中国比较医学杂志最新文献

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RT-SHIV Infected and Passaged in Chinese-Origin Rhesus Macaque 中国恒河猴RT-SHIV的感染与传代

中国比较医学杂志 Pub Date : 2011-01-01 DOI: 10.3969/J.ISSN.1671.7856.2011.04.004

Nailin Yao, W. Wang, Z. Cong, T. Chen, G. Jin, Z. Tao, Zhiwei Chen, Q. Wei

引用次数: 1

Effect of CD8~+ T Cell Depletion in Vivo on Monkeys with Chronic SHIV-KB9 Infection 体内CD8~+ T细胞耗损对慢性SHIV-KB9感染猴子的影响

中国比较医学杂志 Pub Date : 2011-01-01 DOI: 10.3969/J.ISSN.1671.7856.2011.04.001

W. Wang, Z. Cong, H. Liu, Z. Tao, Q. Liu, Q. Wei, Zhiwei Chen, C. Qin

{"title":"Effect of CD8~+ T Cell Depletion in Vivo on Monkeys with Chronic SHIV-KB9 Infection","authors":"W. Wang, Z. Cong, H. Liu, Z. Tao, Q. Liu, Q. Wei, Zhiwei Chen, C. Qin","doi":"10.3969/J.ISSN.1671.7856.2011.04.001","DOIUrl":"https://doi.org/10.3969/J.ISSN.1671.7856.2011.04.001","url":null,"abstract":"Objective CD8+ T cells play an important role in some viral diseases,but the role of CD8+ T cells is not yet fully clear in the asymptomatic phase of HIV infection.The aim of this study was to elucidate the impact of CD8 + T cell in SHIV-infected monkeys with in vivo CD8 + T cells depletion,and to further understand the pathogenesis of AIDS.Methods Eight SHIV-infected rhesus monkeys in the asymptomatic phase were selected and randomly divided into two groups.Anti-CD8 + T antibody cM-T807 were injected intravenously into four monkeys on days 0,3,and 7.Then the CD8 + T cell number in peripheral blood and lymph nodes in the monkeys were detected by flow cytometry,the plasma viral load by real-time RT-PCR,and the cellular immunity by IFN-γ Elispot assay.Results The viral load of the four monkeys was elevated to above of detected after the CD8 + T cell depletion,but the reactions were not uniform.CD4 + T cells,the HIV-1 target cells,rebound and dropped slightly.The infection of monkeys with CD8 + T cell depletion was lighter than that after the SHIV virus first infection(plasma viral load and CD4 cells),which was consistent with the Elispot results.Conclusions CD8 + T cells play an important role in the asymptomatic phase of HIV-1 infection,but with some interindividual variation.","PeriodicalId":10068,"journal":{"name":"中国比较医学杂志","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70181191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Titration of a SHIV1157ipd3N4 Stock by Intravenous Inoculation of Chinese-Origin Rhesus Macaques 中国恒河猴静脉接种SHIV1157ipd3N4原液的测定

中国比较医学杂志 Pub Date : 2011-01-01 DOI: 10.3969/J.ISSN.1671.7856.2011.04.003

Z. Cong, H. Jiang, G. Jin, T. Chen, W. Wang, Z. Tao, Nailin Yao, J. Xiong, F. Wu, Zhiwei Chen, Q. Wei

引用次数: 1