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An Overview and Management of Multiple Chronic Conditions最新文献

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Traditional Chinese Medicine in Geriatrics, Evidences, and the Guideline 中医在老年病学，证据，和指南
An Overview and Management of Multiple Chronic Conditions Pub Date : 2020-11-07 DOI: 10.5772/intechopen.94277
Koh Iwasaski
{"title":"Traditional Chinese Medicine in Geriatrics, Evidences, and the Guideline","authors":"Koh Iwasaski","doi":"10.5772/intechopen.94277","DOIUrl":"https://doi.org/10.5772/intechopen.94277","url":null,"abstract":"The average life span of Japanese is 90 years. So that Japan is an unprecedented super-aging society. However, healthy life span is 10 years shorter than life span. Many spend an average of 10 years in frailty. People become frail, and reached to “geriatric syndrome.”","PeriodicalId":106829,"journal":{"name":"An Overview and Management of Multiple Chronic Conditions","volume":"26 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125158328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Role of Rheumatic and Musculoskeletal Diseases in Multimorbidity 探讨风湿病和肌肉骨骼疾病在多重发病中的作用
An Overview and Management of Multiple Chronic Conditions Pub Date : 2020-06-16 DOI: 10.5772/intechopen.85434
Daniela Simões, R. Lucas
{"title":"Exploring the Role of Rheumatic and Musculoskeletal Diseases in Multimorbidity","authors":"Daniela Simões, R. Lucas","doi":"10.5772/intechopen.85434","DOIUrl":"https://doi.org/10.5772/intechopen.85434","url":null,"abstract":"Non-communicable diseases (NCDs) frequently aggregate due to shared pathophysiological mechanisms, either as sequential steps in the same causal pathway or as common results of the same exposures, leading to a high prevalence of disease co-occurrence, a phenomenon known as multimorbidity. Multimorbidity is a patient-centered concept where all morbidities are regarded of equal importance irrespective of whether they started before or after any other disease in question. Rheumatic and musculoskeletal diseases (RMDs) are among the most prevalent groups of NCDs, and probably due to their high incidence and low case fatality, they are highly susceptible to multimorbidity. Complex patients, such as some of those with multimorbidity, are nowadays the norm, implying a growing concern that clinical practice guidelines fail to adequately address the care of complex patients. The ramifications of suffering from multimorbidity unfold for each patient, within their social, educational, cultural, behavioral, economic, and environmental contexts, which in turn affect disease management.","PeriodicalId":106829,"journal":{"name":"An Overview and Management of Multiple Chronic Conditions","volume":"171 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134535747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Impairment in Chronic Lung Diseases 慢性肺部疾病中的认知障碍
An Overview and Management of Multiple Chronic Conditions Pub Date : 2020-03-25 DOI: 10.5772/INTECHOPEN.91825
E. Tudorache, M. Marc, Daniel Traila, D. Manolescu
{"title":"Cognitive Impairment in Chronic Lung Diseases","authors":"E. Tudorache, M. Marc, Daniel Traila, D. Manolescu","doi":"10.5772/INTECHOPEN.91825","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.91825","url":null,"abstract":"The increase in life expectancy has been accompanied by an escalation of age-related disease incidence. Mild cognitive impairment (MCI) is a decline of cognitive function higher than expected for a certain age, but not severe enough to meet the criteria for dementia. Hypoxemia, smoking history, ageing and several comorbidities are risk factors for both chronic respiratory diseases and cognitive deficit. Up to 70% of patients with chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA) or idiopathic pulmonary fibrosis (IPF) have a form of cognitive impairment. Furthermore, a low neuropsychological performance is an independent predictor of disability and mortality in these populations. Efficient tools for cognitive assessment have been validated for these patients and should be used for better clinical outcomes. The physiopathological mechanisms, clinical impact and prevention strategies for cognitive dysfunction in chronic respiratory diseases will be detailed in the following chapter.","PeriodicalId":106829,"journal":{"name":"An Overview and Management of Multiple Chronic Conditions","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132239749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Enkephalin Therapy Improves Relapsing-Remitting Multiple Sclerosis 脑啡肽治疗改善复发-缓解型多发性硬化症
An Overview and Management of Multiple Chronic Conditions Pub Date : 2020-01-28 DOI: 10.5772/intechopen.91010
Chirag Patel, I. Zagon, G. Thomas, P. McLaughlin
{"title":"Enkephalin Therapy Improves Relapsing-Remitting Multiple Sclerosis","authors":"Chirag Patel, I. Zagon, G. Thomas, P. McLaughlin","doi":"10.5772/intechopen.91010","DOIUrl":"https://doi.org/10.5772/intechopen.91010","url":null,"abstract":"Multiple sclerosis (MS) is accompanied by decreases in serum endogenous enkephalin/endorphins and alterations in inflammatory cytokines. This retrospective analysis of serum levels was conducted in 53 patients with established relapsing-remitting MS treated with the disease-modifying therapies (DMT) glatiramer acetate, dimethyl fumarate or with the biotherapeutic low dose naltrexone (LDN) to elevate enkephalins, an off-label alternative. Opioid growth factor (OGF), an inhibitory endogenous opioid involved in modulating cellular replication, was measured and correlated to serum β-endorphin, IL-17A and TNFα. Results revealed that MS leads to a significant reduction in OGF levels in subjects on DMTs, but patients on LDN had OGF levels comparable to non-MS controls. Individuals on DMTs had significantly elevated TNFα levels, while IL-17A levels were significantly elevated only in patients taking dimethyl fumarate. A direct correlation was established between OGF and IL17A indicating a potential interaction between the OGF-OGFr axis and pro-inflammatory T-helper cells providing insight into the disease etiology.","PeriodicalId":106829,"journal":{"name":"An Overview and Management of Multiple Chronic Conditions","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128765627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Presbycusis-Related Tinnitus and Cognitive Impairment: Gender Differences and Common Mechanisms 老年性耳鸣和认知障碍:性别差异和常见机制
An Overview and Management of Multiple Chronic Conditions Pub Date : 2020-01-23 DOI: 10.5772/intechopen.90956
Weibin Zhang, Zhuowei Yu, Q. Ruan
{"title":"Presbycusis-Related Tinnitus and Cognitive Impairment: Gender Differences and Common Mechanisms","authors":"Weibin Zhang, Zhuowei Yu, Q. Ruan","doi":"10.5772/intechopen.90956","DOIUrl":"https://doi.org/10.5772/intechopen.90956","url":null,"abstract":"Presbycusis-related tinnitus and cognitive impairment are common in the elderly and generate a massive burden on family and society. Except for age, the study explored the gender differences in the prevalence of the three diseases. We found that women have an advantage in maintaining better cognitive and auditory functions. Recent studies suggest the complex links among the three diseases. Peripheral hearing loss can affect sound coding and neural plasticity, which will lead to cognitive impairment and tinnitus. The deficits of the central nervous system, especially central auditory structures, can, in turn, cause the presbycusis. The interaction among three diseases indicated that comprehensive assessment, intervention and treatment in consideration of hearing loss, tinnitus and cognitive impairment are important to decay aging.","PeriodicalId":106829,"journal":{"name":"An Overview and Management of Multiple Chronic Conditions","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115540660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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