Journal of Molecular Pathophysiology最新文献

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Effect of physical activity status and dietary habits on pulmonary functions 体育活动状况和饮食习惯对肺功能的影响

Journal of Molecular Pathophysiology Pub Date : 1900-01-01 DOI: 10.5455/jmp.20190125094008

B. Ibrahim, A. Osman

{"title":"Effect of physical activity status and dietary habits on pulmonary functions","authors":"B. Ibrahim, A. Osman","doi":"10.5455/jmp.20190125094008","DOIUrl":"https://doi.org/10.5455/jmp.20190125094008","url":null,"abstract":"BACKGROUND: There is a widely recognized fact that people who are more physically active and have healthy dietary habits tend to have a higher degree of fitness and physical activity that can promote respiratory health, which increases the efficiency of pulmonary function. \u0000Objective: The aim of the present study to explore the effect of physical activity, physical inactivity and dietary habits on pulmonary function. \u0000Materials and Methods: This cross-sectional study was performed during the period from August to December 2017, at Faculty of Medicine, Omdurman Al-Ahlia University (OAU), Omdurman, Sudan. The study included 207 medical students (100 males - 107 females) between the ages of 15-25 years. The smoker and the asthmatic were excluded. Pulmonary function test (PFT) was measured by using digital portable spirometer and peak flow meter instruments. Arab Teens Lifestyle Study (ATLS) questionnaire was used for determination of physical activity status and dietary habits. \u0000Results: Data analysis showed that PFT parameters were statistically significantly higher in males than females (P value.000). PFT parameters were significantly higher in active subjects (P value 0.003), while the physical inactivity does not affect the PFT parameters. In addition, PFT parameters were significantly positively correlated with many physical activity types. PFT parameters were significantly negatively correlated with many foods staff. PFT parameters were significantly positively correlated to height, weight, sum of metabolic equivalent (sum METs) and age. \u0000Conclusion: Our study concluded that physical activity and regular exercise improve the pulmonary function, and sedentary lifestyle has no direct effect on pulmonary function. Food staff with high fiber content was better than low fiber content for pulmonary function.","PeriodicalId":143935,"journal":{"name":"Journal of Molecular Pathophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131681747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hepatitis C virus infection, genotypes and mechanism of insulin resistance 丙型肝炎病毒感染、基因型及胰岛素抵抗机制

Journal of Molecular Pathophysiology Pub Date : 1900-01-01 DOI: 10.5455/jmp.20190703070703

S. Woyesa, A. Taylor-Robinson

{"title":"Hepatitis C virus infection, genotypes and mechanism of insulin resistance","authors":"S. Woyesa, A. Taylor-Robinson","doi":"10.5455/jmp.20190703070703","DOIUrl":"https://doi.org/10.5455/jmp.20190703070703","url":null,"abstract":"Background: Hepatitis C virus (HCV) infection is a major global public health problem that causes profound metabolic abnormalities, primarily in insulin-sensitive target tissues, notably the phenomenon of steatosis or fatty liver. The route of transmission and genetic mutation of HCV, together with the lack of reliable nation-specific epidemiological data on the distribution of genotypes and sub-genotypes of this RNA virus, provide significant challenges to correct diagnosis and effective treatment. \u0000 \u0000Issue: HCV-induced insulin resistance in HCV-infected individuals is independent of the occurrence of metabolic syndrome and diabetes mellitus, primarily type 2 diabetes mellitus, that causes insulin resistance. Some but not all HCV genotypes exert a steatotic effect. However, the molecular mechanism(s) by which HCV infection causes insulin resistance in insulin target tissues or hepatic steatosis is not elucidated clearly. \u0000 \u0000Findings: Mechanisms proposed by experimental studies include interference with insulin signaling pathways, upregulation of genes controlling gluconeogenesis, phosphorylation of insulin receptor substrate proteins, and induction and overexpression of inflammatory cytokines that interact closely with host lipid metabolism. \u0000 \u0000Conclusion: We review HCV genotypes and subtypes, the mechanisms by which HCV infection induces insulin resistance, the virus genotypes and subtypes that are implicated in this and those that are steatotic. We conclude by discussing proposed mechanisms of steatosis and considering HCV laboratory investigation methods from traditional to current techniques.","PeriodicalId":143935,"journal":{"name":"Journal of Molecular Pathophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117330897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0