MatSciRN: Materials for Bio-Medical Implants (Topic)最新文献

Modification of Polyetheretherketone (PEEK) Implants: From Enhancing Bone Integration to Enabling Multi-Modal Therapeutics 聚醚醚酮(PEEK)种植体的改良:从增强骨整合到实现多模式治疗

MatSciRN: Materials for Bio-Medical Implants (Topic) Pub Date : 2021-03-04 DOI: 10.2139/ssrn.3797424

Miaomiao He, Yong Huang, Huan Xu, G. Feng, Limin Liu, Yubao Li, D. Sun, Li Zhang

{"title":"Modification of Polyetheretherketone (PEEK) Implants: From Enhancing Bone Integration to Enabling Multi-Modal Therapeutics","authors":"Miaomiao He, Yong Huang, Huan Xu, G. Feng, Limin Liu, Yubao Li, D. Sun, Li Zhang","doi":"10.2139/ssrn.3797424","DOIUrl":"https://doi.org/10.2139/ssrn.3797424","url":null,"abstract":"Since its commercialization in 1990s, application of implantable PEEK has grown exponentially in the biomedical field and rapidly transformed a large section of the medical devices landscape. Despite the wide biomedical applications, the lack of bioactivity of PEEK remains a limitation. The commonly seen bacterial infection at the surgical site also requires effective mitigation strategies. Today, there is an increasing demand for functional bone implants with fast bone integration capability as well as other desirable therapeutic functions. As such, modification of PEEK has progressively expanded from offering desirable mechanical properties, enhanced bioactivity / osteointegration, to more recently, tackling bacterial infection / biofilm formation / inflammation and the management of bone cancers. Despite the high volume of PEEK implant papers published in the literature, no review has yet comprehensively covered the recently engaged areas of functional PEEK implants. This paper provides an up-to-date review on the development in PEEK implants the past decade, with particularly focus on modifying PEEK for multi-modal therapeutics (e.g. bone regeneration, anti-bacteria/anti-inflammation, cancer inhibition, etc). We aim to provide a timely update and a better understanding of the latest advancement in the field, which may guide and inspire the R&D of next generation PEEK-based healthcare products.","PeriodicalId":165250,"journal":{"name":"MatSciRN: Materials for Bio-Medical Implants (Topic)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114071226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Orthodontic Brackets and Wires Wear in Different Conditions: A Review 正畸托槽和金属丝在不同情况下的磨损:综述

MatSciRN: Materials for Bio-Medical Implants (Topic) Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3940832

P. Espinoza-Montero, Marjorie Montero-Jiménez, Lenys Fernández, J. L. Paz, Sandra Macías Ceballos

引用次数: 0

LncRNAs Transcriptome Analysis Revealed HIF1A-AS1 as a Mediator of Bone Remodeling Associated with the Micro Structured Titanium Surface LncRNAs转录组分析显示HIF1A-AS1是骨重塑与微观结构钛表面相关的中介

MatSciRN: Materials for Bio-Medical Implants (Topic) Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3441482

Yan Zheng, Yunfei Zheng, L. Jia, Yu Zhang, Ye Lin

{"title":"LncRNAs Transcriptome Analysis Revealed HIF1A-AS1 as a Mediator of Bone Remodeling Associated with the Micro Structured Titanium Surface","authors":"Yan Zheng, Yunfei Zheng, L. Jia, Yu Zhang, Ye Lin","doi":"10.2139/ssrn.3441482","DOIUrl":"https://doi.org/10.2139/ssrn.3441482","url":null,"abstract":"Because of their hierarchical structure, sandblasted and acid etched (SLA) titanium implants are widely used to promote bone apposition. Understanding the molecular mechanisms of SLA titanium implant-enhanced osteogenesis provides clues to improve surface modification methods. However, the epigenetics mechanisms involving SLA surface weren't clear. In this study, we systematically identify the long noncoding RNAs (lncRNAs) and mRNAs related to the superior osseointegration induced by SLA. The mechanical, chemical, and osteogenic characteristics of the fabricated SLA and smooth polished (SMO) titanium surfaces were compared and analyzed. Thousands of lncRNAs and mRNAs within osteogenesis-associated biological processes were differentially expressed in human bone marrow-derived mesenchymal stem cells (hBMSCs) on SLA surface compared with SMO surface. We constructed an mRNA-lncRNA co-expression network to gain insight into the role of differentially expressed lncRNAs and validated the co-expression of HIF1A-AS1/VEGFA, IGF2-AS/GLI2, and HOXD-AS1/FGF10. Further, we identified that the knockdown of HIF1A-AS1 not only decreased the expression of VEGFA, but also significantly inhibited the osteogenic differentiation of hBMSCs. Meanwhile, we found that silencing of lncRNA HIF1A-AS1 reduced the level of phosphorylated mitogen-activated protein kinase (p-MAPK). In conclusion, our study indicated that the SLA surface enhanced osteogenesis partly through differential regulation of lncRNAs, like HIF1A-AS1. Our study also increased the understanding of the role lncRNA HIF1A-AS1 in the differentiation of osteoblast, providing clues for the potential optimization of titanium implant surface.","PeriodicalId":165250,"journal":{"name":"MatSciRN: Materials for Bio-Medical Implants (Topic)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126452178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible Antibiotics Loading and pH-Responsive Release from Polymer Brushes on Contact Lens for Therapy and Prevention of Corneal Infections 隐形眼镜聚合物刷的可逆抗生素负载和ph响应释放用于治疗和预防角膜感染

MatSciRN: Materials for Bio-Medical Implants (Topic) Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3539229

Yingying Jin, Yishun Guo, Aiwu Fang, Shuaiyue Pang, Hao Chen, Yuqin Wang, Jia Qu, Wenya Jiang, Bailiang Wang

引用次数: 0