环境科学与生态学最新文献

{"title":"Sb(Ⅴ) has distinct cellular uptake route and cytotoxic mechanism from Sb(Ⅲ): Anion channel 2 and sulfhydryl binding","authors":"Yangchen Han, Bingyan Liu, Zhipeng Yin, Xiangcheng Shan, Min Zhang, Chuanyong Jing, Wei Jiang","doi":"10.1016/j.jhazmat.2025.138820","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138820","url":null,"abstract":"Antimony (Sb), a metalloid element with important industrial applications, exists as valence states of Sb(III) and Sb(V). Understanding on the Sb induced cytotoxicity, especially Sb(V), is still limited. In this study, human hepatoma (HepG2) and nephrocyte (HEK293T) cell lines were used to investigate the cytotoxicity, uptake and biotransformation of Sb. The mechanisms of cytotoxicity are different for Sb(III) and Sb(V). Sb(III) induces oxidative stress, while Sb(V) binds to sulfhydryl groups (SH) to cause cytotoxicity. Both HepG2 and HEK293T cells took up more Sb(III) than Sb(Ⅴ). We report for the first time that Sb(V) uptake through anion channel 2 (AE2), but Sb(III) uptake is through aquaglyceroporin-9 (AQP9). Higher cellular uptake and different uptake channels may contribute to the higher toxicity of Sb(III) than Sb(V). The reduction of Sb(Ⅴ) to Sb(III) in cells was revealed by HG-HPLC-AFS. Approximately 14.21% of Sb(V) was reduced to Sb(III), but the oxidation of Sb(III) to Sb(V) was not found. Glutathione performed important role in the reduction of Sb(V). Our research elucidates the mechanisms of Sb cytotoxicity and uptake, which provides a theoretical basis to predict the health risks of Sb.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"33 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglia-derived extracellular vesicles mediate fine particulate matter-induced Alzheimer's Disease-like behaviors through the miR-34a-5p/DUSP10/p-p38 MAPK pathway","authors":"Ling Wang, Yi Lin, Ziyi Yang, Ke Zhang, Hongyang Gong, Yaopeng Zheng, Binquan Wang, Xiaoyan Zhang, Mingkuan Sun","doi":"10.1016/j.jhazmat.2025.138853","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138853","url":null,"abstract":"Fine particulate matter (PM2.5), a major component of air pollution, poses significant global health risks. Epidemiological studies have correlated long-term PM2.5 exposure and neurological disorders, including Alzheimer’s disease (AD). Extracellular vesicles (EVs) are recognized as critical mediators of intercellular communication. Understanding the role of microglia EVs in neuronal dysfunction is essential, given the increasing awareness of non-cell-autonomous neurotoxicity. The mechanisms through which microglia and their EVs mediate PM2.5-induced neurotoxicity are poorly understood. This study demonstrated that PM2.5 exposure drives microglial toward the pro-inflammatory M1 phenotype, impairing the brain's immune defenses. PM2.5-treated microglia secrete miR-34a-5p-enriched EVs. These EVs are delivered to neurons, target DUSP10, activate the p-p38 MAPK pathway, increase aberrant tau phosphorylation and pathological Aβ proteins, and induce neuronal apoptosis in the hippocampus and cortical regions. These pathological changes contribute to cognitive and behavioral deficits in PM2.5-exposed mice. Knocking down miR-34a-5p in EVs from PM2.5-treated microglia rescued these phenotypes, mitigating AD-like pathology in mice. Our study identified miR-34a-5p as a critical regulator of neuro apoptosis and AD-like cognitive impairment induced by PM2.5 exposure. These findings underscore the pivotal role of microglial EVs in mediating intercellular communication between glia and neurons, providing valuable insights into the mechanisms underlying PM2.5-induced neurotoxicity.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"9 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling","authors":"Xiarui Fan, Xiaomin Li, Tong Li, Bing Shao, Shan Niu, Wenhong Fan, Qi Wang, Lv Zhong, Xiangrui Wang, Ziwei Wang, Fujun Ma, Guomao Zheng, Hui Peng, Lili Chen, Zhaomin Dong","doi":"10.1016/j.envint.2025.109591","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109591","url":null,"abstract":"Understanding the binding between per- and polyfluoroalkyl substances (PFAS) and proteins is essential for elucidating their toxicokinetics and tissue distribution. Here, we quantified the binding affinities of 14 PFAS to rat liver fatty acid-binding protein (rL-FABP) and rat serum albumin (RSA). Results showed that PFAS exhibit strong binding affinities (K_a) to the rL-FABP (10³ ∼ 10⁵ M⁻¹), particularly among medium- to long-chain perfluorinated carboxylic acids (PFCAs). The binding affinity of PFAS to RSA ranged from approximately 10⁴ to 10⁵ M⁻¹, with 1 to 4 binding sites. Molecular docking results supported that PFAS binding to proteins is an exothermic process driven by van der Waals forces, hydrogen bonding, and electrostatic interactions. Additionally, long-chain PFCAs were shown to adopt a “U”-shaped conformation within the ligand-binding cavities of rL-FABP and RSA. The newly developed physiologically based pharmacokinetic model using measured binding data demonstrates a substantial improvement in the goodness of fit to experimental observations, reducing the prediction error by 20 %∼216 %. Finally, we found that the PFAS liver-blood partition could be mainly explained by the binding affinity ratios of PFAS to liver and blood proteins, which could be further extrapolated from rats to humans, providing useful insights to understand the tissue distribution of PFAS.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"13 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Accelerating Exposure of European Protected Areas to Climate Change","authors":"Marta Cimatti,&nbsp;Valerio Mezzanotte,&nbsp;Risto K. Heikkinen,&nbsp;Maria H. Hällfors,&nbsp;Dirk Nikolaus Karger,&nbsp;Moreno Di Marco","doi":"10.1111/gcb.70261","DOIUrl":"https://doi.org/10.1111/gcb.70261","url":null,"abstract":"<p>All ecosystems are affected by climate change, but differences in the pace of change will render some areas more exposed than others. Such spatial patterns of risk are important when assessing the continued functionality of protected area (PA) networks or planning for their expansion. Europe is undertaking an expansion of the PA network to cover 30% of its land and sea surface by 2030, but this must account for climate risk. Here, we estimate four metrics of future climate risk across Europe: local velocity, analog velocity, magnitude, and residence time, and assess the level of climate exposure of European PAs vs. nonprotected control sites. We also evaluate the intensity of climate risks on &gt; 1000 European species of conservation concern associated with Natura 2000 sites. Our results show large spatial differences in climate change exposure across Europe, with a faster pace and farther shifts in the Boreal, Steppic, and Pannonian regions but slower changes in the Mediterranean, Alpine, Arctic, and Macaronesia regions. The magnitude of climate change was higher for the Arctic, Alpine, and Mediterranean regions, implying large local differences between present and future climate. These spatial risk patterns were largely consistent across scenarios, but with up to three times higher risk under the most pessimistic vs. the most optimistic scenario. Large variation in climate exposure for species of conservation concern was revealed, including 11 species that are highly dependent on Natura 2000 sites and predicted to experience rapid climate change. Our results provide guidance for managing European PAs and expanding their coverage by pinpointing areas offering more stable climates. We emphasize the need for connectivity across the network to support species adaptation via range shifting. This is especially the case in areas facing high climate change magnitude but low velocity, implying that climate conditions similar to current ones will be found nearby.</p>","PeriodicalId":175,"journal":{"name":"Global Change Biology","volume":"31 6","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/gcb.70261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methane dynamics controlled by subsurface metabolic architecture and tidal cycling in a mangrove wetland","authors":"Tzu-Hsuan Tu ,&nbsp;Tai-Yi Lee ,&nbsp;Zih-Huei Yu ,&nbsp;Chun-Hung Lu ,&nbsp;Yueh-Ting Lin ,&nbsp;Pei-Ling Wang","doi":"10.1016/j.scitotenv.2025.179769","DOIUrl":"10.1016/j.scitotenv.2025.179769","url":null,"abstract":"<div><div>Tidal wetlands play a crucial role in global methane cycling. The complex interplay among tidal changes, microbial communities, and methane emissions in the ecosystems remains poorly understood. We investigated the dynamics of methane emissions and oxidizing activities, and related geochemical and microbial characteristics in the Guandu wetland, a subtropical mangrove mudflat influenced by tidal cycles in northern Taiwan. Our results revealed that the Guandu wetland was readily transformed into anoxic conditions (at &gt;3 mm depth) and acted as a net source of methane and CO₂, with emissions peaking at 5–9 h of exposure to the atmosphere. Elevated methane emissions were intimately linked to highly variable methane and sulfate concentrations in the subsurface during low tide. Contrastingly, the methane and sulfate gradients were greatly attenuated during high tide. Methane oxidation rates derived from incubations of surface sediments with methane were positively correlated with the abundances of <em>pmo</em>A genes in surface sediments. Surface communities with the shortest exposure were distinct from subsurface counterparts and surface communities with prolonged exposure or subject to high methane incubations. These lines of evidence suggest that vigorous methane and sulfate cycling and enhanced methane emissions jump start with the development of a strong redox gradient derived from subsurface metabolic architecture and are mediated by the complexly structured community compositions as the tide recedes. Multifaceted analyses at a high temporal resolution are required to better project greenhouse gas emissions from such dynamic environments in the context of climate change schemes.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"988 ","pages":"Article 179769"},"PeriodicalIF":8.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrient and pharmaceutical and personal care product removal from wastewater: a special focus on microalgae and its consortium with Bacteria","authors":"Ubhat Ali ,&nbsp;Surampalli Rao ,&nbsp;Pratik Kumar","doi":"10.1016/j.scitotenv.2025.179804","DOIUrl":"10.1016/j.scitotenv.2025.179804","url":null,"abstract":"<div><div>Pharmaceuticals and personal care products (PPCPs) are ubiquitous and have deleterious effects on the environment as well as flora and fauna. Physicochemical treatment systems are associated with high operational and capital costs. Also, prevalent biologically operated treatment systems majorly rely on heterotrophic bacteria for eliminating both nutrients as well as emerging contaminants. However, owing to the non-specific treatment regimes of the WWTPs, the discharge of PPCPs into the aquatic ecosystems and the resultant biomagnification is inevitable. The inclusion of algae into the treatment systems has broadened the facets of treatment owing to the complex cellular structure and function of the former. The presence of bacterial communities in the phycosphere of algae and their coherent action in the uptake of contaminants form the basis of their consideration for wastewater treatment. This article discusses the fate and global scenario of PPCPs in the water ecosystem based on recent literature, along with providing a glance into the mechanisms of PPCP uptake by algae. The exploration of mutualism or symbiosis between the algal and bacterial communities is one of the primary objectives of this review. The mechanisms of metabolism and the trade-off of nutrient substrates have also been vividly discussed. The usage of algal bacterial consortia (ABC) for nutrient and PPCP removal, along with methods to enhance the removal by phycoremediation, has also been delineated. Commercial and pilot-scale applications of ABC-based systems have been discussed. Challenges and prospects in the implementation of phycoremediation of PPCPs have also been elucidated.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"988 ","pages":"Article 179804"},"PeriodicalIF":8.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastic-radionuclide complexes: Diffusion mechanisms and multidimensional threats","authors":"Bohao Liu ,&nbsp;Ruixin Jin ,&nbsp;Maocai Shen ,&nbsp;Huijuan Zhang","doi":"10.1016/j.scitotenv.2025.179819","DOIUrl":"10.1016/j.scitotenv.2025.179819","url":null,"abstract":"<div><div>Global marine microplastics and pollution radionuclides have emerged as significant research focal points in the field of environmental science, with their potential ecological risks and health threats being complex and far-reaching. Meanwhile, in recent years, the discharge of radioactive nuclear wastewater has also attracted global attention. Microplastics can facilitate the transregional migration and diffusion of radionuclides, while radionuclides can exacerbate the toxic effects of microplastics on living organisms. The combined threat posed by microplastics-radionuclide complexes (MRC) to both ecosystems and human health is compounded. The potential impact of MRC contamination is multi-dimensional, long-term, and global in scope. MRCs can spread to global oceans through ocean currents and may evaporate into the atmospheric circulation, forming radioactive rainfall and polluting terrestrial water sources and soil. The infiltration of groundwater systems further expands the scope of pollution and threatens terrestrial ecosystems. In addition, the potential impacts of wastewater with MRCs have multidimensional, long-term, and global characteristics, involving complex issues such as ecological chain collapse, health risk escalation, and economic cost surges. This paper discusses the current contamination status of MRC, elucidates the adsorption processes, mechanisms, and toxic effects associated with MRC, and critically highlights the knowledge gaps and challenges in MRC research. A comprehensive understanding of the environmental behavior and potential threats posed by MRC is essential for developing effective identification and removal techniques.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"988 ","pages":"Article 179819"},"PeriodicalIF":8.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategic deployment of nature-based solutions for urban flood management in high-density urban landscapes","authors":"Mo Wang ,&nbsp;Jiayu Zhao ,&nbsp;Ziheng Xiong ,&nbsp;Menghan Zhang ,&nbsp;Lie Wang ,&nbsp;Soon Keat Tan","doi":"10.1016/j.ecolind.2025.113681","DOIUrl":"10.1016/j.ecolind.2025.113681","url":null,"abstract":"<div><div>Urban floodings are frequently observed in high-density urban landscapes (HDULs). The rapid rate of urbanization, increased impervious land surface, limited permeable open areas, and climate change add to the challenges in flood management and mitigation in such areas. Constrained by limited space and increased peak stormwater runoff, the conventional grey infrastructure appeared inadequate in its drainage function and capacity, Nature-based solutions (NBS) have emerged as an attractive alternative to urban flood management while offering multifunctional benefits for flood risk reduction, ecosystem restoration, and urban resilience. A comprehensive framework integrating spatial multi-criteria evaluation (SMCE) with analytical hierarchy process (AHP), and entropy weighting (EW) methods is described herein. This framework is used to assess exposure, vulnerability, and adaptability factors influencing flood risks in Shenzhen, China. The study identifies key priority areas for NBS implementation and evaluates four NBS schemes based on their technical feasibility and spatial suitability. Results reveal that indices such as river network density (26.6 %) and impervious surface percentage (26.5 %) significantly influence exposure, while cultural heritage (31.2 %) and emergency shelters (58.0 %) dominate vulnerability and adaptability assessments, respectively. These results are presented in the form of a prioritization map and highlights critical zones requiring immediate intervention. Four schemes of NBS implementation involving green areas of various sizes (8.4–––28.5 km2), comprising certain areal expanse and distribution of pavements, porous surfaces, raingardens, retention ponds and constructed wetlands are evaluated to illustrate the opportunity, potential benefits, and versatility of such schemes in HUDLs.</div></div>","PeriodicalId":11459,"journal":{"name":"Ecological Indicators","volume":"176 ","pages":"Article 113681"},"PeriodicalIF":7.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Density dependent control of resting egg production promotes coexistence of zooplankton","authors":"E.S Zadereev ,&nbsp;I.G Prokopkin","doi":"10.1016/j.ecolmodel.2025.111201","DOIUrl":"10.1016/j.ecolmodel.2025.111201","url":null,"abstract":"<div><div>Resting egg banks are a key factor in plankton coexistence within homogeneous environments, but rapid evolutionary changes may reduce their role in stabilizing species composition. We conducted a series of model simulations to assess the sensitivity of both integrated (total population numbers and biomass) and structural (proportions of different age and sex classes) population characteristics to the life history traits of planktonic cladocerans. We examined the outcomes of direct (within a growing season) and seasonal (across growing seasons) competition between two cladoceran populations, where resting egg production was regulated by density-dependent infochemicals. Results showed that variations in life history traits, such as maximum lifespan and juvenile growth rate, significantly affected competition outcomes. When resting eggs were produced in response to non-specific infochemicals, extinction events were delayed. In contrast, conspecific infochemicals enabled long-term coexistence across a range of trait variations. These findings have broad ecological significance, highlighting how density-dependent mechanisms and life history traits interact to shape species coexistence in dynamic environments. The study underscores the importance of adaptive strategies, like resting egg production, in maintaining biodiversity and population resilience. This knowledge is crucial for understanding species responses to environmental changes. By elucidating the role of infochemicals and trait variability, the research contributes to ecological theory on competition, adaptation, and coexistence.</div></div>","PeriodicalId":51043,"journal":{"name":"Ecological Modelling","volume":"508 ","pages":"Article 111201"},"PeriodicalIF":2.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual growth of green total factor productivity and greenhouse gas emission intensity of smallholder farms in China: Trends and misallocation","authors":"Xiangbo Xu ,&nbsp;Yue Xu ,&nbsp;Ziyi Zhou ,&nbsp;Mingxing Sun ,&nbsp;Yunli Bai ,&nbsp;Linxiu Zhang","doi":"10.1016/j.resconrec.2025.108421","DOIUrl":"10.1016/j.resconrec.2025.108421","url":null,"abstract":"<div><div>Improving green production efficiency while reducing greenhouse gas (GHG) emissions is essential for China’s sustainable agriculture. However, precise measurements of these two indicators at the household and crop levels and the mechanisms underlying their misallocation remain limited. Using two phases of first-hand tracked survey data from rural China (2000 households per phase) and applying the Life Cycle Assessment (LCA) method and Super-SBM model, we reveal that between 2018 and 2022, GHG emission intensity (GEI) and green total factor productivity (GTFP) increased by 12.2 % and 7.7 %, respectively. The rise in GEI was primarily driven by increased fertilizer use, while the improvement in GTFP was driven by yield-enhancing effects from higher input levels. Production factor misallocation was evident, particularly in land, capital, and other inputs, whereas labor misallocation was minimal. Achieving simultaneous reductions in GEI and improvements in GTFP require adjustments in crop planting structure and the level of production factor inputs.</div></div>","PeriodicalId":21153,"journal":{"name":"Resources Conservation and Recycling","volume":"222 ","pages":"Article 108421"},"PeriodicalIF":11.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}