2010-2023年韩国食用动物中分离的耐环丙沙星肠炎沙门氏菌的流行和特征

IF 7.9 2区 农林科学 Q1 VETERINARY SCIENCES
Veterinary Quarterly Pub Date : 2025-12-01 Epub Date: 2025-03-17 DOI:10.1080/01652176.2025.2473733
Md Sekendar Ali, Hee-Seung Kang, Bo-Youn Moon, Ye-Eun Heo, Min Young Kim, Ji-Hyun Choi, Yu-Jeong Hwang, Ji-In Kim, Yeon-Hee Lee, Jae-Myung Kim, Suk-Kyung Lim
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引用次数: 0

摘要

从食用动物、牛(n = 217)、猪(n = 1526)、鸡(n = 3942)和鸭(n = 876)中分离出6561株沙门氏菌。对分离株进行抗生素敏感性、喹诺酮类药物耐药测定区(QRDRs)突变和质粒介导的喹诺酮类药物耐药基因(PMQR)评估。利用多位点序列分型(MLST)和脉冲场凝胶电泳(PFGE)对克隆亲缘关系和遗传多样性进行评价。总体而言,3.1%的分离株表现出对环丙沙星的耐药性。常见的qrdr突变为gyrA中的S83F、D87N和D87G;parC中的T57S和S80I;和L416F。此外,突变因血清型而异。在S. Albany地区,gyrA中S83F和parC中T57S突变较为普遍,而在S. Kentucky地区,gyrA中S83F和D87N突变较为普遍,parC中T57S和S80I突变较为普遍;在南印第安纳州,gyrA中的S83F和D87G、parC中的T57S和S80R、parE中的L416F较为常见。在PMQRs中,主要在S. Albany、S. Indiana和S. Albany分别观察到qnrS、aac(6′)-Ib-cr和qnrB1。在STs中,ST198 S. Kentucky, ST292 S. Albany和ST17 S. Indiana次之。在26个脉冲型中,KX1KA1主要在南肯塔基发现,AX1AA1主要在南奥尔巴尼发现,IX1IA1主要在南印第安纳发现。总的来说,耐环丙沙星沙门氏菌会对人类和其他动物的健康造成危害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence and characterization of ciprofloxacin-resistant Salmonella enterica spp. isolated from food animals during 2010-2023 in South Korea.

We isolated 6,561 Salmonella strains from food animals, cattle (n = 217), pigs (n = 1526), chickens (n = 3942), and ducks (n = 876). Isolates were evaluated for antimicrobial sensitivity, mutations in quinolone resistance determination regions (QRDRs), and plasmid-mediated quinolone resistance (PMQR) genes. Clonal relationship and genetic diversity were assessed by multi-locus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). Overall, 3.1% of isolates exhibited resistance to ciprofloxacin. Commonly identified mutations in QRDRs were S83F, D87N, and D87G in gyrA; T57S and S80I in parC; and L416F in parE. Furthermore, mutations differed by serotypes. In S. Albany, S83F mutation in gyrA and T57S in parC were prevalent, while in S. Kentucky, S83F and D87N in gyrA, T57S and S80I in parC; and in S. Indiana, S83F and D87G in gyrA, T57S and S80R in parC, and L416F in parE were common. Amongst PMQRs, qnrS was mainly observed in S. Albany, aac(6')-Ib-cr in S. Indiana, and qnrB1 in S. Albany. Among STs, ST198 S. Kentucky was predominant, followed by ST292 S. Albany and ST17 S. Indiana. Of 26 pulsotypes, KX1KA1 was mainly identified in S. Kentucky, AX1AA1 in S. Albany, and IX1IA1 in S. Indiana. Taken together, ciprofloxacin-resistant Salmonella can pose health hazards to humans and other animals.

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来源期刊
Veterinary Quarterly
Veterinary Quarterly VETERINARY SCIENCES-
CiteScore
13.10
自引率
1.60%
发文量
18
审稿时长
>24 weeks
期刊介绍: Veterinary Quarterly is an international open access journal which publishes high quality review articles and original research in the field of veterinary science and animal diseases. The journal publishes research on a range of different animal species and topics including: - Economically important species such as domesticated and non-domesticated farm animals, including avian and poultry diseases; - Companion animals (dogs, cats, horses, pocket pets and exotics); - Wildlife species; - Infectious diseases; - Diagnosis; - Treatment including pharmacology and vaccination
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