Journal of Cell Signaling最新文献

The mTOR Family of Proteins and the Regulation of Trophoblast Invasion by Gas6 mTOR蛋白家族与Gas6对滋养细胞侵袭的调控

Journal of Cell Signaling Pub Date : 2019-01-01 DOI: 10.35248/2576-1471.19.4.203

K. M. Hirschi, Kary Ya Fang Tsai, M. Edwards, P. Hall, J. Mejia, Camilo Mejia, P. Reynolds, J. Arroyo

{"title":"The mTOR Family of Proteins and the Regulation of Trophoblast Invasion by Gas6","authors":"K. M. Hirschi, Kary Ya Fang Tsai, M. Edwards, P. Hall, J. Mejia, Camilo Mejia, P. Reynolds, J. Arroyo","doi":"10.35248/2576-1471.19.4.203","DOIUrl":"https://doi.org/10.35248/2576-1471.19.4.203","url":null,"abstract":"Objective: Preeclampsia is an obstetric complication wherein trophoblast invasion is decreased and high levels of serum Gas6 protein are present. Our objective was to assess members of the mTOR family that are plausibly involved in the invasion of trophoblast cells resulting from Gas6/AXL activation. Methods: Human first trimester cell line; (SW71), placental choriocarcinoma cell line (Jeg-3) and pulmonary alveolar type II-like cell line (A549) were treated with Gas6 or Gas6 and R428 (AXL receptor inhibitor) for 24 hours and real time cellular invasion was determined. Western blots were utilized to assess AXL receptor expression in treated and control cells. An Akt/mTOR phospho protein multiplex approach was used to determine the activity of mTOR related proteins. Results: As compared to controls, cell treatments showed: 1) decreased SW71 invasion and increased Jeg-3 and A549 invasion with Gas6, 2) reversal of invasive properties when Gas6 and R428 were co-administered in A549 and SW71 cells, 3) increased expression of pAXL cells with Gas6, 4) decreased pAXL expression when Gas6 and R428 were added, 5) a trend of decreased phosphorylation of mTOR related proteins by Gas6 in trophoblasts, and 6) a trend of increased phosphorylation of mTOR related proteins by Gas6 in lung cancer cells. Conclusions: These experiments revealed that mTOR family members are involved in the activation of AXL receptors during the regulation of cell invasion. The results provide important insight into the mechanism of AXL regulation of trophoblast cell invasion and identify potential avenues that may help in the understanding of obstetric complications associated with the aberrant invasion of trophoblast cells.","PeriodicalId":15288,"journal":{"name":"Journal of Cell Signaling","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88277385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

CD40 Agonist-activated mTORC1 Signaling Synergizes with PD-1 Checkpoint Blockade to Counter T-cell Exhaustion in Chronic Infection CD40激动剂激活的mTORC1信号与PD-1检查点阻断协同对抗慢性感染中的t细胞衰竭

Journal of Cell Signaling Pub Date : 2019-01-01 DOI: 10.35248/2576-1471.19.4.202

Anjuman Ara, J. Xiang

引用次数: 0

A Discussion on the Relationship between Skin Lipid Metabolism and Whole-Body Glucose and Lipid Metabolism: Systematic Review. 皮肤脂质代谢与全身糖脂代谢关系的探讨:系统综述。

Journal of Cell Signaling Pub Date : 2018-01-01 Epub Date: 2018-10-10 DOI: 10.4172/2576-1471.1000189

Sabrina N Dumas, James M Ntambi

{"title":"A Discussion on the Relationship between Skin Lipid Metabolism and Whole-Body Glucose and Lipid Metabolism: Systematic Review.","authors":"Sabrina N Dumas, James M Ntambi","doi":"10.4172/2576-1471.1000189","DOIUrl":"https://doi.org/10.4172/2576-1471.1000189","url":null,"abstract":"The obesity epidemic is a costly public health crisis that is not improving. In addition to the stigma and discomfort associated with carrying extra weight (at the expense of range of movement), obesity also goes hand-in-hand with co-morbidities like fatty liver disease, diabetes, cardiovascular disease, and increased risk of some forms of cancer. Currently there are no long-lasting treatments for obesity other than diet and exercise, which are not feasible for many populations that may not be equipped with the resources and/or support needed to lead a healthy lifestyle. Although there have been some pharmacological breakthroughs for treating obesity, each FDA-approved drug comes with unpleasant side-effects that make adherence unlikely. As a result, alternate approaches are necessary. In this review, we outline the relationship between skin lipid metabolism and whole-body glucose and lipid metabolism. Specifically, by summarizing studies that employed mice that were genetically modified to interrupt lipid metabolism in the skin. As a result, we propose that skin might be an overlooked, but viable target for combating obesity.","PeriodicalId":15288,"journal":{"name":"Journal of Cell Signaling","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2576-1471.1000189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36764627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Smyd1C Mediates CD8 T Cell Death via Regulation of Bcl2-Mediated Restriction of outer Mitochondrial Membrane Integrity. Smyd1C通过调控bcl2介导的线粒体外膜完整性限制介导CD8 T细胞死亡。

Journal of Cell Signaling Pub Date : 2017-09-01 Epub Date: 2017-09-12 DOI: 10.4172/2576-1471.1000163

Hui Nie, Gary Rathbun, Haley Tucker

引用次数: 6

Angiotensin-(1-7) and the Regulation of Anti-Fibrotic Signaling Pathways. 血管紧张素-(1-7)与抗纤维化信号通路的调控。

Journal of Cell Signaling Pub Date : 2017-03-01 Epub Date: 2017-01-27 DOI: 10.4172/2576-1471.1000134

Mark C Chappell, Ebaa M Al Zayadneh

引用次数: 31

Role of MEK1 in TLR4 Mediated Signaling. MEK1在TLR4介导的信号传导中的作用。

Journal of Cell Signaling Pub Date : 2017-03-01 Epub Date: 2017-02-13 DOI: 10.4172/2576-1471.1000135

Christian Bauerfeld, Lobelia Samavati

引用次数: 5

The Current State of FLT3 Inhibition in Acute Myeloid Leukemia - Pitfalls and Promises. FLT3在急性髓系白血病中的抑制现状——缺陷与前景。

Journal of Cell Signaling Pub Date : 2017-01-01 Epub Date: 2017-10-16 DOI: 10.4172/2576-1471.1000166

Katherine A Minson, Deborah DeRyckere, Douglas K Graham

引用次数: 3

The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage Signaling. MOB2与NDR1/2激酶在细胞周期和DNA损伤信号转导中可能存在的相互影响

Journal of Cell Signaling Pub Date : 2016-09-06

Ramazan Gundogdu, Alexander Hergovich

引用次数: 0

The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage Signaling MOB2与NDR1/2激酶在细胞周期和DNA损伤信号传导中的可能串扰

Journal of Cell Signaling Pub Date : 2016-09-06 DOI: 10.4172/2576-1471.1000125

R. Gundogdu, A. Hergovich

引用次数: 6

Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications. 血管紧张素受体:结构、功能、信号传导和临床应用。

Journal of Cell Signaling Pub Date : 2016-06-01 Epub Date: 2016-04-08 DOI: 10.4172/jcs.1000111

Khuraijam Dhanachandra Singh, Sadashiva S Karnik

{"title":"Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.","authors":"Khuraijam Dhanachandra Singh, Sadashiva S Karnik","doi":"10.4172/jcs.1000111","DOIUrl":"https://doi.org/10.4172/jcs.1000111","url":null,"abstract":"Angiotensinogen - a serpin family protein predominantly produced by the liver is systematically processed by proteases of the Renin Angiotensin system (RAS) generating hormone peptides. Specific cell surface receptors for at least three distinct angiotensin peptides produce distinct cellular signals that regulate system-wide physiological response to RAS. Two well characterized receptors are angiotensin type 1 receptor (AT1 receptor) and type 2 receptor (AT2 receptor). They respond to the octapeptide hormone angiotensin II. The oncogene product MAS is a putative receptor for Ang (1-7). While these are G-protein coupled receptors (GPCRs), the in vivo angiotensin IV binding sites may be type 2 transmembrane proteins. These four receptors together regulate cardiovascular, hemodynamic, neurological, renal, and endothelial functions; as well as cell proliferation, survival, matrix-cell interactions and inflammation. Angiotensin receptors are important therapeutic targets for several diseases. Thus, researchers and pharmaceutical companies are focusing on drugs targeting AT1 receptor than AT2 receptor, MAS and AngIV binding sites. AT1 receptor blockers are the cornerstone of current treatment for hypertension, heart failure, renal failure and many types of vascular diseases including atherosclerosis, aortic aneurism and Marfan syndrome.","PeriodicalId":15288,"journal":{"name":"Journal of Cell Signaling","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/jcs.1000111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34747364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 107