International Journal of Neurology and Psychiatry最新文献

筛选
英文 中文
Iron Deposition in Cerebrovascular Diseases: A Post-Mortem Review 铁沉积在脑血管疾病中的研究进展
International Journal of Neurology and Psychiatry Pub Date : 2019-10-02 DOI: 10.31546/ijnp.1001
J. D. Reuck
{"title":"Iron Deposition in Cerebrovascular Diseases: A Post-Mortem Review","authors":"J. D. Reuck","doi":"10.31546/ijnp.1001","DOIUrl":"https://doi.org/10.31546/ijnp.1001","url":null,"abstract":"Introduction In the central nervous system, iron (Fe) linked to proteins, is involved in many important processes such as oxygen transportation, oxidative phosphorylation, and synthesis and metabolism of neurotransmitters [1]. Astrocytes are largely responsible for distributing Fe in the normal brain. As capillary endothelial cells are separated from the neuropil by the end-feet’s of astrocytes, they are ideally positioned to transport Fe to other brain cells [2]. The highest concentrations of Fe in the normal cerebral hemispheres are found in the globus pallidus, followed by the putamen, the caudate nucleus and the thalamus on the transverse relaxation rates R2 and R2* magnetic resonance imaging (MRI) [3]. In the substantia nigra the main high Fe compound in dopamine and norepinephrine neurons is the neuromelanin-iron complex that serves to trap Fe and to provide neuronal protection for oxidative stress [4]. The Fe concentration is lower in infant brains compared to adult ones [5]. It increases during the further aging process in the different human brain regions, but most strongly in the basal ganglia [6-7]. The Fe content decreases after the age of 80 years [8]. This is probably due to progressive age-related neurodegenerative changes [9].","PeriodicalId":110613,"journal":{"name":"International Journal of Neurology and Psychiatry","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125131489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信