Colloidal Nanoparticles for Biomedical Applications XIV最新文献

Colloidal Nanoparticles for Biomedical Applications XIV Pub Date : 2019-05-29 DOI: 10.1117/12.2531200

引用次数: 0

Temporal multiplexing FRET: using single Tb-to-quantum dot pair distance-tuning (Conference Presentation) 时间复用FRET:使用单个tbto量子点对距离调谐(会议报告)

Colloidal Nanoparticles for Biomedical Applications XIV Pub Date : 2019-03-13 DOI: 10.1117/12.2512220

N. Hildebrandt, X. Qiu, Igor L. Medintz, J. Deschamps, Carlos Mingoes, Jiajia Guo

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Imaging single nano-emitters and single cells by electrochemiluminescence microscopy (Conference Presentation) 用电化学发光显微镜成像单个纳米发射器和单个细胞(会议报告)

Colloidal Nanoparticles for Biomedical Applications XIV Pub Date : 2019-03-13 DOI: 10.1117/12.2508621

Junjie Zhu, Cheng Ma

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Third harmonic generation angiography with FeOOH nanoparticle (Conference Presentation) FeOOH纳米颗粒三次谐波血管造影(会议报告)

Colloidal Nanoparticles for Biomedical Applications XIV Pub Date : 2019-03-13 DOI: 10.1117/12.2508495

Tzu-Ming Liu, Chien-Wei Lee, Cheng-Han Wu, Y. Hsieh, Pei‐Chun Wu, Y. Chuang, Chih-Chia Huang

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Bioessential chalcogenides and immunological applications: an in vitro exploration of Selenium nanoparticles as potential carriers and therapeutic agents (Conference Presentation) 生物必需硫属化合物及其免疫学应用:硒纳米颗粒作为潜在载体和治疗剂的体外探索(会议报告)

Colloidal Nanoparticles for Biomedical Applications XIV Pub Date : 2019-03-13 DOI: 10.1117/12.2513343

Brandy A. Vincent, Chrismond D. Smith, J. Mendoza, Ashley N. Tran, J. Méndez, R. Robledo, K. Nash

{"title":"Bioessential chalcogenides and immunological applications: an in vitro exploration of Selenium nanoparticles as potential carriers and therapeutic agents (Conference Presentation)","authors":"Brandy A. Vincent, Chrismond D. Smith, J. Mendoza, Ashley N. Tran, J. Méndez, R. Robledo, K. Nash","doi":"10.1117/12.2513343","DOIUrl":"https://doi.org/10.1117/12.2513343","url":null,"abstract":"In recent years, bioessential element-based chalcogenides, namely Selenium (Se) and Tellurium (Te), have established noted fundamentals as metal-based protective agents. In relation to anti-cancer therapeutics, Se in particular exhibits promising characteristics as potentially effective treatment alternatives due to its notoriety as a highly selective, drug-coordinating element. In addition to their competitive clinical resume, Se nanoparticles packaged as chalcogenides are believed to support anti-inflammatory, antimicrobial and antifungal efforts. Though more is needed to understand the biological effect these materials play within the body, studies postulate that there is significant potential for Se based nanoalloys. Partnering Se with elemental neighbor Te, SexTel-x, these alloys function as target mediators. They are believed to sustain cell viability ARPE-19 cells while initiating apoptotic effects on MDA-MB-453 cancer cells, along with promoting the reduction of reactive oxygen species (ROS) activity. Lastly, cellular integrity is maintained by the lack of DNA fragmentation within normal cells, further supporting the efforts of employing SexTel-x alloys as potential anti-cancer agents. Ultimately, this research will serve as fundamental currency marketing SexTel-x nanoalloys as synergistically compliant anti-inflammatory, anti-cancer therapeutic agents, priming the tone for treatment efficacy.","PeriodicalId":168486,"journal":{"name":"Colloidal Nanoparticles for Biomedical Applications XIV","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127013743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single particle automated Raman trapping analysis (Conference Presentation) 单粒子自动拉曼捕获分析(会议报告)

Colloidal Nanoparticles for Biomedical Applications XIV Pub Date : 2019-03-13 DOI: 10.1117/12.2508224

Jelle Penders, I. Pence, C. Horgan, Mads S. Bergholt, Christopher S. Wood, A. Najer, U. Kauscher, A. Nagelkerke, M. Stevens

引用次数: 0

A needle-like optofluidic probe enables targeted intracellular delivery of molecular cargo into single-cells and tissue ex-vivo (Conference Presentation) 一种针状的光流体探针能够在细胞内靶向递送分子货物到单细胞和离体组织中(会议报告)

Colloidal Nanoparticles for Biomedical Applications XIV Pub Date : 2019-03-13 DOI: 10.1117/12.2524853

A. Doppenberg, M. Meunier, C. Boutopoulos

{"title":"A needle-like optofluidic probe enables targeted intracellular delivery of molecular cargo into single-cells and tissue ex-vivo (Conference Presentation)","authors":"A. Doppenberg, M. Meunier, C. Boutopoulos","doi":"10.1117/12.2524853","DOIUrl":"https://doi.org/10.1117/12.2524853","url":null,"abstract":"Intracellular delivery of molecular cargo is the basis for a plethora of therapeutic applications, including gene therapy and cancer treatment. An efficient method to perform intracellular delivery is the photoactivation of nanomaterials that bear releasable molecular cargo. However, potential in vivo applications of this method are limited by our ability to deliver nanomaterials and light in tissue. \u0000In this paper, we will present method to perform intracellular delivery of molecular cargo on live cells and tissue by using a reusable, needle-like optofluidic probe capable of penetrating soft tissue. The probe consists of a dual-core glass fiber, enabling simultaneous light and liquid delivery. First, we used the optofluidic probe to confine an intracellular delivery mixture, composed of 100 nm gold nanoparticles (AuNP) and membrane-impermeable calcein, in the vicinity of cancer cells and mouse retinal explants. Secondly, we delivered nanosecond (ns) laser pulses (wavelength: 532 nm; duration: 5 ns; 30-90 mJ/cm2) using the same probe and without introducing a AuNP cells incubation step. \u0000We found that AuNP photo-activation caused localized and reversible disruption of the cell membrane, enabling calcein delivery into the cytoplasm. We measured 67% intracellular delivery efficacy and showed that the optofluidic probe can be used to treat cells with single-cell precision. \u0000The method presented here can facilitate in vivo treatments in soft tissue of small animals (e.g. brain, retina), such us nanomaterial-assisted neuro-stimulation, transfection and tumor elimination.","PeriodicalId":168486,"journal":{"name":"Colloidal Nanoparticles for Biomedical Applications XIV","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129006965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A gold nanoparticle bio-optical transponder to dynamically monitor intracellular events (Conference Presentation) 动态监测细胞内事件的金纳米粒子生物光学转发器(会议报告)

Colloidal Nanoparticles for Biomedical Applications XIV Pub Date : 2019-03-13 DOI: 10.1117/12.2510456

G. Strouse

引用次数: 0

Photoluminescence properties of different types of nanocrystals at the ensemble and single emitter level (Conference Presentation) 不同类型纳米晶体在系综和单发射极能级上的光致发光特性(会议报告)

Colloidal Nanoparticles for Biomedical Applications XIV Pub Date : 2019-03-04 DOI: 10.1117/12.2511262

U. Resch‐Genger

引用次数: 0