IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-04-01 Epub Date: 2024-12-17 DOI: 10.1016/j.phytochem.2024.114365

Xiaochun Zhou, Zefeng Zhang, Changxin Liu, Shungang Jiao, Fuxing Ge, Qiuyuan Ding, Yiru Shen, Qiang Guo, Xingyun Chai

引用次数: 0

Comprehensive analysis of the stress associated protein (SAP) family and the function of PagSAP9 from Populus alba × P. glandulosa in salt stress. 应激相关蛋白（SAP）家族的综合分析以及白杨×腺叶杨的 PagSAP9 在盐胁迫中的功能。

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-04-01 Epub Date: 2024-12-17 DOI: 10.1016/j.phytochem.2024.114367

Gaofeng Fan, Yingying Yu, Xiao Zhang, Jiahui Jiang, Shuang Wang, Boru Zhou, Tingbo Jiang

{"title":"Comprehensive analysis of the stress associated protein (SAP) family and the function of PagSAP9 from Populus alba × P. glandulosa in salt stress.","authors":"Gaofeng Fan, Yingying Yu, Xiao Zhang, Jiahui Jiang, Shuang Wang, Boru Zhou, Tingbo Jiang","doi":"10.1016/j.phytochem.2024.114367","DOIUrl":"10.1016/j.phytochem.2024.114367","url":null,"abstract":"Poplar tree growth is frequently hindered by environmental stressors, particularly soil salinization. Enhancing salt tolerance is essential for improving their adaptability and biomass under these conditions. The Stress-Associated Protein (SAP) family, characterized by A20/AN1 zinc finger domains, plays a crucial role in plants' tolerance to abiotic stress. However, functional investigations on SAP proteins in poplar are limited. In our study, we identified 19 SAP members in poplar, distributed unevenly across ten chromosomes and classified them into two major groups based on phylogenetic relationship and structure characteristics. Notably, only three segmental duplications were found, while no tandem duplications were detected. The PagSAP9 gene from Populus alba x P. glandulosa, featured both A20 and AN1 domains, was successfully characterized and localized to both cytoplasm and nucleus. It was predominantly expressed in roots and leaves and showed significantly upregulation under salt stress. And the overexpressing PagSAP9 transgenic poplars enhanced the activities of peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT), alongside reduced malondialdehyde (MDA) content. Additionally, DAB and NBT histological stainings further confirmed the positive effects of PagSAP9 gene. Collectively, these findings highlight the potential of the PagSAP9 gene to improve salt tolerance in poplar, emphasizing the broader applicability of SAP genes in plant stress resistance and providing valuable genetic resources for developing resilient plant varieties.","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":" ","pages":"114367"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypolipidemic sesquiterpenoids with diverse structural skeletons from the medicinal fungus Irpex lacteus. 具有不同结构骨架的降血脂倍半萜类。

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-04-01 Epub Date: 2024-12-16 DOI: 10.1016/j.phytochem.2024.114362

Hongcun Liu, Fandong Kong, Zhenxin Zhu, Yue Lu, Jie Weng, Lifang Yang, Mingguo Jiang

引用次数: 0

Advancing brain tumor therapy: unveiling the potential of PROTACs for targeted protein degradation.

IF 2 4区生物学

Cytotechnology Pub Date : 2025-04-01 Epub Date: 2025-01-31 DOI: 10.1007/s10616-025-00716-8

Saooda Ibrahim, Muhammad Umer Khan, Saadia Noreen, Safia Firdous, Iqra Khurram, Raima Rehman, Muhammad Arshad Javed, Qurban Ali

{"title":"Advancing brain tumor therapy: unveiling the potential of PROTACs for targeted protein degradation.","authors":"Saooda Ibrahim, Muhammad Umer Khan, Saadia Noreen, Safia Firdous, Iqra Khurram, Raima Rehman, Muhammad Arshad Javed, Qurban Ali","doi":"10.1007/s10616-025-00716-8","DOIUrl":"https://doi.org/10.1007/s10616-025-00716-8","url":null,"abstract":"The long-term treatment of malignancies, particularly brain tumors, is challenged by abnormal protein expression and drug resistance. In terms of potency, selectivity, and overcoming drug resistance, Proteolysis Targeting Chimeras (PROTACs), a cutting-edge method used to selectively degrade target proteins, beats traditional inhibitors. This review summarizes recent research on using PROTACs as a therapeutic strategy for brain tumors, focusing on their mechanism, benefits, limitations, and the need for optimization. The review draws from a comprehensive search of peer-reviewed literature, scientific databases, and clinical trial databases. Articles published up to the knowledge cutoff date up to 14 April 2023 were included. Inclusion criteria covered PROTAC-based brain tumor therapies, including preclinical and early clinical studies, with no restrictions on design or publication type. We included studies using in vitro, in vivo brain tumor models, and human subjects. Eligible treatments involved PROTACs targeting proteins linked to brain tumor progression. We evaluated the selected studies for methodology, including design, sample size, and data analysis techniques. A narrative synthesis summarized key outcomes and trends in PROTAC-based brain tumor therapy. Recent research shows PROTACs selectively degrade brain tumor-related proteins with minimal off-target effects. They offer enhanced potency, selectivity, and the ability to combat resistance compared to traditional inhibitors. PROTACs hold promise for brain tumor treatment offering advantages over traditional inhibitors, but more research is needed to refine their mechanisms, efficacy, and safety. Larger-scale trials and translational studies are essential for assessing their clinical utility.","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 2","pages":"54"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of microRNA-124-3p targeting calpain-1 to affect the function of intervertebral disc nucleus pulposus cells.

IF 2 4区生物学

Cytotechnology Pub Date : 2025-04-01 Epub Date: 2025-01-31 DOI: 10.1007/s10616-024-00693-4

Xunan Xu, Yong Liu, Chun Jiang, Peng Jia, Pengfei Cao, Yi He, Yin Zhang

{"title":"Mechanism of microRNA-124-3p targeting calpain-1 to affect the function of intervertebral disc nucleus pulposus cells.","authors":"Xunan Xu, Yong Liu, Chun Jiang, Peng Jia, Pengfei Cao, Yi He, Yin Zhang","doi":"10.1007/s10616-024-00693-4","DOIUrl":"https://doi.org/10.1007/s10616-024-00693-4","url":null,"abstract":"Intervertebral disc degeneration (IVDD) represents a major cause of lower back pain, whose prevalence rises with age. This study probed into the mechanism of microRNA (miR)-124-3p regulating function of nucleus pulposus cells (NPCs) by targeting calpain-1 (CAPN1). Rat IVD NPCs were cultured in vitro and transfected with miR-124-3p mimics, miR-124-3p inhibitor, oe-CAPN1 and their negative controls. The mRNA levels of miR-124-3p and CAPN1 were assessed by RT-qPCR. Cell proliferation, apoptosis and migration were evaluated by CCK-8, flow cytometry and Transwell assays. Levels of CAPN1 protein, apoptosis-related proteins (BAX, Cleaved-Caspase3, BCL-2) and extracellular matrix (ECM) proteins (Collagen II, Aggrecan, Fibronectin, Collagen I, matrix metalloproteinase [MMP]-13) were determined by Western blot. The target binding relationship between miR-124-3p and CAPN1 was verified by dual-luciferase assay. miR-124-3p overexpression facilitated NPC function and the maintenance of ECM homeostasis, as evidenced by increased NPC proliferation and migration, decreased apoptosis, elevated apoptosis-related protein BCL-2 level, diminished BAX and Cleaved-Caspase3 levels, reduced levels of ECM homeostasis-associated factors Collagen I and MMP-13 proteins, as well as raised levels of Collagen II, Aggrecan and Fibronectin proteins. Conversely, miR-124-3p knockdown brought about the opposite results. miR-124-3p targeted CAPN1. Furthermore, overexpression of CAPN1 partially reversed the regulatory effects of miR-124-3p on the ECM homeostasis, proliferation and migration in NPCs, and promoted apoptosis. miR-124-3p contributed to proliferation and migration of IVD NPCs, and reduced their apoptosis by inhibiting CAPN1 expression, thereby modulating ECM homeostasis and maintaining the function of IVD NPCs.","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 2","pages":"53"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenylpropanoid dimers from Chrysanthemum indicum with antioxidant effects via activating the Nrf2 signaling pathway. 菊花苯丙二聚体通过激活Nrf2信号通路具有抗氧化作用。

IF 3.2 2区生物学

Phytochemistry Pub Date : 2025-04-01 Epub Date: 2024-12-24 DOI: 10.1016/j.phytochem.2024.114372

Gui-Min Xue, Jin-Feng Xue, Hao Pan, Hao Feng, Jing-Wei Lei, Hui Chen, Wei-Sheng Feng, Guo-Sheng Li, Yan Wang

{"title":"Phenylpropanoid dimers from Chrysanthemum indicum with antioxidant effects via activating the Nrf2 signaling pathway.","authors":"Gui-Min Xue, Jin-Feng Xue, Hao Pan, Hao Feng, Jing-Wei Lei, Hui Chen, Wei-Sheng Feng, Guo-Sheng Li, Yan Wang","doi":"10.1016/j.phytochem.2024.114372","DOIUrl":"10.1016/j.phytochem.2024.114372","url":null,"abstract":"Five phenylpropanoid dimers chrysanthephenyls A-E, with the 1-O-1'-type (1) and 1-O-2'-type (2-5) ether bond linking modes, were isolated from the aerial parts of Chrysanthemum indicum. Among them, chrysanthephenyls D and E were two pairs of enantiomers, and chrysanthephenyl E was further resolved into its enantiomers (+)-chrysanthephenyl E and (-)-chrysanthephenyl E via chiral-phase HPLC. Their structures were characterized on the basic analysis of the spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR), and their absolute configurations were determined by DP4+ NMR analysis and ECD calculation method. The antioxidant activity of chrysanthephenyls A-E was determined by measuring their free radical scavenging effects using the trolox equivalent antioxidant activity (TEAC) assay, and chrysanthephenyls D and E showed 17 and 15 times better activity respectively than that of the positive control trolox. Moreover, a mechanistic study revealed that the potential antioxidant activity of chrysanthephenyl D decreased the level of reactive oxygen species (ROS) mediated via activating nuclear factor E2-related factor 2 (Nrf2) and its downstream oxidases.","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"232 ","pages":"114372"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico selection against progesterone receptor DNA-binding domain. 黄体酮受体dna结合域和其他类固醇激素受体成员的硅筛选。

IF 2.6 4区生物学

Analytical biochemistry Pub Date : 2025-04-01 Epub Date: 2024-12-22 DOI: 10.1016/j.ab.2024.115752

Tholasi Nadhan Navien, Ramesh Thevendran, Marimuthu Citartan

{"title":"In silico selection against progesterone receptor DNA-binding domain.","authors":"Tholasi Nadhan Navien, Ramesh Thevendran, Marimuthu Citartan","doi":"10.1016/j.ab.2024.115752","DOIUrl":"10.1016/j.ab.2024.115752","url":null,"abstract":"Progesterone receptor is one of the markers used in antibody-based immunohistochemistry for the diagnostics of breast cancer. The shortcomings of antibodies raise the need to focus on alternative molecular recognition. Aptamers are chosen due to their many advantages as compared to antibodies. However, the rigor of conventional SELEX intensifies the efforts to select DNA aptamers using in silico-docking approach. In this study, we performed in silico selection and experimental validation of DNA aptamers against the progesterone receptor DNA binding domain (PR DBD) using the ssDNA sequences derived from human progesterone response elements (PREs). Firstly, a library of sixty-four different ssDNA was subjected to secondary and tertiary structural determination prior to docking using PatchDock. PRDBDapt17 appeared to be the best candidate, with the highest docking scores of 11334. Molecular dynamic simulation also substantiates PRDBDapt17 as the most potent aptamer. This aptamer, PRDBDapt17 was validated by using direct ELASA. Direct ELASA demonstrated a limit of detection of 3.91 nM while the equilibrium dissociation constant was estimated at 366.6 nM. As PRDBDapt17 also interacts with estrogen receptor and androgen receptor, it can also be a potential universal binder of steroid hormone receptors. PRDBDapt17 can be used in the diagnostics of breast cancer.","PeriodicalId":7830,"journal":{"name":"Analytical biochemistry","volume":" ","pages":"115752"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent focus in non-SELEX-computational approach for de novo aptamer design: A mini review. 最近的焦点在非选择性计算方法的从头适体设计：一个小回顾。

IF 2.6 4区生物学

Analytical biochemistry Pub Date : 2025-04-01 Epub Date: 2024-12-26 DOI: 10.1016/j.ab.2024.115756

Ilemobayo Victor Fasogbon, Erick Nyakundi Ondari, Deusdedit Tusubira, Loganathan Rangasamy, Janarthanan Venkatesan, Angela Mumbua Musyoka, Patrick Maduabuchi Aja

{"title":"Recent focus in non-SELEX-computational approach for de novo aptamer design: A mini review.","authors":"Ilemobayo Victor Fasogbon, Erick Nyakundi Ondari, Deusdedit Tusubira, Loganathan Rangasamy, Janarthanan Venkatesan, Angela Mumbua Musyoka, Patrick Maduabuchi Aja","doi":"10.1016/j.ab.2024.115756","DOIUrl":"10.1016/j.ab.2024.115756","url":null,"abstract":"Aptamers, single-stranded nucleic acids that bind to specific targets with high affinity and specificity, hold significant promise in various biomedical and biotechnological applications. The traditional method of aptamer selection, SELEX (Systematic Evolution of Ligands by EXponential Enrichment) takes a lot of work and time. Recent advancements in computational methods have revolutionized aptamer design, offering efficient and effective alternatives. This review examines recent advances in non-SELEX and de novo aptamer design methods, such as Making Aptamers without SELEX (MAWS), AptaLoop, AptaDiff, RNAGEN, RaptGen, Apta-MCTS, UltraSelex, and Torkamanian-Afshar model. These computer methods utilize bioinformatics, machine learning, and molecular modeling to generate high-affinity aptamers, eliminating the need for multiple selection steps in vitro or in vivo. We provide a comprehensive analysis of each method's performance, including binding affinity, specificity, and stability, and discuss their practical applications in diagnostics, therapeutics, and environmental monitoring. Furthermore, we highlight the strengths and limitations of computational methods against the traditional one. The potential challenges, future directions, and emerging.technologies were also presented. This review underscores the transformative impact of computational aptamer design on research and industry, paving the way for rapid and cost-effective development of aptamer-based technologies.","PeriodicalId":7830,"journal":{"name":"Analytical biochemistry","volume":" ","pages":"115756"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer-associated fibroblast-derived exosomal FAM83F regulates KIF23 expression to promote the malignant progression and reduce radiosensitivity in non-small cell lung cancer.

IF 2 4区生物学

Cytotechnology Pub Date : 2025-04-01 Epub Date: 2025-01-25 DOI: 10.1007/s10616-025-00713-x

Yi Li, Mingming Zhou, Xiaogang Hu, Tingting Xie, Wenli Peng, Lina Zhang, Minxin Tang, Rui Hu, Yongpeng He

{"title":"Cancer-associated fibroblast-derived exosomal FAM83F regulates KIF23 expression to promote the malignant progression and reduce radiosensitivity in non-small cell lung cancer.","authors":"Yi Li, Mingming Zhou, Xiaogang Hu, Tingting Xie, Wenli Peng, Lina Zhang, Minxin Tang, Rui Hu, Yongpeng He","doi":"10.1007/s10616-025-00713-x","DOIUrl":"10.1007/s10616-025-00713-x","url":null,"abstract":"Cancer-associated fibroblasts (CAFs) have been shown to play a crucial role in the progression of non-small cell lung cancer (NSCLC). Exosomes derived from CAFs have emerged as important mediators of intercellular communication in the tumor microenvironment, contributing to cancer progression. Therefore, it is essential to further investigate the mechanisms by which CAF-derived exosomes regulate NSCLC. CAFs promoted NSCLC cell proliferation, invasion, and migration, while also suppressing radiosensitivity. We observed an upregulation of FAM83F expression in both NSCLC cells and NSCLC cells treated with conditioned medium from CAFs. Notably, CAF-derived exosomes were found to transfer FAM83F to NSCLC cells, thereby enhancing the malignant properties of the cancer cells. In contrast, FAM83F-deficient CAF-derived exosomes exerted inhibitory effects on NSCLC cell proliferation, invasion, and migration, while also sensitizing the cells to radiotherapy. FAM83F was found to interact with KIF23 in NSCLC cells, and the overexpression of KIF23 attenuated the effects induced by FAM83F-deficient exosomes in NSCLC cells. Moreover, FAM83F-deficient CAF-derived exosomes were effective in inhibiting tumor formation in vivo. Our findings highlight the crucial role of CAF-derived exosomal FAM83F in promoting NSCLC progression and conferring resistance to radiotherapy. Targeting this signaling pathway may offer promising therapeutic strategies for combating NSCLC progression and improving patient outcomes.Supplementary information: The online version contains supplementary material available at 10.1007/s10616-025-00713-x.","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 2","pages":"50"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type IV collagen derived non-collagenous domain α6 (IV) NC1 and its derivative fragments inhibit endothelial cell proliferation and attenuates in-vivo chorioallantoic membrane angiogenesis.

IF 2 4区生物学

Cytotechnology Pub Date : 2025-04-01 Epub Date: 2025-01-25 DOI: 10.1007/s10616-025-00709-7

Aravind Setti, Akbar Pasha, Venkata Krishna Kanth Makani, Manika Pal Bhadra, Smita C Pawar

{"title":"Type IV collagen derived non-collagenous domain α6 (IV) NC1 and its derivative fragments inhibit endothelial cell proliferation and attenuates in-vivo chorioallantoic membrane angiogenesis.","authors":"Aravind Setti, Akbar Pasha, Venkata Krishna Kanth Makani, Manika Pal Bhadra, Smita C Pawar","doi":"10.1007/s10616-025-00709-7","DOIUrl":"10.1007/s10616-025-00709-7","url":null,"abstract":"Targeting tumor angiogenesis with safe endogenous protein inhibitors is a promising therapeutic approach despite the plethora of the first line of emerging chemotherapeutic drugs. The extracellular matrix network in the blood vessel basement membrane and growth factors released from endothelial and tumor cells promote the neovascularization which supports the tumor growth. Contrastingly, small cleaved cryptic fragments of the C-terminal non collagenous domains of the same basement membrane display antiangiogenic effect. In the present study, full length α6(IV)NC1(Hexastatin) and its three subfragments α6S1(IV)NC1, α6S2(IV)NC1, and α6S3(IV)NC1 were validated for their pro-apoptotic and angio-inhibitory property. In order to construct the coding sequence of hexastatin and its three derivative partial peptide fragments were constructed with our proposed method, where the corresponding exons were amplified from the genomic DNA and then assembled together. Coding sequences were cloned and expressed using pLATE31 vector and recombinant proteins were purified with C-terminal His tag. The endogenous NC protein fragments of collagen IV were evaluated in vitro for their role in cytotoxicity on human umbilical vein endothelial cells (HUVECs). The results showed that the NC1 domain and its fragments inhibited the HUVECs cell proliferation, migration, invasion and induced apoptosis. The neovascularization inhibition was studied in in-vitro, via tube formation assay and in-vivo via the CAM Assay. The results showed that blood vessels and inter capillary network were inhibited in endothelial cells and also, in chick embryo treated with recombinant α6(IV)NC1 and its derivatives, except for α6S1(IV)NC1 and these endogenous protein inhibitors act as bio-therapeutics in inhibition of angiogenesis.","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 2","pages":"47"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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