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The insulin receptor. 胰岛素受体。
Diabetes research Pub Date : 1989-01-01 DOI: 10.3998/panc.2012.10
C. de Vries, T. V. van Haeften, T. Wieringa, E. van der Veen
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引用次数: 1
Low molecular weight proteinuria in insulin-dependent diabetes. 胰岛素依赖型糖尿病的低分子量蛋白尿。
Diabetes research Pub Date : 1986-05-01 DOI: 10.1042/CS068013P
J. Fletcher, R. A. Crockson, C. Mijovic, E. Cooper, A. Bradwell, A. Barnett
{"title":"Low molecular weight proteinuria in insulin-dependent diabetes.","authors":"J. Fletcher, R. A. Crockson, C. Mijovic, E. Cooper, A. Bradwell, A. Barnett","doi":"10.1042/CS068013P","DOIUrl":"https://doi.org/10.1042/CS068013P","url":null,"abstract":"Although the protein leak of early diabetic nephropathy is said to be purely a glomerular lesion, there is still controversy as to the existence of a tubular component. We have, therefore, assessed the urine of insulin-dependent diabetics for tubular proteinuria as a feature of early diabetic nephropathy. The urine of 25 patients with increased albumin excretion rate was analyzed by sodium dodecyl polyacrylamide gel electrophoresis. One patient showed high molecular weight proteinuria, 2 showed low molecular weight proteinuria and 2 patients showed both low and high molecular weight proteinuria. The urine was also analyzed for 3 tubular proteins by single radial immunodiffusion. No patient showed elevated beta-2-microglobulin, but alpha-1-microglobulin (A1M) (corrected for creatinine excretion) was elevated in 3 out of 25 patients including 2 of the 4 patients with a low molecular weight pattern. One of the patients with raised A1M also had raised retinol-binding protein concentration. We conclude that, in early diabetic nephropathy, proteinuria can have a proximal tubular, as well as a glomerular, component.","PeriodicalId":11104,"journal":{"name":"Diabetes research","volume":"26 1","pages":"203-6"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74324844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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