{"title":"Updates in Neurology: Nicotinamide Riboside and Mitochondrial Support","authors":"Liz Sutherland","doi":"10.14200/rmd.2022.0001","DOIUrl":"https://doi.org/10.14200/rmd.2022.0001","url":null,"abstract":"Mitochondrial dysfunction is associated with both aging and a wide array of neurodegenerative disorders such as Alzheimer's disease,1 Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Mitochondrial dysfunction increases with age, leading to high levels of reactive oxygen species and prolonged oxidative stress. Therapeutic approaches that help regulate mitochondrial biogenenesis and mitophagy (a specialized form of autophagy that removes impaired mitochondria) could potentially have positive effects on the early stages and severity of neurodegenerative conditions, as well as supporting healthy aging in general.","PeriodicalId":135006,"journal":{"name":"Restorative Medicine Digest","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125520780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Novel Role for Senolytic Therapies","authors":"Liz Sutherland","doi":"10.14200/rmd.2023.0002","DOIUrl":"https://doi.org/10.14200/rmd.2023.0002","url":null,"abstract":"","PeriodicalId":135006,"journal":{"name":"Restorative Medicine Digest","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127011438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TUDCA and Neurodegeneration","authors":"Liz Sutherland","doi":"10.14200/rmd.2023.0005","DOIUrl":"https://doi.org/10.14200/rmd.2023.0005","url":null,"abstract":"Evidence for the neuroprotective effects of TUDCA was first shown in experimental or animal models of Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis,18 and amyotrophic lateral sclerosis (ALS). These preclinical studies found that TUDCA regulates and inhibits apoptosis; reduces production of reactive oxygen species; protects mitochondria; and acts as a chemical chaperone to stabilize the unfolded protein response.8 Several clinical trials are now underway to evaluate the safety and efficacy of TUDCA in the treatment of neurodegeneration. Data from these trials has shown that TUDCA is safe and potentially effective in ALS, which is now the first neurodegenerative condition to be treated with hydrophilic bile acids. Further evidence is being collected with regard to Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and multiple sclerosis.","PeriodicalId":135006,"journal":{"name":"Restorative Medicine Digest","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125763970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiovascular Health Update: Red Yeast Rice","authors":"Liz Sutherland","doi":"10.14200/rmd.2022.0004","DOIUrl":"https://doi.org/10.14200/rmd.2022.0004","url":null,"abstract":"","PeriodicalId":135006,"journal":{"name":"Restorative Medicine Digest","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115741273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Berberine in Cardiovascular and Metabolic Health","authors":"Liz Sutherland","doi":"10.14200/rmd.2023.0001","DOIUrl":"https://doi.org/10.14200/rmd.2023.0001","url":null,"abstract":"Berberine is a highly versatile botanical with extensive physiological activity resulting from its ability to interact with numerous enzyme systems, receptor sites, and cell signaling pathways. Both pre-clinical and clinical studies continue to shed light on berberine's therapeutic potential, corroborating many of its traditional uses. Berberine has antioxidant and anti-inflammatory effects and can help regulate certain metabolic processes. For example, studies show that berberine may improve insulin resistance, support insulin secretion, inhibit lipogenesis, and rebalance the gut microbiome. The roster of novel molecular targets that berberine influences continues to be discovered, with its ability to regulate adenosine monophosphate (AMP) levels and induce AMP-activated protein kinase (AMPK) being chief among them. AMPK activity, which declines with age, is crucial for the proper functioning of cellular metabolism.","PeriodicalId":135006,"journal":{"name":"Restorative Medicine Digest","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124900036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fisetin and Lung Health","authors":"Liz Sutherland","doi":"10.14200/rmd.2023.0004","DOIUrl":"https://doi.org/10.14200/rmd.2023.0004","url":null,"abstract":"Fisetin has been shown to have a positive effect on the complex array of interconnected signaling mechanisms that play a key role in regulating aging and health.","PeriodicalId":135006,"journal":{"name":"Restorative Medicine Digest","volume":"248 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123103340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"LDL Oxidation: A Risk Factor for Atherosclerosis","authors":"Liz Sutherland","doi":"10.14200/rmd.2022.0003","DOIUrl":"https://doi.org/10.14200/rmd.2022.0003","url":null,"abstract":"","PeriodicalId":135006,"journal":{"name":"Restorative Medicine Digest","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133483691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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