IF 3 4区医学

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-03-16 DOI: 10.1080/13685538.2026.2641901

Ting Yang, Jinyu Zhang, Jiongzheng Li, Quanshun Yan, Jing Li

{"title":"Immune-mediated pathways between red blood cell traits and prostate cancer: a causal relationship network based on Mendelian randomization evaluation.","authors":"Ting Yang, Jinyu Zhang, Jiongzheng Li, Quanshun Yan, Jing Li","doi":"10.1080/13685538.2026.2641901","DOIUrl":"10.1080/13685538.2026.2641901","url":null,"abstract":"Background: Although both the immune and hematopoietic systems play important roles in prostate cancer (PCa), few studies have comprehensively investigated the combined influence of these systems on PCa risk.Method: The datasets used to construct causal networks for evaluation via Mendelian randomization and mediation Mendelian randomization (MMR). Nine analytical approaches were applied to evaluate the causal associations.Result: The findings revealed that red blood cell count (RBC) and red cell distribution width (RDW) were related to a modest increased risk of PCa, while mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were related to a modest reduced risk. Further, MMR analyses identified that HLA-DR on dendritic cells mediated the causal effect of RBC on PCa, with a mediated proportion of 12.09%, and that IgD+ CD38- B cell % B cell mediated the effects of RDW and MCHC on PCa, with mediating proportions of 15.07% and 25.96%, respectively. Moreover, the IgD+ CD38- B cell % lymphocytes mediated the causal effect of MCHC on PCa, with a mediated proportion of 29.03%.Conclusion: RBC, RDW, MCH, and MCHC were related to the risk of PCa. Immune cells act as major mediators in this relationship.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"29 1","pages":"2641901"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translation, cultural adaptation, and validation of the Portuguese version of ENDOPAIN-4D questionnaire. ENDOPAIN-4D葡文版问卷的翻译、文化适应和验证。

IF 2.6 3区医学

Journal of Psychosomatic Obstetrics & Gynecology Pub Date : 2026-12-31 Epub Date: 2026-03-12 DOI: 10.1080/0167482X.2026.2643521

Rita Almendra, Emanuel Egas Araújo, Diana Natacha Sousa, Cristina Nogueira-Silva

{"title":"Translation, cultural adaptation, and validation of the Portuguese version of ENDOPAIN-4D questionnaire.","authors":"Rita Almendra, Emanuel Egas Araújo, Diana Natacha Sousa, Cristina Nogueira-Silva","doi":"10.1080/0167482X.2026.2643521","DOIUrl":"10.1080/0167482X.2026.2643521","url":null,"abstract":"Background: The endometriosis painful symptoms-4 dimensions ENDOPAIN-4D is a multidimensional questionnaire designed to assess endometriosis-related pain. This study aimed to translate, culturally adapt, and validate ENDOPAIN-4D for European Portuguese.Methodology: Translation and content validity assessment were assessed in 32 women with endometriosis. For psychometric validation, 386 patients completed an online sociodemographic and clinical questionnaire, the Portuguese ENDOPAIN-4D, and the Endometriosis Health Profile Questionnaire-30 (EHP-30). Statistical analyses included descriptive statistics, exploratory factor analysis, internal consistency, item-total correlation, and concurrent validity.Results: Factor analysis of the \"usual pain\" dimension supported the original four-factor structure, accounting for 63.7% of variance (Cronbach's α = 0.91). A novel three-factor structure was identified for the \"worst pain\" dimension, previously psychometrically untested, with good internal consistency (Cronbach's α = 0.83) and acceptable item-total correlations. Concurrent validity with the EHP-30 ranged from weak to strong across domains.Conclusions: The Portuguese ENDOPAIN-4D is a culturally adapted and validated instrument for multidimensional pain assessment in European Portuguese women with endometriosis, with validity likely limited for other Portuguese-speaking communities. The newly identified three-factor structure for worst pain may aid individualized pain management and follow-up in clinical and psychosomatic care. Further studies should evaluate concurrent validity and the stability and responsiveness of the new algorithms.","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"47 1","pages":"2643521"},"PeriodicalIF":2.6,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2. 利用AbNatiV2对抗体和纳米体设计的原生性和配对可能性进行深度学习评估。

IF 7.9 2区医学

mAbs Pub Date : 2026-12-31 Epub Date: 2026-04-07 DOI: 10.1080/19420862.2026.2646361

Aubin Ramon, Niccolò Frassetto, Haowen Zhao, Xing Xu, Matthew Greenig, Shimobi Onuoha, Pietro Sormanni

{"title":"Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2.","authors":"Aubin Ramon, Niccolò Frassetto, Haowen Zhao, Xing Xu, Matthew Greenig, Shimobi Onuoha, Pietro Sormanni","doi":"10.1080/19420862.2026.2646361","DOIUrl":"10.1080/19420862.2026.2646361","url":null,"abstract":"Most immune-system created antibodies balance good binding and stability with low toxicity and self-reactivity. Quantifying the nativeness of a candidate sequence - its likelihood of belonging to natural immune repertoires - has thus emerged as a valuable strategy for hit selection from synthetic libraries, optimization and humanization, and for guiding de novo design toward developable candidates. We previously introduced AbNatiV, a transformer-based VQ-VAE for nativeness assessment, which proved effective across multiple nanobody engineering tasks. However, AbNatiV1 operated on unpaired sequences, limiting applicability to conventional VH-VL antibodies. Moreover, its performance on nanobody nativeness was constrained by the limited number and diversity of nanobody repertoires available at the time. Here, we sequenced new camelid repertoires, curated additional recent datasets, and present AbNatiV2: an enhanced architecture comprising various models each trained on ≥20 million sequences. AbNatiV2 improves nanobody nativeness classification across held-out and diverse test sets, and more robustly detects nativeness changes upon CDR grafting. We also introduce p-AbNatiV2, a cross-attention model fine-tuned on 3.7 million paired human sequences. p-AbNatiV2 provides residue- and sequence-level humanness for VH/VL pairs and learns pairing-likelihood via noise-contrastive training. On held-out tests, it assigns the native pair a higher score in 74% of cases, substantially outperforming recent pairing models. Together, AbNatiV2 and p-AbNatiV2 extend nativeness assessment and engineering to both nanobodies and conventional antibodies, supporting design decisions at single-residue, Fv-sequence, and paired-domain levels. AbNatiV2 is available as downloadable software and webserver.","PeriodicalId":18206,"journal":{"name":"mAbs","volume":"18 1","pages":"2646361"},"PeriodicalIF":7.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidimensional health evaluation in mid-aged women: cross-sectional study protocol for a future-implementable program. 中年妇女多维健康评估：未来可实施项目的横断面研究方案

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-03-18 DOI: 10.1080/09513590.2026.2645743

Peter Chedraui, Melissa Sánchez-Briones, Marcela Mendoza-Burgos, María C Monteverde-Álvarez, Camilo R Nevárez-Gilbert, Ricardo Echeverría-Castro, Tiziana Fidecicchi, Tommaso Simoncini

{"title":"Multidimensional health evaluation in mid-aged women: cross-sectional study protocol for a future-implementable program.","authors":"Peter Chedraui, Melissa Sánchez-Briones, Marcela Mendoza-Burgos, María C Monteverde-Álvarez, Camilo R Nevárez-Gilbert, Ricardo Echeverría-Castro, Tiziana Fidecicchi, Tommaso Simoncini","doi":"10.1080/09513590.2026.2645743","DOIUrl":"10.1080/09513590.2026.2645743","url":null,"abstract":"Objective: To conduct a comprehensive assessment of physical, functional, emotional, cognitive, nutritional, metabolic, and sexual health in mid-aged women.Methods: This cross-sectional study was conducted at the Universidad Espíritu Santo Clinic (UEES Clinic), Ecuador, as part of a multidisciplinary integrated health initiative. Women aged 40-60 years were recruited through social media outreach by the UEES Research Center and Clinic between 1 October 2024 and 1 October 2025. Interested participants scheduled a clinical evaluation by telephone. Assessments included laboratory tests (complete blood count, FSH, estradiol, HDL-C, triglycerides, glucose, and thyroid hormones [T3, T4]); validated surveys: Menopause Rating Scale (MRS) for climacteric symptoms and quality of life; Center for Epidemiologic Studies Depression Scale, 10-item version (CESD-10) for depressive mood; short Everyday Memory Questionnaire-Revised (EMQ-R) for cognition; and FSFI-6 for sexual function. Participants also underwent anthropometric measurements, body composition analysis, muscle strength testing, and dietary assessment.Discussion: This methods paper describes a multidisciplinary approach for the comprehensive health evaluation of mid-aged women. It enables early identification of factors affecting quality of life and provides a replicable framework relevant to both local and broader Latin American contexts, serving as a model for similar initiatives across the region.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2645743"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive transitions and autoimmunity: implications for women's health in rheumatology and gastroenterology. 生殖过渡和自身免疫：对风湿病和胃肠病学妇女健康的影响。

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-03-17 DOI: 10.1080/09513590.2026.2645835

Lorenzo Cavagna, Marco Vincenzo Lenti, Laura Cucinella, Francesca Bottazzi, Antonio Di Sabatino, Rossella E Nappi

{"title":"Reproductive transitions and autoimmunity: implications for women's health in rheumatology and gastroenterology.","authors":"Lorenzo Cavagna, Marco Vincenzo Lenti, Laura Cucinella, Francesca Bottazzi, Antonio Di Sabatino, Rossella E Nappi","doi":"10.1080/09513590.2026.2645835","DOIUrl":"10.1080/09513590.2026.2645835","url":null,"abstract":"Women's reproductive life encompasses dynamic phases, including menarche, menstrual cycles, pregnancy, lactation, and menopause, as well as transitional periods of variable duration. These stages drive physiological changes that influence both physical and mental well-being and may modulate susceptibility to autoimmunity. The interplay between autoimmunity and reproductive milestones is bidirectional: reproductive stages can affect disease onset and progression, while autoimmune disorders influence fertility, pregnancy outcomes, and the timing of menopause. Persistent challenges in detecting autoimmune diseases, particularly within rheumatology and gastroenterology, underscore the need for targeted screening, multidisciplinary collaboration, and patient-centered strategies. Fertility preservation, preconception counseling, and individualized pregnancy management are essential to safeguard reproductive rights and optimize maternal and neonatal outcomes. Post-reproductive life, especially the menopause transition, represents a vulnerable period in which immune, hormonal, and metabolic changes converge. This manuscript highlights the importance of a comprehensive, lifespan-oriented approach to reproductive well-being in women with autoimmune diseases, integrating preventive, diagnostic, and therapeutic strategies across all stages of reproduction.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2645835"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the molecular mechanisms underlying the inflammation-cancer transformation in Hashimoto thyroiditis using single-cell transcriptomics. 利用单细胞转录组学研究桥本甲状腺炎炎症-癌转化的分子机制。

IF 4.3 4区医学

Autoimmunity Pub Date : 2026-12-31 Epub Date: 2026-03-10 DOI: 10.1080/08916934.2026.2639801

Mengsha Zou, Shang Shi, Huihui Li, Jianan Zhang, Gaoxiang Chen

{"title":"Exploring the molecular mechanisms underlying the inflammation-cancer transformation in Hashimoto thyroiditis using single-cell transcriptomics.","authors":"Mengsha Zou, Shang Shi, Huihui Li, Jianan Zhang, Gaoxiang Chen","doi":"10.1080/08916934.2026.2639801","DOIUrl":"10.1080/08916934.2026.2639801","url":null,"abstract":"Hashimoto thyroiditis (HT) is closely associated with the development of papillary thyroid carcinoma (PTC); however, the tumor immune microenvironment and the molecular mechanisms underlying the 'inflammation-to-cancer' transition in HT-PTC coexistence remain poorly understood. In this study, we integrated single-cell RNA sequencing (scRNA-seq) data from HT-associated and PTC tissues, annotating 11 distinct cell subtypes, including endothelial cells, red blood cells, fibroblasts, follicular epithelial cells (FECs), macrophages, monocytes, T cells, NK cells, B cells, plasma cells, and mast cells. Malignant epithelial cells were identified through copy number variation (CNV) analysis, followed by differential gene expression screening and functional enrichment analysis. Cell-cell communication analysis was employed to delineate intercellular interactions, and key findings were validated using a lipopolysaccharide (LPS)-stimulated Transwell co-culture model incorporating TPC-1 cells, Nthy-ori 3-1 cells, and mast cells. We found that IL1B was significantly upregulated in malignant FECs, and differentially expressed genes were enriched in immune-related processes including antigen presentation and lymphocyte activation. Notably, IL1B- FECs specifically communicated with mast cells via the FN1/CD44 signaling axis. In vitro experiments further confirmed that, under inflammatory conditions, mast cells secreted IL-8, which activated the PI3K/AKT pathway and promoted malignant phenotypes. Collectively, these findings suggest that IL1B⁻ FECs recruit mast cells through the FN1/CD44 axis, and mast cell-derived IL-8 subsequently activates the PI3K/AKT pathway to drive the transformation from HT to PTC, providing novel mechanistic insights into the \"inflammation-to-cancer\" transition.","PeriodicalId":8688,"journal":{"name":"Autoimmunity","volume":"59 1","pages":"2639801"},"PeriodicalIF":4.3,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capacity to care: Provider agency and socio-structural constraints in breast cancer care across public secondary and tertiary hospitals in Soweto. 护理能力：索韦托公立二级和三级医院乳腺癌护理中的提供者机构和社会结构限制。

IF 2.6 3区医学

Global Public Health Pub Date : 2026-12-31 Epub Date: 2026-04-14 DOI: 10.1080/17441692.2026.2657635

Seemela D Malope, Charmaine Blanchard, Ngcwalisa Jama, Maureen Joffe, Shane A Norris

{"title":"Capacity to care: Provider agency and socio-structural constraints in breast cancer care across public secondary and tertiary hospitals in Soweto.","authors":"Seemela D Malope, Charmaine Blanchard, Ngcwalisa Jama, Maureen Joffe, Shane A Norris","doi":"10.1080/17441692.2026.2657635","DOIUrl":"10.1080/17441692.2026.2657635","url":null,"abstract":"Timely breast cancer care remains challenging in South Africa, where both health-system and patient-level barriers contribute to delayed diagnosis and treatment. This study explored healthcare providers' experiences and perspectives on breast cancer care at Chris Hani Baragwanath Academic Hospital in Soweto and its two referring secondary hospitals in Johannesburg. Using a cross-sectional qualitative design informed by phenomenology, we conducted in-depth interviews with 30 providers involved in breast cancer care. Thematic analysis identified intersecting structural and individual barriers, together with provider-led strategies to improve care delivery. System-level constraints included high patient volumes, staff shortages, limited diagnostic capacity, referral delays, inconsistent treatment supplies, and the absence of radiation oncology services at CHBAH, necessitating referral to an affiliated hospital 25 km away. Providers also described patient-related contributors to delay, including fear, denial, symptom misinterpretation, socioeconomic hardship, and limited self-efficacy, often exacerbated by poor communication. Suggested priorities included community and primary care education, provider training, high-risk screening in primary care, and expanded diagnostic and treatment infrastructure, particularly radiation oncology services at CHBAH. Furthermore, providers described pragmatic mitigation strategies, including expedited diagnostic workup, multidisciplinary coordination, electronic records, NGO-supported patient navigation, and temporary disability grants to offset transport costs. In conclusion, these findings provide a foundation for a coordinated response to strengthen oncology care in resource-constrained settings.","PeriodicalId":12735,"journal":{"name":"Global Public Health","volume":"21 1","pages":"2657635"},"PeriodicalIF":2.6,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiota and adenomyosis: exploring mechanisms and therapeutic potential. 微生物群和子宫腺肌症：探索机制和治疗潜力。

IF 3 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2026-04-16 DOI: 10.1080/09513590.2026.2660983

Qi Zhang, Lili Zou, Hongbo Yu, Junjie Wang

{"title":"Microbiota and adenomyosis: exploring mechanisms and therapeutic potential.","authors":"Qi Zhang, Lili Zou, Hongbo Yu, Junjie Wang","doi":"10.1080/09513590.2026.2660983","DOIUrl":"10.1080/09513590.2026.2660983","url":null,"abstract":"Objective: This review comprehensively explores the potential relationship between the microbiota and adenomyosis, aiming to identify specific microbial biomarkers, elucidate the molecular mechanisms underlying the involvement of the microbiota in the disease, and provide insights into more precise and personalized therapeutic strategies for patients with adenomyosis.Methods: This article adopts the narrative review method to comprehensively analyze the literature on the relationship between the microbiota and adenomyosis. A comprehensive literature search was conducted in PubMed, Embase and Web of Science databases. A total of 8 articles were included, among which one was an animal experiment. This review focuses on analyzing the differences in the composition of the microbiota between patients with adenomyosis and healthy control groups, as well as the potential molecular mechanisms by which the microbiota participates in the development of adenomyosis.Results: Studies have demonstrated that the composition of the microbiota in women with adenomyosis differs significantly from that in healthy controls.The potential mechanisms by which microbiota may be involved in adenomyosis are closely associated with immune-inflammatory responses and estrogen regulation, which further affect the progression of adenomyosis.Conclusions: Microbiota may play an important role in the pathogenesis of adenomyosis. Elucidating the specific microbial biomarkers and the underlying molecular mechanisms of microbiota in adenomyosis is crucial for developing novel, precise, and personalized therapeutic strategies, which may provide new options for the treatment of adenomyosis.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2660983"},"PeriodicalIF":3.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The rhetoric of community participation in maternal and perinatal death surveillance and response (MPDSR) in Kenya: Qualitative study. 肯尼亚社区参与孕产妇和围产期死亡监测和应对（MPDSR）的说辞：定性研究。

IF 2.6 3区医学

Global Public Health Pub Date : 2026-12-31 Epub Date: 2026-05-26 DOI: 10.1080/17441692.2026.2679908

Mary Mbuo, Cicely Marston, Alicia Renedo, Loveday Penn-Kekana

{"title":"The rhetoric of community participation in maternal and perinatal death surveillance and response (MPDSR) in Kenya: Qualitative study.","authors":"Mary Mbuo, Cicely Marston, Alicia Renedo, Loveday Penn-Kekana","doi":"10.1080/17441692.2026.2679908","DOIUrl":"10.1080/17441692.2026.2679908","url":null,"abstract":"Maternal and perinatal death surveillance and response (MPDSR) aims to prevent maternal and perinatal deaths by analysing clinical and social data after the death and using these insights to generate knowledge in the form of recommendations. This requires collaboration between health professionals and community members to co-produce knowledge to prevent future deaths. Our study asked: how do interactions between community members and health workers shape knowledge co-production in MPDSR processes? And what are the implications for policy and practice? This qualitative study used interviews, focus groups, and observations of MPDSR sessions in two Kenyan counties. MPDSR aims to prevent deaths by learning from past experiences, yet we found that the policies and tools used in MPDSR may prevent learning. Health workers questioned community members' competence as knowers and undervalued community knowledge. Community members worried that MPDSR sessions were intended to expose 'bad' deaths. These dynamics created contested spaces where different ways of knowing competed for legitimacy. Our findings show MPDSR processes must examine how and why certain forms of knowledge are deemed to be credible and others are excluded. Without recognising diverse perspectives, MPDSR risks producing fragmented understanding, limiting its potential as a participatory and transformative tool for preventing deaths.","PeriodicalId":12735,"journal":{"name":"Global Public Health","volume":"21 1","pages":"2679908"},"PeriodicalIF":2.6,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148029509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restoring dendritic cell migration: a gut reaction to boost vaccine efficacy in aging. 恢复树突状细胞迁移：肠道反应提高疫苗在衰老中的效力。

IF 6.2 2区医学

Oncoimmunology Pub Date : 2026-12-31 Epub Date: 2026-04-09 DOI: 10.1080/2162402X.2026.2657070

Liwei Zhao, Oliver Kepp, Guido Kroemer, Peng Liu

引用次数: 0

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