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Amino Acids, Peptides and Proteins最新文献

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HSV membrane glycoproteins, their function in viral entry and their use in vaccine studies 单纯疱疹病毒膜糖蛋白及其在病毒侵入中的作用及其在疫苗研究中的应用
Amino Acids, Peptides and Proteins Pub Date : 2019-05-09 DOI: 10.1039/9781788013857-00014
D. Stelitano, G. Franci, A. Chianese, S. Galdiero, G. Morelli, M. Galdiero
{"title":"HSV membrane glycoproteins, their function in viral entry and their use in vaccine studies","authors":"D. Stelitano, G. Franci, A. Chianese, S. Galdiero, G. Morelli, M. Galdiero","doi":"10.1039/9781788013857-00014","DOIUrl":"https://doi.org/10.1039/9781788013857-00014","url":null,"abstract":"It has been estimated that the 90% of the world population is affected by HSV-1 or HSV-2 infections. Clinical manifestations associated with these infectious agents range from cold sores and genital lesions to keratitis, encephalitis and meningoencephalitis. Nowadays these viruses represent a global health and economic burden. Despite a century of scientific research a vaccine for HSV-1 and HSV-2 viruses is still not available. However, in the last years HSV glycoproteins have strongly emerged as putative candidates for vaccine development. In this chapter we provide insights into HSV glycoproteins structure, function and the current state of art in the development of a vaccine for these pathogens.","PeriodicalId":111070,"journal":{"name":"Amino Acids, Peptides and Proteins","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125058429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Nanoscale chemical characterisation of peptides and proteins using tip-enhanced Raman spectroscopy 利用尖端增强拉曼光谱对肽和蛋白质进行纳米级化学表征
Amino Acids, Peptides and Proteins Pub Date : 2019-05-09 DOI: 10.1039/9781788013857-00127
Naresh Kumar
{"title":"Nanoscale chemical characterisation of peptides and proteins using tip-enhanced Raman spectroscopy","authors":"Naresh Kumar","doi":"10.1039/9781788013857-00127","DOIUrl":"https://doi.org/10.1039/9781788013857-00127","url":null,"abstract":"Non-destructive and label-free nanoscale chemical characterisation of peptides and proteins is essential in order to comprehend their biological function. Over the last two decades, Tip-enhanced Raman spectroscopy (TERS) has emerged as a powerful analytical tool for highly sensitive topographical and chemical characterisation of a surface at the nanoscale. Herein, the capabilities and potential TERS for nanoscale investigation of amino acids, peptides and proteins are discussed. The unique chemical insights obtained via TERS characterisation of these biomolecules reported in various studies are critically evaluated. Finally, practical guidelines are presented for the acquisition, analysis and interpretation of TERS data from peptides and protein samples.","PeriodicalId":111070,"journal":{"name":"Amino Acids, Peptides and Proteins","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132452068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Branched polymeric polypeptides with poly[Lys] 含聚[Lys]的支链多肽
Amino Acids, Peptides and Proteins Pub Date : 2019-05-09 DOI: 10.1039/9781788013857-00044
F. Hudecz
{"title":"Branched polymeric polypeptides with poly[Lys]","authors":"F. Hudecz","doi":"10.1039/9781788013857-00044","DOIUrl":"https://doi.org/10.1039/9781788013857-00044","url":null,"abstract":"This chapter is to outline the design, synthesis, chemical and functional characterization of a set of structurally related branched polymeric polypeptides with poly[Lys] backbone. It has been documented that the composition and amino acid sequence of the branch could markedly determine the physico-chemical characteristics including solution conformation, the interaction phospholipid mono- or bilayers as well as the biological properties, like cytotoxicity, blood clearance, biodistribution, immunoreactivity of the compound and even related bioconjugates with chemotherapeutic agent, peptide epitope or reporter entity. The synthesis, structural and functional characterization of conjugates, in which (i) various antitumour, antiparasitic compounds (e.g. daunomycin, methotrexate, GnRH analogue), (ii) imaging agents (e.g. radionuclides, fluorophores) or (iii) B- and/or T-cell epitope peptides from viral (e.g. Herpes simplex virus), bacterial (e.g. M. tuberculosis) and various disease (e.g. tumour, Alzheimer disease) related proteins are attached covalently to selected poly[Lys] branched polymeric polypeptides are discussed.","PeriodicalId":111070,"journal":{"name":"Amino Acids, Peptides and Proteins","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124815947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Peptide-mediated pathogenesis of Alzheimer's disease 肽介导的阿尔茨海默病发病机制
Amino Acids, Peptides and Proteins Pub Date : 2019-05-09 DOI: 10.1039/9781788013857-00091
Eugeni M. Ryadnov, M. Ryadnov
{"title":"Peptide-mediated pathogenesis of Alzheimer's disease","authors":"Eugeni M. Ryadnov, M. Ryadnov","doi":"10.1039/9781788013857-00091","DOIUrl":"https://doi.org/10.1039/9781788013857-00091","url":null,"abstract":"This chapter discusses molecular mechanisms involving proteins of three main classes – tau proteins, amyloid-β and presenilins – that lead to the symptoms characteristic of the Alzheimer's disease. A particular focus is placed on primary structure modifications, conformations and conformational transitions of these proteins. The work highlights specialist research findings published over the last few years to the time of its submission. The reviewed literature is sourced from different databases including Web of Science, RCSB Protein Data Bank and PubMed. A reference to background information is also provided to cover an unlimited timeframe. Individual sections are arranged according to each of the three proteins, emphasising the mechanistic implications of each protein in the neuropathology of AD.","PeriodicalId":111070,"journal":{"name":"Amino Acids, Peptides and Proteins","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130154852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Search and destroy: versatile proteins offer unique structural solutions against uracil in DNA 搜索和破坏:多功能蛋白质提供独特的结构解决方案，以对抗DNA中的尿嘧啶
Amino Acids, Peptides and Proteins Pub Date : 2019-05-09 DOI: 10.1039/9781788013857-00001
B. Vértessy
{"title":"Search and destroy: versatile proteins offer unique structural solutions against uracil in DNA","authors":"B. Vértessy","doi":"10.1039/9781788013857-00001","DOIUrl":"https://doi.org/10.1039/9781788013857-00001","url":null,"abstract":"Despite the simplistic general view of DNA being assembled by only four deoxynucleotides, non-canonical bases constitute a significant part of the genome and play an important role in epigenetics and other physiological processes. Uracil is among the most frequently occurring non-canonical base in DNA and in order to maintain normal cell function, proteins involved in uracil-DNA metabolism require an adequate set of specific binding sites that provide ample distinctive power for nucleobases. Here we present on overview of how this distinction is governed by molecular interactions between side chain and main chain atoms of the protein binding sites and the uracil base.","PeriodicalId":111070,"journal":{"name":"Amino Acids, Peptides and Proteins","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123504871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amino Acids, Peptides and Proteins 氨基酸、多肽和蛋白质
Amino Acids, Peptides and Proteins Pub Date : 2017-05-25 DOI: 10.1201/9781315372914-6
S. Damodaran, K. Parkin
{"title":"Amino Acids, Peptides and Proteins","authors":"S. Damodaran, K. Parkin","doi":"10.1201/9781315372914-6","DOIUrl":"https://doi.org/10.1201/9781315372914-6","url":null,"abstract":"","PeriodicalId":111070,"journal":{"name":"Amino Acids, Peptides and Proteins","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132860847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 106
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