IF 6.9 2区生物学

Redox Report Pub Date : 2026-12-31 Epub Date: 2026-10-09 DOI: 10.1080/13510002.2026.2698189

Domenico Aprile, Sura Hilal Ahmed Al-Sammarraie, Alessia Ambrosino, Mohd Shahzaib, Yesuf Siraj, Afshin Samiminemati, Nicola Alessio, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi

{"title":"Coordinated mitochondrial quality control underlies oxidative stress resilience in MUSE stem cells.","authors":"Domenico Aprile, Sura Hilal Ahmed Al-Sammarraie, Alessia Ambrosino, Mohd Shahzaib, Yesuf Siraj, Afshin Samiminemati, Nicola Alessio, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi","doi":"10.1080/13510002.2026.2698189","DOIUrl":"10.1080/13510002.2026.2698189","url":null,"abstract":"Background: Reactive oxygen species (ROS) regulate stem-cell function, but sustained exposure causes oxidative damage, mitochondrial dysfunction and exhaustion. Multilineage-differentiating Stress-Enduring (MUSE) cells, a rare SSEA-3⁺ MSC subset, tolerate ROS-rich environments, although the mechanisms remain unclear.Methods: We compared MUSE, Non-MUSE (SSEA-3⁻) and MSCs after H₂O₂ exposure, assessing ROS clearance, mtDNA integrity, 8-oxo-dG, antioxidant and BER responses, mitochondrial morphology/function, mitophagy and biogenesis, with focus on the PGC-1α/NRF2 axis. Three independent biological replicates were analyzed by imaging, qPCR, flow cytometry and biochemical assays.Results: MUSE cells showed greater resistance to oxidative stress than MSCs and Non-MUSE cells. After H₂O₂, they displayed lower ROS accumulation (~15-25%), preserved mtDNA integrity, reduced 8-oxo-dG, rapid induction of antioxidant and BER-related genes, and maintenance of mitochondrial morphology, membrane potential and respiratory activity. MUSE cells also showed enhanced mitophagy, with >2-fold increased LAMP1-MitoTracker colocalization and induction of PINK1/phospho-Ub-S65, together with increased biogenesis, including ~45% higher COX-I/SDHA ratio, TFAM induction and PGC-1α activation at 48 h.Conclusion: MUSE cells coordinate antioxidant defense, DNA repair, mitophagy and biogenesis through a remove-and-replace program that preserves mitochondrial function during oxidative stress.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"31 1","pages":"2698189"},"PeriodicalIF":6.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of Angelica dahurica polysaccharide on oxidative stress and liver injury induced by ovariectomized/D-galactose in rats. 白芷多糖对去卵巢/ d -半乳糖所致大鼠氧化应激及肝损伤的保护作用。

IF 6.9 2区生物学

Redox Report Pub Date : 2026-12-31 Epub Date: 2026-05-20 DOI: 10.1080/13510002.2026.2674473

Xue-Qin He, Yi-Zhang Li, Li-Ba Xu, Chun-Feng Wu, Du-Dong Wei, Hao-Yu Liu, Fen Qiu

{"title":"Protective effects of Angelica dahurica polysaccharide on oxidative stress and liver injury induced by ovariectomized/D-galactose in rats.","authors":"Xue-Qin He, Yi-Zhang Li, Li-Ba Xu, Chun-Feng Wu, Du-Dong Wei, Hao-Yu Liu, Fen Qiu","doi":"10.1080/13510002.2026.2674473","DOIUrl":"10.1080/13510002.2026.2674473","url":null,"abstract":"Background: Oxidative stress-induced liver injury can progress to severe hepatic conditions. Polysaccharides are promising therapeutic agents, but the protective effects of Angelica dahurica polysaccharide (ADP) against this injury remain unclear.Purpose: This study was conducted to elucidate ADP's protective effects and underlying molecular mechanisms in Ovariectomize/D-galactose (OVX/D-Gal) rats.Methods: Fifty female OVX rats and ten sham-operated (SO) rats were randomly divided into six groups. Except SO group, rats were administered the corresponding doses of ADP and resveratrol respectively, and the model was established by 49-day daily subcutaneous D-Gal injection. Serum and liver samples were collected to examine the hepatic histopathological changes, oxidative stress-related biomarkers, inflammatory factors, and protein and gene expression levels.Results: ADP reduced serum ALT and AST levels (P < 0.01) and improved liver histology. ADP increased SOD and GSH-Px activities , decreased MDA levels (P < 0.05). ADP also lowered pro-inflammatory cytokines levels, upregulated Nrf2, HO-1, and NQO-1 expression, promoted Bcl-2 and suppressed Bax and cleaved caspase-3 (P < 0.05).Conclusions: ADP alleviated OVX/D-Gal-induced oxidative stress and liver injury by increasing antioxidant capacity, inhibiting apoptosis, attenuating inflammation, and activating Nrf2/HO-1/NQO-1 signaling pathway.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"31 1","pages":"2674473"},"PeriodicalIF":6.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13192090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning prediction of functional cure to pegylated interferon-alpha therapy in two HBV populations: Advantaged populations and HBeAg-negative patients. 机器学习预测两种HBV人群聚乙二醇化干扰素- α治疗的功能治愈：优势人群和hbeag阴性患者。

IF 6.8 1区农林科学

Virulence Pub Date : 2026-12-31 Epub Date: 2026-02-16 DOI: 10.1080/21505594.2026.2629088

Jiajie Li, Huilin Li, Caorui Lin, Renquan Jiang, Longfei Wang, Yujue He, Xin Yang, Kaitao Gong, Zhen Xun, Qi Zheng

{"title":"Machine learning prediction of functional cure to pegylated interferon-alpha therapy in two HBV populations: Advantaged populations and HBeAg-negative patients.","authors":"Jiajie Li, Huilin Li, Caorui Lin, Renquan Jiang, Longfei Wang, Yujue He, Xin Yang, Kaitao Gong, Zhen Xun, Qi Zheng","doi":"10.1080/21505594.2026.2629088","DOIUrl":"10.1080/21505594.2026.2629088","url":null,"abstract":"Despite advances in antiviral therapy, the rate of functional cure for chronic hepatitis B (CHB) remains unsatisfactory, and developing an applicable prediction model is pivotal to improving it. Thus, we aimed to identify key predictive factors and develop prognostic models for functional cure in HBeAg-negative patients and the advantaged populations. This retrospective study included 202 HBeAg-negative CHB patients (114 classified as advantaged populations) receiving pegylated interferon-alpha (PEG-IFNα) therapy for model derivation and internal validation, and 183 HBeAg-negative CHB patients (117 classified as advantaged populations) for model external validation. Using 48 routinely collected clinical indicators, we constructed prediction models through LASSO regression followed by multivariable logistic regression. Two nomogram-based models were developed: the SHAN model, based on four independent predictors - ln (HBsAg +1), age, neutrophil percentage (NE%), and sex - was tailored for HBeAg-negative patients. For the advantaged populations, two additional variables - alpha-fetoprotein (AFP) and lactate dehydrogenase (LDH) - were incorporated into the FLASH-N model. Both models demonstrated strong discrimination, with AUCs of 0.908 in the training set and 0.949 in the test set for the SHAN model and an AUC of 0.920 (bootstrap-corrected to 0.889) for the FLASH-N model in the advantaged populations. In external validation, SHAN model achieved an AUC of 0.861, and FLASH-N achieved an AUC of 0.800. Calibration plots and decision curve analysis further confirmed the robustness, accuracy, and clinical utility of both nomograms. By leveraging routinely available baseline variables, these models offer powerful tools for predicting functional cure in CHB, enabling refined risk stratification and more personalized clinical decision-making.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":" ","pages":"2629088"},"PeriodicalIF":6.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematodinium sp. infection alters hemolymph bacteriome composition and function in shore crabs, Carcinus maenas. 血液病感染可改变滨蟹血淋巴菌群组成及功能。

IF 6.8 1区农林科学

Virulence Pub Date : 2026-12-31 Epub Date: 2026-08-19 DOI: 10.1080/21505594.2026.2709259

Jessica E Thomas, Miguel Lurgi, Charlotte E Davies, Andrew F Rowley, Christopher J Coates

{"title":"Hematodinium sp. infection alters hemolymph bacteriome composition and function in shore crabs, Carcinus maenas.","authors":"Jessica E Thomas, Miguel Lurgi, Charlotte E Davies, Andrew F Rowley, Christopher J Coates","doi":"10.1080/21505594.2026.2709259","DOIUrl":"10.1080/21505594.2026.2709259","url":null,"abstract":"Hematodinium sp. is a parasitic dinoflagellate that infects and causes disease in a large fraction of decapod crustaceans in the Northern Hemisphere. The shore crab Carcinus maenas is susceptible to this parasite in its native range of European coastlines and along its invasive fronts. The parasite enters the host from the surrounding water, and fueled by the hemolymph (blood) resources, proliferates until host tissues are overrun. To improve our knowledge of the shore crab-Hematodinium pathosystem, we profiled the hemolymph microbiome of control and Hematodinium-positive crabs with low (early clinical) and high (late clinical) parasite levels through bacterial 16S rRNA V3-V4 meta-barcoding (n = 64). Concurrently, we assessed hemolymph condition through quantification of circulating hemocytes (immune cells) and bacterial colony forming units. Progression of Hematodinium sp. infection coincided with gradual changes in bacterial community composition. These changes were driven by shifts in relative abundances of specific taxa, e.g. Corynebacterium, Flavobacterium. Furthermore, alterations in bacterial communities were accompanied by marked shifts in metabolic signatures from stress and virulence dominated (including biofilm formation) to catabolism, peptide transport, and tissue putrefaction at the terminal stage of parasitemia. We present the first account of microbiome dynamics in healthy shore crabs and those overcome by Hematodinium sp. Our experiments reveal a clear link between bacterial community structure-function and the advancing disease state.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":" ","pages":"2709259"},"PeriodicalIF":6.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of oxidative stress and the Neuropilin-2-induced neuroinflammatory pathway by EMO ameliorates epileptic seizures in the preclinical model of epilepsy. EMO抑制氧化应激和neuropilin -2诱导的神经炎症通路改善癫痫临床前模型的癫痫发作。

IF 7.4 2区生物学

Redox Report Pub Date : 2026-12-31 Epub Date: 2026-03-18 DOI: 10.1080/13510002.2026.2647496

引用次数: 0

Global analyses of a state-dependent impulsive system for an SIRS model with a nonlinear incidence rate. 具有非线性发生率的SIRS模型状态相关脉冲系统的全局分析。

IF 2.7 4区数学

Journal of Biological Dynamics Pub Date : 2026-12-31 Epub Date: 2026-09-18 DOI: 10.1080/17513758.2026.2732280

Chenxi Huang, Sanyi Tang, Qianqian Zhang

{"title":"Global analyses of a state-dependent impulsive system for an SIRS model with a nonlinear incidence rate.","authors":"Chenxi Huang, Sanyi Tang, Qianqian Zhang","doi":"10.1080/17513758.2026.2732280","DOIUrl":"https://doi.org/10.1080/17513758.2026.2732280","url":null,"abstract":"This paper establishes a state-feedback control system based on a nonlinear incidence SIRS model to explore the regulatory mechanism of infectious disease control. We develop a state-dependent impulsive model with threshold-triggered vaccination and isolation interventions once the susceptible population exceeds a predefined level. After investigating the basic properties of the ODE subsystem, we define and classify the Poincaré map and analyze its domain, range and monotonicity, which provides a theoretical basis for studying positive periodic solutions of the impulsive system under different ODE dynamics. The results show that the disease-free periodic solution is globally asymptotically stable for <math><mrow><mi>p</mi><mo>></mo><mn>1</mn></mrow></math>, where <math><mi>p</mi></math> is a parameter directly related to the force of the infection. When <math><mrow><mn>0</mn><mo><</mo><mi>p</mi><mo><</mo><mn>1</mn></mrow></math>, however, the model may exhibit bistability between the disease-free periodic solution and an endemic periodic solution, where the final outcome depends sensitively on the initial infection size, which is consistent with the weak transmissibility and controllable low-level prevalence.","PeriodicalId":48809,"journal":{"name":"Journal of Biological Dynamics","volume":"20 1","pages":"2732280"},"PeriodicalIF":2.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A transformer-based method for the cap analysis of gene expression and gene expression tag associated capping region prediction in RNA. 基于变压器的RNA基因表达Cap分析及基因表达标签相关capping区域预测方法。

IF 4.1 3区生物学

RNA Biology Pub Date : 2026-12-31 Epub Date: 2026-02-16 DOI: 10.1080/15476286.2026.2629530

Dibya Kanti Haldar, Avik Pramanick, Chandrama Mukherjee, Pralay Mitra

{"title":"A transformer-based method for the cap analysis of gene expression and gene expression tag associated capping region prediction in RNA.","authors":"Dibya Kanti Haldar, Avik Pramanick, Chandrama Mukherjee, Pralay Mitra","doi":"10.1080/15476286.2026.2629530","DOIUrl":"10.1080/15476286.2026.2629530","url":null,"abstract":"5' RNA capping is one of the major post-transcriptional modifications for the mobility and stability of RNA molecules. Measuring 5' caps of RNAs can help quantify expression levels of mRNAs and lncRNAs. One of the most successful RNAseq methods that has used capping as a tool to quantify expression of transcription is Cap Analysis of Gene Expression (CAGE). Computational prediction of capping can therefore be used as a precursor to the prediction of transcriptional expression. Unfortunately, there is hardly any computational technique that has focused purely on predicting 5' capping. We have developed a transformer-based method for computational prediction of capping from DNA sequences. Our Llama and ReLoRA-based pre-training model, and Llama and LoRA-based fine-tuning model predict capping associated regions. We have used Leave-one-chromosome-out-cross-validation for our model. The average accuracy, and F1-score after fine-tuning the human genome hg19 (mouse genome mm9) for sequence classification is 79.12% (78.09%) and 78.11% (76.17%), respectively. We noted attention peak-based motifs having an aggregate Wilcoxon rank-sum p-value of 1.075e-10 between the attention peak region and the entire context window for the predicted positive motifs; an aggregate p-value of 7.17e-18 for the predicted negative motifs; and an aggregate p-value of 6.70e-08 between the attention peaks of the predicted positive and the predicted negative motifs. Our Llama-based approach aims to create a sequence-based framework to identify capping associated regions corresponding to CAGE peaks. Our analysis reveals statistically significant motifs from the regions of peak attention scores, which demonstrates biological relevance for some through their resident sites matching with known TF motifs.","PeriodicalId":21351,"journal":{"name":"RNA Biology","volume":" ","pages":"1-15"},"PeriodicalIF":4.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics of virus infection under the influence of antibody and cytokine. 抗体和细胞因子影响下的病毒感染动态。

IF 2.7 4区数学

Journal of Biological Dynamics Pub Date : 2026-12-31 Epub Date: 2026-03-20 DOI: 10.1080/17513758.2026.2645304

Cuicui Jiang, Yanni Tian, Miaoran Yao, Kaifa Wang

引用次数: 0

Oxidative eustress is associated with AMPK and AKT activation, GLUT4 translocation and glucose uptake in skeletal muscle cells and fibres. 氧化应激与骨骼肌细胞和纤维中的AMPK和AKT激活、GLUT4易位和葡萄糖摄取有关。

IF 6.9 2区生物学

Redox Report Pub Date : 2026-12-31 Epub Date: 2026-09-03 DOI: 10.1080/13510002.2026.2721882

Eva Martín-Prieto, Leonardo A Catalano-Iniesta, Escarlata Fernández-Puente, Jesús Palomero

{"title":"Oxidative eustress is associated with AMPK and AKT activation, GLUT4 translocation and glucose uptake in skeletal muscle cells and fibres.","authors":"Eva Martín-Prieto, Leonardo A Catalano-Iniesta, Escarlata Fernández-Puente, Jesús Palomero","doi":"10.1080/13510002.2026.2721882","DOIUrl":"10.1080/13510002.2026.2721882","url":null,"abstract":"Objectives: Reactive oxygen and nitrogen species (RONS) act as signalling molecules under physiological conditions; however, how oxidative eustress regulates glucose uptake in skeletal muscle remains poorly defined. We investigated the role of moderate oxidation in skeletal muscle glucose uptake, focusing on AKT/AMPK phosphorylation, GLUT4 translocation and functional glucose uptake. Methods: AKT and AMPK phosphorylation were analysed in C2C12 myoblasts/myotubes exposed to insulin and redox-modulating stimuli associated with oxidative eustress, including hydrogen peroxide, nitric oxide donors and angiotensin II. GLUT4 translocation was assessed by quantitative immunocytochemistry and confocal fluorescence microscopy in cells expressing a GLUT4 reporter. Glucose uptake was evaluated in isolated skeletal muscle fibres using 6-NBDG. Results: Oxidative eustress was associated with increased AKT and AMPK phosphorylation and enhanced GLUT4 translocation to the plasma membrane. Hydrogen peroxide, nitric oxide donors and angiotensin II increased GLUT4 presence at the plasma membrane and enhanced glucose uptake, with hydrogen peroxide showing a dose-dependent effect. Increased glucose uptake was consistent with GLUT4 translocation. Discussion: These findings support oxidative eustress as a physiological redox mechanism linking AKT/AMPK activation, GLUT4 translocation and glucose uptake in skeletal muscle. Redox signalling may therefore contribute to skeletal muscle glucose metabolism.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"31 1","pages":"2721882"},"PeriodicalIF":6.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IGFBP7 induces phenotypic shift from platelet-mediated autoagglutination to rosetting of Plasmodium knowlesi-infected erythrocytes. IGFBP7诱导诺氏疟原虫感染的红细胞从血小板介导的自身凝集到结簇的表型转变。

IF 6.8 1区农林科学

Virulence Pub Date : 2026-12-31 Epub Date: 2026-08-27 DOI: 10.1080/21505594.2026.2711530

Joo-Yie Chin, Laurent Rénia, Wenn-Chyau Lee

{"title":"IGFBP7 induces phenotypic shift from platelet-mediated autoagglutination to rosetting of Plasmodium knowlesi-infected erythrocytes.","authors":"Joo-Yie Chin, Laurent Rénia, Wenn-Chyau Lee","doi":"10.1080/21505594.2026.2711530","DOIUrl":"10.1080/21505594.2026.2711530","url":null,"abstract":"Zoonotic malaria caused by Plasmodium knowlesi is an emerging infectious disease with persistent transmission in Southeast Asia over the past two decades. This zoonosis causes potentially life-threatening hematological complications such as thrombocytopenia. While mechanisms behind the malaria-induced acute thrombocytopenia remain to be fully deciphered, it is believed to be associated with the cytoadherence of Plasmodium-infected erythrocytes (IRBC) to platelets. Of note, platelet-mediated cytoadherence of IRBC gives rise to platelet-mediated clumping of IRBC, also known as IRBC autoagglutination. Nevertheless, most of the autoagglutination studies were performed with P. falciparum. In this study, we characterized autoagglutination of P. knowlesi and P. falciparum, and investigated the relationship between IRBC autoagglutination and rosetting rates (another IRBC cytoadherence phenomenon). Autoagglutination was found to be dependent on the presence of human serum and platelets, where the presence of platelets favored IRBC autoagglutination over rosetting. The autoagglutination of P. knowlesi and P. falciparum was mediated by CD36, where antibody blockade of CD36 inhibited autoagglutination and drove the IRBC to form more rosettes with the uninfected erythrocytes (URBC). Antibody blocking of P-selectin reduced only the autoagglutination of P. falciparum with no effect on the rosetting rates. Notably, the presence of IGFBP7 (a human-derived protein that facilitates the formation of type II rosettes) suppressed autoagglutination while stimulating rosetting rates of IRBC. Given the ability of IGFBP7 to alter the Plasmodium-mediated cytoadherence dynamics between autoagglutination and rosetting, this human protein may alter the pathobiology of malaria, hence the disease outcomes of the infection.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"17 1","pages":"2711530"},"PeriodicalIF":6.8,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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