Romania Journal of Pharmaceutical Practice最新文献

Quantitative characterisation of extended-release tablets with quetiapine using NIR-chemometric methods 用nir化学计量学方法定量表征喹硫平缓释片

Romania Journal of Pharmaceutical Practice Pub Date : 2021-06-30 DOI: 10.37897/rjphp.2021.2.4

Teodora Dragan, L. Rus, A. Muntean, A. L. Vonica-Țincu, I. Tomuțǎ

{"title":"Quantitative characterisation of extended-release tablets with quetiapine using NIR-chemometric methods","authors":"Teodora Dragan, L. Rus, A. Muntean, A. L. Vonica-Țincu, I. Tomuțǎ","doi":"10.37897/rjphp.2021.2.4","DOIUrl":"https://doi.org/10.37897/rjphp.2021.2.4","url":null,"abstract":"This study aims to develop and validate NIR-chemometric methods for quantifying the API (quetiapine) and two excipients in extended-release tablets without sample preparation. The calibration samples were prepared following an experimental design with three variables (quetiapine, HPMC and microcrystalline cellulose) and five levels (concentration 80-90-100-110-120% of API). The validation set included three concentration levels (90-100-110%). The best calibration algorithms have used the same pre-treatment method (SNV), and different factors: 7 PLS factors (R² -0,966 and RMSEP-6,84) for quetiapine, 8 PLS factors (R²-0,927 and RMSEP 6,84) for HPMC and 3 PLS factors (R²-0,983 and RMSEP-7,26) for microcrystalline cellulose. The methods were fully validated according to the ICH guidance using these calibration models. Regarding the trueness of the methods, the recovery was between 98.51 and 99.43 for quetiapine, between 98.61 and 100.85 for HPMC, and between 100.61 and 101.78 for microcrystalline cellulose. According to data obtained, the accuracy profile was ± 5 for quetiapine and HPMC, and ± 6 for microcrystalline cellulose. Linearity profile was also in establish intervals at accuracy and the R2 value was 0.983 for quetiapine, 0.948 for HPMC and 0.997 for microcrystalline cellulose. In conclusion, the developed NIR-chemometric methods have suitable reproducibility, accuracy, linearity and can be used for quantitative characterisation of extended-release tablets with quetiapine, with any sample preparation.","PeriodicalId":124207,"journal":{"name":"Romania Journal of Pharmaceutical Practice","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115800706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cannabinoids – important therapeutic approach in the field of oncology 大麻素-肿瘤领域的重要治疗方法

Romania Journal of Pharmaceutical Practice Pub Date : 2021-06-30 DOI: 10.37897/rjphp.2021.2.1

N. Blebea, L. Bucur, S. Negreș

引用次数: 0

Phytochemical analysis of herbal teas containing caffeic acid 含咖啡酸草药茶的植物化学分析

Romania Journal of Pharmaceutical Practice Pub Date : 2021-06-30 DOI: 10.37897/rjphp.2021.2.3

Mihai Todoran, L. Hanga, D. Benedec

{"title":"Phytochemical analysis of herbal teas containing caffeic acid","authors":"Mihai Todoran, L. Hanga, D. Benedec","doi":"10.37897/rjphp.2021.2.3","DOIUrl":"https://doi.org/10.37897/rjphp.2021.2.3","url":null,"abstract":"Objectives. The present analysis was to investigate the content of caffeic acid derivatives, antioxidant activity, and the presence of caffeic acid in alcoholic extracts obtained from 16 simple teas from the following medicinal plants: Vaccinium mуrtilluѕ, Camеllia ѕinеnѕiѕ, Coffea arabica, Mеlіssa οffіcіnalіs, Οcіmum basіlіcum, Rοsmarіnus οffіcіnalіs, Salvіa οffіcіnalіs, Ηyssοрus οffіcіnalіs, Αrtеmіsіa absіntһіum, Cynara scοlymus, Calendula officinalis, Cοrіandrum satіvum, Fοеnіculum vulgarе, Carum carvі, Rοsa canіna, Crataеgus mοnοgyna. Materials and methods. The presence of caffeic acid was evaluated using the thin layer chromatography method (TLC). The total content of phenylpropanoids from the medicinal herbs alcoholic extracts was determined using a spectrophotometric method. Outcomes. Results were in the range of 0.046-2.426% caffeic acid derivatives (CAE%). The antioxidant properties were measured using the DPPH radical scavenging mechanism. The results were found to be in the range of 63.93% and 0.38% inhibition level (I%). The greatest antioxidant activity was measured for Camellia sinensis (I = 45.54%), followed by Vaccinium myrtillus (I = 50.289%). Conclusions. In this paper it was shown that these medicinal plants are rich in caffeic acid derivatives with antioxidant action capitalized in the prevention of serious diseases.","PeriodicalId":124207,"journal":{"name":"Romania Journal of Pharmaceutical Practice","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133913463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic activity of Pinus cembra L. needle extract: A preliminary study on HeLa cell line 松针提取物对HeLa细胞株细胞毒活性的初步研究

Romania Journal of Pharmaceutical Practice Pub Date : 2021-06-30 DOI: 10.37897/rjphp.2021.2.5

C. Lungu, C. Mihai, G. Vochița, Daniela Gherghel, S. Miron, A. C. Aprotosoaie, A. Miron

引用次数: 1

A non-destructive NIR spectroscopic method combined with chemometry for simultaneous assay of paracetamol and caffeine in tablets 非破坏性近红外光谱法结合化学测定法同时测定片剂中对乙酰氨基酚和咖啡因

Romania Journal of Pharmaceutical Practice Pub Date : 2021-06-30 DOI: 10.37897/rjphp.2021.2.2

D. Muntean, Alina Porfire, C. Alecu, Sonia Iurian, T. Casian, Alexandru Gâvan, I. Tomuțǎ

{"title":"A non-destructive NIR spectroscopic method combined with chemometry for simultaneous assay of paracetamol and caffeine in tablets","authors":"D. Muntean, Alina Porfire, C. Alecu, Sonia Iurian, T. Casian, Alexandru Gâvan, I. Tomuțǎ","doi":"10.37897/rjphp.2021.2.2","DOIUrl":"https://doi.org/10.37897/rjphp.2021.2.2","url":null,"abstract":"The use of near infrared (NIR) spectroscopy to predict the concentration of two active pharmaceutical ingredients (APIs), paracetamol and caffeine, in intact tablets, has been evaluated in this study. A partial least squares (PLS) regression model was developed using spectral data obtained on a calibration set consisting of 28 formulations containing 80, 90, 100, 110 and 120% of each API. Regression models were developed for each API, both using un-processed spectral data as well as after applying various spectra pre-processing methods. Cross-validation was used to select best calibration model. The selected model was validated in terms of precision, trueness, accuracy and linearity in a concentration ranging from 90 to 110% of the targeted APIs concentration. The applicability of the method was tested on tablets containing 300 mg paracetamol and 30 mg caffeine as targeted composition, and the API content predicted by the proposed NIR-chemometric method was not statistically different from the one obtained by HPLC method, used as a reference method. Thus, the method presented in the current paper is a step forward towards the implementation NIR as useful tool for monitoring the manufacturing process of fixed-dose combination tablets with paracetamol and caffeine.","PeriodicalId":124207,"journal":{"name":"Romania Journal of Pharmaceutical Practice","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117063489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A brief analysis of parenteral medicines delivered in community pharmacies for off-label use in pediatric 社区药房提供的儿科超说明书用药的肠外用药简要分析

Romania Journal of Pharmaceutical Practice Pub Date : 2021-06-30 DOI: 10.37897/rjphp.2021.2.6

E. Dinte, D. Matei, Teodora Zehan

{"title":"A brief analysis of parenteral medicines delivered in community pharmacies for off-label use in pediatric","authors":"E. Dinte, D. Matei, Teodora Zehan","doi":"10.37897/rjphp.2021.2.6","DOIUrl":"https://doi.org/10.37897/rjphp.2021.2.6","url":null,"abstract":"Objectives. The current paper aims to obtain an overview regarding the use of parenteral medicines recommended for the pediatric sector and delivered in Romanian community pharmacies. Materials and methods. A retrospective observational study was developed, based on a questionnaire which was distributed in community pharmacies in Romania. Results. The parenteral medicines were delivered in 100 community pharmacies which partake in the study, and which are distributed in 22 counties in Romania. The total number of parenteral medicines considered in the study were aimed for pediatric use and they represented approximately 5% of the total number of medicines prescribed for children delivered in the respective pharmacies. Of these, most of them are medicines authorized for adults, delivered for off-label use, by other routes of administration, in their original form or reformulated in the form of other pharmaceutical preparations, during the compounding activity in the pharmacy. Conclusions. The parenteral medications most prescribed for pediatric use and delivered in community pharmacies are injectable solutions and powders for parenteral use. They are used as off-label medication in children, by other routes of administration, both to capitalize the therapeutic action of the active principle, and also as a vehicle for other medications with oral route or external route of administration.","PeriodicalId":124207,"journal":{"name":"Romania Journal of Pharmaceutical Practice","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130446336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0