医学最新文献

{"title":"Antigen anisotropy: The overlooked geometric determinant of vaccine immunogenicity and fidelity.","authors":"Daniel Santiago","doi":"10.1080/21645515.2026.2638640","DOIUrl":"10.1080/21645515.2026.2638640","url":null,"abstract":"<p><p>Antigen anisotropy, the directional dependence of protein conformation, epitope exposure, and conformational dynamics, is an under-appreciated determinant of vaccine immunogenicity. Preserving this geometric fidelity may influence outcomes such as neutralization breadth, affinity maturation, and B/T-cell response quality. Native antigens engage B-cell receptors, T-cell receptors, and MHC through oriented interactions that rely on spatial and dynamic constraints for effective immune recognition. This framework is increasingly relevant amid widespread use of nucleoside-modified mRNA vaccines, as recent studies suggest platform-specific deviations in antigen geometry and processing. Platform interventions including chemical inactivation (e.g., formaldehyde and β-propiolactone), formulation and storage conditions, and mRNA design choices (e.g., N¹-methylpseudouridine incorporation, codon optimization) can introduce perturbations that influence folding, glycan shielding, epitope presentation, and hydrodynamic behavior. These effects can generate antigen ensembles that diverge from native forms, and may plausibly contribute to differences in response breadth and quality. Prioritizing anisotropy preservation offers a complementary design principle for next generation vaccines, one that seeks to more closely recapitulate the geometric and dynamic features of natural infection and may improve the predictability and durability of protective immunity.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2638640"},"PeriodicalIF":4.2,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bis-(di-4-phenyl-benzylaminethiocarbonyl)disulfide sensitizes ABCC2/ALDH3A1 overexpressing NSCLC cells to cisplatin.","authors":"Jolanta Kryczka, Jakub Mateusz Kryczka, Łukasz Janczewski, Sho Shimida, Andrzej Frączyk, Beata Kolesińska, Joanna Boncela, Ewa Brzeziańska-Lasota","doi":"10.1080/15384047.2026.2683169","DOIUrl":"10.1080/15384047.2026.2683169","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer presents complex etiopathology involving a mix of genetic predispositions and environmental factors. The best treatment modality is surgical resection. However, it becomes ineffective in the advanced metastatic stage. Thus, cisplatin-based chemotherapy, though restricted by an intrinsic and/or acquired chemo-resistant phenotype, remains the first-line therapy for advanced non-small-cell cancer (NSCLC).</p><p><strong>Methods: </strong>Various tools were used to verify the mRNA expression and protein levels of ABC and ALDH proteins in patient-derived non-small-cell lung cancer (NSCLC) samples (GSE102287, GSE43580) and cell lines A549 and NCI-H158 (including their respective cisplatin-resistant variants) to verify the cisplatin-sensitizing abilities of newly synthesized bis-(di-4-phenyl-benzylaminethiocarbonyl)disulfide-non-toxic ALDH and ABCC2 inhibitors.</p><p><strong>Results: </strong>We identified significant molecular differences in the expression levels of ABCC1, ABCC5, ABCC3, ALDH7A1, and ALDH3A1. Additionally, a fairly significant patient subgroup (Z-score > 1.5), characterized by ABCC2 and ALDH3A1 overexpression, was identified. Importantly, <i>in vitro,</i> ABCC2 and ALDH3A1 accompany the acquisition of cisplatin resistance in A549 cells. Bis-(di-4-phenyl-benzylaminethiocarbonyl)disulfide reverses cisplatin resistance in a cisplatin-resistant variant of A549 cells (via ALDH and ABCC2 inhibition) but not in NCI-H158 cells.</p><p><strong>Conclusions: </strong>Molecular categorization of NSCLC cancer is essential for predicting therapy outcomes, enabling the use of bis-(di-4-phenyl-benzylaminethiocarbonyl)disulfide as a cisplatin therapy enhancer for NSCLC patients' subpopulation with significant ABCC2 and ALDH3A1 overexpression.</p>","PeriodicalId":9536,"journal":{"name":"Cancer Biology & Therapy","volume":"27 1","pages":"2683169"},"PeriodicalIF":5.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13387110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Temporal meaning-making of women's emotional experiences during the infertility treatment process: a qualitative study\".","authors":"Nevra Karaca Biçakçi, Ayşe Çalmaz, Birsen Altay","doi":"10.1080/17482631.2026.2672214","DOIUrl":"10.1080/17482631.2026.2672214","url":null,"abstract":"<p><strong>Purpose: </strong>This study examines women's emotional experiences during infertility treatment through the perspective of temporality, focusing on pre-diagnosis meanings, treatment experiences, and future expectations.</p><p><strong>Method: </strong>Using a descriptive phenomenological approach, semi-structured in-depth interviews were conducted with 19 women undergoing infertility treatment. Data were analyzed using Giorgi's method.</p><p><strong>Results: </strong>Infertility represents a 'biographical disruption' deeply affecting self-perception and social identity. Pre-diagnosis meanings attributed to motherhood deepen the trauma at diagnosis. The treatment process is an 'extended present' oscillating between hope and uncertainty, involving bodily objectification and intense social pressure.</p><p><strong>Conclusion: </strong>Infertility is a multi-layered traumatic process. Health professionals should adopt a supportive care approach prioritizing women's temporal integrity and psychosocial well-being alongside medical outcomes.</p>","PeriodicalId":51468,"journal":{"name":"International Journal of Qualitative Studies on Health and Well-Being","volume":"21 1","pages":"2672214"},"PeriodicalIF":2.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13173580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial empowerment following orthognathic surgery for patients born with cleft lip and/or palate.","authors":"Joakim Lundberg, Mats Sjöström, Jenny Molin","doi":"10.1080/17482631.2026.2674347","DOIUrl":"10.1080/17482631.2026.2674347","url":null,"abstract":"<p><strong>Background: </strong>Individuals born with cleft lip and/or palate (CLP) may experience functional, esthetic and psychosocial challenges. While orthognathic surgery is performed to correct jaw discrepancies, knowledge about patients' experiences of this treatment remains limited, as previous research has largely relied on quantitative quality-of-life measures.</p><p><strong>Objective: </strong>This study aimed to illuminate the experiences of individuals with CLP undergoing orthognathic surgery.</p><p><strong>Methods: </strong>An inductive qualitative design was used. Individual semi-structured interviews were conducted with 16 adults treated with orthognathic surgery. Data were analyzed using qualitative content analysis.</p><p><strong>Results: </strong>One overarching theme, <i>Emerging empowered through a life-changing challenge,</i> described surgery as, for many, a transformative process extending beyond functional and esthetic correction. Three themes described participants' experiences: being highly motivated for change, overcoming tough setbacks through a stable backing system, and enhancing self-confidence. While many participants described increased confidence and social ease over time, empowerment was neither universal nor immediate, with some reported neutral or context-dependent psychosocial outcomes.</p><p><strong>Conclusions: </strong>Orthognathic surgery may be experienced as a transformative process within a lifelong CLP trajectory, with potential to foster psychosocial empowerment and renewed self-confidence. These findings highlight both the transformative possibilities and the contextual variability of surgical outcomes in person-centered cleft care.</p>","PeriodicalId":51468,"journal":{"name":"International Journal of Qualitative Studies on Health and Well-Being","volume":"21 1","pages":"2674347"},"PeriodicalIF":2.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13182144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"There's no place like home, but…\": dependent older adults' narratives on the health and well-being limits of ageing in place.","authors":"Sandra Escapa, Albert Julià, Marga Marí-Klose, Maria Cursach, Pedro Gallo","doi":"10.1080/17482631.2026.2647084","DOIUrl":"10.1080/17482631.2026.2647084","url":null,"abstract":"<p><strong>Background: </strong>In ageing societies, understanding the lived experiences of dependent older adults is essential for designing care policies that support health, dignity, and well-being. While ageing in place is widely promoted, less is known about how dependent older adults themselves define its limits.</p><p><strong>Aim: </strong>This study examines how dependent older adults describe the conditions under which ageing in place supports-or undermines- their dignity and quality of life.</p><p><strong>Methods: </strong>We conducted 30 in-depth interviews with individuals aged 65 and older in Barcelona, Spain, all officially recognized as having some degree of dependency. Interviews were analysed using a thematic approach, according to environmental gerontology and person-environment fit frameworks.</p><p><strong>Results: </strong>Ageing in place emerged not as a fixed preference but as a fragile and continuously negotiated process of the person-place relationship. Remaining at home is sustained by symbolic autonomy and attachment to familiar environments, supporting control over daily routines and a sense of dignity. At the same time, participants described a state of care liminality, continuously reassessing their ability to remain at home in light of anticipated health decline. Three interconnected boundaries emerged: deteriorating health, perceived burden on family members, and loneliness.</p><p><strong>Conclusions: </strong>Ageing in place among dependent older adults should be understood as a conditional and relational process rather than a universal ideal. Recognising older adults' own definitions of its limits is essential for designing responsive care policies.</p>","PeriodicalId":51468,"journal":{"name":"International Journal of Qualitative Studies on Health and Well-Being","volume":"21 1","pages":"2647084"},"PeriodicalIF":2.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reshaping immunotherapy sequencing strategy: equivalent survival with induction plus consolidation vs. consolidation-only strategy in unresectable stage III NSCLC.","authors":"Wenlu Chen, Anqi Zhao, Yu Liang, Xin Cao, Baixue Wu, Yuying Zhou, Wenbo Zhang, Meng Zhao, Qing Hou, Ningning Yao, Feng Li, Jianchun Duan, Shuangping Zhang, Nan Bi, Jianzhong Cao","doi":"10.1080/2162402X.2026.2670221","DOIUrl":"10.1080/2162402X.2026.2670221","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy and safety of a sequential combination of chemoradiotherapy (CRT) with immune checkpoint inhibitors (ICIs) administered as induction plus consolidation versus consolidation-only in patients with unresectable stage III non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>This retrospective study enrolled 265 patients treated at two centers between March 2019 and August 2023. Patients were categorized into a consolidation-only group (<i>n</i> = 153) and an induction plus consolidation group (<i>n</i> = 112). Propensity score matching (PSM, 1:1 ratio) was used to balance baseline characteristics. Progression-free survival (PFS) and overall survival (OS) were assessed using Kaplan-Meier analysis and log-rank tests. Adverse events (AEs) were evaluated according to CTCAE v5.0.</p><p><strong>Results: </strong>Before PSM, no significant survival differences were observed between groups (2-y PFS: 52.6% vs. 63.5%, <i>p</i> = 0.085; 2-y OS: 91.7% vs. 81.2%, <i>p</i> = 0.822). After PSM, outcomes remained comparable (2-y PFS: 56.8% vs. 62.2%, <i>p</i> = 0.179; 2-y OS: 94.9% vs. 87.9%, <i>p</i> = 0.514). Before PSM, the most common AE was pneumonitis (60.7% vs. 55.1%, <i>p</i> = 0.442). The induction plus consolidation group showed a lower incidence of anemia (<i>p</i> = 0.004) but a higher incidence of ALT/AST elevation (14.3% vs. 5.1%, <i>p</i> = 0.022). The incidence of all other AEs was comparable (<i>p</i> > 0.05). After PSM, only anemia was significantly higher in the consolidation-only group (52.8% vs. 27.8%, <i>p</i> = 0.004).</p><p><strong>Conclusion: </strong>In treatment-tolerant patients, induction plus consolidation therapy demonstrated comparable efficacy and safety to consolidation-only therapy in unresectable stage III NSCLC.</p>","PeriodicalId":48714,"journal":{"name":"Oncoimmunology","volume":"15 1","pages":"2670221"},"PeriodicalIF":6.2,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13182959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled non-steroidal anti-inflammatory drug-peptide hydrogel to effectively mitigate ocular inflammation.","authors":"Yuhan Hu, Yu Li, Yuqin Wu, Yutuo Zhu, Jinrun Chen, Yinghao Ding, Zhimou Yang, Xingyi Li","doi":"10.1080/10717544.2026.2677302","DOIUrl":"10.1080/10717544.2026.2677302","url":null,"abstract":"<p><p>Pranoprofen (Pra) eye drop has been widely used in clinical practice for the efficient mitigation of ocular inflammation, but it often suffers from poor bioavailability owing to the existence of various ocular barriers (i.e. tear barrier and corneal epithelial barrier). In this study, we rationally designed and synthesized a Pra-peptide conjugate using a D-form tripeptide (i.e. phenylalanine-phenylalanine-aspartic acid; ffd) motif, and the resulting conjugate (i.e. Pra-ffd) spontaneously self-assembled into single-component supramolecular hydrogel for efficient mitigation of ocular inflammation. The generated hydrogel was thoroughly characterized using a rheometer and transmission electron microscopy (TEM). The proposed Pra-ffd hardly caused cytotoxicity in RAW 264.7, L929, and human corneal epithelial cells (HCEC). The Pra-ffd hydrogel dose-dependently reduced the levels of proinflammatory cytokines (e.g. PGE₂, TNF-<i>α</i>, and IL-6) and intracellular reactive oxygen species (ROS) accumulation in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage. In addition, topical instillation of the Pra-ffd hydrogel exhibited good ocular tolerance and prolonged precorneal retention (>20 min), resulting in higher bioavailability compared with the Pra solution. Using an endotoxin-induced uveitis (EIU) rabbit model, we demonstrated that topical instillation of Pra-ffd hydrogel effectively mitigated the inflammatory response in the anterior chamber and significantly reduced the entry of inflammatory cells from the circulation by preserving the integrity of the blood-aqueous humor barrier. Overall, the Pra-ffd hydrogel represents a promising ocular drug delivery platform for the treatment of inflammatory ocular disorders.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2677302"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13215406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148028355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADAR1-circRAB5A-BIP axis governs radiotherapy resistance in colorectal cancer through coordinating protective autophagy and apoptosis.","authors":"Wangsheng Chen, Xu Zhang, Zhengfei Zhao, Wang Xin, Jianxin Li, Xiangming Che","doi":"10.1080/15384047.2026.2677975","DOIUrl":"10.1080/15384047.2026.2677975","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) ranks among the most prevalent malignancies globally, and radiotherapy remains a critical treatment modality. However, its efficacy is frequently compromised by acquired radioresistance. The endoplasmic reticulum chaperone protein BIP plays a pivotal role in regulating radioresistance by coordinating the balance between protective autophagy and apoptosis, though the regulatory roles of circular RNAs (circRNAs) in this process remain poorly understood.</p><p><strong>Materials: </strong>Differentially expressed circRAB5A (hsa-circ-0123297) was identified from the GSE186940 dataset. Its expression was validated in radioresistant CRC clinical samples and cell lines. Mechanistic investigations involved ADAR1 binding assays, circRAB5A gain/loss-of-function studies, autophagy-apoptosis profiling, ubiquitination analysis, TRIM21-mediated degradation assays, and <i>in vivo</i> xenograft models.</p><p><strong>Results & conclusion: </strong>CircRAB5A was significantly downregulated in radioresistant CRC clinical samples and cell lines. This downregulation was driven by ADAR1, which suppressed circRAB5A biogenesis by binding to Alu Jo/Jr elements. Functional assays showed circRAB5A depletion conferred radioresistance in CRC cells by promoting protective autophagy and inhibiting apoptosis. Mechanistically, circRAB5A destabilized BIP by enhancing TRIM21-mediated ubiquitination. The circRAB5A/BIP axis further modulates the autophagy-apoptosis balance through the p-Akt/Beclin1 signaling pathway, thereby influencing radiosensitivity. <i>In vivo</i> xenograft experiments demonstrated that stable knockdown of circRAB5A attenuated the anti-tumor effects of radiation, whereas knockdown of BIP sensitized CRC cells to radiotherapy even at low doses. Collectively, the ADAR1/circRAB5A/BIP molecular circuitry governs CRC radioresistance by regulating the autophagy-apoptosis balance. Our findings highlight that low circRAB5A expression may serve as a potential biomarker for radioresistance, and that targeting this axis, particularly BIP, represents a promising strategy for overcoming radioresistance in CRC.</p>","PeriodicalId":9536,"journal":{"name":"Cancer Biology & Therapy","volume":"27 1","pages":"2677975"},"PeriodicalIF":5.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploiting the dynamics of hyperthermia-enhanced delivery of thermosensitive liposomal doxorubicin to solid tumors.","authors":"Pouya Namakshenas, Johannes Crezee, H Petra Kok","doi":"10.1080/10717544.2026.2670077","DOIUrl":"10.1080/10717544.2026.2670077","url":null,"abstract":"<p><p>Thermosensitive liposomal (TSL) drug delivery with intravascular release under hyperthermia is a promising approach for chemotherapy of solid tumors, where the hyperthermia schedule strongly influences delivery efficacy. This study uses mathematical modeling to evaluate these effects. A compartmental modeling approach was used to simulate TSL-encapsulated doxorubicin (DOX) delivery. The model was calibrated and validated against published <i>in vivo</i> data from murine tumor models. Key variables included hyperthermia timing relative to TSL-DOX administration (0-60 min), duration (15-90 min), and heating pattern (continuous vs. fractional). Tumor cells exhibiting multidrug resistance (MDR), based on uptake characteristics of non-small cell lung cancer (NSCLC) and breast cancer cells, were modeled by varying cellular efflux rates. Initiating hyperthermia at peak plasma TSL levels increased the maximum intracellular DOX concentration by up to twofold compared with a 60-min delay. Tumor models characterized by NSCLC-like uptake were less responsive to prolonged hyperthermia than MCF-7 and MDA-468 breast cancer cells, showing minimal additional intracellular accumulation beyond 60 min. Low-MDR tumor models exhibited greater hyperthermia-enhanced uptake than high-MDR models. Prolonged hyperthermia increased systemic exposure to free DOX; however, the relative enhancement in tumor exposure exceeded that in systemic plasma. Continuous hyperthermia yielded a 20% higher intracellular DOX concentration after 60 min compared with a fractional schedule (4 × 15 min with 15-min cool-down intervals). For optimal delivery, hyperthermia in the stationary phase is most effective when synchronized with peak plasma TSL-DOX levels. Hyperthermia duration may require cancer-type-specific adjustment. These findings provide a mechanistic basis to inform hyperthermia protocol design.</p>","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2670077"},"PeriodicalIF":8.0,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13162552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147867208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The real-world economic impact of herpes zoster disease in patients with selected underlying conditions in Spain.","authors":"Helena Moza Moríñigo, Andrea García, Eleftherios Zarkadoulas, María Del Rosario Cambronero Mártinez, Javier Varas, Alba Martín, María García, Alfonsina Trento, Ignacio Hernández, Laura Amanda Vallejo-Aparicio","doi":"10.1080/21645515.2026.2620909","DOIUrl":"10.1080/21645515.2026.2620909","url":null,"abstract":"<p><p>People with underlying diseases are at-increased-risk of suffering from herpes zoster (HZ). However, the economic impact of HZ on these populations is not well described. This study aimed to quantify the clinical and economic impact of HZ in patients with comorbidities (diabetes, chronic obstructive pulmonary disease, heart disease, kidney disease, asthma) and immune disorders (inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis, COVID-19 and psoriatic arthritis) in Spain. This is an observational, retrospective case-control study using the BIG-PAC electronic records from 01 Jan 2014 to 31 Aug 2021. Healthcare resource use and costs over 12 months following HZ diagnosis were compared between patients and controls, matched by propensity scores. The total annual economic burden was estimated using HZ-related costs per patient and HZ crude incidence over the study period, together with the estimated prevalence of each comorbidity in the Spanish population aged ≥18 y. Mean incremental costs per HZ episode were €1,108 in patients with comorbidities and €1,203 in patients with immune disorders. Indirect costs accounted for 4.7% and 22.9% of incremental costs in people with comorbidities and immune disorders, respectively. Mean annual crude HZ incidence rates were 613.6 cases per 100,000 people with comorbidities and 659.0 cases per 100,000 people with autoimmune disorders. Total annual costs due to HZ in these populations were estimated at €121 million. HZ may cause a significant economic burden in Spain from a societal perspective in patients with underlying conditions, highlighting the importance of improving vaccination programs.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2620909"},"PeriodicalIF":4.2,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}