Die Ophthalmologie最新文献

{"title":"[When two are better than one-Epikeratophakia].","authors":"Elias Flockerzi, Tim Berger, Yaser Abu Dail, Berthold Seitz","doi":"10.1007/s00347-025-02304-9","DOIUrl":"10.1007/s00347-025-02304-9","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"764"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progression assessment for geographic atrophy].","authors":"Anna Sophia Jauch, Marlene Saßmannshausen, Petrus Chang, Leon von der Emde, Maximilian Pfau, Frank G Holz, Thomas Ach","doi":"10.1007/s00347-025-02318-3","DOIUrl":"10.1007/s00347-025-02318-3","url":null,"abstract":"<p><p>In addition to the development of macular neovascularization (MNV), geographic atrophy (GA) is one of the late stages of age-related macular degeneration (AMD) and can lead to irreversible severe visual impairment. Standardized and precise quantification of GA areas, based primarily on fundus autofluorescence and optical coherence tomography (OCT) imaging, is important for progression monitoring. Various factors such as foveal involvement, lesion location, focality of GA and perilesional autofluorescence patterns play an important role in the assessment of GA progression. Automated analytical techniques based on artificial intelligence (AI) are emerging in the detection, assessment, quantification and prediction of disease progression. As there is currently no causal therapy for GA, measuring progression in GA is becoming increasingly more important in order to monitor current treatment options with complement inhibitors and to test in studies novel therapeutic approaches to slow down the course of the disease. A progression analysis based on structural and functional degeneration parameters could optimize the counselling of patients, treatment decisions and patient monitoring in the future.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"773-781"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Assessment of chronic degenerative eye disease progression].","authors":"Christian van Oterendorp, Claudia Lommatzsch","doi":"10.1007/s00347-025-02320-9","DOIUrl":"https://doi.org/10.1007/s00347-025-02320-9","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":"122 10","pages":"765-766"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Letrozole-induced central serous chorioretinopathy].","authors":"Vesna Bosic, Berthold Seitz, Alaa Din Abdin","doi":"10.1007/s00347-025-02248-0","DOIUrl":"10.1007/s00347-025-02248-0","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"838-842"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Anterior chamber migration of an Ozurdex implant with Carlevale intraocular lens].","authors":"Anton Sonntag, Daniel Röck, Karl Ulrich Bartz-Schmidt, Tobias Röck","doi":"10.1007/s00347-025-02247-1","DOIUrl":"10.1007/s00347-025-02247-1","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"843-846"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Intralental foreign body].","authors":"Julian Bucur, Silvia Theresa Schaffner, Michael Müller, Thomas Kohnen","doi":"10.1007/s00347-025-02284-w","DOIUrl":"10.1007/s00347-025-02284-w","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"763"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Excimer laser-assisted keratoplasty is successful in the management of complex cases of intracorneal ring segments in keratoconus].","authors":"P Teping, L Hamon, B Seitz, L Daas","doi":"10.1007/s00347-025-02309-4","DOIUrl":"10.1007/s00347-025-02309-4","url":null,"abstract":"<p><strong>Introduction: </strong>Analysis of visual acuity, keratometry and aberrometry (coma) after intrastromal corneal ring segment (ICRS) implantation in keratoconus (KC) and the evolution of visual acuity after subsequent excimer laser-assisted penetrating keratoplasty (PKP).</p><p><strong>Patients and methods: </strong>Retrospective analysis of a case series of 7 patients from the Homburg Keratoconus Center (HKC), who received excimer laser PKP for unsatisfactory visual acuity 3.2 ± 3.0 years after ICRS implantation. Uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA) in logMAR, flat (K1), steep (K2) and mean keratometry, (Kmean), higher order aberrations (HOA, coma) and regularity of astigmatism were analyzed via tomography. Data of the PKP group (PG) were compared to a control group (CG) of 7 age-adapted satisfied patients after ICRS implantation without the need of PKP. Data analysis was performed before and 7.4 ± 4.5 months after PKP.</p><p><strong>Results: </strong>Prior to PKP, data analysis showed a significantly lower UCVA of 0.94 ± 0.54 and BCVA of 0.49 ± 0.07 in the PG compared to the CG (UCVA 0.40 ± 0.35; CDVA 0.06 ± 0.05, p < 0.01). The K1 was significantly higher in the PG prior to PKP compared to the CG (47.1 ± 3.1 vs. 43.0 ± 2.7 D, p = 0.02) but K2 (p = 0.86) and Kmean (p = 0.12) were not. Regularity of peripheral (p = 0.54) and central (p = 0.69) astigmatism as well as coma (p = 0.39) did not show significant differences between the PG and KG prior to PKP. Excimer laser-assisted PKP was possible without any obstacles in all 7 eyes. In addition, BCVA increased significantly from 0.49 ± 0.07 to 0.33 ± 0.1 (p < 0.001) 6 months after PKP. The K1 decreased significantly after PKP (p = 0.002).</p><p><strong>Conclusion: </strong>After unsuccessful ICRS implantation, patients seem to present with lower visual acuity and higher K1 despite similar values for K2, Kmean and coma. These patients may profit from an excimer laser assisted PKP, which can be performed without any obstacles despite the ICRS in place.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"819-825"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progression assessment of glaucoma].","authors":"Christian van Oterendorp, Claudia Lommatzsch","doi":"10.1007/s00347-025-02302-x","DOIUrl":"10.1007/s00347-025-02302-x","url":null,"abstract":"<p><p>Progression monitoring is essential for glaucoma management. In addition to perimetry, optical coherence tomography (OCT) has become established as a valuable supplement. It provides morphological information on the retinal nerve fiber layer (RNFL), the neuroretinal rim and the density of retinal ganglion cells in the macula. Event-based and trend-based analyses can be used for the quantitative analysis of glaucoma progression. Various biomarkers have stage-dependent strengths and weaknesses and should be complementarily applied. The minimization of measurement errors is important for valid progression analyses. In the future other techniques and artificial intelligence (AI) could improve the progression analysis.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"795-802"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Keratoconus progression assessment].","authors":"Elias Flockerzi, Berthold Seitz, Stefan Johann Lang","doi":"10.1007/s00347-025-02313-8","DOIUrl":"10.1007/s00347-025-02313-8","url":null,"abstract":"<p><p>Keratectasias including keratoconus are pathological curvature anomalies of the human cornea, which can progress and lead to permanent visual impairment. Corneal crosslinking can be used to stabilize the disease. Criteria for performing crosslinking have been defined by legislation in Germany, including an increase of the maximum anterior surface curvature Kmax by ≥ 1 diopter within 12 months. Unfortunately, there is still a lack of generally applicable standards for assessment of keratectasia progression. This overview presents the possibilities of topographic, tomographic and biomechanical assessment of progression in keratoconus.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"782-788"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Drug safety and mandatory reporting].","authors":"Christian Behles, Robert Hoffmann, Dennis Lex","doi":"10.1007/s00347-025-02330-7","DOIUrl":"10.1007/s00347-025-02330-7","url":null,"abstract":"<p><p>The spontaneous reporting system for cases of suspected side effects is a central instrument for detecting possible side effects after a pharmaceutical preparation has received marketing authorization. It provides important information (signals) on the occurrence of rare, previously unknown side effects, on increases in the frequency of known side effects that may also be due to quality defects, or on changes in the type or severity of known side effects. In recent decades, this system has made a significant contribution to the identification of drug-related risks that only arise upon widespread use following approval and to the introduction of appropriate measures to minimize risk.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"856-868"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}