International Journal of Novel Trends in Pharmaceutical Sciences最新文献

Assessment of Management and Life Style Modification in Uterine Fibroid Patient's 子宫肌瘤患者治疗及生活方式改变的评价

International Journal of Novel Trends in Pharmaceutical Sciences Pub Date : 2021-09-08 DOI: 10.26452/ijntps.v11i3.1446

Rajyalakshmi Swetha C H, Vyshnavi A, Satyasri D, Mahima P

{"title":"Assessment of Management and Life Style Modification in Uterine Fibroid Patient's","authors":"Rajyalakshmi Swetha C H, Vyshnavi A, Satyasri D, Mahima P","doi":"10.26452/ijntps.v11i3.1446","DOIUrl":"https://doi.org/10.26452/ijntps.v11i3.1446","url":null,"abstract":"Uterine fibroids, also known as uterine Leiomyomas or fibroids, are benign smooth muscle tumours of the uterus that can be seen in women of child bearing age. Women in their first trimester of pregnancy suffer no symptoms, but others may experience painful or heavy periods. The presence of fibroids might occasionally make it more difficult to become pregnant; however, this is uncommon. Approximately 20 percent to 80 percent of women develop fibroids by the time they reach the age of 50. If there are no symptoms, it is typically not necessary to seek medical attention. Paracetamol (acetaminophen) and other nonsteroidal anti-inflammatory medicines (NSAIDs) may be used to relieve pain and bleeding, while ibuprofen and other NSAIDs may be used to relieve pain and bleeding. It is possible that women who have heavy periods will require iron supplements. The use of medications from the gonadotropin-releasing hormone agonist family may help to reduce the growth of fibroids, but they are both expensive and associated with negative side effects. Patient counselling and education will aid in lowering the risk to patients and slowing the progression of the study. The work done to determine the causes of anaemia will aid in increasing knowledge about anaemia, including dietary modifications, and decreasing the progression of the study by providing patient counselling and education. The findings of a six month study of 75 cases of fibroids discovered in 362 samples revealed that uterine fibroids are the most common malignancy in women of reproductive age. Uterine fibroids are not only found in women of null parity; they can also be found in women with multiple pregnancies. On the contrary, the prevalence of anaemia, heavy bleeding with clots, and metrorrhagia in fibroids is rather high, which has an impact on psychological state as a result of the stigma associated with the sickness status, and which interferes with everyday activities.","PeriodicalId":159799,"journal":{"name":"International Journal of Novel Trends in Pharmaceutical Sciences","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123891181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Drug Utilisation Pattern and Clinical Presentation in Covid19 Patients Based on the Disease Severity 基于病情严重程度的新型冠状病毒肺炎患者用药模式及临床表现评价

International Journal of Novel Trends in Pharmaceutical Sciences Pub Date : 2021-07-13 DOI: 10.26452/IJNTPS.V11I2.1412

K. Hema, Peddoju Moulika, Dinesh Kumar Kukunuri, Ganta Saidhulu, K. Dhivya, K. Karthik

{"title":"Evaluation of Drug Utilisation Pattern and Clinical Presentation in Covid19 Patients Based on the Disease Severity","authors":"K. Hema, Peddoju Moulika, Dinesh Kumar Kukunuri, Ganta Saidhulu, K. Dhivya, K. Karthik","doi":"10.26452/IJNTPS.V11I2.1412","DOIUrl":"https://doi.org/10.26452/IJNTPS.V11I2.1412","url":null,"abstract":"Coronavirus disease of 2019 (COVID-19) is an extremely communicable disease characterized by the serious acute respiratory influenza virus 2, a recently identified novel viral disease (SARS-CoV-2). Hitherto, the quantity of established instances worldwide has reached 135 million, and the number of deaths is 2.9 million. In India, the cases were found to be 20 million and the mortality rate is 3,51,000. This virus was first identified in Wuhan City, Hubei Province in China, at the end of 2019. Until now, it affected more than 200 countries. The treatment pattern and clinical presentations were assessed in COVID 19 patients. A total of 146 patients, severe patients (n = 71) and non-severe patients (n = 75) where included in the study. The mean age of the study population was found to be 58.76±14.32 and the most common symptoms of patients include fever, fatigue, dry cough, and diarrhea there is no statistically significant difference in the clinical features between severe and non-severe patients. There is no significant difference in the laboratory findings except lymphocyte count, CORADS and N/L ratio between severe and non-severe patients. COVID-19 affects all age groups especially the elderly. The risk for severe illness with COVID-19 increases with age. COVID 19 patients were presented with various the risk factors and the clinical features in the severe and non severe conditions patients, our study shows great significance to prevent the patient turning to critical condition during diagnosis and treatment.","PeriodicalId":159799,"journal":{"name":"International Journal of Novel Trends in Pharmaceutical Sciences","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125375799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preparation and evaluation of repaglinide nanosuspensions 瑞格列奈纳米混悬液的制备与评价

International Journal of Novel Trends in Pharmaceutical Sciences Pub Date : 2020-06-26 DOI: 10.26452/ijntps.v9i1.1166

Jogu. Chandrudu

引用次数: 0

Evaluation of in-vitro antidiabetic activity of leaf juice of Plectranthus amboinicus (lour.) 羊草叶汁体外抗糖尿病活性评价

International Journal of Novel Trends in Pharmaceutical Sciences Pub Date : 2020-06-17 DOI: 10.26452/ijntps.v10i1.1143

Pavan Kumar Kurakula, Tharun D, Mahantesh S, Krishna O, Sudheer A, Mujahid Sm, Sai vikas S

{"title":"Evaluation of in-vitro antidiabetic activity of leaf juice of Plectranthus amboinicus (lour.)","authors":"Pavan Kumar Kurakula, Tharun D, Mahantesh S, Krishna O, Sudheer A, Mujahid Sm, Sai vikas S","doi":"10.26452/ijntps.v10i1.1143","DOIUrl":"https://doi.org/10.26452/ijntps.v10i1.1143","url":null,"abstract":"Diabetes mellitus ‘the disease of modern civilization’ is characterized by chronic hyperglycaemia. The management of elevated post prandial glucose is critical to control the sequale of complications and α-amylase, α-glucosidases are responsible for elevated plasma glucose. Enzyme inhibitors in current clinical practice like acarbose, voglibose etc. are known to cause various gastrointestinal side effects. The present study was aimed to screen for potential α-amylase and α-glucosidase inhibitors from natural sources by in–vitro antidiabetic assays to overcome the side effects and toxicity. Different concentrations of leaf juice of Plectranthus amboinicus Lour. (20, 40, 60, 80 &100 μg/ml) were tested against fungal α-amylase and α-glucosidases isolated from albino rat small intestine and a prominent dose dependent inhibition of the enzymes was observed comparable with the marketed product, Acarbose. The IC50 values of LJPA and acarbose on fungal α-amylase was found to be 83.15 &52.15 μg/ml respectively. The IC50 values of LJPA and acarbose on α-glucosidase was found to be 92.44 &54.84 μg/ml respectively. The protein concentration of leaf juice was found to be 10.6 mg/ml.","PeriodicalId":159799,"journal":{"name":"International Journal of Novel Trends in Pharmaceutical Sciences","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128599777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential application of exosome in drug delivery 外泌体在药物传递中的潜在应用

International Journal of Novel Trends in Pharmaceutical Sciences Pub Date : 2019-10-28 DOI: 10.26452/ijntps.v9i3.1335

Sravanthi Ch, Purushothaman M, Madhusudhan M, Kathiravan P, Srikanth Choudary P

引用次数: 0

Herbal Oil and its Anti-arthritic Activity 草药油及其抗关节炎活性

International Journal of Novel Trends in Pharmaceutical Sciences Pub Date : 2019-09-29 DOI: 10.26452/ijntps.v9i3.1331

Dinesh Babu J, Vinaya J, Sravan Kumar P, Akhila CR

{"title":"Herbal Oil and its Anti-arthritic Activity","authors":"Dinesh Babu J, Vinaya J, Sravan Kumar P, Akhila CR","doi":"10.26452/ijntps.v9i3.1331","DOIUrl":"https://doi.org/10.26452/ijntps.v9i3.1331","url":null,"abstract":"Inflammation and arthritis are interrelated conditions that are caused by each other. This disorder majorly occurs in elderly patients. It is a major problem in the world that affects the joints and causes inflammation in the joints causing pain and tenderness in the joints. This is mainly triggered by the inflammation caused by the malfunctioning of the immune system of the own body. This disease leads to severe damage to the cartilage of the joints in the body. This will lead to the ankylosing of the joints and resulting in the pain of the joints. There are few other diseases like inflammation of the pleural cavities, scleritis and other lesions that are usually seen in the cutaneous, subcutaneous tissue. Overall, it is a problem in the immune system of the body. The researchers now had concentrated on the utilization of the herbs and medicinal plants to treat arthritis effectively. They are found to be safe and effective compared to the synthetic immune suppressant drugs. They are also the cheapest sources of drugs. So the herbs had been investigated for the production of the newer molecules that treat arthritis effectively and relatively safer with that of the existing drugs. The plant extract of the stem bark of the plant Berberis orthobotrys was collected and extracted using ethanol. This was used to prepare oil formulation, and this was investigated for the anti-arthritic activity. The oil formulation showed a better activity compared to the extract and compared to the standard.","PeriodicalId":159799,"journal":{"name":"International Journal of Novel Trends in Pharmaceutical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129663063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Investigation of the Effect of Polyherbal Syrup Formulation on Brain Enzymes 复方中草药糖浆制剂的制备及对脑酶的影响研究

International Journal of Novel Trends in Pharmaceutical Sciences Pub Date : 2019-09-26 DOI: 10.26452/ijntps.v9i3.1330

Purushothaman M, Madhusudhan M, Kathiravan P, Sravanthi Ch, Srikanth Choudary P

{"title":"Preparation and Investigation of the Effect of Polyherbal Syrup Formulation on Brain Enzymes","authors":"Purushothaman M, Madhusudhan M, Kathiravan P, Sravanthi Ch, Srikanth Choudary P","doi":"10.26452/ijntps.v9i3.1330","DOIUrl":"https://doi.org/10.26452/ijntps.v9i3.1330","url":null,"abstract":"Convulsions and seizures are the major neurological conditions that are the symptoms of brain diseases like brain stroke, aneurysm and other oxidative brain damage. This affects most of the people in the world as a symptom of other diseases and as a disorder on its own. Herbs are found to be the alternatives of the synthetic drugs that cause the side effects and are common in synthetic drugs as discussed above. So herbal extracts are safe and potent and do not contain or contain a very less amount of side effects. So, they can be used effectively in treating many conditions, including epilepsy. Most of the herbs show their potency by exhibiting the antioxidant activity. Since the oxidative free radicals that are generated in the brain are the cause of disturbance in the protective enzymes in the brain, the estimation of the protective enzymes in the brain during epilepsy. This work was carried out to prepare an effective polyherbal syrup to treat epilepsy effectively. The formulation was tested in 2 doses of 100 and 200mg, and they are also investigated for the activity to normal the enzymes that are in the brain, which help to fight the free radicals. From this, it can be advocated that the herbs in the syrup helped the formulation's antioxidant activity to attribute to the anti-epileptic activity in experimental animals.","PeriodicalId":159799,"journal":{"name":"International Journal of Novel Trends in Pharmaceutical Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127353756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Registration Process in Drugs Delivery Process 药品交付过程中的注册程序

International Journal of Novel Trends in Pharmaceutical Sciences Pub Date : 2018-06-28 DOI: 10.26452/ijntps.v8i3.1319

Kranthi A, Priyanka G, Sravani G, Linga Naik A

引用次数: 0

Investigation on Polyherbal Antipyretic Syrup for Fever 复方解热糖浆治疗发热的研究

International Journal of Novel Trends in Pharmaceutical Sciences Pub Date : 2018-06-25 DOI: 10.26452/ijntps.v8i1.1307

Jagadeeshwari S, Soujanya H, Purushothaman M, Shiva Kumar K

{"title":"Investigation on Polyherbal Antipyretic Syrup for Fever","authors":"Jagadeeshwari S, Soujanya H, Purushothaman M, Shiva Kumar K","doi":"10.26452/ijntps.v8i1.1307","DOIUrl":"https://doi.org/10.26452/ijntps.v8i1.1307","url":null,"abstract":"Fever is an important and notable sign and symptom of many diseases that are caused in the human body. They are the result of any inflammatory condition, infection or any other disease occur due to any external agents. There are a lot of drugs that are used to control pyrosis in the body. Fever is simply elevation of the body temperature. The chemical constituents isolated from the plants were effective in treating many diseases and were seemed to be potent against all the conditions. Even with the advent of the synthetic drugs, herbal leads have been the drugs of choice in many diseases like CHF, Cancers and more. The plant vitex was extracted using the ethanol water mixture and this extract was used to produce the poly herbal antipyretic syrup. This was investigated on the yeast induced pyrexia and it showed a better activity compared to the standard paracetamol drug and also a marketed formulation. This can be supported by the antioxidant and antibacterial properties of vitex and also supported by the Piper longum that contains piperine which as usually acts as a penetration enhancer in pharmaceutical applications.","PeriodicalId":159799,"journal":{"name":"International Journal of Novel Trends in Pharmaceutical Sciences","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114661697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0