Extracellular Vesicles and Their Importance in Human Health最新文献

Introductory Chapter: An Overview to the Extracellular Vesicles 导论章:细胞外囊泡概述

Extracellular Vesicles and Their Importance in Human Health Pub Date : 2020-03-04 DOI: 10.5772/intechopen.90820

Ana Gil-Bona, J. Reales-Calderón

引用次数: 0

Milk Exosomes: Isolation, Biochemistry, Morphology, and Perspectives of Use 乳外泌体:分离、生化、形态和应用前景

Extracellular Vesicles and Their Importance in Human Health Pub Date : 2019-06-04 DOI: 10.5772/INTECHOPEN.85416

S. Sedykh, E. E. Burkova, L. V. Purvinsh, Daria A. Klemeshova, E. Ryabchikova, G. Nevinsky

{"title":"Milk Exosomes: Isolation, Biochemistry, Morphology, and Perspectives of Use","authors":"S. Sedykh, E. E. Burkova, L. V. Purvinsh, Daria A. Klemeshova, E. Ryabchikova, G. Nevinsky","doi":"10.5772/INTECHOPEN.85416","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.85416","url":null,"abstract":"Cells of the multicellular organisms communicate with each other in many different ways, among which extracellular vesicles play a unique role. Almost all cell types secrete vesicles into the extracellular space and deliver their contents to recipient cells. Today, one of the groups of extracellular vesicles that is of particular interest for studying is exosomes—membrane vesicles with a diameter of 40–100 nm. Exosomes are secreted by cells and found in various biological fluids—blood, tears, saliva, urine, cerebrospinal fluid, and milk. Exosomes provide not only targeted delivery of molecular signals to recipient cells but also carry unique markers, which makes them a promising substrate in diagnostic studies, primarily due to their small RNA and protein contents. The milk of cows, horses, humans, and other mammals is a unique source of exosomes since these organisms can produce liters of milk per day, which is much higher than the volume of exosomes produced in cell culture fluid or blood plasma. Unfortunately, milk exosomes are currently much less studied than exosomes of blood or culture fluid. This review examines the methods of the isolation, biochemical analysis (composition of proteins, lipids, and nucleic acids), morphology, and prospects for the use of milk exosomes.","PeriodicalId":125648,"journal":{"name":"Extracellular Vesicles and Their Importance in Human Health","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132408184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Effects of Vesicular Membranes Reordering on the Activity of Lipid Metabolizing Enzymes 囊泡膜重排序对脂质代谢酶活性的影响

Extracellular Vesicles and Their Importance in Human Health Pub Date : 2019-06-03 DOI: 10.5772/INTECHOPEN.85972

Dino G. Salinas

引用次数: 0

Extracellular Vesicles in Cancer 癌症中的细胞外囊泡

Extracellular Vesicles and Their Importance in Human Health Pub Date : 2019-05-31 DOI: 10.5772/INTECHOPEN.85117

A. Voichitoiu, B. Radu, L. Pavelescu, D. Crețoiu, A. Deftu, N. Suciu, S. Crețoiu

引用次数: 8

Part One: Extracellular Vesicles as Valuable Players in Diabetic Cardiovascular Diseases 第一部分:细胞外囊泡在糖尿病心血管疾病中的重要作用

Extracellular Vesicles and Their Importance in Human Health Pub Date : 2019-05-30 DOI: 10.5772/INTECHOPEN.85225

M. Gherghiceanu, N. Alexandru, S. Magda, A. Constantin, M. Nemecz, A. Filippi, O. Ioghen, L. Ceafalan, F. Bojin, G. Tanko, V. Paunescu, D. Vinereanu, E. Stępień, A. Georgescu

{"title":"Part One: Extracellular Vesicles as Valuable Players in Diabetic Cardiovascular Diseases","authors":"M. Gherghiceanu, N. Alexandru, S. Magda, A. Constantin, M. Nemecz, A. Filippi, O. Ioghen, L. Ceafalan, F. Bojin, G. Tanko, V. Paunescu, D. Vinereanu, E. Stępień, A. Georgescu","doi":"10.5772/INTECHOPEN.85225","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.85225","url":null,"abstract":"Extracellular vesicles (EVs) are particles released in the extracellular space from all cell types in physiological and pathological conditions and emerge as a new way of cell-cell communication by transferring their biological contents into target cells. The levels and composition of circulating EVs differ from a normal condition to a pathological one, making them real circulating biomarkers. EVs have a very complex contribution in both health and disease, most likely in relationship between diabetes and cardiovascular disease. The involvement of EVs to the development of cardiovascular complications in diabetes remains an open discussion for therapists. Circulating EVs may offer a continuous access path to circulating information on the disease state and a new perspective in finding a correct diagnosis, in estimating a prognosis and also in applying an effective therapy. Besides their role as biomarkers and targets for therapy, EVs can be exploited as biological tools in influencing the different processes affected in diabetic cardiovascular diseases. This chapter will summarize the current knowledge about EVs as biological vectors modulating diabetic cardiovascular diseases, including atherosclerosis, coronary artery disease, and peripheral arterial disease. Finally, we will point out EVs’ considerable value as clinical biomarkers, therapeutic targets, and potential biomedical tools for the discovery of effective therapy in diabetic cardiovascular diseases.","PeriodicalId":125648,"journal":{"name":"Extracellular Vesicles and Their Importance in Human Health","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114279116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Cellular-Defined Microenvironmental Internalization of Exosomes 细胞定义的外泌体微环境内化

Extracellular Vesicles and Their Importance in Human Health Pub Date : 2019-04-20 DOI: 10.5772/INTECHOPEN.86020

Amber Gonda, Ron B. Moyron, Janviere Kabagwira, P. Vallejos, N. Wall

引用次数: 9