BOHR International Journal of Current Research in Diabetes and Preventive Medicine最新文献

{"title":"Risks of Overtraining and Compulsive Exercising on Human Health","authors":"Gudisa Bereda","doi":"10.54646/bijrdpm.005","DOIUrl":"https://doi.org/10.54646/bijrdpm.005","url":null,"abstract":"David Miranda, a physical therapist and the proprietor of Excel Rehabilitation Services in Gonzales, Louisiana, asserts that excessive exercise is harmful to human health and counterproductive. Women who exercise excessively run a higher risk of developing the “female athlete triad,” which includes eating disorders, osteoporosis, and loss of bone mineral density. Intense exercise has been shown to lower libido in men; this may be due to physical exhaustion and low testosterone levels. According to German research that was recently published online in the journal Heart, excessive high-intensity exercise may actually increase the risk of dying from a heart attack or stroke in people who already have heart disease. Too much exercise without adequate recovery might cause low testosterone levels and high amounts of the stress hormone cortisol. Overtraining can increase stress hormone levels, and increase the risk of injury, weariness, and muscle loss. The Wall Street Journal’s article “A Workout Ate My Marriage,” which was published in 2010, describes how spouses grow more estranged from one another as they become fixated on a particular exercise goal, such as extreme weight loss or an Ironman triathlon, at the expense of quality time with loved ones.","PeriodicalId":154243,"journal":{"name":"BOHR International Journal of Current Research in Diabetes and Preventive Medicine","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123521906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auricular Perichondritis in a Patient with Personal Antecedents of Type II Diabetes and Radical Mastoidectomy","authors":"Sandu Alexandra-Irina, Stefanescu Cristian Dragos","doi":"10.54646/bijrdpm.2023.08","DOIUrl":"https://doi.org/10.54646/bijrdpm.2023.08","url":null,"abstract":"Auricular perichondritis is a rare but severe complication that can occur in patients who experienced ear trauma or those suffering from an immunosuppressive condition. Its treatment is difficult, time consuming and the prognosis is usually poor. We present the case of a 68-year-old patient with personal antecedents of ear surgery, type II diabetes and signs of poor local hygiene, who was admitted to our ENT department with a swollen, painful, erythematous pinna, treated empirically for a period of 3 weeks with systemic antibiotics (cefuroxime), local drainage and application of antiseptic medication (iodine solution, boric acid). Considering the long hospitalization time and the multiple comorbidities of our patient, the present case report is aimed to highlight the importance of a diversified approach of treatment in patients vulnerable to auricular perichondritis.","PeriodicalId":154243,"journal":{"name":"BOHR International Journal of Current Research in Diabetes and Preventive Medicine","volume":"703 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116964784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Cardiomyopathy: An Update on Its Pathophysiology With Specific Emphasis on Epigenetics Modifications Besides Treatment – A Systematic Review","authors":"Kochar Kaur Kulvinder, K. A. Gautam Nand, Singh Mandeep","doi":"10.54646/bijrdpm.001","DOIUrl":"https://doi.org/10.54646/bijrdpm.001","url":null,"abstract":"Diabetes mellitus (DM) represents a significant lifestyle disease. Of the types of DM, type 2 DM aids maximuminthedevelopmentofcardiovasculardisease(CVD)alongwithdiabeticcardiomyopathy(DbCM),which iscorrelatedwithsignificantmortalityalongwithcomorbidityindiabeticpatients.DbCMisanon-canonicalcardiac illness that exhibits cardiac remodelling occurs when there is DM but not when there is any concomitant conditions like hypertension, valve disease, or coronary artery disease (CAD). DbCM is linked to altered mitochondrial structure and function, as well as aberrant cardiac metabolism. Additional physiological and pathological signaling mechanisms include inflammation, oxidative stress (OS), and others; besides, in the diabetic environment, there are various cardiomyopathy-inducing factors such as reactive oxygen species (ROS)-modulated OS, hyperglycemic situations, cytokines-modulated These mediators induce inflammatory responses, cell death, including apoptosis, pyroptosis,andautophagy,aswellastheepigeneticcontrolofabnormalmolecularpathways.Thelasttenyearshave demonstrated the importance of miRNAs and long noncoding RNAs (lncRNAs) in controlling key biological processessuchcelldeath,mitochondrialdysfunction,andelectricalremodelling.Cardiomyopathyisasignificantevent regardingcardiacremodelingeventinDbCM.Considerableproofexistsregardingthepartofepigeneticsindiabetic correlated cell demise. Epigenetic controlling modes like histone alterations, DNA methylation, and miRNA along with lncRNAs control cardiac cell demise in the diabetic environment. Akin to that, other modes such as mitochondrialimpairmentandOSarecontrolledbymiRNAalongwithlncRNAs.Findingthesemodeshasgivenprovisionof generationofinnovativetherapyapproachesforDbCM.miRNAsalongwithlncRNAshaveillustratedtranslational capacity in the form of Besides treatment options, There are other DbCM-specific diagnostic and prognostic biomarkers available. HDACs were further shown to have a crucial role in controlling the pathogenesis of DbCM.","PeriodicalId":154243,"journal":{"name":"BOHR International Journal of Current Research in Diabetes and Preventive Medicine","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116396934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Abdominal Adiposity on Pulmonary Function Test Values in Healthy Female Population with Different Body Positions","authors":"E. R. Haridas, D. Rajan","doi":"10.54646/bijrdpm.002","DOIUrl":"https://doi.org/10.54646/bijrdpm.002","url":null,"abstract":"Background: According to the WHO, female obesity is double that of the male population, and obesity is associated with respiratory disorders due to changes in the biomechanics of the diaphragm. Pulmonary function test (PFT) is usually done in an upright posture, but obese people might not be able to sit up during PFT. Hence, this study investigates changes in position that alter the PFT values in healthy females with abdominal fat deposition. Method: This experimental study was done on 34 randomly selected female college students (18–25 years old) with a waist-hip ratio of ≥0.85 cm2 . In three distinct positions—supine, sitting, and side-lying—the forced vital capacity and forced expiratory volume in one second (FEV1) standard spirometric tests were compared. Result: Statistical analysis was done using SPSS software. Descriptive data were found by mean and standard deviation. An analysis of variance and the Bonferroni test were applied to find a significant difference in test score between three different body positions. There is a significant difference among the tested three positions; a p > 0.05 was found between supine versus sitting and supine versus side-lying, whereas the mean value between side-lying versus sitting showed a statistically significant difference of p < 0.05. Conclusion: Change in position has significant effects on spirometric parameters in healthy asymptomatic females with central obesity. But a statistically significant and clinically improved result was found in sitting versus side lying position. Hence, this study suggests that adopting a side-lying position for evaluating lung function will not make much difference in PFT values.","PeriodicalId":154243,"journal":{"name":"BOHR International Journal of Current Research in Diabetes and Preventive Medicine","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117299018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Covid-19 Lockdown and Online Studies on Fitness in College Students in and Around Kerala","authors":"E. R. Haridas, D. Rajan, P. Sithara, R. Athira, M. Haris, Joju J Mathew","doi":"10.54646/bijrdpm.004","DOIUrl":"https://doi.org/10.54646/bijrdpm.004","url":null,"abstract":"Coronavirus disease (COVID-19) is a newly discovered infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In March 2020, WHO declared the COVID-19 outbreak a pandemic. As a result, schools and colleges were forced to shut down all over the world. This makes all students population to study from home through online classes. The objective of the study was to find out the relationship between COVID19, fitness, and lifestyle changes in students. A sample of 300 students (aged between 18 and 25 years) from Kerala, Tamil Nadu, and Karnataka participated in this online survey sent through a Google Form. The survey consisted of 15 questions regarding the student’s activity level, food habits, and health. 90% of the population did not have any medical limitations to stay active during this survey. Out of this, more than half (53%) of the study population has marked that the pandemic has influenced their fitness status. The sedentary behaviour among the population has increased. 49.7% of the population was physically less active, and 37.7% was not at all active. The possible reasons could be lack of time to do exercise, altered sleeping behaviour, increased laziness, and increased online time. 60.7% population have marked that they do not eat more during pandemic and their food habits were good. 47.7% wish to improve their overall health but not decrease weight. Only 16.7% of the population needs to reduce their weight. This is associated with better access to fresh, homemade food. This indicates that majority of studied student population has good eating habits, but they are not able to stay physically fit due to inability to stay physically active. This study concludes that physical activity limitation is the major factor found to have decreased during the COVID-19 pandemic’s online learning. Majority of students’ eating habits have improved due to lockdown, but their fitness status has remained low due to online learning","PeriodicalId":154243,"journal":{"name":"BOHR International Journal of Current Research in Diabetes and Preventive Medicine","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122590613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Hybrid Description of Diabetes Mellitus","authors":"Gudisa Bereda","doi":"10.54646/bijrdpm.006","DOIUrl":"https://doi.org/10.54646/bijrdpm.006","url":null,"abstract":"Elevated blood sugar levels, which are either brought on by inadequate insulin synthesis by the pancreas or by incorrect insulin usage by the body, characterize diabetes mellitus, a chronic metabolic disease. Diabetes mellitus can cause renal failure, and those with the condition are at least 10 times more likely to have to amputate a foot due to diabetes than those without it. High blood sugar levels are thought to contribute to kidney and heart problems. A rapid rate of beta cell malfunction and sequences resulting from an absolute lack of insulin hormone secretion may be used to describe type 1 diabetes mellitus. Type 1 diabetes mellitus often manifests itself in young patients, although it may also affect adults. Diabetic neuropathy, one of the most severe microvascular complications of diabetes mellitus, is characterized by a metabolic-vascular disorder that compromises the structure and function of peripheral somatic or autonomic nerves without inducing inflammation. Dehydration brought on by osmotic diuresis, which impacts hyperviscosity and a hypercoagulable condition, and elevated blood glucose levels are typical symptoms of a hyperosmolar hyperglycemic state. People with type 1 diabetes are 12 times more likely than those with type 2 diabetes to develop diabetic nephropathy.","PeriodicalId":154243,"journal":{"name":"BOHR International Journal of Current Research in Diabetes and Preventive Medicine","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121520273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences Between Hyperglycemic Hyperosmolar Non-Ketotic Syndrome and Diabetic Ketoacidosis","authors":"Gudisa Bereda","doi":"10.54646/bijrdpm.003","DOIUrl":"https://doi.org/10.54646/bijrdpm.003","url":null,"abstract":"Since high blood glucose levels might result from inadequate insulin levels, diabetic ketoacidosis is more common in those with insulin-dependent diabetes mellitus. Diabetic ketoacidosis develops only when there is insufficient insulin in the body to convert blood sugar into energy. The liver then uses the acids created by this process, known as ketones, to breakdown fat for energy. Osmotic diuresis, which results in significant amounts of urine production and volume depletion, as well as dehydration, occurs when an excessive amount of glucose enters the renal tubules of an individual with diabetes. Non-insulin-dependent diabetes mellitus can be more likely to cause hyperglycemic hyperosmolar nonketotic syndrome. More often than not, people with non-insulin-dependent diabetes mellitus who do not have their diabetes under control will experience hyperglycemic and hyperosmolar non-ketotic syndrome. The majority of cases of hyperglycemic hyperosmolar non-ketotic syndrome occur in people with non-insulin-dependent diabetes mellitus who also have another condition that reduces fluid intake.","PeriodicalId":154243,"journal":{"name":"BOHR International Journal of Current Research in Diabetes and Preventive Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114870882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of clinical patterns of diabetic neuropathy in patients of type 2 diabetes mellitus in a tertiary care hospital","authors":"Susmitha Suresh, S. Raj, P. Manoj","doi":"10.54646/bijrdpm.2023.07","DOIUrl":"https://doi.org/10.54646/bijrdpm.2023.07","url":null,"abstract":"Introduction: Diabetic neuropathy manifests with sensory, motor, and autonomic functions. The symptoms of neuropathy are highly unpleasant, affecting the quality of life. The diagnosis of diabetic neuropathy is often delayed, so there remains a substantial need for its early diagnosis for timely management. Objective: The aim of this study was to describe patterns of diabetic neuropathy, study nerve conduction study (NCS) findings in diabetic patients with symptoms of neuropathy, and find the relationship between clinical patterns of neuropathy and worsening glycemic control. Methods: This is a hospital-based cross-sectional study of 104 known cases of diabetes mellitus patients with symptoms of neuropathy visiting Sree Gokulam Medical College and undergoing NCS as a part of the investigation. The Fisher’s exact test was used accordingly. Results: The mean age of the study population was 63.1 ± 6.1 years. The mean body mass index was 27.1 ± 3.2 kg/m2 . Overall, 97.1% patients had HbA1c above 7%. Approximately 54.8% of patients presented with tingling sensation, 42.3% with burning sensation, 31.7% complained of pain, 16.3% presented with numbness, 51% patients had abnormal NCS findings in sural and peroneal nerves, 54.8% in superficial peroneal nerve, 46.2% in tibial nerve, and 31.7% patients had abnormal NCS findings in median nerve. Based on the patterns of neuropathy, 68.2% had sensory motor polyneuropathy, 5.8% had carpal tunnel syndrome, 20.2% had small fiber neuropathy (normal NCS), 2.9% had tibial mononeuropathy, and 2.9% had ulnar mononeuropathy. No association was found between the clinical patterns of neuropathy and glycemic control (HbA1c). Conclusion: The most common pattern of neuropathy was sensory motor polyneuropathy. The common nerves involved were sural, peroneal, and superficial peroneal nerve, and the most common presenting complaint was tingling sensation, followed by burning sensation. There was no relationship between clinical patterns of neuropathy and worsening glycemic control.","PeriodicalId":154243,"journal":{"name":"BOHR International Journal of Current Research in Diabetes and Preventive Medicine","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127645718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}