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Nebulizer, Inhaled Remdesivir Nanoparticle Co-administered with Withania Somnifera may Minimize the Hepatotoxicity in COVID-19 雾化剂、吸入瑞德西韦纳米颗粒与苦参草合用可最大限度地降低COVID-19的肝毒性
Materials Highlights Pub Date : 2021-07-01 DOI: 10.2991/mathi.k.210708.001
R. Velmurugan, P. M. Kumar, K. Nair
{"title":"Nebulizer, Inhaled Remdesivir Nanoparticle Co-administered with Withania Somnifera may Minimize the Hepatotoxicity in COVID-19","authors":"R. Velmurugan, P. M. Kumar, K. Nair","doi":"10.2991/mathi.k.210708.001","DOIUrl":"https://doi.org/10.2991/mathi.k.210708.001","url":null,"abstract":"Remdesivir is a broad spectrum antiviral agent meant to inhibit viral RNA polymerases against members of several virus families, including filoviruses. Although reported for significant clinical improvements in COVID-19, a detailed observation of the connection with the drawbacks of remdesivir therapy was poor pulmonary distribution and hepatotoxicity (transaminase elevation) was recorded that resulted in discontinuation of remdesivir therapy. Nanodrug delivery facilitates a large drug payload to the targeted site improving the efficacy. With the lesser dose administered, could be expected for minimized adverse events. Additional payload of ashwagandha will protect the liver from the damages caused if any. Remdesivir in nanoformulation may be a safe and an effective therapeutic agent for COVID 19 when co-adminstered with ashwagandha.","PeriodicalId":166766,"journal":{"name":"Materials Highlights","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130353242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Recent Advances in Nanofabrication of the Morphology-Controlled Hypercrosslinked Polymers 形态控制型超交联聚合物纳米制备研究进展
Materials Highlights Pub Date : 2021-07-01 DOI: 10.2991/mathi.k.210708.002
Wenliang Song, Mingxin Zhang, Mingjie Liu, Yinning Huang, Dengguang Yu
{"title":"Recent Advances in Nanofabrication of the Morphology-Controlled Hypercrosslinked Polymers","authors":"Wenliang Song, Mingxin Zhang, Mingjie Liu, Yinning Huang, Dengguang Yu","doi":"10.2991/mathi.k.210708.002","DOIUrl":"https://doi.org/10.2991/mathi.k.210708.002","url":null,"abstract":"","PeriodicalId":166766,"journal":{"name":"Materials Highlights","volume":"10 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127615018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Bispecific Antibodies for the Treatment of Cancer 治疗癌症的双特异性抗体
Materials Highlights Pub Date : 2021-06-01 DOI: 10.2991/mathi.k.210617.001
Nerisha Chouhan
{"title":"Bispecific Antibodies for the Treatment of Cancer","authors":"Nerisha Chouhan","doi":"10.2991/mathi.k.210617.001","DOIUrl":"https://doi.org/10.2991/mathi.k.210617.001","url":null,"abstract":"","PeriodicalId":166766,"journal":{"name":"Materials Highlights","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130830113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural and Optical Properties of BaO Nanoparticles Synthesized by Facile Co-precipitation Method 易溶共沉淀法合成BaO纳米颗粒的结构和光学性质
Materials Highlights Pub Date : 1900-01-01 DOI: 10.2991/MATHI.K.210226.001
Manauwar Ali Ansari, N. Jahan
{"title":"Structural and Optical Properties of BaO Nanoparticles Synthesized by Facile Co-precipitation Method","authors":"Manauwar Ali Ansari, N. Jahan","doi":"10.2991/MATHI.K.210226.001","DOIUrl":"https://doi.org/10.2991/MATHI.K.210226.001","url":null,"abstract":"This paper presents the synthesis of Barium Oxide Nanoparticles (BaO-NPs) on a large-scale by a simple and cost-effective co-precipitation method. The as-synthesized BaO-NPs were characterized in aspects of their structural, morphological, compositional","PeriodicalId":166766,"journal":{"name":"Materials Highlights","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131822348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
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