Guilt by association: ILD genetics and co-morbidities最新文献

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S143 Serum CYFRA 21–1 as a prognostic marker in scleroderma-associated interstitial lung disease 血清CYFRA 21-1作为硬皮病相关间质性肺疾病的预后标志物

Guilt by association: ILD genetics and co-morbidities Pub Date : 2018-12-01 DOI: 10.1136/THORAX-2018-212555.149

C. Stock, R. Hoyles, C. Daccord, M. Kokosi, V. Alfieri, C. Campochiaro, J. Donovan, L. Mori, T. Maher, V. Kouranos, G. Margaritopoulos, P. George, P. Molyneaux, F. Chua, D. Abraham, V. Ong, C. Denton, A. Wells, E. Renzoni

{"title":"S143 Serum CYFRA 21–1 as a prognostic marker in scleroderma-associated interstitial lung disease","authors":"C. Stock, R. Hoyles, C. Daccord, M. Kokosi, V. Alfieri, C. Campochiaro, J. Donovan, L. Mori, T. Maher, V. Kouranos, G. Margaritopoulos, P. George, P. Molyneaux, F. Chua, D. Abraham, V. Ong, C. Denton, A. Wells, E. Renzoni","doi":"10.1136/THORAX-2018-212555.149","DOIUrl":"https://doi.org/10.1136/THORAX-2018-212555.149","url":null,"abstract":"Interstitial lung disease (ILD) is the main cause of death in systemic sclerosis (SSc). The progression of SSc associated ILD (SSc-ILD) is highly variable. Markers predictive of progressive ILD are needed early in the disease course, to appropriately target patients at risk of developing progressive pulmonary fibrosis. CYFRA 21–1 (CYFRA) is a tumour marker expressed by type I/type II pneumocytes and respiratory bronchiolar epithelial cells, released into the blood following cell lysis. Serum levels of CYFRA were measured in both a retrospective (n=180) and a prospective (n=118) cohort of SSc patients. Retrospective cohort mean age: 49.1 (range 47.08–51.05), 77.25% female, prospective cohort age: 56.4 (54.10–58.73), 76.23% female. Median FVC% predicted and DLCO% predicted: retrospective cohort: 80.1% (IQR:67.2–95.5) and 55.5% (44.3–68.35), respectively – prospective cohort: 73.8% (57.2–87) and 39.9% (29.2–48.8), respectively. ILD was defined as the presence of fibrosis on chest imaging (chest x-ray or HRCT) and/or a forced vital capacity (FVC)","PeriodicalId":164956,"journal":{"name":"Guilt by association: ILD genetics and co-morbidities","volume":"123 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128368061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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