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Ankle Fusion Rates using Composite Peptide-enriched Bone Graft 使用复合肽骨移植的踝关节融合率

The open orthopaedics journal Pub Date : 2024-02-12 DOI: 10.2174/0118743250283784231211111719

Luke S. McKinnon, Michael J. Symes, Andrew Wines, R. Mittal

{"title":"Ankle Fusion Rates using Composite Peptide-enriched Bone Graft","authors":"Luke S. McKinnon, Michael J. Symes, Andrew Wines, R. Mittal","doi":"10.2174/0118743250283784231211111719","DOIUrl":"https://doi.org/10.2174/0118743250283784231211111719","url":null,"abstract":"\u0000 \u0000 Joint fusion is a widely accepted treatment option for debilitating arthritis and deformity in the foot and ankle. Autologous bone grafting has long been accepted as the gold standard form of bone grafting; however, it can still be associated with non-union. This study aims to investigate joint fusion rates using Composite Peptide Enhanced Bone Graft (CPEBG) as an adjunct during ankle fusion surgery.\u0000 \u0000 \u0000 \u0000 Data was collected retrospectively for patients over the age of 18 years, undergoing ankle fusion between June 2016 and August 2020 with autologous bone graft and CPEBG. All patients had their primary or secondary procedure performed by a single surgeon with follow-up at 6 and 12 months post-operatively. Data included baseline demographic data and procedural characteristics. The primary endpoint was to assess joint union at 6 and 12 months, respectively. Secondary objectives included post-operative pain, mobility and the use of walking aids.\u0000 \u0000 \u0000 \u0000 Radiographic union rates for the primary group were 40/48 (83%) and 43/48 (90%) at 6 and 12 months and 2/3 (67%) and 3/3 (100%) at 6 and 12 months for the secondary group, respectively. The overall non-union rate for primary ankle fusions was 8%, while no non-unions were observed in the secondary group.\u0000 \u0000 \u0000 \u0000 CPEBG in foot and ankle fusion procedures yields similar union rates compared to other graft options. Further well-designed randomised control trials are warranted to confirm these findings.\u0000","PeriodicalId":101384,"journal":{"name":"The open orthopaedics journal","volume":"10 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ankle Fusion Rates using Composite Peptide-enriched Bone Graft 使用复合肽骨移植的踝关节融合率

The open orthopaedics journal Pub Date : 2024-02-12 DOI: 10.2174/0118743250283784231211111719

Luke S. McKinnon, Michael J. Symes, Andrew Wines, R. Mittal

{"title":"Ankle Fusion Rates using Composite Peptide-enriched Bone Graft","authors":"Luke S. McKinnon, Michael J. Symes, Andrew Wines, R. Mittal","doi":"10.2174/0118743250283784231211111719","DOIUrl":"https://doi.org/10.2174/0118743250283784231211111719","url":null,"abstract":"\u0000 \u0000 Joint fusion is a widely accepted treatment option for debilitating arthritis and deformity in the foot and ankle. Autologous bone grafting has long been accepted as the gold standard form of bone grafting; however, it can still be associated with non-union. This study aims to investigate joint fusion rates using Composite Peptide Enhanced Bone Graft (CPEBG) as an adjunct during ankle fusion surgery.\u0000 \u0000 \u0000 \u0000 Data was collected retrospectively for patients over the age of 18 years, undergoing ankle fusion between June 2016 and August 2020 with autologous bone graft and CPEBG. All patients had their primary or secondary procedure performed by a single surgeon with follow-up at 6 and 12 months post-operatively. Data included baseline demographic data and procedural characteristics. The primary endpoint was to assess joint union at 6 and 12 months, respectively. Secondary objectives included post-operative pain, mobility and the use of walking aids.\u0000 \u0000 \u0000 \u0000 Radiographic union rates for the primary group were 40/48 (83%) and 43/48 (90%) at 6 and 12 months and 2/3 (67%) and 3/3 (100%) at 6 and 12 months for the secondary group, respectively. The overall non-union rate for primary ankle fusions was 8%, while no non-unions were observed in the secondary group.\u0000 \u0000 \u0000 \u0000 CPEBG in foot and ankle fusion procedures yields similar union rates compared to other graft options. Further well-designed randomised control trials are warranted to confirm these findings.\u0000","PeriodicalId":101384,"journal":{"name":"The open orthopaedics journal","volume":"65 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long Term Results of Innovative Procedure in Surgical Management of Chronic Lymphedema. 慢性淋巴水肿外科治疗创新手术的长期结果。

The open orthopaedics journal Pub Date : 2016-11-17 eCollection Date: 2016-01-01 DOI: 10.2174/1874325001610010543

Seyed R Mousavi

{"title":"Long Term Results of Innovative Procedure in Surgical Management of Chronic Lymphedema.","authors":"Seyed R Mousavi","doi":"10.2174/1874325001610010543","DOIUrl":"https://doi.org/10.2174/1874325001610010543","url":null,"abstract":"Background: Lymphedema is the result of impaired lymphatic drainage by the affected organ. This abnormality can be primary or secondary. Different operative approaches have been introduced to treat chronic lymphedema.Materials and methods: This retrospective study included 816 patients who were diagnosed with chronic lower extremity lymphedema and did not respond to non-operative management for at least six months. Data was collected over 25 years, between March 1987 and March 2013. Doppler ultrasonography of the deep venous system was routinely undertaken in all patients to confirm patency. The patients underwent surgery and their progress was followed for at least one year postoperatively.Results: All patients were operated by the suggested technique and long term fallow-up which is a modified form of the Homan's technique. The outcome was excellent, and 89.2% of patients were free of complication and 2% had poor results. The most common complication was wound seroma and wound infection.Conclusion: The long term results and considering the difficulties associated with the treatment of chronic lymphedema and the variety of surgical options, our method achieved excellent results, and may be proposed for the standard operative procedure for treating intractable forms of this disease.","PeriodicalId":101384,"journal":{"name":"The open orthopaedics journal","volume":"10 ","pages":"543-549"},"PeriodicalIF":0.0,"publicationDate":"2016-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71435091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0