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[Symptomatic Rathke's cyst of the pituitary gland-When the eye uncovers the invisible]. [有症状的Rathke脑垂体囊肿-当眼睛发现了看不见的东西]。
Die Ophthalmologie Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.1007/s00347-025-02182-1
A Struppe, Alaadin Abdin, Berthold Seitz, Loïc Hamon
{"title":"[Symptomatic Rathke's cyst of the pituitary gland-When the eye uncovers the invisible].","authors":"A Struppe, Alaadin Abdin, Berthold Seitz, Loïc Hamon","doi":"10.1007/s00347-025-02182-1","DOIUrl":"10.1007/s00347-025-02182-1","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"304-307"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitteilungen der DOG. 狗的信息。
Die Ophthalmologie Pub Date : 2025-04-01 DOI: 10.1007/s00347-025-02229-3
{"title":"Mitteilungen der DOG.","authors":"","doi":"10.1007/s00347-025-02229-3","DOIUrl":"https://doi.org/10.1007/s00347-025-02229-3","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":"122 4","pages":"334-336"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[EyeMatics-Multicenter data evaluation of real-world data with interoperable medical informatics]. [EyeMatics--利用可互操作的医疗信息学对真实世界数据进行多中心数据评估]。
Die Ophthalmologie Pub Date : 2025-04-01 Epub Date: 2024-11-14 DOI: 10.1007/s00347-024-02135-0
Lea Holtrup, Julian Varghese, Alexander K Schuster, Broder Poschkamp, Christopher Hampf, Dagmar Waltemath, Leonie Wahle, Myriam Lipprandt, David A Merle, Philipp Berens, Oliver Kohlbacher, Vinodh Kakkassery, Martin Bartos, Focke Ziemssen, Thomas Wendt, Katja Hoffmann, Nicole Eter
{"title":"[EyeMatics-Multicenter data evaluation of real-world data with interoperable medical informatics].","authors":"Lea Holtrup, Julian Varghese, Alexander K Schuster, Broder Poschkamp, Christopher Hampf, Dagmar Waltemath, Leonie Wahle, Myriam Lipprandt, David A Merle, Philipp Berens, Oliver Kohlbacher, Vinodh Kakkassery, Martin Bartos, Focke Ziemssen, Thomas Wendt, Katja Hoffmann, Nicole Eter","doi":"10.1007/s00347-024-02135-0","DOIUrl":"10.1007/s00347-024-02135-0","url":null,"abstract":"<p><p>The evaluation of real-world data (RWD) enables insights to be gained from a wide range of patient data collected in routine clinical practice. In addition, multicenter analyses represent a broad and representative patient population and have the potential to capture the actual treatment situation. As a basis for this, the definition of datasets and an infrastructure for data exchange is necessary. Data integration centers (DIC) have already been established at (university) hospitals throughout Germany in order to extract RWD for scientific analyses from the various source systems and integrate them into research-compatible data infrastructures. The project described here aims to demonstrate the added value of this data integration using a case of application in ophthalmology, defining a core dataset as an ophthalmology extension module and establishing a cross-site data exchange infrastructure. As a first step, the treatment success of eye diseases treated with intravitreal injection (IVI) should be improved. To achieve this goal a dashboard for clinical data is provided that clearly visualizes the merged data. Furthermore, algorithms will be developed to identify new imaging biomarkers that can be used for treatment monitoring and predict treatment outcomes.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"270-277"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Secondary calcification of a multifocal additive intraocular lens]. [多焦人工晶状体继发性钙化]。
Die Ophthalmologie Pub Date : 2025-04-01 Epub Date: 2025-02-24 DOI: 10.1007/s00347-025-02203-z
Lars H B Mackenbrock, Timur M Yildirim, Gerd U Auffarth, Ramin Khoramnia
{"title":"[Secondary calcification of a multifocal additive intraocular lens].","authors":"Lars H B Mackenbrock, Timur M Yildirim, Gerd U Auffarth, Ramin Khoramnia","doi":"10.1007/s00347-025-02203-z","DOIUrl":"10.1007/s00347-025-02203-z","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"257"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Artificial intelligence in medicine-Opportunities and risks from an ethical perspective]. [医学中的人工智能——从伦理角度看的机遇和风险]。
Die Ophthalmologie Pub Date : 2025-04-01 Epub Date: 2025-04-02 DOI: 10.1007/s00347-025-02224-8
Saskia Metan, Florian Bruns
{"title":"[Artificial intelligence in medicine-Opportunities and risks from an ethical perspective].","authors":"Saskia Metan, Florian Bruns","doi":"10.1007/s00347-025-02224-8","DOIUrl":"10.1007/s00347-025-02224-8","url":null,"abstract":"<p><p>Imaging disciplines, such as ophthalmology, offer a wide range of opportunities for the beneficial use of artificial intelligence (AI). The analysis of images and data by trained algorithms has the potential to facilitate making the diagnosis and patient care and not just in ophthalmology. If AI brings about advances in clinical practice that benefit patients, this is ethically to be welcomed; however, respect for the self-determination of patients and data security must be guaranteed. Traceability and explainability of the algorithms would strengthen trust in automated decision-making and enable ultimate medical responsibility. It should be noted that algorithms are only as good and unbiased as the data used to train them. If the use of AI is likely to lead to a loss of skills on the part of doctors (deskilling), this must be counteracted, for example through improved training. Accompanying medical ethics research is necessary to identify those aspects of the use of AI that require regulation. In principle, care must be taken to ensure that AI serves people and adapts to their needs, not the other way round.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"278-285"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[MiHUBx: a digital progress hub for the use of intersectoral clinical data sets using the example of diabetic macular edema]. [MiHUBx：以糖尿病性黄斑水肿为例，使用跨部门临床数据集的数字进展中心]。
Die Ophthalmologie Pub Date : 2025-04-01 Epub Date: 2024-12-18 DOI: 10.1007/s00347-024-02146-x
Gabriel Stolze, Vinodh Kakkassery, Danny Kowerko, Martin Bartos, Katja Hoffmann, Martin Sedlmayr, Katrin Engelmann
{"title":"[MiHUBx: a digital progress hub for the use of intersectoral clinical data sets using the example of diabetic macular edema].","authors":"Gabriel Stolze, Vinodh Kakkassery, Danny Kowerko, Martin Bartos, Katja Hoffmann, Martin Sedlmayr, Katrin Engelmann","doi":"10.1007/s00347-024-02146-x","DOIUrl":"10.1007/s00347-024-02146-x","url":null,"abstract":"<p><strong>Background: </strong>Evidence-based treatment recommendations are helpful in the corresponding discipline-specific treatment but can hardly take data from real-world care into account. In order to make better use of this in everyday clinical practice, including with respect to predictive statements about disease development or treatment success, models with data from treatment must be developed in order to use them for the development of assistive artificial intelligence.</p><p><strong>Goal: </strong>The aim of the Use Case 1 of the medical informatics hub in Saxony (MiHUBx) is the development of a model based on treatment and research data for a treatment algorithm supported by biomarkers and also the development of the necessary digital infrastructure.</p><p><strong>Material and methods: </strong>Step by step, the necessary partners in hospitals and practices will be brought together technically or through research questions within Use Case 1 \"Ophthalmology meets Diabetology\", a regional digital progress hub in health, the medical informatics hub in Saxony (MiHUBx ) of the nationwide medical informatics initiative (MII).</p><p><strong>Results: </strong>Based on joint studies with diabetologists, robust serological and imaging biomarkers were selected that provide evidence of the development of diabetic macular edema (DME). In the future, these and other scientifically proven prognostic markers will be incorporated into a treatment algorithm that is supported by artificial intelligence (AI). For this purpose, model procedures are being developed together with medical informatics specialists. At the same time, a data integration center (DIZ) was established.</p><p><strong>Conclusion: </strong>In addition to the structured and technical combination of the previously disseminated and partially heterogeneous treatment data, the Use Case 1 defines the chances and hurdles for using such real-world data to develop artificial intelligence.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"262-269"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Uveal effusion syndrome due to immune-mediated reaction to pembrolizumab]. [派姆单抗免疫介导反应引起的葡萄膜积液综合征]。
Die Ophthalmologie Pub Date : 2025-04-01 DOI: 10.1007/s00347-025-02215-9
V Schöneberger, J Schätzel, L Kinzel, F Schaub, T A Fuchsluger, C Brockmann
{"title":"[Uveal effusion syndrome due to immune-mediated reaction to pembrolizumab].","authors":"V Schöneberger, J Schätzel, L Kinzel, F Schaub, T A Fuchsluger, C Brockmann","doi":"10.1007/s00347-025-02215-9","DOIUrl":"https://doi.org/10.1007/s00347-025-02215-9","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ocular graft versus host disease]. 眼移植物抗宿主病。
Die Ophthalmologie Pub Date : 2025-04-01 Epub Date: 2025-03-31 DOI: 10.1007/s00347-025-02212-y
Philipp Steven, Tina Dietrich-Ntoukas
{"title":"[Ocular graft versus host disease].","authors":"Philipp Steven, Tina Dietrich-Ntoukas","doi":"10.1007/s00347-025-02212-y","DOIUrl":"10.1007/s00347-025-02212-y","url":null,"abstract":"<p><p>Ocular graft versus host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) is predominantly an inflammatory and destructive ocular surface disease with increasing incidence. It not only leads to a reduced quality-of-life but can also impair vision and in severe cases lead to blindness. The occurrence of GVHD can lead to a severe, often refractory disorders of the ocular surface, which is associated with chronic inflammation. The occurrence of corneal involvement is a major problem. The establishment of comprehensive care structures and individually adapted stage-appropriate treatment in interdisciplinary collaboration with colleagues in hemato-oncology is therefore of particular importance.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"321-333"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Traumatic lamellar macular hole and epiretinal gliosis after cosmetic laser iridoplasty]. [激光虹膜成形术后外伤性板层黄斑裂孔和视网膜上胶质瘤]。
Die Ophthalmologie Pub Date : 2025-04-01 Epub Date: 2025-01-28 DOI: 10.1007/s00347-025-02184-z
Konstantin Wisdorf, Hevi Hami, Randolf A Widder, Gernot F Rössler, David Kiessling
{"title":"[Traumatic lamellar macular hole and epiretinal gliosis after cosmetic laser iridoplasty].","authors":"Konstantin Wisdorf, Hevi Hami, Randolf A Widder, Gernot F Rössler, David Kiessling","doi":"10.1007/s00347-025-02184-z","DOIUrl":"10.1007/s00347-025-02184-z","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"308-311"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Complaints and complications after intravitreal injection (IVI) and potential risk factors]. [玻璃体内注射（IVI）后的主诉、并发症及潜在危险因素]。
Die Ophthalmologie Pub Date : 2025-03-31 DOI: 10.1007/s00347-025-02222-w
Lisa Prange, Daniel Böhringer, Thomas Reinhard, Hansjürgen Agostini, Felicitas Bucher
{"title":"[Complaints and complications after intravitreal injection (IVI) and potential risk factors].","authors":"Lisa Prange, Daniel Böhringer, Thomas Reinhard, Hansjürgen Agostini, Felicitas Bucher","doi":"10.1007/s00347-025-02222-w","DOIUrl":"https://doi.org/10.1007/s00347-025-02222-w","url":null,"abstract":"<p><strong>Background: </strong>Intravitreal injections (IVI) are the most commonly used procedure worldwide in the treatment of retinal vascular diseases.</p><p><strong>Objective: </strong>This study investigates the endophthalmitis rate, the frequency of subjective complaints and potential risk factors associated with IVI.</p><p><strong>Material and methods: </strong>In the first part of this monocentric study the number of cases of endophthalmitis and potential risk factors were analyzed based on routine hospital documentation of 123,373 IVI procedures from 2013 to 2022. In the second part, subjective complaints and potential risk factors following IVI were investigated through a survey involving 584 patients.</p><p><strong>Results: </strong>From 2013 to 2022 a total of 27 cases of endophthalmitis occurred following IVI (0.02%). The analysis of potential risk factors (age, gender, disinfection method, number of prior injections, day of the week, year, bilateral injection) revealed that none of these factors were associated with an increased risk of endophthalmitis. The initial identification of bilateral injection as a risk factor was disproven through further analysis and classified as a statistical artifact. More than 10% of patients reported complaints the day after the injection, such as foreign body sensation (18%), seeing air bubbles (17%), itching (12%) and reddening of the eyes (11%). Subconjunctival hemorrhage (4%) or severe pain the day after the injection (2%) occurred less frequently. Male patients reported severe pain the day after less often (odds ratio 0.18, 95% confidence interval 0.03-0.72). Nearly 2% of patients sought unplanned ophthalmologist visits or considered treatment discontinuation due to the complaints.</p><p><strong>Conclusion: </strong>Subjective complaints are more prevalent than severe complications and can jeopardize treatment adherence. Therefore, providing information about expected discomfort is advisable.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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