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Leptin: A Metabolic Signal for the Differentiation of Pituitary Cells 瘦素:垂体细胞分化的代谢信号
Leptin [Working Title] Pub Date : 2021-12-03 DOI: 10.5772/intechopen.100922
Gwen V. Childs, Angela K. Odle, Melanie C. MacNicol, Melody L. Allensworth-James, Tiffany K. Miles, Noor Akhter, Mohsin M. Syed, Angus M. MacNicol
{"title":"Leptin: A Metabolic Signal for the Differentiation of Pituitary Cells","authors":"Gwen V. Childs, Angela K. Odle, Melanie C. MacNicol, Melody L. Allensworth-James, Tiffany K. Miles, Noor Akhter, Mohsin M. Syed, Angus M. MacNicol","doi":"10.5772/intechopen.100922","DOIUrl":"https://doi.org/10.5772/intechopen.100922","url":null,"abstract":"Pituitary cell function is impacted by metabolic states and therefore must receive signals that inform them about nutritional status or adiposity. A primary signal from adipocytes is leptin, which recent studies have shown regulates most pituitary cell types. Subsets of all pituitary cell types express leptin receptors and leptin has been shown to exert transcriptional control through classical JAK/STAT pathways. Recent studies show that leptin also signals through post-transcriptional pathways that involve the translational regulatory protein Musashi. Mechanistically, post-transcriptional control would permit rapid cellular regulation of critical pre-existing pituitary transcripts as energy states change. The chapter will review evidence for transcriptional and/or post-transcriptional regulation of leptin targets (including Gnrhr, activin, Fshb, Gh, Ghrhr, and Pou11f1) and the consequences of the loss of leptin signaling to gonadotrope and somatotrope functions.","PeriodicalId":171258,"journal":{"name":"Leptin [Working Title]","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121586717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leptin and Female Reproductive Health 瘦素与女性生殖健康
Leptin [Working Title] Pub Date : 2021-11-19 DOI: 10.5772/intechopen.101226
Shyam Pyari Jaiswar, Apala Priyadarshini
{"title":"Leptin and Female Reproductive Health","authors":"Shyam Pyari Jaiswar, Apala Priyadarshini","doi":"10.5772/intechopen.101226","DOIUrl":"https://doi.org/10.5772/intechopen.101226","url":null,"abstract":"Leptin is a peptide hormone, secreted primarily by the adipose tissue, placenta being the second leptin-producing tissue in humans. Apart from playing an integral role in food intake regulation and energy balance, leptin is an important signalling molecule affecting human reproduction. Accumulated evidence suggests that leptin has potential roles in the regulation of GnRH and LH secretion, puberty, pregnancy, and lactation. Deregulation of leptin levels has been associated with several reproductive disorders including infertility, recurrent pregnancy loss, and polycystic ovary syndrome. This chapter illustrates the importance of leptin in female reproductive health, its role in the metabolic regulation of reproductive axis and its eventual pathophysiological implications in prevalent reproductive disorders.","PeriodicalId":171258,"journal":{"name":"Leptin [Working Title]","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115069702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Biodiversity of the Adipocyte-Derived Hormone, Leptin 脂肪细胞衍生激素瘦素的生物多样性
Leptin [Working Title] Pub Date : 2021-10-09 DOI: 10.5772/intechopen.100576
R. Manjunathan, Dharanibalan Kasiviswanathan, J. Selvaraj
{"title":"Biodiversity of the Adipocyte-Derived Hormone, Leptin","authors":"R. Manjunathan, Dharanibalan Kasiviswanathan, J. Selvaraj","doi":"10.5772/intechopen.100576","DOIUrl":"https://doi.org/10.5772/intechopen.100576","url":null,"abstract":"The adipocyte derived hormone leptin is known for its pivotal role in the regulation of a variety of physiological functions mainly associated with metabolism and energy homeostasis. One of the major functions of leptin is pertain with its angiogenic induction in support of organ development as well as under pathological conditions such as atherosclerosis and cancer. Leptin is a well-known pro-angiogenic growth factor which exerts its role through Ob-R receptor present on endothelial cells. The therapeutic application of leptin is based on its potential to maintain various functions at pathological conditions. In this book chapter, the multi-diversity potentials of leptin are discussed in detail.","PeriodicalId":171258,"journal":{"name":"Leptin [Working Title]","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125912665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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