IEEE Transactions on Biomedical Circuits and Systems最新文献_第9页

A Wireless IC for Wide-Range Neurochemical Monitoring Using Amperometry and Fast-Scan Cyclic Voltammetry 应用安培法和快速扫描循环伏安法进行大范围神经化学监测的无线集成电路

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2007-05-27 DOI: 10.1109/ISCAS.2007.378094

M. Roham, P. Mohseni

{"title":"A Wireless IC for Wide-Range Neurochemical Monitoring Using Amperometry and Fast-Scan Cyclic Voltammetry","authors":"M. Roham, P. Mohseni","doi":"10.1109/ISCAS.2007.378094","DOIUrl":"https://doi.org/10.1109/ISCAS.2007.378094","url":null,"abstract":"An integrated circuit for real-time wireless monitoring of neurochemical activity in the nervous system is described. The chip is capable of conducting measurements in both fast-scan cyclic voltammetry (FSCV) and amperometry modes for a wide input current range. The chip architecture employs a second-order DeltaSigma modulator (DeltaSigmaM) and a frequency-shift-keyed transmitter operating near 433 MHz. It is fabricated using the AMI 0.5-mum double-poly triple-metal n-well CMOS process, and requires only one off-chip component for operation. A measured current resolution of 12 pA at a sampling rate of 100 Hz and 132 pA at a sampling rate of 10 kHz is achieved in amperometry and 300-V/s FSCV modes, respectively, for any input current in the range of plusmn430 nA. The modulator core and the transmitter draw 22 and 400 muA from a 2.6-V power supply, respectively. The chip has been externally interfaced with a carbon-fiber microelectrode implanted acutely in the caudate-putamen of an anesthetized rat, and, for the first time, extracellular levels of dopamine elicited by electrical stimulation of the medial forebrain bundle have been successfully recorded wirelessly using 300-V/s FSCV.","PeriodicalId":13151,"journal":{"name":"IEEE Transactions on Biomedical Circuits and Systems","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2007-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/ISCAS.2007.378094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62144839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Analysis and Simple Circuit Design of Double Differential EMG Active Electrode. 双差动肌电有源电极分析及简单电路设计。

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 1900-01-01 DOI: 10.1109/TBCAS.2015.2492944

F. Guerrero, E. Spinelli, M. Haberman

{"title":"Analysis and Simple Circuit Design of Double Differential EMG Active Electrode.","authors":"F. Guerrero, E. Spinelli, M. Haberman","doi":"10.1109/TBCAS.2015.2492944","DOIUrl":"https://doi.org/10.1109/TBCAS.2015.2492944","url":null,"abstract":"In this paper we present an analysis of the voltage amplifier needed for double differential (DD) sEMG measurements and a novel, very simple circuit for implementing DD active electrodes. The three-input amplifier that standalone DD active electrodes require is inherently different from a differential amplifier, and general knowledge about its design is scarce in the literature. First, the figures of merit of the amplifier are defined through a decomposition of its input signal into three orthogonal modes. This analysis reveals a mode containing EMG crosstalk components that the DD electrode should reject. Then, the effect of finite input impedance is analyzed. Because there are three terminals, minimum bounds for interference rejection ratios due to electrode and input impedance unbalances with two degrees of freedom are obtained. Finally, a novel circuit design is presented, including only a quadruple operational amplifier and a few passive components. This design is nearly as simple as the branched electrode and much simpler than the three instrumentation amplifier design, while providing robust EMG crosstalk rejection and better input impedance using unity gain buffers for each electrode input. The interference rejection limits of this input stage are analyzed. An easily replicable implementation of the proposed circuit is described, together with a parameter design guideline to adjust it to specific needs. The electrode is compared with the established alternatives, and sample sEMG signals are obtained, acquired on different body locations with dry contacts, successfully rejecting interference sources.","PeriodicalId":13151,"journal":{"name":"IEEE Transactions on Biomedical Circuits and Systems","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TBCAS.2015.2492944","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62964972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Clinical Outcome Prediction Using Single-Cell Data. 利用单细胞数据预测临床预后。

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 1900-01-01 DOI: 10.1109/TBCAS.2016.2577641

M. Pouyan, V. Jindal, M. Nourani

引用次数: 0

Graphical Features of Functional Genes in Human Protein Interaction Network. 人类蛋白质相互作用网络中功能基因的图形特征。

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 1900-01-01 DOI: 10.1109/TBCAS.2015.2487299

Pei Wang, Yao Chen, Jinhu Lü, Qingyun Wang, Xinghuo Yu

{"title":"Graphical Features of Functional Genes in Human Protein Interaction Network.","authors":"Pei Wang, Yao Chen, Jinhu Lü, Qingyun Wang, Xinghuo Yu","doi":"10.1109/TBCAS.2015.2487299","DOIUrl":"https://doi.org/10.1109/TBCAS.2015.2487299","url":null,"abstract":"With the completion of the human genome project, it is feasible to investigate large-scale human protein interaction network (HPIN) with complex networks theory. Proteins are encoded by genes. Essential, viable, disease, conserved, housekeeping (HK) and tissue-enriched (TE) genes are functional genes, which are organized and functioned via interaction networks. Based on up-to-date data from various databases or literature, two large-scale HPINs and six subnetworks are constructed. We illustrate that the HPINs and most of the subnetworks are sparse, small-world, scale-free, disassortative and with hierarchical modularity. Among the six subnetworks, essential, disease and HK subnetworks are more densely connected than the others. Statistical analysis on the topological structures of the HPIN reveals that the lethal, the conserved, the HK and the TE genes are with hallmark graphical features. Receiver operating characteristic (ROC) curves indicate that the essential genes can be distinguished from the viable ones with accuracy as high as almost 70%. Closeness, semi-local and eigenvector centralities can distinguish the HK genes from the TE ones with accuracy around 82%. Furthermore, the Venn diagram, cluster dendgrams and classifications of disease genes reveal that some classes of disease genes are with hallmark graphical features, especially for cancer genes, HK disease genes and TE disease genes. The findings facilitate the identification of some functional genes via topological structures. The investigations shed some light on the characteristics of the compete interactome, which have potential implications in networked medicine and biological network control.","PeriodicalId":13151,"journal":{"name":"IEEE Transactions on Biomedical Circuits and Systems","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TBCAS.2015.2487299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62964882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

System-on-Chip Considerations for Heterogeneous Integration of CMOS and Fluidic Bio-Interfaces. 片上系统对CMOS和流体生物接口异质集成的考虑。

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 1900-01-01 DOI: 10.1109/TBCAS.2016.2522402

Timir Datta-Chaudhuri, E. Smela, P. Abshire

{"title":"System-on-Chip Considerations for Heterogeneous Integration of CMOS and Fluidic Bio-Interfaces.","authors":"Timir Datta-Chaudhuri, E. Smela, P. Abshire","doi":"10.1109/TBCAS.2016.2522402","DOIUrl":"https://doi.org/10.1109/TBCAS.2016.2522402","url":null,"abstract":"CMOS chips are increasingly used for direct sensing and interfacing with fluidic and biological systems. While many biosensing systems have successfully combined CMOS chips for readout and signal processing with passive sensing arrays, systems that co-locate sensing with active circuits on a single chip offer significant advantages in size and performance but increase the complexity of multi-domain design and heterogeneous integration. This emerging class of lab-on-CMOS systems also poses distinct and vexing technical challenges that arise from the disparate requirements of biosensors and integrated circuits (ICs). Modeling these systems must address not only circuit design, but also the behavior of biological components on the surface of the IC and any physical structures. Existing tools do not support the cross-domain simulation of heterogeneous lab-on-CMOS systems, so we recommend a two-step modeling approach: using circuit simulation to inform physics-based simulation, and vice versa. We review the primary lab-on-CMOS implementation challenges and discuss practical approaches to overcome them. Issues include new versions of classical challenges in system-on-chip integration, such as thermal effects, floor-planning, and signal coupling, as well as new challenges that are specifically attributable to biological and fluidic domains, such as electrochemical effects, non-standard packaging, surface treatments, sterilization, microfabrication of surface structures, and microfluidic integration. We describe these concerns as they arise in lab-on-CMOS systems and discuss solutions that have been experimentally demonstrated.","PeriodicalId":13151,"journal":{"name":"IEEE Transactions on Biomedical Circuits and Systems","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TBCAS.2016.2522402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62965834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A Mixed-Signal VLSI System for Producing Temporally Adapting Intraspinal Microstimulation Patterns for Locomotion. 一种产生时间适应的脊柱内微刺激模式的混合信号VLSI系统。

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 1900-01-01 DOI: 10.1109/TBCAS.2015.2501419

K. Mazurek, B. J. Holinski, D. Everaert, V. Mushahwar, R. Etienne-Cummings

引用次数: 0

High density, high radiance μLED matrix for optogenetic retinal prostheses and planar neural stimulation 用于光遗传视网膜假体和平面神经刺激的高密度、高亮度μLED基质

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 1900-01-01 DOI: 10.1109/TBCAS.2016.2623949

A. Soltan, B. McGovern, E. Drakakis, M. Neil, P. Maaskant, M. Akhter, J. Lee, P. Degenaar

引用次数: 27