中国现代医学杂志最新文献

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The study of myocardial protective effect of creatine phosphate sodium in liver transplant patients 磷酸肌酸钠对肝移植患者心肌保护作用的研究

中国现代医学杂志 Pub Date : 2013-01-01 DOI: 10.14725/dcc.v2n28-11

Kang Yu-qing

引用次数: 0

Study on the relationship between serum level of leptin, endothelin and different stages of diabetic retinopathy in type 2 diabetes patients 2型糖尿病患者血清瘦素、内皮素水平与不同阶段糖尿病视网膜病变关系的研究

中国现代医学杂志 Pub Date : 2011-06-20 DOI: 10.3760/CMA.J.ISSN.1008-1372.2011.06.010

Ying Wang, Jian-fen Wei, Xiu-ping Jin, Su Liu

{"title":"Study on the relationship between serum level of leptin, endothelin and different stages of diabetic retinopathy in type 2 diabetes patients","authors":"Ying Wang, Jian-fen Wei, Xiu-ping Jin, Su Liu","doi":"10.3760/CMA.J.ISSN.1008-1372.2011.06.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2011.06.010","url":null,"abstract":"Objective To evaluate the relationship between serum levels of leptin, endothelin and diabetic retinopathy in type 2 diabetes patients. Methods Leptin, endothelia, FBG, PBG, HBA1C, CHOL, TG and other clinical characteristics were tested in 80 type2 diabetes patients and 30 control case. All diabetes patients were divided into three group: non-diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy(PDR) according to the examination results of fundus. Correlations between levels of serum leptin and other parameters were analyzed. Results Plasma level of leptin in the type 2 diabetes with PDR group[(17.41±5.81)μg/L] were higher than that in control, NPDR and NDR group (P＜0.01). Plasma level of ET in the type 2 diabetes with PDR group[(80.68±13.57)mg/L] were higher than that in control, NPDR and NDR group (P＜0.01). The serum leptin levels were positively correlated with BMI(r＝0.468,P＜0.01). Conclusions Serum leptin and endothelin levels were elevated in patient with diabetic retinopathy as diabetic retinopathy aggravated and serum level of leptin and endothelin raised. \u0000 \u0000Key words: \u0000Diabetes mellitus/ME; Leptin/ME; Endothelins/ME; Diabetic retinopathy","PeriodicalId":10076,"journal":{"name":"中国现代医学杂志","volume":"13 1","pages":"757-759"},"PeriodicalIF":0.0,"publicationDate":"2011-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69916391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental study of genistein in preventing and treating transplant arteriosclerosis in arotic transplantation of rat 染料木素防治大鼠关节移植动脉硬化的实验研究

中国现代医学杂志 Pub Date : 2006-01-01 DOI: 10.1097/00007890-200607152-02451

Chen Bi-cheng

{"title":"Experimental study of genistein in preventing and treating transplant arteriosclerosis in arotic transplantation of rat","authors":"Chen Bi-cheng","doi":"10.1097/00007890-200607152-02451","DOIUrl":"https://doi.org/10.1097/00007890-200607152-02451","url":null,"abstract":"[Objective] To study the protective effects of genistein(GEN) in preventing and treating transplant arteriosclerosis and potential mechanisms. [Methods] Arotic transplantation was performed with male Brown-Norway rats as donors and male Lewis rats as recipients. The recipients in the experiment was randomly divided into four groups: (1) high-dose group (n=8), the recipients were administered with GEN at a dose of 20 mg/kg body weight for 60 days continuously; (2) high-low dose group (n=8), at a dose of 20 mg/kg for 14 days and at dose of 2 mg/kg for 46 days continuously; (3) solvent control (n=5), 0.5 mL DMSO for 60 days; (4) control (n=5), no treatment. Histological changes were monitored 60 days after transplantation, and the average depth of intima was calculated with computer imaging analysis systes. Immunohistochemistry was used to detect infiltration of CD4+, CD8+ T lymphocyte in the transplanted vessels, and ELISA to detect the change of VEGF in different group. [Results] Compared with two control groups, there were less lymphocytes and macrophages infiltration, the average depth of intima in two experimental groups markedly lowed (seperatedly P 0.001) and infiltration of CD4+, CD8+ T lymphocyte in the transplanted vessels was less (seperatedly P 0.01). Expression of VEGF in high dose group was lower than that in two control (8.6731±1.0466 Vs 21.8340±0.7558 and 23.2068±1.2028 P 0.01), but there was no statistic difference compared with high-low dose group. [Conclusion] Genistein can prevent the development of graft arteriosclerosis and the lowed infiltration of lymphocytes and the influenced expression of growth factors may be involved in the mechanisms.","PeriodicalId":10076,"journal":{"name":"中国现代医学杂志","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00007890-200607152-02451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61487511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0