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Handbook of Harnessing Biomaterials in Nanomedicine最新文献

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Novel RNA Interference (RNAi)-Based Nanomedicines for Treating Viral Infections 新型RNA干扰(RNAi)纳米药物治疗病毒感染
Handbook of Harnessing Biomaterials in Nanomedicine Pub Date : 2021-01-25 DOI: 10.1201/b11620-8
Nyree E. Maes, Skye Zeller, Priti Kumar
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引用次数: 0
Single-Chain Polymer Nanoparticles for Application in Nanomedicine 单链聚合物纳米颗粒在纳米医学中的应用
Handbook of Harnessing Biomaterials in Nanomedicine Pub Date : 2021-01-25 DOI: 10.1201/9781003125259-3
I. Odriozola, M. Aiertza, G. Cabañero, H. Grande, I. Loinaz
{"title":"Single-Chain Polymer Nanoparticles for Application in Nanomedicine","authors":"I. Odriozola, M. Aiertza, G. Cabañero, H. Grande, I. Loinaz","doi":"10.1201/9781003125259-3","DOIUrl":"https://doi.org/10.1201/9781003125259-3","url":null,"abstract":"","PeriodicalId":148092,"journal":{"name":"Handbook of Harnessing Biomaterials in Nanomedicine","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133297401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doxil® — The First FDA-Approved Nano-Drug: From an Idea to a Product Doxil®-第一个fda批准的纳米药物:从想法到产品
Handbook of Harnessing Biomaterials in Nanomedicine Pub Date : 2021-01-25 DOI: 10.1201/9781003125259-16
Y. Barenholz, A. Gabizon
{"title":"Doxil® — The First FDA-Approved Nano-Drug: From an Idea to a Product","authors":"Y. Barenholz, A. Gabizon","doi":"10.1201/9781003125259-16","DOIUrl":"https://doi.org/10.1201/9781003125259-16","url":null,"abstract":"Doxorubicin in liposomes (abbreviated and registered as Doxil) is an anticancer nano-drug. Doxil is based on three unrelated principles: (T) using sterically stabilized liposomes, steric stabilization being achieved by the presence of pegylated distearoyl phosphatidylethanolamine (2000Da PEG-DSPE), which results in long blood circulation time of the liposomes; pi] high and stable remote loading of doxorubicin driven by a transmembrane ammonium sulfate gradient, which also allows for drug release at the tumor; and (iii) having the liposome lipid bilayer in the \"liquid ordered\" phase based on the high-Tm (53°C) hydrogenated soy phosphatidylcholine, and on cholesterol. In order to take advantage of the enhanced permeability and retention (EPR) effect and to achieve passive targeting of the liposomes into the tumor, the liposomes are nanoscale. This chapter describes the downs and ups of pre-Doxil and Doxil formulations, and how the lessons learned from the failure of pre-Doxil liposomal doxorubicin formulations were turned into the","PeriodicalId":148092,"journal":{"name":"Handbook of Harnessing Biomaterials in Nanomedicine","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134072224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Polyethylene Glycol Polyester Block Copolymers: Biocompatible Carriers for Nanoparticulate Drug Delivery 聚乙二醇聚酯嵌段共聚物:纳米颗粒药物递送的生物相容性载体
Handbook of Harnessing Biomaterials in Nanomedicine Pub Date : 2021-01-25 DOI: 10.1201/9781003125259-4
D. Hart, Yunqi Zhao, M. Forrest
{"title":"Polyethylene Glycol Polyester Block Copolymers: Biocompatible Carriers for Nanoparticulate Drug Delivery","authors":"D. Hart, Yunqi Zhao, M. Forrest","doi":"10.1201/9781003125259-4","DOIUrl":"https://doi.org/10.1201/9781003125259-4","url":null,"abstract":"","PeriodicalId":148092,"journal":{"name":"Handbook of Harnessing Biomaterials in Nanomedicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130316175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Complement Activation, Immunogenicity, and Immune Suppression as Potential Side Effects of Liposomes 补体活化、免疫原性和免疫抑制作为脂质体的潜在副作用
Handbook of Harnessing Biomaterials in Nanomedicine Pub Date : 2021-01-25 DOI: 10.1201/9781003125259-12
J. Szebeni, Y. Barenholz
{"title":"Complement Activation, Immunogenicity, and Immune Suppression as Potential Side Effects of Liposomes","authors":"J. Szebeni, Y. Barenholz","doi":"10.1201/9781003125259-12","DOIUrl":"https://doi.org/10.1201/9781003125259-12","url":null,"abstract":"","PeriodicalId":148092,"journal":{"name":"Handbook of Harnessing Biomaterials in Nanomedicine","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125891774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Polysaccharides as Nanomaterials for Therapeutics 多糖作为纳米材料用于治疗
Handbook of Harnessing Biomaterials in Nanomedicine Pub Date : 2012-01-31 DOI: 10.4032/9789814364270
Shoshy Mizrahy, D. Peer
{"title":"Polysaccharides as Nanomaterials for Therapeutics","authors":"Shoshy Mizrahy, D. Peer","doi":"10.4032/9789814364270","DOIUrl":"https://doi.org/10.4032/9789814364270","url":null,"abstract":"","PeriodicalId":148092,"journal":{"name":"Handbook of Harnessing Biomaterials in Nanomedicine","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128927124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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