Gene Regulations and Metabolism最新文献

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Metabolic Pathways 代谢途径
Gene Regulations and Metabolism Pub Date : 1961-10-01 DOI: 10.7551/mitpress/3215.003.0014
Steffen Schmidt, T. Dandekar
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引用次数: 214
Toward Computer Simulation of the Whole Cell 迈向全细胞的计算机模拟
Gene Regulations and Metabolism Pub Date : 1900-01-01 DOI: 10.7551/mitpress/3215.003.0015
M. Tomita
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引用次数: 1
Specificity of Protein-DNA Interactions 蛋白质- dna相互作用的特异性
Gene Regulations and Metabolism Pub Date : 1900-01-01 DOI: 10.7551/mitpress/3215.003.0007
G. Stormo
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引用次数: 2
Automation of Protein Sequence Characterization and Its Application in Whole Proteome Analysis 蛋白质序列鉴定自动化及其在全蛋白质组分析中的应用
Gene Regulations and Metabolism Pub Date : 1900-01-01 DOI: 10.7551/mitpress/3215.003.0004
R. Apweiler, M. Biswas, W. Fleischmann, E. Kriventseva, N. Mulder
{"title":"Automation of Protein Sequence Characterization and Its Application in Whole Proteome Analysis","authors":"R. Apweiler, M. Biswas, W. Fleischmann, E. Kriventseva, N. Mulder","doi":"10.7551/mitpress/3215.003.0004","DOIUrl":"https://doi.org/10.7551/mitpress/3215.003.0004","url":null,"abstract":"","PeriodicalId":111388,"journal":{"name":"Gene Regulations and Metabolism","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131441947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Information Fusion and Metabolic Network Control 信息融合与代谢网络控制
Gene Regulations and Metabolism Pub Date : 1900-01-01 DOI: 10.7551/mitpress/3215.003.0005
A. Freier, R. Hofestädt, Matthias Lange, U. Scholz
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引用次数: 1
Gene Networks Description and Modeling in the GeneNet System GeneNet系统中基因网络的描述与建模
Gene Regulations and Metabolism Pub Date : 1900-01-01 DOI: 10.7551/mitpress/3215.003.0010
N. Kolchanov, E. A. Ananko, V. A. Likhoshvai, O. Podkolodnaya, E. Ignatieva, A. Ratushny, Y. Matushkin
{"title":"Gene Networks Description and Modeling in the GeneNet System","authors":"N. Kolchanov, E. A. Ananko, V. A. Likhoshvai, O. Podkolodnaya, E. Ignatieva, A. Ratushny, Y. Matushkin","doi":"10.7551/mitpress/3215.003.0010","DOIUrl":"https://doi.org/10.7551/mitpress/3215.003.0010","url":null,"abstract":"","PeriodicalId":111388,"journal":{"name":"Gene Regulations and Metabolism","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122253565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Regulation of Cellular States in Mammalian Cells from a Genomewide View 从全基因组角度看哺乳动物细胞状态的调控
Gene Regulations and Metabolism Pub Date : 1900-01-01 DOI: 10.7551/mitpress/3215.003.0011
Sui Huang
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引用次数: 61
Predicting Protein Function and Nworks on a Genomewide Scale 在全基因组范围内预测蛋白质功能和网络
Gene Regulations and Metabolism Pub Date : 1900-01-01 DOI: 10.7551/mitpress/3215.003.0013
E. Marcotte
{"title":"Predicting Protein Function and Nworks on a Genomewide Scale","authors":"E. Marcotte","doi":"10.7551/mitpress/3215.003.0013","DOIUrl":"https://doi.org/10.7551/mitpress/3215.003.0013","url":null,"abstract":"Perhaps the most significant finding from the more than 80 genomes that have been sequenced as of 2002 has been the extent of our ignorance about the constituents of cells. In virtually every genome sequenced, the majority of genes have never been studied directly. In spite of this, for about half of the genes at least one near or distant relative has been studied, so we glean our knowledge from the activities of these relatives. Until recently such methods for extending information to proteins with similar sequences or structures (homology-based methods) have been the only form of inference about protein function. Homology-based annotation, with algorithms such as BLAST (Alt-schul et al., 1997; http://www.ncbi.nlm.nih.gov/BLAST), has been wildly successful in extending knowledge from the small set of experimentally characterized proteins to the tens of thousands of proteins found in genome sequencing projects. However, these methods perform as one might expect: they provide information only for proteins with very closely related functions. They reveal little about proteins that work together but typically have unrelated sequences or structures. Thus, the homology-based methods cannot be used to reconstruct metabolic or signaling pathways or other protein interaction networks. That such a bias exists shows that there are different aspects to protein function; methods that reveal one aspect do not necessarily reveal others. The two most important aspects of protein function, defined in figure 9.1, will be referred to as the molecular function and the cellular function of proteins. The homology-based methods tend to find only the molec","PeriodicalId":111388,"journal":{"name":"Gene Regulations and Metabolism","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123219783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Discovery of DNA Regulatory Motifs DNA调控基序的发现
Gene Regulations and Metabolism Pub Date : 1900-01-01 DOI: 10.7551/mitpress/3215.003.0009
A. McGuire, G. Church
{"title":"Discovery of DNA Regulatory Motifs","authors":"A. McGuire, G. Church","doi":"10.7551/mitpress/3215.003.0009","DOIUrl":"https://doi.org/10.7551/mitpress/3215.003.0009","url":null,"abstract":"","PeriodicalId":111388,"journal":{"name":"Gene Regulations and Metabolism","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127970056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Are the Eyes Homologous? 眼睛是同源的吗?
Gene Regulations and Metabolism Pub Date : 1900-01-01 DOI: 10.7551/mitpress/3215.003.0002
J. Ahouse
{"title":"Are the Eyes Homologous?","authors":"J. Ahouse","doi":"10.7551/mitpress/3215.003.0002","DOIUrl":"https://doi.org/10.7551/mitpress/3215.003.0002","url":null,"abstract":"","PeriodicalId":111388,"journal":{"name":"Gene Regulations and Metabolism","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130299861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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