Quinazolinone and Quinazoline Derivatives最新文献

Synthesis of Quinazoline and Quinazolinone Derivatives 喹唑啉及其衍生物的合成

Quinazolinone and Quinazoline Derivatives Pub Date : 2020-04-15 DOI: 10.5772/intechopen.89180

H. Hashem

引用次数: 3

Biological Activity of Quinazolinones 喹唑啉酮类药物的生物活性

Quinazolinone and Quinazoline Derivatives Pub Date : 2020-01-29 DOI: 10.5772/intechopen.90621

A. Radwan, F. Alanazi

{"title":"Biological Activity of Quinazolinones","authors":"A. Radwan, F. Alanazi","doi":"10.5772/intechopen.90621","DOIUrl":"https://doi.org/10.5772/intechopen.90621","url":null,"abstract":"The chemical structure of quinazolinones includes benzene ring fused with 2-pyrimidinone (1), 4-pyrimidinone (2) or 2,4-pyrimidinedione (3) ring, and are named as quinazolin-2(1H)-one, quinazolin-4(3H)-one or quinazolin-2,4(1H, 3H)-one, respectively. The chemical structure of quinazolinones constitutes a crucial scaffold of natural and synthetic compounds with various therapeutic and biological activities. Quinazolinones are first synthesized by Stefan Niementowski (1866–1925) and named after Niementowski quinazolinone synthesis. Quinazolinones have strongly attracted the interest of medicinal chemist as they constitute a large class of compounds that exhibited broad spectrum of biological activities including antimicrobial, antimalarial, anticonvulsant, anticancer, anti-leishmanial, anti-inflammatory, etc. This chapter provides a brief overview on the recent advances on chemical and pharmacological aspects of quinazolinone derivatives published in the last decade. inhibitions by ovine COX and carrageenan-induced rat paw oedema methods. Four compounds showed potent anti-inflammatory activity with oedema inhibition percentage of 49 ± 1.16, 45 ± 0.82, 46 ± 1.36 and 54 ± 1.83 using indomethacin drug as reference.","PeriodicalId":138118,"journal":{"name":"Quinazolinone and Quinazoline Derivatives","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134413408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

4(3H)-Quinazolinone Derivatives: Syntheses, Physical Properties, Chemical Reaction, and Biological Properties 4(3H)-喹唑啉酮衍生物:合成、物理性质、化学反应和生物性质

Quinazolinone and Quinazoline Derivatives Pub Date : 2020-01-22 DOI: 10.5772/intechopen.90104

S. Abbas

引用次数: 2

Quinazolinone and Quinazoline Derivatives: Synthesis and Biological Application 喹唑啉酮及喹唑啉衍生物:合成及生物应用

Quinazolinone and Quinazoline Derivatives Pub Date : 2019-12-13 DOI: 10.5772/intechopen.89203

Satyendra Mishra

引用次数: 5

Synthesis and Pharmacological Research Regarding New Compounds with Quinazolin-4-One Structure 喹唑啉-4- 1结构新化合物的合成及药理研究

Quinazolinone and Quinazoline Derivatives Pub Date : 2019-09-12 DOI: 10.5772/INTECHOPEN.89164

C. Chiriță, Carmen Limban, D. Nuță, Emil Ștefănescu, S. Negreș, C. E. Zbârcea, C. D. Marineci, O. Șeremet, Mihaela M. Trandafir, A. Missir, I. Chiriţă

{"title":"Synthesis and Pharmacological Research Regarding New Compounds with Quinazolin-4-One Structure","authors":"C. Chiriță, Carmen Limban, D. Nuță, Emil Ștefănescu, S. Negreș, C. E. Zbârcea, C. D. Marineci, O. Șeremet, Mihaela M. Trandafir, A. Missir, I. Chiriţă","doi":"10.5772/INTECHOPEN.89164","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.89164","url":null,"abstract":"The quinazoline scaffold is found in the chemical structure of many marketed drugs used in CNS disorders as antidepressants, anxiolytics, or hypnotics. Also, the carbamate ester derivatives have different certain therapeutic actions, such as hyp-notic or parasympathomimetic ones. We have obtained new 4(3H)-quinazolinones by bringing together in the same structure the quinazoline nucleus and carbamate ester group. The compounds named Q1–Q5 were characterized by measuring the melting points, by determining the infrared and NMR spectra, and by elemental analysis. The pharmacological tests evidenced that the compounds have a very low acute toxicity, lethal doses being >2000 mg/kg bw. The compounds had different actions observed in forced swimming test (FST), tail suspension test (TST), or elevated plus maze (EPM), probably influenced by the presence of different radicals on the nucleus. Thus, Q1 with a nitro group in structure manifested the highest antidepressant effect, showing a reduction of immobilization time in FST and TST. On the other hand, Q3 and Q5, with two groups methoxy, respective ethoxy, had a slight anxiolytic effect, highlighted by an increase of the time spent in open arms and a decrease of the time spent in closed arms of EPM.","PeriodicalId":138118,"journal":{"name":"Quinazolinone and Quinazoline Derivatives","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131982897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quinazoline Based Synthesis of some Heterocyclic Schiff Bases 喹唑啉类杂环席夫碱的合成

Quinazolinone and Quinazoline Derivatives Pub Date : 2015-12-24 DOI: 10.5772/INTECHOPEN.89871

V. Navale, R. Shinde, S. Patil, A. Vibhute, S. Zangade

引用次数: 2