Proceedings. International Conference on Intelligent Networking and Collaborative Systems最新文献

筛选
英文 中文
Precision Dosing Management with Intelligent Computing in Digital Health. 数字健康中的智能计算精确剂量管理。
Proceedings. International Conference on Intelligent Networking and Collaborative Systems Pub Date : 2020-08-01 Epub Date: 2020-08-21 DOI: 10.1007/978-3-030-57796-4_26
Hong Lu, Sara Rosenbaum, Wei Lu
{"title":"Precision Dosing Management with Intelligent Computing in Digital Health.","authors":"Hong Lu,&nbsp;Sara Rosenbaum,&nbsp;Wei Lu","doi":"10.1007/978-3-030-57796-4_26","DOIUrl":"https://doi.org/10.1007/978-3-030-57796-4_26","url":null,"abstract":"<p><p>Pediatric dosing is not only critical for successful pediatric trials in drug development but also paramount to safety and effective treatment at bedside. Due to the complex pharmacokinetic of children compared to adults, several challenges are posed in managing dosing precisely during drug development and after drug approval to clinicians. In particular, given the real-world practice, understanding the impact of development on the dose-exposure-response relationship is essential in optimizing the dosing to children of different ages. In this paper we propose a novel intelligent computing framework to examine how the growth and maturation create size- and age-dependent variability in pharmacokinetics and pharmacodynamics, and summarize the use of modeling-based approaches for dose finding in pediatric drug development, allowing clinicians to anticipate probable treatment effects and to have a higher likelihood of achieving optimal dose regimens early, as well as reducing the drug development cycling time and cost.</p>","PeriodicalId":101369,"journal":{"name":"Proceedings. International Conference on Intelligent Networking and Collaborative Systems","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71432062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信