Transplantation of human neural stem cells repairs neural circuits and restores neurological function in the stroke-injured brain.

IF 5.9 2区 医学 Q2 CELL BIOLOGY
Neural Regeneration Research Pub Date : 2026-03-01 Epub Date: 2024-11-13 DOI:10.4103/NRR.NRR-D-24-00363
Peipei Wang, Peng Liu, Yingying Ding, Guirong Zhang, Nan Wang, Xiaodong Sun, Mingyue Li, Mo Li, Xinjie Bao, Xiaowei Chen
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引用次数: 0

Abstract

JOURNAL/nrgr/04.03/01300535-202603000-00040/figure1/v/2025-06-16T082406Z/r/image-tiff Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke. Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury, which limits the ability to observe long-term behavioral recovery. Here, we used a severe stroke rat model with 150 minutes of ischemia, which produced severe behavioral deficiencies that persisted at 12 weeks, to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke. Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function, reduced infarction volume, long-term human neural stem cell survival, and improved local inflammatory environment and angiogenesis. We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo , formed stable functional synaptic connections with host neurons, and exhibited the electrophysiological properties of functional mature neurons, indicating that they replaced the damaged host neurons. The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke, which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.

移植人类神经干细胞可修复神经回路,恢复中风脑损伤的神经功能。
外源性神经干细胞(NSC)移植已成为治疗慢性中风最有前景的方法之一。最近的研究表明,大多数缺血再灌注模型大鼠在损伤后会自发恢复,这限制了观察长期行为恢复的能力。在此,我们使用缺血150分钟的严重中风大鼠模型,研究神经干细胞对慢性中风神经恢复的治疗效果。我们的研究表明,接受人类神经干细胞治疗的中风模型大鼠运动功能长期持续恢复,梗死体积缩小,人类神经干细胞长期存活,局部炎症环境和血管生成得到改善。我们还证明,移植的人类神经干细胞在体内分化为成熟的神经元,与宿主神经元形成稳定的功能性突触连接,并表现出功能性成熟神经元的电生理特性,表明它们替代了受损的宿主神经元。研究结果表明,人类胎儿来源的神经干细胞对严重中风模型的神经功能恢复具有长期作用,这表明基于人类神经干细胞的疗法可能有效修复中风患者受损的神经回路。
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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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