Lipid insightsPub Date : 2016-02-01eCollection Date: 2015-01-01DOI: 10.4137/LPI.S31785
Patrick Williamson
{"title":"Phospholipid Scramblases.","authors":"Patrick Williamson","doi":"10.4137/LPI.S31785","DOIUrl":"https://doi.org/10.4137/LPI.S31785","url":null,"abstract":"<p><p>The distribution of phospholipid types between the two leaflets of a membrane bilayer is a controlled feature of membrane structure. One of the two membrane catalytic activities governing this distribution randomizes the composition of the two leaflets-the phospholipid scramblases. Two proteins (Xkr8 and TMEM16F) required for the activation of these activities have been identified. One of these proteins (TMEM16F) is quite clearly a scramblase itself and provides insight into the mechanism by which transbilayer phospholipid movement is facilitated. </p>","PeriodicalId":101442,"journal":{"name":"Lipid insights","volume":"8 Suppl 1","pages":"41-4"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/LPI.S31785","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72212579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}