International Psychogeriatrics / Ipa最新文献

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Regional functional synchronizations in dementia with Lewy bodies and Alzheimer's disease 路易体痴呆和阿尔茨海默病的区域功能同步

International Psychogeriatrics / Ipa Pub Date : 2016-03-15 DOI: 10.1017/S1041610216000429

L. Peraza, S. Colloby, Liam Deboys, J. O'Brien, Marcus Kaiser, John-Paul Taylor

{"title":"Regional functional synchronizations in dementia with Lewy bodies and Alzheimer's disease","authors":"L. Peraza, S. Colloby, Liam Deboys, J. O'Brien, Marcus Kaiser, John-Paul Taylor","doi":"10.1017/S1041610216000429","DOIUrl":"https://doi.org/10.1017/S1041610216000429","url":null,"abstract":"ABSTRACT Background: Dementia with Lewy bodies (DLB) is a common cause of dementia in the elderly population after Alzheimer's disease (AD), and at early stages differential diagnosis between DLB and AD might be difficult due to their symptomatic overlap, e.g. cognitive and memory impairments. We aimed to investigate functional brain differences between both diseases in patients recently diagnosed. Methods: We investigated regional functional synchronizations using regional homogeneity (ReHo) in patients clinically diagnosed with DLB (n = 19) and AD (n = 18), and for comparisons we also included healthy controls (HC, n = 16). Patient groups were matched by age, education, and by the level of cognitive impairment (MMSE p-value = 0.36). Additionally, correlations between ReHo values and clinical scores were investigated. Results: The DLB group showed lower ReHo in sensory-motor cortices and higher ReHo in left middle temporal gyrus when compared with HCs (p-value < 0.001 uncorrected). The AD group demonstrated lower ReHo in the cerebellum and higher ReHo in the left/right lingual gyri, precuneus cortex, and other occipital and parietal regions (p-value < 0.001 uncorrected). Conclusions: Our results agree with previous ReHo investigations in Parkinson's disease (PD), suggesting that functional alterations in motor-related regions might be a characteristic of the Lewy body disease spectrum. However, our results in AD contradict previously reported findings for this disease and ReHo, which we speculate are a reflection of compensatory brain responses at early disease stages. ReHo differences between patient groups were at regions related to the default mode and sensory-motor resting state networks which might reflect the aetiological divergences in the underlying disease processes between AD and DLB.","PeriodicalId":131865,"journal":{"name":"International Psychogeriatrics / Ipa","volume":"20 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132829948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Older people coping with low mood: a qualitative study 老年人应对情绪低落:一项定性研究

International Psychogeriatrics / Ipa Pub Date : 2015-12-17 DOI: 10.1017/S1041610215002264

M. von Faber, Geertje van der Geest, G. M. van der Weele, J. Blom, R. van der Mast, R. Reis, J. Gussekloo

{"title":"Older people coping with low mood: a qualitative study","authors":"M. von Faber, Geertje van der Geest, G. M. van der Weele, J. Blom, R. van der Mast, R. Reis, J. Gussekloo","doi":"10.1017/S1041610215002264","DOIUrl":"https://doi.org/10.1017/S1041610215002264","url":null,"abstract":"ABSTRACT Background: To gain new insight into support for older people with low mood, the perceptions, strategies, and needs of older people with depressive symptoms were explored. Methods: Two in-depth interviews were held with 38 participants (aged ≥77 years) who screened positive for depressive symptoms in general practice. To investigate the influence of the presence of complex health problems, 19 persons with and 19 without complex problems were included. Complex problems were defined as a combination of functional, somatic, psychological or social problems. Results: All participants used several cognitive, social or practical coping strategies. Four patterns emerged: mastery, acceptance, ambivalence, and need for support. Most participants felt they could deal with their feelings sufficiently, whereas a few participants with complex problems expressed a need for professional support. Some participants, especially those with complex problems, were ambivalent about possible interventions mainly because they feared putting their fragile balance at risk due to changes instigated by an intervention. Conclusion: Most older participants with depressive symptoms perceived their coping strategies to be sufficient. The general practitioners (GPs) can support self-management by talking about the (effectiveness of) personal coping strategies, elaborating on perceptions of risks, providing information, and discussing alternative options with older persons.","PeriodicalId":131865,"journal":{"name":"International Psychogeriatrics / Ipa","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124100227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Speech and orofacial apraxias in Alzheimer's disease – CORRIGENDUM 阿尔茨海默病中的言语和口面部失用症-勘误

International Psychogeriatrics / Ipa Pub Date : 2013-07-08 DOI: 10.1017/S1041610213001208

M. Cera, K. Ortiz, P. Bertolucci, T. Minett

引用次数: 1