Open Journal of Asthma最新文献

Immunosenescence and ACE2 protein expression: Association with SARS-CoV-2 in older adults 老年人免疫衰老和ACE2蛋白表达:与SARS-CoV-2相关

Open Journal of Asthma Pub Date : 2022-10-29 DOI: 10.17352/oja.000018

Altamirano Gustavo Acosta, Rodríguez Carlos E Miguel, Reyes-Montes María del Rocío, Duarte-Escalante Esperanza, Acosta-Reyes Rocío, Torres-Estrella Carlos U, Valencia-Ledezma Omar E

{"title":"Immunosenescence and ACE2 protein expression: Association with SARS-CoV-2 in older adults","authors":"Altamirano Gustavo Acosta, Rodríguez Carlos E Miguel, Reyes-Montes María del Rocío, Duarte-Escalante Esperanza, Acosta-Reyes Rocío, Torres-Estrella Carlos U, Valencia-Ledezma Omar E","doi":"10.17352/oja.000018","DOIUrl":"https://doi.org/10.17352/oja.000018","url":null,"abstract":"At the end of 2019, in Wuhan, China, an outbreak of cases of respiratory tract infection emerged and its progressive infection mainly affects adults, generating many cases of pneumonia. A type of coronavirus named SARS-CoV-2, with genomic similarity to SARS-CoV and MERS-CoV, was identified as the etiological agent. The evolution of this pandemic has made it possible to verify the similarity in the pathophysiological mechanisms between these three viruses, identifying the Angiotensin-Converting protein-Enzyme 2 (ACE2) as the primary receptor for SARS-CoV-2. This age group is more prone to developing extrapulmonary complications from SARS-CoV-2 since the clinical and pathological findings suggest a particular relationship between greater expression of ACE2 and the comorbidities of chronic degenerative diseases and the greater expression of ACE2 at the level of the respiratory tract. It has also revealed the mechanisms by which the virus evades the innate immune response and the Th1-type adaptive response. The objective of this work was to analyze immunosenescence and its relationship with SARS-CoV-2 infection, through the review of the most recent articles (2021-2022), which describes the senescent state of the elderly. In addition, it intends to highlight the probable causes for which the most vulnerable population group (adults over 60 years of age) is more prone to presenting complications during the infection.","PeriodicalId":151186,"journal":{"name":"Open Journal of Asthma","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123920115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is asthma over-diagnosed in Cyprus? A clinical study at the outpatient’s primary care level 塞浦路斯的哮喘是否被过度诊断?门诊初级保健水平的临床研究

Open Journal of Asthma Pub Date : 2022-09-28 DOI: 10.17352/oja.000017

Armeftis Charis, Lemessios Marinos, Anastas S. Christos, Gratziou Christina, Siafakas Nikolaos, Katsaounou Paraskevi, Bakakos Petros

{"title":"Is asthma over-diagnosed in Cyprus? A clinical study at the outpatient’s primary care level","authors":"Armeftis Charis, Lemessios Marinos, Anastas S. Christos, Gratziou Christina, Siafakas Nikolaos, Katsaounou Paraskevi, Bakakos Petros","doi":"10.17352/oja.000017","DOIUrl":"https://doi.org/10.17352/oja.000017","url":null,"abstract":"Background: Although asthma is a common disease accurate diagnosis is missing and it has been reported that often it is over or under-diagnosed. Aim: To investigate if a physician’s diagnosis of asthma in Cyprus is correct by using a structured algorithm at the outpatient primary care level. Subjects and Methods: Sixty adults with a self-reported physician diagnosis of asthma, mean age of 47,8 years (29 males and 31 females) were included in the study. Medical history and physical examination, pre-post bronchodilation spirometry and methacholine bronchial challenge test was used to confirm or rule out the diagnosis as well as a three months follow-up. In addition, the cost of treatment was estimated. Results: Sixteen subjects (27%) had a positive pre-post bronchodilation spirometric test and were considered asthmatics. In 9 out of the 44 remaining subjects a positive Methacholine provocation test confirmed the diagnosis of asthma. The rest of the subjects (n = 35) went into a 3 months observational period during which only 2 showed asthmatic symptoms and were considered asthmatics by a second methacholine test that confirmed the diagnosis. Therefore, a correct asthma diagnosis was established in only 27(45%) of subjects. The annual average cost of medication for asthma confirmed the group was 313 euro/patient (171-454, 95% CI) and the average 2-year unnecessary (asthma ruled-out group) cost of treatment was approximately 297 euro/patient. (179-415, 95% CI). Conclusions: Physician-diagnosed asthma overestimates the actual prevalence of disease in adults in Cyprus since it was shown that more than half of the participants did not have Asthma. These individuals consume unneeded medications at a significant cost. Thus, the correct diagnosis of Asthma should be made by using more specific tests starting at the primary care level.","PeriodicalId":151186,"journal":{"name":"Open Journal of Asthma","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122137189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of ST2 as a biomarker of respiratory dysfunction after interstitial pneumonia ST2作为间质性肺炎后呼吸功能障碍的生物标志物的作用

Open Journal of Asthma Pub Date : 2021-07-30 DOI: 10.17352/oja.000015

Maria Civita Cedrone, Luca Marino, M. Suppa, G. Bertazzoni

引用次数: 0

Inclusion of steps to enhance mucus clearance may provide benefit for symptomatic COVID patients by reducing total viral load, time to recovery, risk of complications and transmission risk 纳入加强粘液清除的步骤可能会通过减少病毒总载量、恢复时间、并发症风险和传播风险，为有症状的COVID患者带来益处

Open Journal of Asthma Pub Date : 2021-07-15 DOI: 10.17352/oja.000014

Given John, S. Charles

引用次数: 0