发布求助
文献互助 智能选刊 最新文献

Journal of Gannan Medical University最新文献

筛选
英文 中文
MR-Based Methods for pH Measurement in Brain Tumors: Current Status and Clinical Potential 基于核磁共振的脑肿瘤pH测量方法:现状和临床潜力
Journal of Gannan Medical University Pub Date : 2011-09-22 DOI: 10.5772/23300
Xiao-Fang Cheng, R. Wu
{"title":"MR-Based Methods for pH Measurement in Brain Tumors: Current Status and Clinical Potential","authors":"Xiao-Fang Cheng, R. Wu","doi":"10.5772/23300","DOIUrl":"https://doi.org/10.5772/23300","url":null,"abstract":"Alteration in tissue pH is an indicator of many pathological processes.In tumors,the pH gradient exists between the intracellular(pHi) and extracellular(pHe) compartments.pHe is usually lower,and pHi could be higher or unchanging compared with normal tissue,which can be correlated with prognosis and response to treatment.In recent years,non-invasive MR-based methods have been developed to assess tissue pH in brain tumors.In addition to protons(1H) and phosphorus(31P),pH measurement approaches have been applied with other NMR nuclei such as fluorine(19F) and carbon(13C).By using hyperpolarized 13C-labelled bicarbonate,the average tumor interstitial pH was found significantly lower than the surrounding tissue in mouse tumor model.Gd(3+)-based pH sensors and chemical exchange-dependent saturation transfer(CEST) and paramagnetic(PARACEST) agents are useful for further delineation of brain tumors.This article primarily focuses on the measurement of pH in brain tumors with MR-based methods and relevant clinical potential.","PeriodicalId":112386,"journal":{"name":"Journal of Gannan Medical University","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121336442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书