医学最新文献

{"title":"Peripheral nervous system and gut microbiota: Emerging evidence on increased mechanistic understanding to reveal innovative strategies for peripheral nerve regeneration.","authors":"Giulia Ronchi, Matilde Cescon, Giovanna Gambarotta, Kirsten Haastert-Talini","doi":"10.4103/NRR.NRR-D-24-01310","DOIUrl":"10.4103/NRR.NRR-D-24-01310","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"1560-1561"},"PeriodicalIF":5.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoproteasome as a therapeutic target in obesity-related brain inflammation and metabolic disorders.","authors":"Javiera Álvarez-Indo, Nicolás Albornoz, Andrea Soza, Patricia V Burgos","doi":"10.4103/NRR.NRR-D-24-01358","DOIUrl":"10.4103/NRR.NRR-D-24-01358","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"1554-1555"},"PeriodicalIF":5.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal ion channel modulation by Drimys winteri compounds: Opening a new chemical space to neuropharmacology.","authors":"Macarena E Meza, Oscar Ramirez-Molina, Oscar Flores, Katherine Fariña-Oliva, Pamela A Godoy, Jorge Fuentealba, Gonzalo E Yévenes","doi":"10.4103/NRR.NRR-D-24-01194","DOIUrl":"10.4103/NRR.NRR-D-24-01194","url":null,"abstract":"<p><p>Numerous pathological states of the nervous system involve alterations in neuronal excitability and synaptic dysfunction, which depend on the function of ion channels. Due to their critical involvement in health and disease, the search for new compounds that modulate these proteins is still relevant. Traditional medicine has long been a rich source of neuroactive compounds. For example, the indigenous Mapuche people have used the leaves and bark of the Drimys winteri tree for centuries to treat various diseases. Consequently, several studies have investigated the biological effects of compounds in Drimys winteri , highlighting sesquiterpenes such as α-humulene, drimenin, polygodial, and α-, β-, γ-eudesmol. However, there is currently no literature review focusing on the ability of these sesquiterpenes to modulate ion channels. This review summarizes the current knowledge about neuroactive compounds found in Drimys winteri , with special emphasis on their direct actions on neuronal ion channels. Several Drimys winteri sesquiterpenes modulate a diverse array of neuronal ion channels, including transient receptor potential channels, gamma-aminobutyric acid A receptors, nicotinic acetylcholine receptors, and voltage-dependent Ca 2+ and Na + channels. Interestingly, the modulation of these molecular targets by Drimys winteri sesquiterpenes correlates with their therapeutic actions. The promiscuous pharmacological profile of Drimys winteri sesquiterpenes suggests they modulate multiple protein targets in vivo , making them potentially useful for treating complex, multifactorial diseases. Further studies at the molecular level may aid in developing multi-targeted drugs with enhanced therapeutic effects.</p>","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"1373-1382"},"PeriodicalIF":5.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin and mitochondrial stress: New insights into age-related neurodegeneration.","authors":"Silvia Carloni, Francesca Luchetti, Maria Gemma Nasoni, Walter Balduini, Walter Manucha, Russel J Reiter","doi":"10.4103/NRR.NRR-D-24-01380","DOIUrl":"https://doi.org/10.4103/NRR.NRR-D-24-01380","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":"21 4","pages":"1564-1565"},"PeriodicalIF":5.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of circular RNAs in neurovascular remodeling after stroke.","authors":"Zhenguo Yang, Chi Kwan Tsang","doi":"10.4103/NRR.NRR-D-24-01291","DOIUrl":"10.4103/NRR.NRR-D-24-01291","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"1550-1551"},"PeriodicalIF":5.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell type-dependent role of transforming growth factor-β signaling on postnatal neural stem cell proliferation and migration.","authors":"Kierra Ware, Joshua Peter, Lucas McClain, Yu Luo","doi":"10.4103/NRR.NRR-D-24-00623","DOIUrl":"10.4103/NRR.NRR-D-24-00623","url":null,"abstract":"<p><p>JOURNAL/nrgr/04.03/01300535-202603000-00039/figure1/v/2025-06-16T082406Z/r/image-tiff Adult neurogenesis continuously produces new neurons critical for cognitive plasticity in adult rodents. While it is known transforming growth factor-β signaling is important in embryonic neurogenesis, its role in postnatal neurogenesis remains unclear. In this study, to define the precise role of transforming growth factor-β signaling in postnatal neurogenesis at distinct stages of the neurogenic cascade both in vitro and in vivo , we developed two novel inducible and cell type-specific mouse models to specifically silence transforming growth factor-β signaling in neural stem cells in ( mGFAPcre - ALK5fl/fl - Ai9 ) or immature neuroblasts in ( DCXcreERT2 - ALK5fl/fl - Ai9 ). Our data showed that exogenous transforming growth factor-β treatment led to inhibition of the proliferation of primary neural stem cells while stimulating their migration. These effects were abolished in activin-like kinase 5 (ALK5) knockout primary neural stem cells. Consistent with this, inhibition of transforming growth factor-β signaling with SB-431542 in wild-type neural stem cells stimulated proliferation while inhibited the migration of neural stem cells. Interestingly, deletion of transforming growth factor-β receptor in neural stem cells in vivo inhibited the migration of postnatal born neurons in mGFAPcre - ALK5fl/fl - Ai9 mice, while abolishment of transforming growth factor-β signaling in immature neuroblasts in DCXcreERT2 - ALK5fl/fl - Ai9 mice did not affect the migration of these cells in the hippocampus. In summary, our data supports a dual role of transforming growth factor-β signaling in the proliferation and migration of neural stem cells in vitro . Moreover, our data provides novel insights on cell type-specific-dependent requirements of transforming growth factor-β signaling on neural stem cell proliferation and migration in vivo .</p>","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"1151-1161"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin remodels the myelin landscape.","authors":"Bandy Chen","doi":"10.4103/NRR.NRR-D-24-01495","DOIUrl":"10.4103/NRR.NRR-D-24-01495","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"1120-1121"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Phf8 ['feɪt] control: Epigenetic regulation during oligodendroglial development.","authors":"Marco Kremp, Michael Wegner","doi":"10.4103/NRR.NRR-D-24-01414","DOIUrl":"10.4103/NRR.NRR-D-24-01414","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"1110-1111"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights of neuronal death and neuroprotective therapeutic approaches in stroke.","authors":"Chun Li, Yuping Luo, Siguang Li","doi":"10.4103/NRR.NRR-D-24-01324","DOIUrl":"10.4103/NRR.NRR-D-24-01324","url":null,"abstract":"<p><p>Stroke, particularly ischemic stroke, is the leading cause of long-term disability and mortality worldwide. It occurs due to the occlusion of the cerebral arteries, which significantly reduces the delivery of blood, oxygen, and essential nutrients to brain tissues. This deprivation triggers a cascade of cellular events that ultimately leads to neuronal death. Recent studies have clarified the multifactorial pathogenesis of ischemic stroke, highlighting the roles of energy failure, excitotoxicity, oxidative stress, neuroinflammation, and apoptosis. This review aimed to provide a comprehensive insight into the fundamental mechanisms driving neuronal death triggered by ischemia and to examine the progress of neuroprotective therapeutic approaches designed to mitigate neuronal loss and promote neurological recovery after a stroke. Additionally, we explored widely accepted findings regarding the potential pathways implicated in neuronal death during ischemic stroke, including the interplay of apoptosis, autophagy, pyroptosis, ferroptosis, and necrosis, which collectively influence neuronal fate. We also discussed advancements in neuroprotective therapeutics, encompassing a range of interventions from pharmacological modulation to stem cell-based therapies, aimed at reducing neuronal injury and enhancing functional recovery following ischemic stroke. Despite these advancements, challenges remain in translating mechanistic insights into effective clinical therapies. Although neuroprotective strategies have shown promise in preclinical models, their efficacy in human trials has been inconsistent, often due to the complex pathology of ischemic stroke and the timing of interventions. In conclusion, this review synthesizes mechanistic insights into the intricate interplay of molecular and cellular pathways driving neuronal death post-ischemia. It sheds light on cutting-edge advancements in potential neuroprotective therapeutics, underscores the promise of regenerative medicine, and offers a forward-looking perspective on potential clinical breakthroughs. The ongoing evolution of precision-targeted interventions is expected to significantly enhance preventative strategies and improve clinical outcomes.</p>","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"869-886"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of astrocyte on gamma-aminobutyric acid tone regulation during developmental period.","authors":"Erva Ozkan, Wuhyun Koh","doi":"10.4103/NRR.NRR-D-24-01484","DOIUrl":"https://doi.org/10.4103/NRR.NRR-D-24-01484","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":"21 3","pages":"1118-1119"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}