{"title":"Systemic Morphine but Not Local Administration Shows Preventive Anti-Inflammatory Effect in a Rat Model of Capsaicin-Induced Paw Edema","authors":"Giuseppe Gagliardi","doi":"10.19080/jcmah.2023.12.555840","DOIUrl":"https://doi.org/10.19080/jcmah.2023.12.555840","url":null,"abstract":"Peripheral opioids and analogues have demonstrated their efficacy in controlling inflammatory response and hyperalgesia. However, it is not yet clear whether the effect on edematogenic response is determined by the action at peripheral level or by systemic opioid receptors. Methods: In this study we investigated the effects of subcutaneous, intraplantar and intraperitoneal morphine injection in rats with acute capsaicin-induced hind paw inflammation. The experiment was conducted on 50 male Sprague-Dawley rats randomly divided into 5 groups of equal numerosity. Group 1 was control group; group 2 was treated with 5 mg/kg morphine by intraperitoneal injection; group 3 with 5 mg/kg morphine injected in the back subcutaneously; group 4 and group 5 were treated respectively with 0.05 mg/kg and 0.1 mg/kg morphine locally injected in the paw before induction of neurogenic edema. Neurogenic edema was induced by the administration of 50 mcg capsaicin in 50 mcl saline in the paw. The edema was measured using a calibrated plethysmometer.","PeriodicalId":145038,"journal":{"name":"Journal of Complementary Medicine & Alternative Healthcare","volume":"6 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139262785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Evidence Based Review of Vitamin D in COVID-19 Severity and Mortality","authors":"J. Nishikawa","doi":"10.19080/jcmah.2023.12.555830","DOIUrl":"https://doi.org/10.19080/jcmah.2023.12.555830","url":null,"abstract":"Introduction: This evidence-based review aims to explore the association between vitamin D status and the severity and mortality of COVID-19, providing insights for healthcare professionals and policymakers in managing the disease. Methods: A systematic review process was conducted to identify relevant studies on vitamin D and COVID-19 using electronic databases and specific search terms. Thirteen studies were selected and analyzed, including quantitative research at levels III, IV, and V.","PeriodicalId":145038,"journal":{"name":"Journal of Complementary Medicine & Alternative Healthcare","volume":"62 51","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131639172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of Osteopathic Manipulative Treatment (OMT) Vs Physiotherapy in Chronic Lateral Epicondylitis","authors":"Altadonna Giulio, Cappelli Davide, Orlandi Magli Antonella, Raffa Debora, Spinnato Paolo, Filardo Giuseppe, Tedeschi Roberto, Benedetti Maria Grazia","doi":"10.19080/jcmah.2022.11.555818","DOIUrl":"https://doi.org/10.19080/jcmah.2022.11.555818","url":null,"abstract":"Background: Several rehabilitative treatments have been proposed for Lateral Elbow Tendinopathy (LET). Therapeutic exercise showed the greatest beneficial effects together with patient education, and multimodal treatment subject specific. In recent years, osteopathic manipulative treatment (OMT) has been proposed as treatment for LET. The aim of the study was to focus on this emerging approach by comparing it to more traditional physiotherapy. Methods: Thirty-two patients with a diagnosis of LET were enrolled and randomly assigned to two groups: the OMT group and the physiotherapy group. In the former, patients underwent OMT according to the common techniques. In the latter, patients underwent a physiotherapy protocol consisting in stretching and strengthening exercises, and laser therapy. Outcome measures included the Patient-Rated Tennis Elbow Evaluation (PRTEE), the Mayo Elbow Performance, and VAS for pain. Assessment was carried out at baseline (T0), after 1 (T1) and 3 (T2) months. In addition, an ultrasound assessment of the elbow common extensor tendon was performed at T0 and T2. Results: Both the OMT and the Physiotherapy group showed a statistically significant improvement along the follow-up for VAS for pain and PRTEE score. No significant difference was found for the Mayo Score in the Physiotherapy group. Ultrasound assessment confirmed the presence of abnormalities of vascularization, echogenicity, and thickness of the tendon at T0, partially reduced at T2. Conclusion: OMT and physiotherapy resulted both effective in the treatment of LET, offering a significant clinical improvement which helped patients recovering their functional activities in the short-term follow-up.","PeriodicalId":145038,"journal":{"name":"Journal of Complementary Medicine & Alternative Healthcare","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123087146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioanalytical Approach-Ageing, Exercise and Oxidative Stress","authors":"A. Valado","doi":"10.19080/jcmah.2020.11.555810","DOIUrl":"https://doi.org/10.19080/jcmah.2020.11.555810","url":null,"abstract":"Abstract: Exercise interferes with the ageing, causing changes in markers of the antioxidant system, such as nitric oxide (NO) and uric acid. Aim: The objective of this study was to evaluate if regular exercise affects the ageing process by causing changes in the antioxidant markers, nitric oxide and uric acid, in individuals aged ≥ 65 years, subjected to an exercise plan. Methods: The study involved 12 participants distributed in an experimental and control group. The experimental group performed exercises guided by a physiotherapist during 12 weeks. Three blood samples were collected from participants: T0, at the start of the study; T1, after 12 weeks of exercise and T2, 12 weeks after finishing the exercise. NO and uric acid were quantified with commercial kits. The statistics were performed using SPSS and the ANOVA and Student t-tests were applied. Result: In the experimental group, the mean values of NO showed an increase between T0 and T1, with a slight decrease between T1 and T2. Similar effects were observed for the uric acid concentration in the experimental group, with statistical significance from T0 to T1. Conclusion: After exercise, there was an increase in blood uric acid and NO levels, highlighting the importance of moderate and controlled exercise practice. Therefore, exercise seems relevant and beneficial in activating antioxidant mechanisms.","PeriodicalId":145038,"journal":{"name":"Journal of Complementary Medicine & Alternative Healthcare","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141220224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Complementary and Alternative Therapies to Reduce Morbidity in Oestrogen Deficiency Associated Osteoporosis: A Review","authors":"Kaveri Kuttappa","doi":"10.19080/jcmah.2020.11.555808","DOIUrl":"https://doi.org/10.19080/jcmah.2020.11.555808","url":null,"abstract":"Objective: To review and analyze the clinical studies performed on the role of complementary and alternative medicine, individually or combined, in reducing morbidity in estrogen deficiency associated osteoporosis. The morbidity is assessed in terms of the frequency of fractures, improvement in bone marrow density (BMD) and change in bone turnover parameters. Background: with increasing age, there is a decreased absorption and storage of vitamin D and calcium, which are essential for maintaining bone health. This condition is further worsened estrogen deficiency, as well as in postmenopausal women. When faced with such a scenario, the body resorbs calcium from the bones to overcome the loss, and causes subsequent weakening of the bones and thus, increased susceptibility to frequent fractures and decreases in bone density. Search methods: The study is based on review of clinical studies sourced from PubMed, Medline, Cochrane Database, and Journals specific to studies related to yoga, Ayurveda and naturopathy, with correlation to Ayurveda & Modern text. Result: 16 out of the 17 research articles that have been reviewed showed that yoga, Ayurveda and naturopathy have a positive effect on BMD, bone growth and preserving the bone architecture.","PeriodicalId":145038,"journal":{"name":"Journal of Complementary Medicine & Alternative Healthcare","volume":"131 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141224930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}