环境科学与生态学最新文献

{"title":"Network toxicological and molecular docking in investigating the mechanisms of toxicity of agricultural chemical pyraclostrobin","authors":"Shen-sui Li ,&nbsp;Xu-dong Tian ,&nbsp;Ju-kun Song ,&nbsp;Ya-dong Wu ,&nbsp;Wei-li Wang ,&nbsp;Zheng-long Tang ,&nbsp;Jin-bo Wang","doi":"10.1016/j.ecoenv.2025.118244","DOIUrl":"10.1016/j.ecoenv.2025.118244","url":null,"abstract":"<div><div>The safety of agricultural products is significant to human health. Pyraclostrobin (PYR), a common methoxycarbonyl fungicide, is a crucial role in the prevention of fungal infections during the transport and storage of agricultural products, including vegetables and fruits. Using a multi-analytical approach, integrating toxicological database mining, protein-protein interaction (PPI) network analysis, and molecular docking, this study aimed to elucidate the molecular mechanisms underlying the toxicity of PYR. A total of 162 and 129 targets were identified for cancer and kidney injury, respectively, with PPI analysis pinpointing five vital targets per condition. Functional enrichment through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) pathway annotations revealed significant associations with pathways related to prostate cancer and renal impairment pathways. Molecular docking confirmed PYR's binding affinity to these targets, indicating its potential role in disease pathogenesis. Our findings underscore the imperative for stringent safety assessments of PYR, particularly concerning the risks posed by chronic exposure, and emphasize the urgency for further research to inform public health and environmental policies.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"297 ","pages":"Article 118244"},"PeriodicalIF":6.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal variations and inequalities in global traffic-sourced PM2.5 exposure","authors":"Pei Yu, Rongbin Xu, Yiwen Zhang, Tingting Ye, Wenhua Yu, Gongbo Chen, Bo Wen, Xu Yue, Shanshan Li, Yuming Guo","doi":"10.1016/j.envint.2025.109492","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109492","url":null,"abstract":"Traffic emission is a major source of ambient fine particulate matter with aerodynamic diameter less than 2.5 µm (PM_2.5) pollution. However, little is known about the global population exposure to traffic-sourced PM_2.5 at high spatiotemporal resolutions. This study, utilizing chemical transport and machine learning models, estimated global daily traffic-sourced PM_2.5 at a 0.25° × 0.25° spatial resolution during 2000–2019. The results showed that global population-weighted average traffic-sourced PM_2.5 concentrations increased, aligning with the trend in total PM_2.5 concentrations, rising from 5.8 µg/m³ (contributing to 15.3 % of global total PM_2.5) in 2000–2009 to 6.6 µg/m³ (16.4 % of total PM_2.5) in 2010–2019. Our analysis showed that the increasing trend of traffic-sourced PM_2.5 contributed 36.0 % to the global increasing trend of total PM_2.5. The increasing traffic-sourced PM_2.5 were primarily in Asia, while Europe, North America, and Oceania experienced decreasing trends. Higher concentrations or proportions of traffic-sourced PM_2.5 generally occur during colder months, especially in Asia, and in countries with higher socioeconomic levels. The top ten countries with the highest traffic PM_2.5 proportion in both decades are all high-income countries. Inequalities existed both between and within countries/territories assessed by the Gini index. Compared to total PM_2.5 exposure, traffic-sourced PM_2.5 exposure demonstrated greater inequalities at the global level, within and between countries. Our study provides essential data for identifying high-risk traffic-related PM_2.5 exposure areas, assessing regional pollution control effectiveness, exploring health impacts, and promoting environmental justice.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"24 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How are diameter growth, forest structure and carrying capacity related in tree populations?","authors":"Thiago Floriani Stepka ,&nbsp;Patrícia Povoa de Mattos ,&nbsp;Afonso Figueiredo Filho ,&nbsp;Sebastião do Amaral Machado ,&nbsp;Evaldo Muñoz Braz","doi":"10.1016/j.ecolmodel.2025.111141","DOIUrl":"10.1016/j.ecolmodel.2025.111141","url":null,"abstract":"<div><div>This study modeled the diameter growth of <em>Araucaria angustifolia, Cedrela fissilis</em>, and <em>Ocotea porosa</em> as a function of age and analyzed how these factors are related to diameter distribution. This analysis was used to describe behavior in terms of age and lifespan, and also determined periods of technical growth stagnation for each species. Diameter growth was evaluated via partial trunk analysis using increment cores from 30 trees per species in six study locations in southern Brazil (totaling 480 cores), collected in proportion to diameter distribution. Twelve biological models were utilized to estimate diameter growth as a function of age of the species in the different locations. The Weibull probabilistic density function with three parameters was adjusted to represent the diametric structure and indicate carrying capacity. Distinct ages were identified in the different study locations, indicating successions in separate periods during the past as well as locations with the least alterations (oldest successions). The diameters at the technical age of stagnation and carrying capacity were found to be generally similar, demonstrating the relationship between diameter structure and diameter increment. Maximum vigor in the three species was found to occur at diameters considerably smaller than the maximum value, suggesting that attainment of significant ages and diameters may not fully reflect the inherent potential of all individuals within the species under study. The maximum diameter increment vigor in the species under analysis was observed during the early stages of development, and tended to diminish in the subsequent phases.</div></div>","PeriodicalId":51043,"journal":{"name":"Ecological Modelling","volume":"506 ","pages":"Article 111141"},"PeriodicalIF":2.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic signatures of pathogen suppression effect of Baltic eelgrass meadows in surrounding seawater","authors":"Caroline Utermann-Thüsing ,&nbsp;Daniel Mendez ,&nbsp;Paolo Stincone ,&nbsp;Daniel Petras ,&nbsp;Deniz Tasdemir","doi":"10.1016/j.scitotenv.2025.179518","DOIUrl":"10.1016/j.scitotenv.2025.179518","url":null,"abstract":"<div><div>Organic molecules exuded into water column by marine organisms represent a significant portion of marine dissolved organic matter (DOM) that modulates biochemical interactions. Secreted allelochemicals have been suggested to be involved in regulation of pathogen abundance in seagrass meadows, however, seagrass exometabolome has remained unstudied. We aimed to identify seagrass exometabolites, within and outside meadows, and explore their potential involvement in pathogen suppression under varying environmental conditions. We collected seawater (SW) samples from eelgrass (<em>Zostera marina</em>)-vegetated (V) and non-vegetated (NV) areas across 5 locations spanning 270 km of coastline along the German Baltic Sea. Comparative LC-MS/MS-based untargeted computational metabolomics combined with statistical analyses and machine learning tools were employed to pinpoint (exo)metabolomic signatures of eelgrass leaves. Simultaneously, we measured abiotic parameters and the abundance of three common pathogenic taxa in seawater, and investigated spatiotemporal variations. Here we show the correlation of pathogen biomass and eelgrass pathogen reduction effect with increasing seawater temperature, eutrophication and anthropogenic influences. Exometabolomics studies revealed that eelgrass exudates contributed significantly to overall seawater DOM at molecular level, while SW overlying eelgrass meadows contained many chemical features unique to the eelgrass leaf metabolome. We identified four flavone aglycones as key biomarkers distinguishing SW-V and SW-NV samples. Their drastically increased concentrations correlated with the lowest pathogen biomass, suggesting their role in pathogen regulation. These combined analytical and microbiological approaches indicate that flavones are defensive allelochemicals released into eelgrass meadows upon environmental stress and serve as potential bioindicators of eelgrass’ sanitation effect.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"979 ","pages":"Article 179518"},"PeriodicalIF":8.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green gentrification drives socio-cultural shifts from provisioning to cultural valuation of ecosystem services","authors":"Celina Aznarez ,&nbsp;Juan Pablo Pacheco ,&nbsp;María Candelaria Domínguez ,&nbsp;Isabel Gadino ,&nbsp;Hugo Inda ,&nbsp;Fabiana Castellarini","doi":"10.1016/j.ecoser.2025.101731","DOIUrl":"10.1016/j.ecoser.2025.101731","url":null,"abstract":"<div><div>Gentrification influences the social distribution of Ecosystem Services (ES) which can affect their use, perception and valuation, and lead to socio-ecological conflicts. This is particularly evident in coastal urban areas, where local underprivileged communities depending on ES for their livelihoods are often displaced due to real estate and tourism activities. Here, we analyse the use, perception and valuation of ES regarding the socio-economic status in a gentrified coastal area in Uruguay with an ongoing plan of urban transformation. We combined semi-structured interviews, participatory observation and mapping, for the identification, valuation, frequency of use, main pressures and trade-offs of ES. We evidenced a contrasting use and valuation of ES between neighbourhoods of different socio-economic status. Affluent neighbourhoods mainly recognized cultural-recreational ES, with sporadic use during summertime. Contrarily, residents of underprivileged areas identified a wider range of ES, used all year long, and had a higher valuation of provisioning ES due to their high dependence for basic needs. Accelerated gentrification, driven by the local urban management plan might exacerbate ES distributive inequities, and raise environmental justice concerns due to the restricted access to ES by the highly reliant underprivileged residents. This might induce a homogenisation in the use and valuation of ES towards cultural-recreational ones, more used and valued by affluent users. We emphasise the need for inclusive urban planning that acknowledges and integrates the diverse values and dependencies on ES across different socio-economic groups, to ensure sustainable and equitable development, preserve local livelihoods, and maintain ecological integrity.</div></div>","PeriodicalId":51312,"journal":{"name":"Ecosystem Services","volume":"73 ","pages":"Article 101731"},"PeriodicalIF":6.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using sulfur and oxygen isotope values to partition riverine sulfate sources and illustrate their responses to hydrological processes","authors":"Ying Cao ,&nbsp;Yuxiao He ,&nbsp;Dong Zhang ,&nbsp;Yong Qin ,&nbsp;Zhiqi Zhao ,&nbsp;Cong Zhang ,&nbsp;Shanggui Gong","doi":"10.1016/j.jenvman.2025.125539","DOIUrl":"10.1016/j.jenvman.2025.125539","url":null,"abstract":"<div><div>Orogenesis contributes to the elevation of highly eroded rock strata, whose interactions with the atmosphere, water, and biota result in the release of dissolved substances. The fluvial transport of dissolved sulfate (SO₄²⁻) from mountains to oceans is a critical component of the global sulfur cycle. However, anthropogenic activities have significantly increased the concentrations of sulfate and altered isotope compositions. It is imperative to delineate the impacts of anthropogenic disturbances and clear their transport mechanisms. To address this issue, spatial and temporal water samples were collected from the Qin River Basin (QRB) between 2012 and 2015. Sulfate sulfur and oxygen isotope values (δ³⁴S-SO₄^2- and δ¹⁸O-SO₄^2-), alongside Bayesian isotope mixing models (BIMMs) were employed to identify pathways of anthropogenic inputs and quantify their contributions. The average mainstream SO₄²⁻ concentration, δ³⁴S-SO₄^2- and δ¹⁸O-SO₄^2- values in the upper reaches (<em>n</em> = 18), middle (<em>n</em> = 9), and lower reaches (<em>n</em> = 44) were 1.09 mmol/L, 1.5 ‰ and 5.6 ‰; 1.34 mmol/L, 6.8 ‰ and 6.9 ‰; 2.31 mmol/L, 8.5 ‰ and 7.7 ‰, respectively. BIMMs results from spatial water samples indicated an increasing trend in contributions from gypsum, loess, sewage and chemical fertilizer but a decreasing trend from coal mine drainage (CMD) and pedogenic sulfate sources to riverine sulfate along the river. Results from temporal water samples at the outlet indicated that pedogenic sulfate, CMD, and loess sulfate were transport-limited, conversely, gypsum and chemical fertilizer were source-limited, and sewage has chemostatic behaviors. Despite a significant reduction in annual water discharge since 1956–2000, the average annual sulfate flux from 2013 to 2015 exceeded historical values, with approximately 45 % of riverine sulfate derived from anthropogenic input, and the flow-weighted average δ³⁴S-SO₄^2- and δ¹⁸O‒SO₄^2- values changed to 7.9 ± 1.2 ‰ and 6.4 ± 0.2 ‰. These findings illuminated the profound impacts of anthropogenic inputs on riverine sulfate flux in Qin River and offer a robust methodology for partitioning aqueous pollution sources and delineating their transport mechanisms in the complex environmental settings.</div></div>","PeriodicalId":356,"journal":{"name":"Journal of Environmental Management","volume":"384 ","pages":"Article 125539"},"PeriodicalIF":8.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIR408-encoded peptide, miPEP408, regulates cadmium stress response through sulfur assimilation pathway","authors":"Ravi Shankar Kumar, Tapasya Datta, Hiteshwari Sinha, Prabodh Kumar Trivedi","doi":"10.1016/j.jhazmat.2025.138420","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138420","url":null,"abstract":"Small peptides encoded by pri-miRNAs (miPEPs), have been identified as significant plant growth and development regulators. However, their roles in plant-environment interactions and heavy metal stress response remain largely unexplored. Here, we demonstrate that Arabidopsis <em>MIR408</em>-encoded peptide (miPEP408) plays a significant role in cadmium (Cd) stress response by modulating the sulfur assimilation pathway. Using a combination of exogenous synthetic peptide assays, CRISPR/Cas9-mediated knockout mutants (<em>miPEP408</em>^<em>CR</em>), and overexpression lines (<em>miPEP408OX</em>), we analyzed phenotypic and molecular levels to elucidate the function of miPEP408 under Cd stress. Our results suggest that miPEP408 regulates miR408 expression and its targets in response to Cd exposure. Plants treated with exogenous miPEP408 or overexpressing miPEP408 exhibited reduced glutathione (GSH) levels, suppression of sulfur assimilation pathway genes, and heightened sensitivity to Cd. <em>miPEP408</em>^<em>CR</em> plants showed enhanced GSH levels, upregulation of sulfur assimilation genes, and improved Cd detoxification. Furthermore, miPEP408 influenced the expression of Cd transporters and Cd accumulation in plants. In conclusion, this study establishes miPEP408 as a key regulator of Cd stress response in <em>Arabidopsis</em>, functioning through modulation of the sulfur assimilation pathway and metal transporter gene expression. These findings underscore the indispensable role of miPEPs in enhancing plant resilience to heavy metal stress.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"8 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Propensity of a low‑cost adsorbent derived from agricultural wastes to interact with cationic dyes in aqueous solutions","authors":"Emee Das,&nbsp;Suprakash Rabha,&nbsp;Karishma Talukdar,&nbsp;Manisha Goswami,&nbsp;Arundhuti Devi","doi":"10.1007/s10661-025-14055-w","DOIUrl":"10.1007/s10661-025-14055-w","url":null,"abstract":"","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"197 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Key Role of Vicariance for Soil Animal Biogeography in a Biodiversity Hotspot Region","authors":"Xue Pan,&nbsp;Holger Kreft,&nbsp;Jing-Zhong Lu,&nbsp;Yabin Du,&nbsp;Stefan Scheu,&nbsp;Mark Maraun","doi":"10.1111/geb.70043","DOIUrl":"https://doi.org/10.1111/geb.70043","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The Indo-Australian Archipelago is known as a biodiversity hotspot with high levels of endemism typically ascribed to vicariance as reflected by the ‘Wallace's line’. However, it is unknown how vicariance has affected belowground biodiversity, especially process-based beta diversity. Here, we relate beta diversity of soil oribatid mite (Oribatida, Acari) assemblages to geographic distance as well as climatic and soil factors to explore the factors shaping the diversity of oribatid mites across 11 regions of the Indo-Australian Archipelago.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Location&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Indo-Australian Archipelago.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Time Period&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Present.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Major Taxa Studied&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Oribatida, Acari.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We compiled a list of 2549 oribatid mite species in the Indo-Australian Archipelago and investigated the level of endemism and beta diversity of oribatid mites in the 11 regions at species, genus and family level. We then summarised the biogeographical dissimilarity patterns of oribatid mites using ordination and clustering methods and compared the patterns with the zoological boundaries based on aboveground taxa such as Wallace's, Lydekker's, Weber's and Holt's lines. We integrated data on geography, climate and soil to reveal the key drivers of species compositional dissimilarity of oribatid mites among regions using Mantel tests.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Generally, the level of endemism of oribatid mite assemblages in the 11 regions was high; they formed three groups (west of New Guinea, New Guinea and south of New Guinea) with dissimilarity changing from northwest to southeast. The patterns reflect and integrate the lines of Weber, Lydekker and Holt. Species turnover generally correlated with geographic distance, reflecting the critical role of vicariance in dispersal-limited oribatid mites.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Main Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our results, for the first time, demonstrate contrasting patterns in below- and aboveground organisms in the Indo-Australian Archipelago, and elucidate how geographic distance-based vicariance has structured soil animal diversity in this biodiversity hotspot regio","PeriodicalId":176,"journal":{"name":"Global Ecology and Biogeography","volume":"34 5","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/geb.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arsenic exposure activates microglia, inducing neuroinflammation and promoting the occurrence and development of Alzheimer's disease-like neurodegeneration in mice","authors":"Bo Zhang ,&nbsp;Jiaojiao Wang ,&nbsp;Junhong Chen ,&nbsp;Xueli Pan","doi":"10.1016/j.ecoenv.2025.118251","DOIUrl":"10.1016/j.ecoenv.2025.118251","url":null,"abstract":"<div><div>Health damage caused by environmental arsenic pollution has attracted widespread attention, with Alzheimer’s disease (AD) thought to be one of the adverse effects of long-term arsenic exposure. In this study, we sought to investigate the relationship between arsenic exposure and AD-like neurodegeneration and to determine the role of microglia in the process of AD-like neurodegeneration induced by arsenic exposure. The relationship between arsenic exposure and AD-like neurodegeneration was investigated using cognitive assessments and biological experiments. Arsenic exposure induced memory impairment in C57BL/6 mice and resulted in a significant increase in the number of Aβ⁺ and pTau⁺ cells in the entorhinal cortex and hippocampus with neuronal granular vacuolar degeneration and necroptosis, accompanied by upregulated expression of related proteins, which showed dose- and time-response relationships. Arsenic exposure intensified memory decline in FAD^4T mice with accelerated AD-like neurodegeneration. Correlation analysis showed a negative correlation between memory impairment and neurodegeneration in the entorhinal cortex and hippocampus in mice. Arsenic exposure also activated microglia in the entorhinal cortex and hippocampus, with enlargement of the cytosol, shortened and thickened cell protrusions, hypertrophic changes, and abnormal proliferation, as well as upregulated expression of the pro-inflammatory cytokines TNF-α and IL-1β. Arsenic exposure induced overactivation of microglia in the entorhinal cortex and hippocampus of FAD^4T mice, resulting in de-branching or bulbous protrusions and fragmented cytoplasm. Our findings suggest that arsenic exposure promotes the occurrence and development of AD-like neurodegeneration via the activation of microglia, which induces neuroinflammation in mice.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"297 ","pages":"Article 118251"},"PeriodicalIF":6.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}