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B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA最新文献

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Sputum Eosinophil Peroxidase Identifies a Subset of Asthmatics with Severe Airflow Obstruction and Frequent Exacerbations 痰嗜酸性过氧化物酶识别哮喘患者的一个子集严重气流阻塞和频繁恶化
B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2362
M. Tang, M. Peters, A. Charbit, E. Dunican, W. Raymond, M. Castro, A. Coverstone, S. Erzurum, S. Comhair, A. Hastie, W. Moore, M. Johansson, N. Jarjour, B. Levy, E. Israel, B. Phillips, D. Mauger, E. Bleecker, S. Wenzel, M. Fajt, W. Phipatanakul, P. Woodruff, J. Fahy, The National Heart Lung and Blood Institute (NHLBI
{"title":"Sputum Eosinophil Peroxidase Identifies a Subset of Asthmatics with Severe Airflow Obstruction and Frequent Exacerbations","authors":"M. Tang, M. Peters, A. Charbit, E. Dunican, W. Raymond, M. Castro, A. Coverstone, S. Erzurum, S. Comhair, A. Hastie, W. Moore, M. Johansson, N. Jarjour, B. Levy, E. Israel, B. Phillips, D. Mauger, E. Bleecker, S. Wenzel, M. Fajt, W. Phipatanakul, P. Woodruff, J. Fahy, The National Heart Lung and Blood Institute (NHLBI","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2362","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2362","url":null,"abstract":"","PeriodicalId":166658,"journal":{"name":"B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114996951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated Exhaled Nitric Oxide with Low Airway Epithelial Catalase Expression Predicts a Poorly Controlled Asthma Phenotype 呼出一氧化氮升高伴气道上皮过氧化氢酶低表达预示控制不良的哮喘表型
B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2363
B. Lee, M. Peters, J. Fahy, J. Zein, X. Li, D. Meyers, E. Bleecker, W. Moore, N. Jarjour, L. Denlinger, M. Castro, B. Gaston, E. Israel, B. Levy, D. Mauger, S. Wenzel
{"title":"Elevated Exhaled Nitric Oxide with Low Airway Epithelial Catalase Expression Predicts a Poorly Controlled Asthma Phenotype","authors":"B. Lee, M. Peters, J. Fahy, J. Zein, X. Li, D. Meyers, E. Bleecker, W. Moore, N. Jarjour, L. Denlinger, M. Castro, B. Gaston, E. Israel, B. Levy, D. Mauger, S. Wenzel","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2363","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2363","url":null,"abstract":"","PeriodicalId":166658,"journal":{"name":"B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129900723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Dupilumab in Pediatric Patients with Uncontrolled, Moderate-to-Severe Asthma With and Without Ongoing Atopic Comorbid Disease: LIBERTY ASTHMA VOYAGE Dupilumab在伴有或不伴有持续特应性共病的未控制的中重度哮喘患儿中的疗效:LIBERTY Asthma VOYAGE
B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2364
T. Guilbert, A. Deschildre, D. Jackson, P. Bégin, R. Zeiger, S. Szefler, A. Altincatal, R. Gall, J. Jacob-Nara, P. Rowe, Y. Deniz, M. Djandji
{"title":"Efficacy of Dupilumab in Pediatric Patients with Uncontrolled, Moderate-to-Severe Asthma With and Without Ongoing Atopic Comorbid Disease: LIBERTY ASTHMA VOYAGE","authors":"T. Guilbert, A. Deschildre, D. Jackson, P. Bégin, R. Zeiger, S. Szefler, A. Altincatal, R. Gall, J. Jacob-Nara, P. Rowe, Y. Deniz, M. Djandji","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2364","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2364","url":null,"abstract":"","PeriodicalId":166658,"journal":{"name":"B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116094080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent Reductions in OCS Use in Patients with Severe, OCS-Dependent Asthma Treated with Dupilumab: LIBERTY ASTHMA TRAVERSE Study 使用Dupilumab治疗的严重OCS依赖性哮喘患者的OCS使用持续减少:LIBERTY Asthma TRAVERSE研究
B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2365
M. Gurnell, C. Domingo Ribas, K. Rabe, A. Menzies-Gow, D. Price, G. Brusselle, M. Wechsler, C. Xia, M. Djandji, R. Gall, J. Jacob-Nara, P. Rowe, Y. Deniz, S. Siddiqui
{"title":"Persistent Reductions in OCS Use in Patients with Severe, OCS-Dependent Asthma Treated with Dupilumab: LIBERTY ASTHMA TRAVERSE Study","authors":"M. Gurnell, C. Domingo Ribas, K. Rabe, A. Menzies-Gow, D. Price, G. Brusselle, M. Wechsler, C. Xia, M. Djandji, R. Gall, J. Jacob-Nara, P. Rowe, Y. Deniz, S. Siddiqui","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2365","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2365","url":null,"abstract":"","PeriodicalId":166658,"journal":{"name":"B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129661232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High TSLP Responses in the Pediatric Airway Epithelium Are Linked to a Global Pro-Inflammatory State Instead of Type 2 Polarization 儿童气道上皮的高TSLP反应与全局促炎状态有关，而不是2型极化
B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2361
E. Chorvinsky, K. Salka, B.S. Bera, S. Gaviria, H. Aguilar, R. Kahanowitch, G. Gayoso Liviac, X. Xu Chen, J. Weinstock, M.A. Arroyo Morr, M. Gutierrez, D. Pillai, G. Nino
{"title":"High TSLP Responses in the Pediatric Airway Epithelium Are Linked to a Global Pro-Inflammatory State Instead of Type 2 Polarization","authors":"E. Chorvinsky, K. Salka, B.S. Bera, S. Gaviria, H. Aguilar, R. Kahanowitch, G. Gayoso Liviac, X. Xu Chen, J. Weinstock, M.A. Arroyo Morr, M. Gutierrez, D. Pillai, G. Nino","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2361","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2361","url":null,"abstract":"","PeriodicalId":166658,"journal":{"name":"B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124693170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinically Meaningful Improvements in St George’s Respiratory Questionnaire Score with Tezepelumab Versus Placebo in Patients with Severe, Uncontrolled Asthma: Results from the Phase 3 NAVIGATOR Study Tezepelumab与安慰剂在严重、未控制哮喘患者的圣乔治呼吸问卷评分中有临床意义的改善:来自3期NAVIGATOR研究的结果
B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2360
M. Kraft, J. Corren, C. Ambrose, B. Cook, N. Clarke, G. Hunter, N. Molfino, S. Ponnarambil
{"title":"Clinically Meaningful Improvements in St George’s Respiratory Questionnaire Score with Tezepelumab Versus Placebo in Patients with Severe, Uncontrolled Asthma: Results from the Phase 3 NAVIGATOR Study","authors":"M. Kraft, J. Corren, C. Ambrose, B. Cook, N. Clarke, G. Hunter, N. Molfino, S. Ponnarambil","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2360","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2360","url":null,"abstract":"","PeriodicalId":166658,"journal":{"name":"B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133052131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent Mucus Plugs in Asthma Associate with Changes in Airflow Over Time 哮喘患者持续黏液堵塞与气流随时间变化有关
B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2357
M. Tang, B. Elicker, T. Henry, D. Gierada, M. Schiebler, B. Huang, M. Peters, M. Castro, E. Hoffman, S. B. Fain, S. Ash, J. Choi, C. Hall, B. Phillips, D. Mauger, L. Denlinger, N. Jarjour, E. Israel, W. Phipatanakul, B. Levy, S. Wenzel, E. Bleecker, P. Woodruff, J. Fahy, E. Dunican, The National Heart Lung and Blood Institute (NHLBI
{"title":"Persistent Mucus Plugs in Asthma Associate with Changes in Airflow Over Time","authors":"M. Tang, B. Elicker, T. Henry, D. Gierada, M. Schiebler, B. Huang, M. Peters, M. Castro, E. Hoffman, S. B. Fain, S. Ash, J. Choi, C. Hall, B. Phillips, D. Mauger, L. Denlinger, N. Jarjour, E. Israel, W. Phipatanakul, B. Levy, S. Wenzel, E. Bleecker, P. Woodruff, J. Fahy, E. Dunican, The National Heart Lung and Blood Institute (NHLBI","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2357","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2357","url":null,"abstract":"","PeriodicalId":166658,"journal":{"name":"B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115878357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Polyclonal Airway Autoimmune Response Is Associated with Clinical Indices of Asthma Severity 多克隆气道自身免疫反应与哮喘严重程度的临床指标相关
B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2358
B. Salter, N. Zhao, K. Son, A. Gheva-Dvorkin, K. Radford, N. Lavigne, C. Huang, M. Kjarsgaard, N. Khalidi, P. Nair, M. Mukherjee
{"title":"A Polyclonal Airway Autoimmune Response Is Associated with Clinical Indices of Asthma Severity","authors":"B. Salter, N. Zhao, K. Son, A. Gheva-Dvorkin, K. Radford, N. Lavigne, C. Huang, M. Kjarsgaard, N. Khalidi, P. Nair, M. Mukherjee","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2358","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2358","url":null,"abstract":"","PeriodicalId":166658,"journal":{"name":"B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA","volume":"178 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128636596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Tezepelumab Reduces Biomarkers of Airway Remodeling, MMP-10 and MMP-3: Exploratory Results from the Phase 3 NAVIGATOR Study Tezepelumab降低气道重塑、MMP-10和MMP-3的生物标志物:来自3期NAVIGATOR研究的探索性结果
B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2359
T. Pham, B. Cook, J. Parnes, G. Colice, J. Griffiths
{"title":"Tezepelumab Reduces Biomarkers of Airway Remodeling, MMP-10 and MMP-3: Exploratory Results from the Phase 3 NAVIGATOR Study","authors":"T. Pham, B. Cook, J. Parnes, G. Colice, J. Griffiths","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2359","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2359","url":null,"abstract":"","PeriodicalId":166658,"journal":{"name":"B15. NOVEL BIOMARKERS AND USES OF THERAPEUTICS IN ASTHMA","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125765338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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