Leishmaniasis - General Aspects of a Stigmatized Disease [Working Title]最新文献

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Use of Cell Biology to Identify Cellular Targets in Drug Development Process against Leishmania Sp. 利用细胞生物学鉴定抗利什曼原虫药物开发过程中的细胞靶点。
Leishmaniasis - General Aspects of a Stigmatized Disease [Working Title] Pub Date : 2021-12-30 DOI: 10.5772/intechopen.101662
Gabrielle dos Santos da Silva e Miranda, Joseane Lima Prado Godinho, Sara Teixeira de Macedo-Silva, Brunno Renato Farias Verçoza, Alisson Amaral da Rocha, Milena Barenco Pires de Abreu Sodré, Victor Feliciano dos Santos Ramos, Juliany Cola Fernandes Rodrigues
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引用次数: 0
Toward New Antileishmanial Compounds: Molecular Targets for Leishmaniasis Treatment 抗利什曼病新化合物:治疗利什曼病的分子靶点
Leishmaniasis - General Aspects of a Stigmatized Disease [Working Title] Pub Date : 2021-12-04 DOI: 10.5772/intechopen.101132
H. Istanbullu, Gulsah Bayraktar
{"title":"Toward New Antileishmanial Compounds: Molecular Targets for Leishmaniasis Treatment","authors":"H. Istanbullu, Gulsah Bayraktar","doi":"10.5772/intechopen.101132","DOIUrl":"https://doi.org/10.5772/intechopen.101132","url":null,"abstract":"The leishmaniases are a group of diseases caused by protozoan parasites—Leishmania sp. Leishmaniasis is classified among the 20 neglected diseases by WHO. Although the disease has been known for more than 120 years, the number of drugs used for the treatment is still limited to 5–6. The first-line drugs against leishmaniasis are pentavalent antimonials, which were introduced to the treatment 70 years ago—despite all their side effects. Molecular targets are becoming increasingly important for efficacy and selectivity in postgenomic drug research studies. In this chapter, we have discussed potential therapeutic targets of antileishmanial drug discovery such as pteridine reductase (PTR1), trypanothione reductase (TR), N-myristoyltransferase (NMT), trypanothione synthetase (TryS), IU-nucleoside hydrolase, and topoisomerases, enzymes and their inhibitors reported in the literature.","PeriodicalId":120014,"journal":{"name":"Leishmaniasis - General Aspects of a Stigmatized Disease [Working Title]","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132610318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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