Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title]最新文献

Vitrectomy in Diabetic Retinopathy 玻璃体切除术治疗糖尿病视网膜病变

Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title] Pub Date : 2022-01-28 DOI: 10.5772/intechopen.101358

Payal Naresh Shah, Mahesh P. Shanmugam, Divyansh K. Mishra

引用次数: 0

Anatomic and Topographic Vitreous and Vitreoretinal Interface Features during Chromovitrectomy of A, B, C Stages of Proliferative Diabetic Vitreoretinopathy (P. Kroll’s Classification of Proliferative Diabetic Vitreoretinopathy, 2007):Fyodorov’s Eye Micro 增殖性糖尿病性玻璃体视网膜病变A、B、C期玻璃体和玻璃体视网膜界面的解剖和地形学特征(P. Kroll 's Classification of Proliferative Diabetic玻璃体视网膜病变，2007):Fyodorov’s Eye Micro

Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title] Pub Date : 2022-01-16 DOI: 10.5772/intechopen.101724

N. Kislitsyna, S. Novikov

引用次数: 0

Current Management of Diabetic Macular Edema 糖尿病性黄斑水肿的当前处理

Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title] Pub Date : 2022-01-05 DOI: 10.5772/intechopen.100157

Ogugua Ndubuisi Okonkwo, T. Akanbi, Chineze Thelma Agweye

{"title":"Current Management of Diabetic Macular Edema","authors":"Ogugua Ndubuisi Okonkwo, T. Akanbi, Chineze Thelma Agweye","doi":"10.5772/intechopen.100157","DOIUrl":"https://doi.org/10.5772/intechopen.100157","url":null,"abstract":"Diabetic macular edema is a complication of diabetes mellitus (DM) which contributes significantly to the burden of visual impairment amongst persons living with diabetes. Chronic hyperglycemia triggers a cascade of pathologic changes resulting in breakdown of the retinal blood barrier. Understanding the pathophysiological and biochemical changes occurring in diabetes has led to developing novel therapeutics and effective management strategies for treating DME. The clinical utility of optical coherence tomography (OCT) imaging of the retina provides a detailed assessment of the retina microstructure, valid for individualization of patient treatment and monitoring response to treatment. Similarly, OCT angiography (dye-less angiography), another innovation in imaging of DME, provides an understanding of retinal vasculature in DME. From the earlier years of using retinal laser photocoagulation as the gold standard for treating DME, to the current use of intravitreal injection of drugs, several clinical trials provided evidence on safety and efficacy for the shift to intravitreal steroids and anti-vascular endothelial growth factor use. The short durability of available drugs leading to frequent intravitreal injections and frequent clinic visits for monitoring constitute an enormous burden. Therefore, extended durability drugs are being designed, and remote monitoring of DME may be a solution to the current challenges.","PeriodicalId":159046,"journal":{"name":"Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title]","volume":"361 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131562898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive Optics Imaging Technique in Diabetic Retinopathy 糖尿病视网膜病变的自适应光学成像技术

Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title] Pub Date : 2021-12-03 DOI: 10.5772/intechopen.101266

F. Balta, Irina Elena Cristescu, Ioana Teodora Tofolean

引用次数: 0

Diabetic Retinopathy and Stem Cell Therapy 糖尿病视网膜病变和干细胞治疗

Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title] Pub Date : 2021-10-28 DOI: 10.5772/intechopen.100812

Sevil Kestane

{"title":"Diabetic Retinopathy and Stem Cell Therapy","authors":"Sevil Kestane","doi":"10.5772/intechopen.100812","DOIUrl":"https://doi.org/10.5772/intechopen.100812","url":null,"abstract":"This overview was evaluated by the development of diabetic retinopathy (DR) and the stem cell therapy approach. DR is a microvascular complication of diabetes mellitus, characterized by damage to the retinal blood vessels leading to progressive loss of vision. However, the pathophysiological mechanisms are complicated and not completely understood yet. The current treatment strategies have included medical, laser, intravitreal, and surgical approaches. It is known that the use of mesenchymal stem cells (MSC), which has a great potential, is promising for the treatment of many degenerative disorders, including the eye. In retinal degenerative diseases, MSCs were ameliorated retinal neurons and retinal pigmented epithelial cells in both in vitro and in vivo studies. Stem cell therapies show promise in neurodegenerative diseases. However, it is very important to know which type of stem cell will be used in which situations, the amount of stem cells to be applied, the method of application, and its physiological/neurophysiological effects. Therefore, it is of great importance to evaluate this subject physiologically. After stem cell application, its safety and efficacy should be followed for a long time. In the near future, widespread application of regenerative stem cell therapy may be a standard treatment in DR.","PeriodicalId":159046,"journal":{"name":"Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title]","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130290528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Lipid, Protein-Derived Toxic Molecules, and Deficiency of Antioxidants behind the Pathogenesis of Diabetic Retinopathy (DR) in Type 2 Diabetes Mellitus 脂质、蛋白衍生毒性分子和抗氧化剂缺乏在2型糖尿病视网膜病变(DR)发病机制中的作用

Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title] Pub Date : 2021-09-20 DOI: 10.5772/intechopen.99904

Subhasish Pramanik, L. Mondal, S. Chowdhury, Chiranjit Bose, Debgopal Bera, Koena Bhattacharjee

{"title":"Role of Lipid, Protein-Derived Toxic Molecules, and Deficiency of Antioxidants behind the Pathogenesis of Diabetic Retinopathy (DR) in Type 2 Diabetes Mellitus","authors":"Subhasish Pramanik, L. Mondal, S. Chowdhury, Chiranjit Bose, Debgopal Bera, Koena Bhattacharjee","doi":"10.5772/intechopen.99904","DOIUrl":"https://doi.org/10.5772/intechopen.99904","url":null,"abstract":"To determine the role of NADPH-oxidase mediated formation of different lipid, protein-derived molecules, and depletion of vitamin-C level in vitreous behind the endothelial dysfunction-induced vascular endothelial growth factor secretion and pathogenesis of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM). Fourteen T2DM patients with mild non-proliferative diabetic retinopathy (MNPDR), 11 patients without diabetic retinopathy (DNR), 17 T2 DM subjects with high-risk proliferative diabetic retinopathy (HRPDR), and 5 healthy individuals without DM underwent vitreous analysis for estimation NADPH oxidase, lipid peroxide like malondialdehyde (MDA), 4-Hydroxy-noneal (HNE) and advanced lipoxidation end product (ALE) like Hexanoyl-lysine (HLY), protein carbonyl compound (PCC), Vitamin-C and concentration of vascular endothelial growth factor (VEGF) secretion following standard spectrophotometric methods and enzyme-linked immunosorbent assay (ELISA). Vitreous concentration of NADPH-oxidase, different protein and lipid-derived molecule, and VEGF were found to be significantly elevated among DNR and of DR subjects with different grades compared to HC subjects whereasthe vitamin-C level was found to be decreased among different DR subjects and DNR subjects in comparison to healthy individuals. Oxidative stress-mediated lipid and protein-derived biomolecules not only add important mediators in the pathogenesis of DR, but also accelerate the progression and severity of microangiopathy.","PeriodicalId":159046,"journal":{"name":"Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title]","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129660863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Treatment Algorithm in Proliferative Diabetic Retinopathy. From Protocols to the Real World 增殖性糖尿病视网膜病变的治疗方法。从协议到现实世界

Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title] Pub Date : 2021-09-13 DOI: 10.5772/intechopen.99843

J. Gonzalez-Cortes, J. E. Gonzalez-Cantu, A. Sudhalkar, S. Mota, A. Bilgic, Javier Alan Garza-Chavarria, J. Mohamed-Hamsho

{"title":"Treatment Algorithm in Proliferative Diabetic Retinopathy. From Protocols to the Real World","authors":"J. Gonzalez-Cortes, J. E. Gonzalez-Cantu, A. Sudhalkar, S. Mota, A. Bilgic, Javier Alan Garza-Chavarria, J. Mohamed-Hamsho","doi":"10.5772/intechopen.99843","DOIUrl":"https://doi.org/10.5772/intechopen.99843","url":null,"abstract":"Diabetes mellitus is a global epidemic that leads to multiple macrovascular and microvascular complications. The complex interrelated pathophysiological mechanisms triggered by hyperglycemia underlie the development of diabetic retinopathy (DR). Proliferative diabetic retinopathy (PDR) is a microvascular complication, considered the main cause of irreversible blindness in patients of productive age in the world. On the other hand, diabetic macular edema (DME) remains the clinical feature most closely associated with vision loss. In general, both manifestations are due to an increase in inflammatory factors, such as specific pro-inflammatory prostaglandins, interleukins and angiogenic substances including vascular endothelial growth factor (VEGF). Laser photocoagulation and VEGF inhibitors have been shown to be effective in the treatment of PDR and DME. Currently, randomized protocols suggest that VEGF inhibitors therapy could displace laser photocoagulation in the treatment of PDR with and without the presence of DME. The ongoing discussion still prevails about the different treatment modalities for both retinal manifestations in real-world settings.","PeriodicalId":159046,"journal":{"name":"Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title]","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126370668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of Inflammation in Diabetic Retinopathy 炎症在糖尿病视网膜病变中的作用

Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title] Pub Date : 2021-09-11 DOI: 10.5772/intechopen.100175

Anuj Sharma, D. Arora

{"title":"Role of Inflammation in Diabetic Retinopathy","authors":"Anuj Sharma, D. Arora","doi":"10.5772/intechopen.100175","DOIUrl":"https://doi.org/10.5772/intechopen.100175","url":null,"abstract":"As the global burden of diabetes is increasing there is a corresponding increase in the complications associated with the same. Diabetic retinopathy is a sight threatening complication of diabetes mellitus which was considered to be a microvasculopathy. Recent evidence however, has brought to light that inflammation may be a key player in the pathogenesis of this condition. Levels of inflammatory mediators like Hypoxia inducible factor, TNF-α, IL-6 and IL-1B amongst others have been noted to be elevated in the diabetic vitreous gel. The concept of the neurovascular unit better explains the changes that take place resulting in the breakdown of the blood retinal barriers and how these inflammatory mediators affect the morphology of the retina at a cellular level. Glial cells form a key instrument of this neurovascular structure and are also the cells from where the inflammatory response is initiated. Understanding of the pathogenesis of diabetic retinopathy will help us in finding targeted therapies which may provide long term benefits and possible cure. Few anti-inflammatory medications have shown promise albeit in a small clinical or experimental laboratory setting. However, future research may lead to better understanding of the disease and a better pharmacological intervention.","PeriodicalId":159046,"journal":{"name":"Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title]","volume":"60 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120904485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

High-Risk Diabetic Maculopathy: Features and Management 高风险糖尿病黄斑病变:特征和管理

Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title] Pub Date : 2021-09-05 DOI: 10.5772/intechopen.99748

Maya G. Pandova

引用次数: 0

Local Inflammatory Biomarkers and Potential Inflammation-Targeting Therapies in Diabetic Retinopathy 糖尿病视网膜病变的局部炎症生物标志物和潜在的炎症靶向治疗

Diabetic Eye Disease - From Therapeutic Pipeline to the Real World [Working Title] Pub Date : 2021-09-01 DOI: 10.5772/intechopen.99807

I. Damian, S. Nicoară

引用次数: 1