农林科学最新文献

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Development of an artificial intelligence-based algorithm for the detection of left atrial enlargement from feline thoracic radiographs. 开发一种基于人工智能的算法,用于从猫胸片检测左心房肿大。
IF 5.2 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-01 Epub Date: 2026-01-19 DOI: 10.1080/01652176.2025.2611847
Carlotta Valente, Marek Wodzinski, Carlo Guglielmini, Helen Poser, Alessandro Zotti, Nicolò Mastromattei, David Chiavegato, Roberto Venturini, Parminder S Basran, Weihow Hsue, Qingyue Zhang, Tommaso Banzato
{"title":"Development of an artificial intelligence-based algorithm for the detection of left atrial enlargement from feline thoracic radiographs.","authors":"Carlotta Valente, Marek Wodzinski, Carlo Guglielmini, Helen Poser, Alessandro Zotti, Nicolò Mastromattei, David Chiavegato, Roberto Venturini, Parminder S Basran, Weihow Hsue, Qingyue Zhang, Tommaso Banzato","doi":"10.1080/01652176.2025.2611847","DOIUrl":"10.1080/01652176.2025.2611847","url":null,"abstract":"<p><p>A heart-convolutional neural network (heart-CNN) was developed and tested for the automatic detection of left atrial enlargement (LAE) from feline thoracic radiographs. A retrospective and multicenter study was performed. Right lateral and dorso-ventral and/or ventro-dorsal thoracic radiographs of cats with concomitant echocardiographic examination were selected from the internal databases of both academic and private referral institutions. Radiographic images were classified as no LAE, mild, moderate and severe LAE, based on echocardiographic reports. Heart-CNN performance was evaluated using confusion matrices and receiver operating characteristic curves for both radiographic projections considering a multiclass and a binary classification. Considering the multiclass classification, for the right lateral view, the area under the curve (AUC) was of 0.73, 0.68, 0.64 and 0.78 for the no LAE, mild, moderate and severe LAE groups, respectively. The AUCs for the dorso-ventral and/or ventro-dorsal images were 0.73, 0.64, 0.63 and 0.76 for the no LAE, mild, moderate and severe LAE groups, respectively. In the binary classification, AUCs were 0.83 and 0.81 for right lateral and dorso-ventral and/or ventro-dorsal projections, respectively. The developed AI-based tool seems to be a promising support for automatic identification of more advanced stages of LAE in cats.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2611847"},"PeriodicalIF":5.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolomic profiling of neat uterine luminal fluid in cows: local enrichment and nutritional modulation. 奶牛纯子宫腔液的代谢组学分析:局部富集和营养调节。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-01 Epub Date: 2026-01-07 DOI: 10.1080/01652176.2025.2611849
Masroor Sagheer, Quinn A Hoorn, Mariangela Bc Maldonado, Kasey M Schalich, Nadia Ashrafi, Romana A Mimi, Stewart F Graham, Vimal Selvaraj, Peter J Hansen
{"title":"Metabolomic profiling of neat uterine luminal fluid in cows: local enrichment and nutritional modulation.","authors":"Masroor Sagheer, Quinn A Hoorn, Mariangela Bc Maldonado, Kasey M Schalich, Nadia Ashrafi, Romana A Mimi, Stewart F Graham, Vimal Selvaraj, Peter J Hansen","doi":"10.1080/01652176.2025.2611849","DOIUrl":"10.1080/01652176.2025.2611849","url":null,"abstract":"<p><p>Uterine luminal fluid influences embryonic development and the subsequent phenotype of offspring, yet its detailed metabolomic composition remains poorly characterized. Here, minimally invasive transcervical techniques were employed to collect neat uterine fluid from postpartum dairy cows and cyclic beef cows to allow for metabolomic profiling <i>via</i> targeted mass spectrometry. Objectives were to 1) compare the metabolomic profile of uterine fluid with plasma in dairy cows and 2) assess the impact of dietary rumen-protected methionine and stage of estrous cycle (day 0 vs 7) on plasma and uterine fluid metabolomic profile in beef cows. Results revealed that the concentrations of many metabolites, including amino acids, signaling molecules (e.g. dopamine, gamma-aminobutyric acid) and lipids (e.g. ceramides, diacylglycerols), were higher in uterine fluid than in plasma. An oral bolus of rumen-protected methionine increased uterine concentration of methionine on day 0 of the estrous cycle. The uterine metabolome remained relatively stable between days 0 and 7 although there was temporal variability for a select number of metabolites (cysteine, methionine, methionine sulfoxide, asymmetric dimethylarginine, ceramides, and glycerophospholipids). Correlations between plasma and uterine fluid concentrations were strong or moderate for many amino acids. Collectively, these findings highlight that the uterine lumen is a specialized, selectively regulated biochemical compartment.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2611849"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteriophage vB_SalS_KY05 controls Salmonella in poultry without disrupting cecal microbiota composition. 噬菌体vB_SalS_KY05控制家禽沙门氏菌而不破坏盲肠菌群组成。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-01 Epub Date: 2026-01-21 DOI: 10.1080/01652176.2026.2617464
Wun-Yuan Wu, Reuben Wang, Yu-Ning An, Yuan-Yu Lin
{"title":"Bacteriophage vB_SalS_KY05 controls <i>Salmonella</i> in poultry without disrupting cecal microbiota composition.","authors":"Wun-Yuan Wu, Reuben Wang, Yu-Ning An, Yuan-Yu Lin","doi":"10.1080/01652176.2026.2617464","DOIUrl":"10.1080/01652176.2026.2617464","url":null,"abstract":"<p><p>Salmonellosis is a major food safety challenge in poultry production, requiring effective antibiotic alternatives. We isolated a polyvalent <i>Tequintavirus</i>, vB_SalS_KY05, from a Taiwanese poultry farm and evaluated its biological properties and <i>in vivo</i> efficacy against <i>Salmonella enterica</i> serovars Typhimurium and Enteritidis, and <i>Escherichia coli</i>. The objective of this study was to comprehensively characterize vB_SalS_KY05 and assess its potential as a biocontrol agent for poultry farming. Genome analysis confirmed a lytic lifestyle with no detectable virulence or antimicrobial resistance genes. The phage remained stable at pH 4-10, at 41 °C, and in water for 7 days. For improved biosafety, large-scale amplification was achieved by switching the propagation host to non-pathogenic <i>E. coli</i> K12. <i>In vivo</i>, SPF chickens challenged with <i>S.</i> Typhimurium received low-dose (10<sup>5</sup> PFU/mL) or high-dose (10<sup>8</sup> PFU/mL) phage <i>via</i> drinking water. Low-dose treatment reduced splenic <i>Salmonella</i>, improved albumin-to-globulin ratios, and enriched beneficial taxa like <i>Lactobacillus crispatus</i> and <i>Blautia coccoides</i>. In contrast, high-dose treatment resulted in phage-bacteria coexistence and increased potentially harmful taxa including <i>Erysipelatoclostridium</i>. Overall, cecal microbiota composition remained largely unchanged. These findings indicate vB_SalS_KY05 is a promising biocontrol candidate, highlighting the importance of dose optimization to enhance pathogen control while preserving gut microbiota stability in poultry production.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2617464"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of future-oriented alternative poultry livestock products utilizing Protaetia brevitarsis seulensis larvae. 利用短白弧菌幼虫开发面向未来的替代畜禽产品。
IF 4.9 3区 农林科学
Food Science of Animal Resources Pub Date : 2026-12-01 Epub Date: 2026-02-17 DOI: 10.1007/s44463-025-00006-z
Ju Yi Shin, Hyeong Sang Kim
{"title":"Development of future-oriented alternative poultry livestock products utilizing <i>Protaetia brevitarsis seulensis</i> larvae.","authors":"Ju Yi Shin, Hyeong Sang Kim","doi":"10.1007/s44463-025-00006-z","DOIUrl":"10.1007/s44463-025-00006-z","url":null,"abstract":"<p><p>Integration of advanced technologies from the Fourth Industrial Revolution is accelerating the growth of the food technology sector. Rising global meat consumption driven by population growth raises concerns about food security, environmental impact, and animal ethics, increasing interest in alternative protein sources. Among these, <i>Protaetia brevitarsis seulensis</i> larvae have drawn attention due to their high nutritional value and functional properties such as antioxidant, anti-inflammatory, and anticancer effects. Compared with conventional livestock, they offer enhanced sustainability, efficient resource use, and high-quality protein and micronutrient content. In the Republic of Korea, <i>Protaetia brevitarsis seulensis</i> larvae are approved as food ingredients and are increasingly applied to processed products. Incorporating these larvae into meat products, particularly chicken-based items like sausages and patties, has shown improvements in nutritional and functional quality. Unlike general reviews of edible insects, this study focuses specifically on their potential in poultry-based applications, offering a novel perspective. This targeted approach highlights their advantages as functional ingredients in health-oriented meat alternatives. Despite promising attributes, challenges such as consumer acceptance, regulatory clarity, and mass production remain. Future research should aim to optimize rearing and processing technologies and develop public education strategies to facilitate adoption. Overall, <i>Protaetia brevitarsis seulensis</i> larvae represent a promising alternative protein that could support sustainable food systems while reducing the environmental footprint of livestock production.</p>","PeriodicalId":12459,"journal":{"name":"Food Science of Animal Resources","volume":"46 1","pages":"37"},"PeriodicalIF":4.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress on biological functions of astragalus stems and leaves and their application in cattle production: a review. 黄芪茎叶生物学功能及其在奶牛生产中的应用研究进展
IF 2 3区 农林科学
Animal Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-02-24 DOI: 10.1080/10495398.2026.2631838
Chunfang Ma, Jinbao Zhang, Qi Yang, Qiaoe Zhang
{"title":"Research progress on biological functions of astragalus stems and leaves and their application in cattle production: a review.","authors":"Chunfang Ma, Jinbao Zhang, Qi Yang, Qiaoe Zhang","doi":"10.1080/10495398.2026.2631838","DOIUrl":"10.1080/10495398.2026.2631838","url":null,"abstract":"<p><p><i>Astragalus</i> stems and leaves (ASL) represent a promising feed additive to improve cattle health and production efficiency. They are rich in nutrients and active substances, such as polysaccharides, flavonoids, alkaloids, exhibit antioxidant, antibacterial, anti-inflammatory, and other biological functions. With the advantages of high yield and low price, ASL are excellent potential feedstuff resources that could alleviate the shortage of conventional feed and reduce feeding costs. This review highlights the botanical characteristics, phytochemical components, nutritional and pharmacological effects of ASL, as well as their applications in cattle production, which could be beneficial for animal nutrition regulation and forage development.</p>","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"37 1","pages":"2631838"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12934339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of the administration route and dose on the expression and antibody responses of a reporter and avian influenza self-amplifying mRNA vaccine in poultry. 给药途径和剂量对禽报告型和禽流感自扩增mRNA疫苗表达和抗体应答的影响
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-01 Epub Date: 2026-01-06 DOI: 10.1080/01652176.2025.2603307
Janne Snoeck, Xiaole Cui, Pieter Vervaeke, Niek N Sanders, An Garmyn
{"title":"Influence of the administration route and dose on the expression and antibody responses of a reporter and avian influenza self-amplifying mRNA vaccine in poultry.","authors":"Janne Snoeck, Xiaole Cui, Pieter Vervaeke, Niek N Sanders, An Garmyn","doi":"10.1080/01652176.2025.2603307","DOIUrl":"10.1080/01652176.2025.2603307","url":null,"abstract":"<p><p>Vaccination is routinely used in industrial poultry to control infectious diseases. Vaccines based on mRNA and self-amplifying RNA (saRNA) are approved for human use, but research on their application in poultry is limited. In this study the saRNA vaccine platform is evaluated in poultry. First, a luciferase-encoding saRNA (luc-saRNA) was tested as a model vaccine across different administration routes and doses in broilers. High luciferase expression, and anti-luciferase antibodies were observed after intramuscular (IM), subcutaneous (SC), and in ovo (IO) administration. After a second Luc-saRNA injection, seroconversion rates and antibody titers increased in the IM and SC group to almost 100%. Higher doses of Luc-saRNA increased luciferase production. However, they did not linearly increase antibody production, as all tested doses (0.20-5.0 µg) elicited an equipotent immune response. A vaccination experiment with saRNA encoding the hemagglutinin head-domain (HA-HD) of H5N1 avian influenza showed hemagglutinin inhibition (HI) titers that are indicative for protection after a single injection and these titers remained above the protective threshold during 6 weeks without boosting. When boosted, the HI titers increased four-fold. This study confirms effective protein translation and immune response induction in chickens with IM or SC administered saRNA-LNPs, even at the lowest dose of 0.20 µg.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2603307"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of five viruses commonly implicated with bovine respiratory disease using loop-mediated isothermal amplification. 利用环介导的等温扩增技术检测与牛呼吸道疾病有关的五种病毒。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-01 Epub Date: 2026-01-12 DOI: 10.1080/01652176.2025.2607418
Josiah Levi Davidson, Murali Kannan Maruthumuthu, Mohamed Kamel, Suraj Mohan, Ana Pascual-Garrigos, Andres Dextre, Ruth Eunice Centeno-Delphia, Jacquelyn P Boerman, Deepti Pillai, Jennifer Koziol, Aaron Ault, Jon P Schoonmaker, Timothy A Johnson, Mohit S Verma
{"title":"Detection of five viruses commonly implicated with bovine respiratory disease using loop-mediated isothermal amplification.","authors":"Josiah Levi Davidson, Murali Kannan Maruthumuthu, Mohamed Kamel, Suraj Mohan, Ana Pascual-Garrigos, Andres Dextre, Ruth Eunice Centeno-Delphia, Jacquelyn P Boerman, Deepti Pillai, Jennifer Koziol, Aaron Ault, Jon P Schoonmaker, Timothy A Johnson, Mohit S Verma","doi":"10.1080/01652176.2025.2607418","DOIUrl":"10.1080/01652176.2025.2607418","url":null,"abstract":"<p><p>Herein, we present novel quantitative loop-mediated isothermal amplification (qLAMP) and reverse-transcription qLAMP (RT-qLAMP) assays for the detection of five viruses implicated with the onset and progression of bovine respiratory disease (BRD): Bovine Alphaherpesvirus Type 1 (BHV-1), Bovine Adenovirus Type 3 (BAV-3), Bovine Respiratory Syncytial Virus (BRSV), Bovine Viral Diarrhea Virus Type 1 (BVDV-1), and Bovine Parainfluenza Virus Type 3 (BPIV-3). Using contrived samples spiked with whole viruses, our extraction-free assays have limits of detection between 30 and 1,057 copies per reaction (1.8% final sample concentration) with minimal sample processing. Using dual-tipped swabs and 1.4 mL resuspension volumes, limits of detection are on the order of 2 × 10<sup>5</sup> copies per swab for BAV-3 and BHV-1 and between 6.31 × 10<sup>6</sup> to 8.22 × 10<sup>6</sup> copies per swab for BPIV-3, BRSV, and BVDV-1. Analytical sensitivities ranged from 73 - 100% and analytical specificities ranged from 90 - 100%. Additionally, we introduced a streamlined pipeline to minimize the experimental workload to design, screen, select, and characterize LAMP performance for developing assays. Our assays support the development of colorimetric LAMP assays that enable the sensitive and specific detection of these viruses' chute side to aid in diagnosing and treating BRD. The associated pipeline enables more rapid development of LAMP-based diagnostic tools targeting emerging pathogens.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2607418"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12798664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An underlying mechanism of bovine mastitis: PGE2 regulates Staphylococcus aureus-induced inflammatory response through TLR2, TLR4, and NLRP3 in macrophages. 牛乳腺炎的潜在机制:PGE2通过巨噬细胞中的TLR2、TLR4和NLRP3调节金黄色葡萄球菌诱导的炎症反应。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-01 Epub Date: 2026-01-17 DOI: 10.1080/01652176.2026.2615759
Zhiguo Gong, Zhuoya Yu, Peipei Ren, Shuangyi Zhang, Ruifeng Gao, Jiamin Zhao, Yixin Wang, Shaojie Qin, Wenhui Bao, Feng Shuang
{"title":"An underlying mechanism of bovine mastitis: PGE<sub>2</sub> regulates <i>Staphylococcus aureus</i>-induced inflammatory response through TLR2, TLR4, and NLRP3 in macrophages.","authors":"Zhiguo Gong, Zhuoya Yu, Peipei Ren, Shuangyi Zhang, Ruifeng Gao, Jiamin Zhao, Yixin Wang, Shaojie Qin, Wenhui Bao, Feng Shuang","doi":"10.1080/01652176.2026.2615759","DOIUrl":"10.1080/01652176.2026.2615759","url":null,"abstract":"<p><p><i>Staphylococcus aureus</i> (<i>S. aureus</i>) evades host immunity by modulating macrophage functions, including immune regulation and phagocytosis, ultimately contributing to bovine mastitis. This study aimed to elucidate the molecular mechanisms of <i>S. aureus</i>-induced bovine mastitis from both host and pathogen perspectives, focusing on prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) as a key regulator. During bovine mastitis, macrophages were recruited into the mammary gland with elevated inflammatory mediators. <i>S. aureus</i> lipoproteins amplified inflammation by activating MAPK and NF-κB pathways <i>via</i> TLR2, TLR4, and NLRP3, leading to elevated secretion of mediators, including PGE<sub>2</sub>, in bBMMs. Inhibition of TLR2, TLR4, or NLRP3 decreased COX-2 and mPGES-1 expression, suppressing PGE<sub>2</sub> synthesis, while inhibition of COX-2 or mPGES-1 can regulate the expression of TLR2 and NLRP3, as well as the activation of MAPKs and NF-κB signaling pathways. Excess PGE<sub>2</sub> can regulate inflammation and phagocytosis mediated by TLR2, TLR4, and NLRP3. <i>S. aureus</i> lipoproteins promote PGE<sub>2</sub> synthesis <i>via</i> TLR2, TLR4, and NLRP3 signaling, while PGE<sub>2</sub>, in turn, modulates receptor activity, inflammation, and phagocytosis. These findings reveal crucial functional cross-talk between PGE<sub>2</sub> and innate immune receptors in <i>S. aureus</i>-induced mastitis, suggesting that targeting this interaction may provide novel therapeutic strategies.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2615759"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrative metabolomic and transcriptomic analysis reveals stage-specific shifts in hepatic lipid metabolism of broiler chickens. 综合代谢组学和转录组学分析揭示了肉仔鸡肝脏脂质代谢的阶段性变化。
IF 2 3区 农林科学
Animal Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-02-03 DOI: 10.1080/10495398.2026.2622124
Jingjing Li, Yidan Xu, Peng Ren, Xia Xiong, Mohan Qiu, Chunlin Yu, Yiping Liu, Chaowu Yang
{"title":"Integrative metabolomic and transcriptomic analysis reveals stage-specific shifts in hepatic lipid metabolism of broiler chickens.","authors":"Jingjing Li, Yidan Xu, Peng Ren, Xia Xiong, Mohan Qiu, Chunlin Yu, Yiping Liu, Chaowu Yang","doi":"10.1080/10495398.2026.2622124","DOIUrl":"10.1080/10495398.2026.2622124","url":null,"abstract":"<p><p>Managing fat accumulation is a critical goal in the poultry industry, with the liver being the primary site for lipid metabolism in chickens. This study used non-targeted metabolomics to investigate dynamic changes in metabolite composition in chicken liver across five physiological stages. A total of 1121 metabolites were identified, with 749 and 372 detected in positive- and negative-ion modes, respectively. The regulation of hepatic lipolysis involves numerous metabolic pathways, making it a complex process. We performed trend analysis of lipid, carbohydrate and amino acid-related metabolites. Age exerted major effects on hepatic metabolism, significantly enriching pathways including alpha-linolenic acid metabolism, linoleic acid metabolism, steroid hormone biosynthesis, 2-oxocarboxylic acid metabolism and nicotinate and nicotinamide metabolism. Transcriptomic analysis identified 12 lipid-metabolism-related genes, showing a tendency of continuously increase. Potential functional genes influencing lipid metabolism-related pathways were identified through a comprehensive analysis of differential lipid-related metabolites and genes, including <i>fatty acid desaturase 2</i> (<i>FADS2</i>), <i>acetyl-CoA acetyltransferase 2</i> (<i>ACAT2</i>), <i>apovitellenin 1</i> (<i>APOV1</i>), <i>vitellogenin 1</i> (<i>VTG1</i>), <i>membrane-bound O-acyltransferase domain-containing protein 2</i> (<i>MBOAT2</i>) <i>and ELOVL fatty acid elongase 1</i> (<i>ELOVL1</i>). These findings could help improve understanding of hepatic metabolism during different physiological stages and identify valuable biomarkers for specific metabolite accumulation.</p>","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"37 1","pages":"2622124"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review on kefir beverages from milk and water: health benefits, processing and applications. 牛奶和水制成的开菲尔饮料:健康益处、加工和应用综述。
IF 4.9 3区 农林科学
Food Science of Animal Resources Pub Date : 2026-12-01 Epub Date: 2026-02-11 DOI: 10.1007/s44463-025-00004-1
Joyce Jen Li Lim, Nyuk Ling Chin, Chun Wie Chong, Adiratna Mat Ripen, Syahmeer How, Sze Qi Teoh
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