accounted for 70% of all leg ulcers and estimated one percent of the population where age as an essential factor has increased its prevalence. The chronicity and refractory nature of venous ulcer had a great effect on the quality of life and work productivity of patients apart from, the expenditure of significant amount of medical resources and efforts. Therefore, the ultimate goal of (VLU) management was to induce a rapid healing without recurrence which mainly helped to improve the quality of life (QoL). The first therapeutic procedure used in treatment of VLU was compression therapy where the application of effective graduated compression decreased the overload in venous system and venous reflux. Furthermore, it accelerated the capillary of blood flow and decreased the capillary of fluid leakage which in return alleviated the limb edema.","PeriodicalId":173730,"journal":{"name":"Wound Healing [Working Title]","volume":"232 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122531059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contribution of Topical Agents to Wound Healing","authors":"Tadej Voljc, D. Semenič","doi":"10.5772/INTECHOPEN.97170","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.97170","url":null,"abstract":"The process of wound healing is often accompanied by bacterial infection or critical colonization, which leads to an extension of the inflammatory response phase and delayed epithelization. In the review of scientific articles, we found the description and mode of action of topical antiseptic agents, including silver and sodium hypochlorite solution, to control the spread of microorganisms. The value of hyaluronic acid for wound healing is described. Furthermore, a novel treatment option with microspheres is mentioned. Attachment of cells to microspheres establishes a local cytokine response that acts anti-inflammatory, cell attachment results also in morphological and functional cell changes that reactivate healing.","PeriodicalId":173730,"journal":{"name":"Wound Healing [Working Title]","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125945524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interferon Therapy for Hypertrophic Scars and Keloids","authors":"AmalorpavaMary Loordhuswamy, S. Elango","doi":"10.5772/INTECHOPEN.96789","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.96789","url":null,"abstract":"Interferons (IFNs) belong to the family of cytokines are widely used to treat keloids owing to their ability to increase collagenase activity thereby reducing the production of collagen and other extracellular matrix (ECM). Intralesional injection of IFN-α – 2b increases the collagenase level by inhibiting the secretion of metalloproteinases, an inhibitor of collagenase. Moreover, the anti-fibrotic activity of IFNs, interfere with fibroblast mediated collagen synthesis. On the other hand, combinatorial therapy has been preferred recently along with IFN due to its side effects observed in various clinical trials conducted only with IFN. Triamcinolone acetonide (TAC) and CO2 lasers along with IFNs are found to be the potential therapy for the treatment of scars and keloids. In this chapter, IFN mediated therapy for the treatment of scars and keloids, its benefits and limitations and the advantages of combinatorial therapy with the appropriate literature support are discussed.","PeriodicalId":173730,"journal":{"name":"Wound Healing [Working Title]","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126567089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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