IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-06-04 DOI: 10.1080/01652176.2025.2509504

Belén Agüero, Nicole D Tischler, Raúl Alegria, Simone Cárdenas-Cáceres, Felipe Berríos, Patricio Espinoza, Nicolás A Muena, Nicolás Galarce, Galia Ramírez, Patricio Retamal, Víctor Neira

{"title":"Longitudinal study on SARS-CoV-2 antibody responses in companion animals, Chile.","authors":"Belén Agüero, Nicole D Tischler, Raúl Alegria, Simone Cárdenas-Cáceres, Felipe Berríos, Patricio Espinoza, Nicolás A Muena, Nicolás Galarce, Galia Ramírez, Patricio Retamal, Víctor Neira","doi":"10.1080/01652176.2025.2509504","DOIUrl":"10.1080/01652176.2025.2509504","url":null,"abstract":"SARS-CoV-2 infection susceptibility in dogs and cats has been documented, with identified risk factors contributing to transmission dynamics. Understanding viral prevalence and the evolution of emerging variants across pandemic waves can clarify the potential role of pets as reservoirs. This study evaluated 3298 serum samples (1921 dogs, 1377 cats) collected from 2020 to 2024. Samples were analyzed using ELISA and viral neutralization assays, revealing a positivity rate of 2.7%. We assessed neutralizing antibody titers (nAbs) against the Wuhan-Hu-1 and Omicron BA.1 strains, finding higher titers in felines compared to canines. A marked reduction in samples exceeding the detection limit was observed after November 2022. Longitudinal data from up to 30 months in a dog and 15 months in two cats demonstrated sustained antibody responses, with increased nAb titers in 7 of 14 monitored animals. Multivariable logistic regression of 275 samples indicated that a pet's vaccination status was associated with an increased risk of infection, while spring season, the owner's number of COVID-19 vaccinations, and the owner's vaccination status were protective factors. These results emphasize the significance of vaccination strategies for both human and animal health, supporting the One Health approach.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"1-12"},"PeriodicalIF":7.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome-wide study of mRNAs modified by m⁶A RNA methylation in the testis development of dairy goats. m6A RNA甲基化修饰的mrna在奶山羊睾丸发育中的转录组研究。

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-04-30 DOI: 10.1080/10495398.2025.2496641

Xinyang Ren, Yingxin Qu, Akang Shari, Guang Li

{"title":"Transcriptome-wide study of mRNAs modified by m6A RNA methylation in the testis development of dairy goats.","authors":"Xinyang Ren, Yingxin Qu, Akang Shari, Guang Li","doi":"10.1080/10495398.2025.2496641","DOIUrl":"https://doi.org/10.1080/10495398.2025.2496641","url":null,"abstract":"N6-methyladenosine (m6A) is an important epigenetic modification in RNA, playing a crucial role in regulating the production and aging of animal testicular sperm. This study extracted mRNA from the testicular tissue of male goats before and after sexual maturity, generating a methylation map through preliminary experiments and methylation immunoprecipitation sequencing. The results showed that during the development of dairy goats, the expression levels of marker genes related to testicular development and methylation-related enzymes changed significantly. A total of 36,602 peaks and 11,223 genes were identified in the two groups, including 2989 differential peaks (427 upregulated and 2562 downregulated) and 1457 differentially expressed genes (833 upregulated and 624 downregulated). The abundance of m6A was positively correlated with gene expression levels. This study reports for the first time the mRNA profiles of m6A modifications across the entire transcriptome during testicular development in Guanzhong dairy goats, providing a new perspective for genetic improvement in goats.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2496641"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying sex-based disparities in porcine mitochondrial function. 确定猪线粒体功能的性别差异。

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-04-10 DOI: 10.1080/10495398.2025.2488068

Hao Liu, Wenshu Shi, Xing Zhang, Xinmiao He, Xingbo Zhao

{"title":"Identifying sex-based disparities in porcine mitochondrial function.","authors":"Hao Liu, Wenshu Shi, Xing Zhang, Xinmiao He, Xingbo Zhao","doi":"10.1080/10495398.2025.2488068","DOIUrl":"https://doi.org/10.1080/10495398.2025.2488068","url":null,"abstract":"In pigs, the effect of sex on production and reproductive traits has been largely reported, however, whether sex exerts its influence through regulating mitochondrial function is still unclear. In this study, we constructed 15 male cells and 15 female fibroblasts derived from 35-day and 50-day fetuses, newborn piglets and 1-year-old pigs to identify the sex effect on mitochondrial functions. Results indicated significant differences on cellular and molecular characteristics between male and female cells, including energy metabolic trait, mitochondrial DNA (mtDNA) replication and transcription, and mRNA expressions of mitochondrial biogenesis genes and mitoprotease genes. Referring to sex, males exhibited significantly higher oxygen consumption rate productions, levels of reactive oxygen species (ROS) and mtDNA copy numbers than those with females in muscle and ear fibroblasts. And the expressions of mtDNA, mitochondrial biogenesis genes (POLG, PPARGC1A, TFAM and TWNK) and XPNPEP3 were higher in males than females in ear fibroblasts derived from 1-year-old adult pigs (EFA cells). While, the cell proliferation and expressions of genes related to ROS metabolism were not influenced by sex. The results highlight the effect of sex on mitochondrial function and gene expression, and provide important data for a comprehensive understanding of the mechanisms underlying sex regulation of energy metabolism-related traits in pigs.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2488068"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Yin and Yang supplement on reproductive performance, antioxidant and immunity of dairy goats. 阴阳补充对奶山羊繁殖性能、抗氧化性和免疫力的影响。

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-01-19 DOI: 10.1080/10495398.2025.2450349

Kang Wang, Zhi Yang, Fumei Yang, Guanzong Li, Yulin Sun, Gang Duan, Jun He, Wang Sun, Ke Zhou, Zhihao Xiong, Feiyan Dai

{"title":"Effects of Yin and Yang supplement on reproductive performance, antioxidant and immunity of dairy goats.","authors":"Kang Wang, Zhi Yang, Fumei Yang, Guanzong Li, Yulin Sun, Gang Duan, Jun He, Wang Sun, Ke Zhou, Zhihao Xiong, Feiyan Dai","doi":"10.1080/10495398.2025.2450349","DOIUrl":"10.1080/10495398.2025.2450349","url":null,"abstract":"This study aims to explore the effects of Yin and Yang Double Supplement Compound Chinese Medicine Preparations (YYSBFF) on the reproductive performance, antioxidant levels, and immunity of dairy goats. For the experiment, 36 Alps milk goats were selected and randomly divided into an experimental group and a control group, with 18 goats in each group. The ewes in the experimental group were fed with YYSBFF for 14 d prior to breeding and farrowing. The results of the experiment showed that the estrus rate, embryo acceptance rate, and lamb birth weight in the experimental group were higher than those in the control group, and the weak lamb rate was significantly lower. Moreover, the experimental group exhibited higher levels of reproductive hormones (FSH, LH), antioxidant factors (T-SOD, GSH-Px, MDA), and immunoglobulins (IgA, IgM, IgG) compared to the control group. There were no significant differences in liver and kidney function indicators (ALT, AST, TP, ALB, CREA, UREA) between the experimental and control groups (p > .05). These findings indicate that YYSBFF can enhance the reproductive performance of dairy goats by regulating the level of sex hormones, while also improving the body's antioxidant and immune abilities.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2450349"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrigenomic evidence of phytogenic cytoprotective functions in the ovary and liver provides mechanistic support for improved laying hen performance. 卵巢和肝脏植物性细胞保护功能的营养基因组学证据为提高蛋鸡生产性能提供了机制支持。

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-02-13 DOI: 10.1080/10495398.2025.2463995

Ioannis Brouklogiannis, Konstantinos C Mountzouris

{"title":"Nutrigenomic evidence of phytogenic cytoprotective functions in the ovary and liver provides mechanistic support for improved laying hen performance.","authors":"Ioannis Brouklogiannis, Konstantinos C Mountzouris","doi":"10.1080/10495398.2025.2463995","DOIUrl":"10.1080/10495398.2025.2463995","url":null,"abstract":"The study assessed the inclusion level effects of a phytogenic blend (PB) on performance and critical molecular biomarkers related to detoxification (Aryl hydrocarbon receptor; AhR) and antioxidant (Nuclear factor-erythroid 2-related factor 2; Nrf2) responses in layers' ovary and liver. Layers (n = 385; 21-week-old; Hy-Line Brown) were allotted to 5 treatments with 7 replicates of 11 hens each, for a 12-week feeding trial. Treatments were: control (CON) without PB or supplementation with PB at 250 (PB250), 750 (PB750), 1000 (PB1000) and 1500 mg/kg diet (PB1500), respectively. Performance was determined weekly for the 12-week experimental period. At the 6th and 12th experimental week ovarian and liver samples were collected for gene expression analysis. Increasing PB inclusion level, improved linearly and quadratically overall laying rate, egg mass and FCR, with optimal (P ≤ 0.001) performance notable in the PB750 compared to CON. The nutrigenomic analysis revealed that PB inclusion resulted (P ≤ 0.05) in consistent beneficial modulation of the AhR/Nrf2 pathway-related genes assessed at the 6th and 12th experimental week, both in the ovary and the liver of laying hens. In conclusion, PB beneficially modulated the ovarian and hepatic adaptive cytoprotection and supported the laying performance improvements recorded, with PB750 displaying the optimal benefits.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2463995"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peony seed meal supplementation enhances semen quality in aged Qinchuan bulls. 添加牡丹籽粕可提高秦川老年公牛精液质量。

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-05-17 DOI: 10.1080/10495398.2025.2503752

Shaojie Cao, Shiwei Li, Kaixue Lu, Juntai Fu, Chengwei Yang, Jiahui Qu, Juanjuan Li, Xianlin Zhao

{"title":"Peony seed meal supplementation enhances semen quality in aged Qinchuan bulls.","authors":"Shaojie Cao, Shiwei Li, Kaixue Lu, Juntai Fu, Chengwei Yang, Jiahui Qu, Juanjuan Li, Xianlin Zhao","doi":"10.1080/10495398.2025.2503752","DOIUrl":"https://doi.org/10.1080/10495398.2025.2503752","url":null,"abstract":"Healthy Qinchuan bulls aged 8.5-9.5 years were selected and randomly divided into 6 groups based on 0%, 2%, 4%, 6%, 8%, and 10% dietary supplementation of peony seed meal for three months. Overall, linear motility (LM), progressive motility (PM), straight-line velocity (VSL), curvilinear velocity (VCL), and the percentage increase of all sperm grades (A to D) were affected (p<0.05) by the dietary supplementation. LM (29.5 vs. 24.1%), PM (69.4 vs. 60.0%), VLS (38.0 vs. 33.3 μm/s), and VCL (48.3 vs. 44.3 μm/s) were consistently higher in the 6% peony seed meal dietary supplementation groups than in the control group, respectively. A similar pattern was observed in the 8% group. Inversely to sperm grades C and D, grades A and B were higher in all treated groups than the control group, except for the 2% group in sperm grade A. Moreover, the levels of the enzymes Superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR; except for 2% peony seed group), and glutathione peroxidase (GSH-px) were higher than the control group. The level of malondialdehyde (MDA) was lower in all treated groups than in the control group. Dietary supplementation of 2-8% peony seed meal improves the semen quality of aged Qinchuan bulls.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2503752"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isatidis root polysaccharides ameliorates post-weaning diarrhea by promoting intestinal health and modulating the gut microbiota in piglets. 伊沙提斯根多糖通过促进仔猪肠道健康和调节肠道微生物群来改善断奶后腹泻。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-01-03 DOI: 10.1080/01652176.2024.2447600

Miao Zhou, Zenghao Yan, Deqin Wang, Chuyuan Li, Leli Wang, Rui Li, Jie Yin, Yulong Yin

{"title":"Isatidis root polysaccharides ameliorates post-weaning diarrhea by promoting intestinal health and modulating the gut microbiota in piglets.","authors":"Miao Zhou, Zenghao Yan, Deqin Wang, Chuyuan Li, Leli Wang, Rui Li, Jie Yin, Yulong Yin","doi":"10.1080/01652176.2024.2447600","DOIUrl":"https://doi.org/10.1080/01652176.2024.2447600","url":null,"abstract":"This study aimed to investigate the effects of dietary isatidis root polysaccharide (IRP) on diarrhea, immunity, and intestinal health in weanling piglets. Forty healthy piglets were randomly assigned to five groups receiving varying dosages of IRP. The findings indicated that different concentrations of IRP significantly reduced diarrhea scores (p < 0.01). Notably, the serum levels of immunoglobulin A and immunoglobulin G increased linearly and quadratically (p < 0.01), while immunoglobulin M also showed a linear increase (p < 0.05) in IRP-fed piglets. The secretory immunoglobulin A levels in ileal contents were significantly higher compared to control piglets (p < 0.01). Key intestinal health parameters, including villus height, villus height-to-crypt depth ratio, and goblet cell numbers, showed linear and quadratic increases in both the jejunum and ileum (p < 0.05), while crypt depth decreased significantly (p < 0.01). Additionally, the expression of IL-10, ZO-1, occludin, and mucin2 was upregulated linearly and quadratically in IRP-fed piglets (p < 0.05). In cultured IPEC-J2 cells, ZO-1 and occludin expression levels significantly increased upon exposure to 400 μg/mL IRP (p < 0.01). Furthermore, the relative abundances of Escherichia coli, Ralstonia pickettii, and Desulfovibrio fairfieldensis decreased linearly with increasing dietary IRP concentration. In conclusion, IRP shows promise as an effective dietary supplement for mitigating diarrhea and enhancing intestinal health in early weaned piglets.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"1-15"},"PeriodicalIF":7.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel polymorphism at ARHGAP24 gene and its association with growth traits in Hu sheep. 湖羊ARHGAP24基因新多态性及其与生长性状的关系。

IF 1.7 3区农林科学

Animal Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-06-11 DOI: 10.1080/10495398.2025.2513958

Huili Shan, Liang Yong Guo, Xin Huang, Xiaowei Zhang, Yongqing Jiang, Sangang He, Junfang Jiang

{"title":"Novel polymorphism at ARHGAP24 gene and its association with growth traits in Hu sheep.","authors":"Huili Shan, Liang Yong Guo, Xin Huang, Xiaowei Zhang, Yongqing Jiang, Sangang He, Junfang Jiang","doi":"10.1080/10495398.2025.2513958","DOIUrl":"https://doi.org/10.1080/10495398.2025.2513958","url":null,"abstract":"It is essential to identify potential genes and genetic variants associated with growth traits to enhance sheep breeding. Previous studies have suggested that the Rho GTPase-activating protein 24 (ARHGAP24) gene may influence the growth of some animals. However, no association has been established between polymorphisms in the ARHGAP24 gene and sheep growth traits. In this study, single-nucleotide polymorphisms (SNPs) in the ARHGAP24 gene of Hu sheep were detected, and functional SNPs associated with Hu sheep growth traits were identified. Twenty-six SNPs were discovered in Hu sheep. Association analysis revealed NC_056059.1:g.455981A > G was significantly associated with average daily gain from six months to one year of age, while NC_056059.1:g.456083 A > G was significantly associated with average daily gain from weaning to six months of age. The relative fluorescence activity (firefly luciferase and sea kidney luciferase) of haplotype GGGG was significantly lower than that of haplotypes GGAA, AAAA and AAGG. Furthermore, ARHGAP24 mRNA expression in the longissimus dorsi muscle of six-months-old sheep was significantly lower than birth sheep. The results showed that NC_056059.1:g.455981A > G and g NC_056059.1:g.456083A > G of ARHGAP24 gene were related to some growth traits of Hu sheep, and ARHGAP24 mRNA was differentially expressed in longissimus dorsi muscle of Hu sheep at different months of age, which could be used as a candidate gene for molecular marker-assisted selection of Hu sheep.","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"36 1","pages":"2513958"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodological rigour and reporting quality of the literature on wildlife rescue, rehabilitation, and release: a global systematic review. 野生动物救援、康复和释放文献的方法严谨性和报告质量：一项全球系统综述。

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-04-07 DOI: 10.1080/01652176.2025.2478138

Gloeta N Massie, Louis J Backstrom, Daniel P Holland, Mandy B A Paterson, Richard A Fuller

{"title":"Methodological rigour and reporting quality of the literature on wildlife rescue, rehabilitation, and release: a global systematic review.","authors":"Gloeta N Massie, Louis J Backstrom, Daniel P Holland, Mandy B A Paterson, Richard A Fuller","doi":"10.1080/01652176.2025.2478138","DOIUrl":"10.1080/01652176.2025.2478138","url":null,"abstract":"Wildlife rescue, rehabilitation, and release is a global practice with a broad body of scientific literature; nonetheless, no studies have assessed and quantified the methodological rigour and reporting quality of this literature. In this PRISMA systematic review, we assessed and quantified the reporting of controls, randomisation, blinding, experimental animal data, and housing and husbandry data in 152 primary studies on wildlife rescue, rehabilitation, and release published between 1980 and 2021. We then tested for associations between reporting and study characteristics. Of the 152 reviewed studies, one study reported a control, randomisation, and blinding; 17 studies reported species, age, sex, weight, and body condition; and 14 studies reported housing size, housing location, type of food, provision of water, and provision of enrichment. No study reported all 13 of these elements. Studies published in veterinary-focused journals reported lower methodological rigour and had lower reporting quality than studies published in other types of journals. Studies on mammals had higher reporting quality than studies on birds and on reptiles, and studies that included the word \"welfare\" had higher reporting quality than studies that did not. The overall low methodological rigour and reporting quality of the literature limits study replicability and applicability and impedes meta-analyses.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"1-12"},"PeriodicalIF":7.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutralizing antibody levels as a key factor in determining the immunogenic efficacy of the novel PEDV alpha coronavirus vaccine. 中和抗体水平是决定新型PEDV α冠状病毒疫苗免疫原性效果的关键因素

IF 7.9 2区农林科学

Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-05-28 DOI: 10.1080/01652176.2025.2509506

Guangli Hu, Xin Luo, Jiamin Liao, Chuangchao Zou, Yihui Huang, Rui Geng, Zhiqing Zhao, Hanqin Shen, Yongchang Cao, Ouyang Peng, Hao Zhang

{"title":"Neutralizing antibody levels as a key factor in determining the immunogenic efficacy of the novel PEDV alpha coronavirus vaccine.","authors":"Guangli Hu, Xin Luo, Jiamin Liao, Chuangchao Zou, Yihui Huang, Rui Geng, Zhiqing Zhao, Hanqin Shen, Yongchang Cao, Ouyang Peng, Hao Zhang","doi":"10.1080/01652176.2025.2509506","DOIUrl":"10.1080/01652176.2025.2509506","url":null,"abstract":"Porcine epidemic diarrhea virus (PEDV) causes significant global agricultural losses. Despite commercial inactivated and live attenuated vaccines, persistent outbreaks underscore the need for more effective solutions. Here, we isolated a novel Chinese PEDV variant, PEDV ShXXY2-2023, with amino acid substitutions in key neutralizing epitopes (N-terminal domain, receptor-binding domain, and CO-26K equivalent epitope) compared to vaccine strains. An inactivated ShXXY2-2023 vaccine induced higher neutralizing antibodies and superior cross-protection versus commercial vaccines. Vaccinated sows conferred enhanced protection to offspring, improving piglet survival post-challenge. Maternal serum neutralizing antibody titers correlated strongly with piglet survival; titers of 1:377-1:774 at one week prepartum yielded >80% protective efficacy. These findings emphasize neutralizing antibodies' critical role in PEDV prevention and position ShXXY2-2023 as a promising vaccine candidate, with broader implications for coronavirus vaccine development.","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"45 1","pages":"1-20"},"PeriodicalIF":7.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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