{"title":"Metal-Organic Frameworks","authors":"M. V. Dias-Souza, C. G. Dias","doi":"10.4018/978-1-7998-4760-1.CH009","DOIUrl":"https://doi.org/10.4018/978-1-7998-4760-1.CH009","url":null,"abstract":"In the field of bioinorganic chemistry, porosity has been explored for the development of metal-organic frameworks (MOFs), innovative polymers, or networks composed of metal centers that stabilize organic molecules with high contact surface and well-defined crystalline structures. MOFs have also been investigated for drug therapies due to their high loading capacity, thermal stability, low electrical conductivity, biodegradability, biocompatibility, easy functionalization, and size considered adequate to control drug release in vivo. MOFs can be sensitive to variations in pH, magnetism, temperature, pressure, light, and humidity, making them desirable for vectorizing extended release systems. Among the most investigated pharmacological groups for association with MOFs are anti-inflammatory and antineoplasic drugs. Here the authors explore the recent advances of MOFs-based drug delivery systems, their current limitations, and discuss the evidences towards their potential clinical use.","PeriodicalId":139314,"journal":{"name":"Emerging Applications and Implementations of Metal-Organic Frameworks","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128177402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metal-Organic Frameworks for Heavy Metal Removal From Water","authors":"Mintu Maan Dutta, Paran J. Borpatra","doi":"10.4018/978-1-7998-4760-1.CH006","DOIUrl":"https://doi.org/10.4018/978-1-7998-4760-1.CH006","url":null,"abstract":"Clean and safe drinking water is one of the most important and essential components on earth for human survival. However, due to the various anthropogenic activities, the surface and groundwater have been contaminated with heavy metals and radionuclides, and it has become a serious problem of concern globally. These non-biodegradable heavy metal ions from water tends to accumulate in the soil and living organisms and causes serious health hazards in humans. Thus, the finding of recyclable, water-stable MOFs, and multi-functional MOFs (hybrid MOFs) with superior adsorption capability have emerged as a novel material for the removal of heavy metal species (such as Cr(III)/Cr(VI), Cu(II), Hg(II), Cd(II), As(III)/As(V), Pb(II), radionuclides U(VI), Se(IV)/(VI), Cs(I) from aqueous solution. This chapter deals with the recent development of MOFs and their application in heavy metal removal from water.","PeriodicalId":139314,"journal":{"name":"Emerging Applications and Implementations of Metal-Organic Frameworks","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128253268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}