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Remaking a connection: molecular players involved in post-injury synapse formation. 重塑连接:参与损伤后突触形成的分子角色。
IF 5.9 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2025-06-01 Epub Date: 2024-06-26 DOI: 10.4103/NRR.NRR-D-24-00265
Diogo Tomé, Ramiro D Almeida
{"title":"Remaking a connection: molecular players involved in post-injury synapse formation.","authors":"Diogo Tomé, Ramiro D Almeida","doi":"10.4103/NRR.NRR-D-24-00265","DOIUrl":"10.4103/NRR.NRR-D-24-00265","url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"20 6","pages":"1719-1720"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell pan-omics, environmental neurology, and artificial intelligence: the time for holistic brain health research. 单细胞泛组学、环境神经学和人工智能:全面脑健康研究的时代。
IF 5.9 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2025-06-01 Epub Date: 2024-06-26 DOI: 10.4103/NRR.NRR-D-24-00324
Paolo Abondio, Francesco Bruno
{"title":"Single-cell pan-omics, environmental neurology, and artificial intelligence: the time for holistic brain health research.","authors":"Paolo Abondio, Francesco Bruno","doi":"10.4103/NRR.NRR-D-24-00324","DOIUrl":"10.4103/NRR.NRR-D-24-00324","url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"20 6","pages":"1703-1704"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurogenesis dynamics in the olfactory bulb: deciphering circuitry organization, function, and adaptive plasticity. 嗅球的神经发生动态:破译电路组织、功能和适应性可塑性。
IF 5.9 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2025-06-01 Epub Date: 2024-06-26 DOI: 10.4103/NRR.NRR-D-24-00312
Moawiah M Naffaa
{"title":"Neurogenesis dynamics in the olfactory bulb: deciphering circuitry organization, function, and adaptive plasticity.","authors":"Moawiah M Naffaa","doi":"10.4103/NRR.NRR-D-24-00312","DOIUrl":"10.4103/NRR.NRR-D-24-00312","url":null,"abstract":"<p><p>Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. Moreover, the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased complexity and restructuring of neural network structures, as well as the addition of new granule granule cells that aid in olfactory adaptation. Additionally, the manuscript underscores the importance of employing precise methodologies to elucidate the specific roles of adult neurogenesis amidst conflicting data and varying experimental paradigms. Understanding these processes is essential for gaining insights into the complexities of olfactory function and behavior.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":"1565-1581"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder. 外周线粒体 DNA 作为重度抑郁症的神经炎症生物标志物。
IF 5.9 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2025-06-01 Epub Date: 2024-06-26 DOI: 10.4103/NRR.NRR-D-23-01878
Jinmei Ye, Cong Duan, Jiaxin Han, Jinrong Chen, Ning Sun, Yuan Li, Tifei Yuan, Daihui Peng
{"title":"Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder.","authors":"Jinmei Ye, Cong Duan, Jiaxin Han, Jinrong Chen, Ning Sun, Yuan Li, Tifei Yuan, Daihui Peng","doi":"10.4103/NRR.NRR-D-23-01878","DOIUrl":"10.4103/NRR.NRR-D-23-01878","url":null,"abstract":"<p><p>In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":"1541-1554"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease. 苍白球在帕金森病运动和非运动症状中的作用。
IF 5.9 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2025-06-01 Epub Date: 2024-06-03 DOI: 10.4103/NRR.NRR-D-23-01660
Yimiao Jiang, Zengxin Qi, Huixian Zhu, Kangli Shen, Ruiqi Liu, Chenxin Fang, Weiwei Lou, Yifan Jiang, Wangrui Yuan, Xin Cao, Liang Chen, Qianxing Zhuang
{"title":"Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease.","authors":"Yimiao Jiang, Zengxin Qi, Huixian Zhu, Kangli Shen, Ruiqi Liu, Chenxin Fang, Weiwei Lou, Yifan Jiang, Wangrui Yuan, Xin Cao, Liang Chen, Qianxing Zhuang","doi":"10.4103/NRR.NRR-D-23-01660","DOIUrl":"10.4103/NRR.NRR-D-23-01660","url":null,"abstract":"<p><p>The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore, bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico-striato-pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease, particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremor-dominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia-thalamus network. Therefore, the composition of the globus pallidus neurons, the neurotransmitters that act on them, their electrical activity, and the neural circuits they form can guide the search for new multi-target drugs to treat Parkinson's disease in clinical practice. Examining the potential intra-nuclear and neural circuit mechanisms of deep brain stimulation associated with the globus pallidus can facilitate the management of both motor and non-motor symptoms while minimizing the side effects caused by deep brain stimulation.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":"1628-1643"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decline and fall of aging astrocytes: the human perspective. 衰老星形胶质细胞的衰退与衰亡:人类视角。
IF 5.9 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2025-06-01 Epub Date: 2024-06-26 DOI: 10.4103/NRR.NRR-D-24-00418
Alexei Verkhratsky, Alexey Semyanov
{"title":"Decline and fall of aging astrocytes: the human perspective.","authors":"Alexei Verkhratsky, Alexey Semyanov","doi":"10.4103/NRR.NRR-D-24-00418","DOIUrl":"10.4103/NRR.NRR-D-24-00418","url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"20 6","pages":"1713-1714"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dendritic spine degeneration: a primary mechanism in the aging process. 树突棘退化:衰老过程的主要机制。
IF 5.9 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2025-06-01 Epub Date: 2024-06-26 DOI: 10.4103/NRR.NRR-D-24-00311
Gonzalo Flores, Leonardo Aguilar-Hernández, Fernado García-Dolores, Humberto Nicolini, Andrea Judith Vázquez-Hernández, Hiram Tendilla-Beltrán
{"title":"Dendritic spine degeneration: a primary mechanism in the aging process.","authors":"Gonzalo Flores, Leonardo Aguilar-Hernández, Fernado García-Dolores, Humberto Nicolini, Andrea Judith Vázquez-Hernández, Hiram Tendilla-Beltrán","doi":"10.4103/NRR.NRR-D-24-00311","DOIUrl":"10.4103/NRR.NRR-D-24-00311","url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"20 6","pages":"1696-1698"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How dopamine tunes parvalbumin interneurons in the hippocampus: new experimental observations in Alzheimer's disease. 多巴胺如何调节海马中的副发光体中间神经元:对阿尔茨海默病的新实验观察。
IF 5.9 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2025-05-01 Epub Date: 2024-06-26 DOI: 10.4103/NRR.NRR-D-24-00322
Livia La Barbera, Paraskevi Krashia, Annalisa Nobili
{"title":"How dopamine tunes parvalbumin interneurons in the hippocampus: new experimental observations in Alzheimer's disease.","authors":"Livia La Barbera, Paraskevi Krashia, Annalisa Nobili","doi":"10.4103/NRR.NRR-D-24-00322","DOIUrl":"https://doi.org/10.4103/NRR.NRR-D-24-00322","url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"20 5","pages":"1405-1406"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microglial dysfunction and genetic risk for neurodegenerative disease. 小胶质细胞功能障碍与神经退行性疾病的遗传风险
IF 5.9 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2025-05-01 Epub Date: 2024-06-26 DOI: 10.4103/NRR.NRR-D-24-00146
Debra S MacDonald, Jay Penney
{"title":"Microglial dysfunction and genetic risk for neurodegenerative disease.","authors":"Debra S MacDonald, Jay Penney","doi":"10.4103/NRR.NRR-D-24-00146","DOIUrl":"https://doi.org/10.4103/NRR.NRR-D-24-00146","url":null,"abstract":"","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"20 5","pages":"1401-1402"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The complex effects of miR-146a in the pathogenesis of Alzheimer's disease. miR-146a 在阿尔茨海默病发病机制中的复杂作用。
IF 5.9 2区 材料科学
ACS Applied Materials & Interfaces Pub Date : 2025-05-01 Epub Date: 2024-06-03 DOI: 10.4103/NRR.NRR-D-23-01566
Yunfan Long, Jiajia Liu, Yu Wang, Haidong Guo, Guohong Cui
{"title":"The complex effects of miR-146a in the pathogenesis of Alzheimer's disease.","authors":"Yunfan Long, Jiajia Liu, Yu Wang, Haidong Guo, Guohong Cui","doi":"10.4103/NRR.NRR-D-23-01566","DOIUrl":"https://doi.org/10.4103/NRR.NRR-D-23-01566","url":null,"abstract":"<p><p>Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral abnormalities. Neuroinflammatory plaques formed through the extracellular deposition of amyloid-β proteins, as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins, comprise two typical pathological features of Alzheimer's disease. Besides symptomatic treatment, there are no effective therapies for delaying Alzheimer's disease progression. MicroRNAs (miR) are small, non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological processes. Indeed, miR-146a, a NF-κB-regulated gene, has been extensively implicated in the development of Alzheimer's disease through several pathways. Research has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this disorder. MiR-146a is believed to reduce amyloid-β deposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway; however, there is also evidence supporting that it can promote these processes through many other pathways, thus exacerbating the pathological manifestations of Alzheimer's disease. It has been widely reported that miR-146a mediates synaptic dysfunction, mitochondrial dysfunction, and neuronal death by targeting mRNAs encoding synaptic-related proteins, mitochondrial-related proteins, and membrane proteins, as well as other mRNAs. Regarding the impact on glial cells, miR-146a also exhibits differential effects. On one hand, it causes widespread and sustained inflammation through certain pathways, while on the other hand, it can reverse the polarization of astrocytes and microglia, alleviate neuroinflammation, and promote oligodendrocyte progenitor cell differentiation, thus maintaining the normal function of the myelin sheath and exerting a protective effect on neurons. In this review, we provide a comprehensive analysis of the involvement of miR-146a in the pathogenesis of Alzheimer's disease. We aim to elucidate the relationship between miR-146a and the key pathological manifestations of Alzheimer's disease, such as amyloid-β deposition, tau protein hyperphosphorylation, neuronal death, mitochondrial dysfunction, synaptic dysfunction, and glial cell dysfunction, as well as summarize recent relevant studies that have highlighted the potential of miR-146a as a clinical diagnostic marker and therapeutic target for Alzheimer's disease.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"20 5","pages":"1309-1323"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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