New Insights into Systemic Sclerosis [Working Title]最新文献

New Insights into Systemic Sclerosis [Working Title] Pub Date : 2019-08-12 DOI: 10.5772/INTECHOPEN.88546

O. Kodet, S. Oreská

引用次数: 0

Gastrointestinal Involvement in Systemic Sclerosis: Overview, Neglected Aspects, Malnutrition, Body Composition and Management 系统性硬化症的胃肠道介入:概述，被忽视的方面，营养不良，身体组成和管理

New Insights into Systemic Sclerosis [Working Title] Pub Date : 2019-07-26 DOI: 10.5772/INTECHOPEN.88286

S. Oreská, M. Tomčík

引用次数: 2

Renal Involvement in Systemic Sclerosis 系统性硬化症的肾脏受累

New Insights into Systemic Sclerosis [Working Title] Pub Date : 2019-07-09 DOI: 10.5772/INTECHOPEN.87187

Tomáš Soukup, Jan Toms, Sabina Oreska, Eva Honsova, Roman Safranek

{"title":"Renal Involvement in Systemic Sclerosis","authors":"Tomáš Soukup, Jan Toms, Sabina Oreska, Eva Honsova, Roman Safranek","doi":"10.5772/INTECHOPEN.87187","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.87187","url":null,"abstract":"Scleroderma renal crisis (SRC) is classical renal disease in systemic sclerosis (SSc). SRC is a relatively rare manifestation, approximately in 5% of patients. In terms of severity, manifestation in the form of SRC is the most common cause of acute organ failure. In SSc patients, SRC is defined as a new onset of accelerated arterial hypertension and rapidly progressive anuric or oliguric renal failure. SRC is primarily vascular injury with increased activity of the renin-angiotensin activity. These events lead to release or activation of cytokines and growth factors that result in the typical proliferative vascular lesions. Successful approach is routine use of angiotensin-converting enzyme inhibitors in the treatment of SRC (except prevention) and other advances in renal replacement therapy in SSc management. It is crucial to detect manifestations of SRC early and to manage appropriately in collaboration with intensive care medicine, cardiologists, and nephrologists. In contrast to SRC, clinical presentation of interstitial renal disease is poor, often without evidence of renal abnormality. Interestingly, other renal manifestations are glomerulonephritis and vasculitis. These manifestations are associated with overlapping mechanisms. The objective of this chapter is to focus on actual knowl-edge about the renal involvement in SSc and current treatment principles and possibilities.","PeriodicalId":127513,"journal":{"name":"New Insights into Systemic Sclerosis [Working Title]","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121623602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Advances in Management of Pulmonary Hypertension Associated with Systemic Sclerosis 肺动脉高压合并系统性硬化症的治疗进展

New Insights into Systemic Sclerosis [Working Title] Pub Date : 2019-05-15 DOI: 10.5772/INTECHOPEN.86217

J. Swisher, S. Kailash

{"title":"Advances in Management of Pulmonary Hypertension Associated with Systemic Sclerosis","authors":"J. Swisher, S. Kailash","doi":"10.5772/INTECHOPEN.86217","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86217","url":null,"abstract":"Pulmonary hypertension is a well-known complication of systemic sclerosis. Patients with systemic sclerosis may develop a pulmonary arteriopathy characterized by vascular remodeling, increased pulmonary vascular resistance, and right ventricular failure. Pulmonary hypertension may also arise in systemic sclerosis as a consequence of interstitial lung disease or left ventricular dysfunction. Vascular remodeling is more prevalent than other forms of pulmonary hypertension in systemic sclerosis. The pathogenesis of pulmonary vascular remodeling in this disease state is not completely understood; however, there is evidence of a complex process involving genetic susceptibility, risk factors, vascular injury, and endothelial dysfunction. In those patients with pulmonary arterial hypertension, survival prognosis is extremely poor if the diagnosis is delayed or goes undetected and untreated. In recent years, a number of disease-targeted therapies have been developed that improve functional capacity, hemodynamics, and survival. Early detection and treatment with one or more targeted therapies are essential to improving survival when systemic sclerosis is complicated by pulmonary arterial hypertension.","PeriodicalId":127513,"journal":{"name":"New Insights into Systemic Sclerosis [Working Title]","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129047678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Biopsychosocial Aspects in Management of Scleroderma Patients 硬皮病患者管理的生物心理社会方面

New Insights into Systemic Sclerosis [Working Title] Pub Date : 2019-05-10 DOI: 10.5772/INTECHOPEN.86220

M. Špiritović

{"title":"Biopsychosocial Aspects in Management of Scleroderma Patients","authors":"M. Špiritović","doi":"10.5772/INTECHOPEN.86220","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86220","url":null,"abstract":"Systemic sclerosis (SSc) is a rare, chronic connective tissue disease with characteristic fibrosis of the skin, musculoskeletal system, and internal organs. It is a heterogeneous and polymorphic disorder, in which fatigue, sleep disturbances, stiffness, and joint pain are among the most significant clinical symptoms. However, the presence of stiffening and thickening of the skin usually has a negative impact on the appearance of these patients, and the degree of self-dissatisfaction can fundamentally interfere with their personality. Self-consciousness and self-conception of the patient, accompanied by depression, can also be affected. Thus we cannot regard this disease and approach it only from a biomedical point of view and should not underestimate the approach to the psychosocial nature of the treatment. Biological, psychological, and social factors are interconnected, and imbalances in their complex interactions disrupt health and cause or worsen the disease. That is why it is necessary to create a so-called biopsychosocial comfort of an individual with SSc and to develop a number of activities in the sense of a complex treatment. This chapter focuses on the psychosomatic approach to health and illness and the development of the biopsychosocial model in medicine just as it should be used in patients with SSc.","PeriodicalId":127513,"journal":{"name":"New Insights into Systemic Sclerosis [Working Title]","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131860518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sexual Dysfunction in Patients with Systemic Sclerosis 系统性硬化症患者的性功能障碍

New Insights into Systemic Sclerosis [Working Title] Pub Date : 2019-05-03 DOI: 10.5772/INTECHOPEN.86219

B. Heřmánková

引用次数: 8