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Marbofloxacin (2nd edition) (Veterinary Medicinal Products) 马勃沙星（第 2 版）（兽药产品）

Food Safety Pub Date : 2023-12-01 DOI: 10.14252/foodsafetyfscj.D-23-00015

引用次数: 0

Isotianil (2nd edition) (Pesticides) 异噻菌胺（第 2 版）（杀虫剂）

Food Safety Pub Date : 2023-12-01 DOI: 10.14252/foodsafetyfscj.d-23-00014

{"title":"Isotianil (2nd edition) (Pesticides)","authors":"","doi":"10.14252/foodsafetyfscj.d-23-00014","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.d-23-00014","url":null,"abstract":"Abstract Food Safety Commission of Japan (FSCJ) conducted a risk assessment of isotianil (CAS No. 224049-04-1), an isothiazole agent for induced resistance to blast disease. This evaluation was requested from Ministry of Agriculture, Forestry and Fisheries (MAFF) on the reevaluation article of Agricultural Chemicals Regulation Act. Additional information including the fate in livestock (goats and chickens) and genotoxicity, and also the list of published scientific literature were newly submitted from the MAFF. The following data were used in the assessment; fate in plants (including paddy rice and potatoes), residues in crops, fate in livestock (goats and chickens), residues in livestock products, fate in animals (rats), subacute toxicity (rats, mice and dogs), chronic toxicity (rats and dogs), carcinogenicity (rats and mice), two-generation reproductive toxicity (rats), developmental toxicity (rats and rabbits), and genotoxicity. Major adverse effects of isotianil were observed in the stomach (mucosal epithelium hyperplasia of the forestomach limiting ridge in rats), the liver (including organ weight gain), and the kidney (including chronic nephropathy). No adverse effects were observed on carcinogenicity, fertility, teratogenicity, and genotoxicity. The lowest no-observed-adverse-effect level (NOAEL) obtained from the studies described above was 2.83 mg/kg bw per day in a one-year chronic toxicity study in rats. FSCJ specified an acceptable daily intake (ADI) of 0.028 mg/kg bw per day based on the NOAEL after applying a safety factor of 100. An acute reference dose (ARfD) was judged unnecessary to be specified, based on the results of a single oral administration of isotianil and other related tests.","PeriodicalId":12423,"journal":{"name":"Food Safety","volume":"225 ","pages":"78 - 80"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Resistant Bacteria Monitoring in Raw Seafood Retailed: a Pilot Study Focused on Vibrio and Aeromonas 零售生海鲜中耐药细菌的监测:一项以弧菌为重点的试点研究和& lt; i> Aeromonas

Food Safety Pub Date : 2023-01-01 DOI: 10.14252/foodsafetyfscj.d-23-00006

Akira Fukuda, Ryu Tsunashima, Masaru Usui

{"title":"Antimicrobial Resistant Bacteria Monitoring in Raw Seafood Retailed: a Pilot Study Focused on Vibrio and Aeromonas","authors":"Akira Fukuda, Ryu Tsunashima, Masaru Usui","doi":"10.14252/foodsafetyfscj.d-23-00006","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.d-23-00006","url":null,"abstract":"In aquaculture, bacterial infections in sea animals are treated using antimicrobials. As seafood is frequently consumed in its raw form, seafood contaminated with water-borne antimicrobial-resistant bacteria presents a potential transmission route to humans and can influence food safety. In this study, we aimed to determine the abundance of water-borne bacteria in retail raw seafood and to characterize their antimicrobial resistance profiles. In total, 85 retail raw seafood samples (32 fish, 26 shellfish, 25 mollusks, and two crustaceans) were purchased from supermarkets in Japan, and water-borne bacteria were isolated. The isolated bacterial species predominantly included Vibrio spp. (54.1%) and Aeromonas spp. (34.1%). Vibrio or Aeromonas spp. were isolated from more than 70% of the seafood samples. Tetracycline-, sulfamethoxazole-, and/or trimethoprim/sulfamethoxazole-resistant Vibrio or Aeromonas spp. isolates were detected in seven (21.9%) fish samples (two wild-caught and five farm-raised) harboring tet, sul, and/or dfr genes. Sulfamethoxazole- and trimethoprim/sulfamethoxazole-resistant isolates were only detected in farm-raised fish. Tetracycline and sulfamethoxazole are commonly used in aquaculture. These results suggest that water-borne bacteria like Vibrio and Aeromonas spp. should be the primary focus of antimicrobial-resistant bacteria monitoring to effectively elucidate their spread of bacteria via seafood.","PeriodicalId":12423,"journal":{"name":"Food Safety","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136304449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0