Journal of Heavy Metal Toxicity and Diseases最新文献

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Effects of Mercury, Lead, Arsenic and Zinc to Human Renal Oxidative Stress and Functions: A Review 汞、铅、砷和锌对人体肾脏氧化应激和功能的影响

Journal of Heavy Metal Toxicity and Diseases Pub Date : 1900-01-01 DOI: 10.21767/2473-6457.10027

J. Salazar-Flores, J. Torres-Jasso, Danie Rojas Bravo, Zoyla M. Reyna Villela, E. D. T. Sanchez

{"title":"Effects of Mercury, Lead, Arsenic and Zinc to Human Renal Oxidative Stress and Functions: A Review","authors":"J. Salazar-Flores, J. Torres-Jasso, Danie Rojas Bravo, Zoyla M. Reyna Villela, E. D. T. Sanchez","doi":"10.21767/2473-6457.10027","DOIUrl":"https://doi.org/10.21767/2473-6457.10027","url":null,"abstract":"Background: Heavy metals such as mercury (Hg), lead (Pb) and arsenic (As) are \u0000 elements that promote the generation of reactive oxygen species (ROS) and \u0000 reactive nitrogen species (RNS) involved in the etiology of oxidative stress. They \u0000 cause oxidative damage to membrane lipids, proteins and DNA, thereby activating \u0000 pathways of apoptosis and tissue degeneration. Some chemical species derived \u0000 from these metals include methyl mercury (CH3Hg+), tetraethyl lead [(CH3CH2)4Pb], \u0000 arsenate (AsO43-) and arsenite (AsO2-), all of which have the capacity to induce \u0000 oxidative stress and renal damage. \u0000Purpose: To comprehensively review the effects of Hg, Pb, As and Zinc (Zn) on \u0000 renal oxidative status. \u0000Methods: Literature survey was done using key words such as heavy metals, \u0000 oxidative stress and kidney damage using search engines for free scientific \u0000 publications such as PubMed database, FreeFullPDF.com and Google Scheler. \u0000Results: It was revealed that Hg, Pb and As contribute significantly to oxidative \u0000 stress by stimulating the generation of free radicals, oxidation of biomolecules, \u0000 deregulation of pro-oxidant proteins, and activation of pro-inflammatory \u0000 molecules, which ultimately lead to renal damage. There is a strong association \u0000 between exposure to these heavy metals and chronic renal damage, since their \u0000 bioaccumulation deregulates glomerular filtration and tubular secretion due to \u0000 excessive production of ROS and activation of apoptotic pathways. However, \u0000 studies have shown that Zn possesses renoprotective and antioxidant effects, and \u0000 its deficiency leads to oxidative stress. \u0000Conclusion: The results of this survey suggest that deficiencies of Hg, Pb, As and \u0000 Zn produce different degrees of oxidative damage which negatively impact on \u0000 renal health.","PeriodicalId":150700,"journal":{"name":"Journal of Heavy Metal Toxicity and Diseases","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133613904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34